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Protein

Alpha-S2-casein

Gene

CSN1S2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Important role in the capacity of milk to transport calcium phosphate.
Casocidin-I inhibits the growth of E.coli and S.carnosus.

GO - Molecular functioni

  • protein homodimerization activity Source: AgBase
  • zymogen binding Source: AgBase

GO - Biological processi

  • defense response to bacterium Source: UniProtKB-KW
  • response to 11-deoxycorticosterone Source: AgBase
  • response to dehydroepiandrosterone Source: AgBase
  • response to estradiol Source: AgBase
  • response to growth hormone Source: AgBase
  • response to progesterone Source: AgBase

Keywordsi

Molecular functionAntibiotic, Antimicrobial, Milk protein

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-S2-casein
Cleaved into the following chain:
Alternative name(s):
Casocidin-I
Gene namesi
Name:CSN1S2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Protein family/group databases

Allergomei10198 Bos d 10.0101
167 Bos d 8
2735 Bos d 10

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 151 PublicationAdd BLAST15
ChainiPRO_000000446016 – 222Alpha-S2-caseinAdd BLAST207
PeptideiPRO_0000004461165 – 203Casocidin-1Add BLAST39

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei23Phosphoserine1 Publication1
Modified residuei24Phosphoserine1 Publication1
Modified residuei25Phosphoserine1 Publication1
Modified residuei28Phosphoserine1 Publication1
Modified residuei46Phosphoserine1 Publication1
Modified residuei71Phosphoserine1 Publication1
Modified residuei72Phosphoserine1 Publication1
Modified residuei73Phosphoserine1 Publication1
Modified residuei76Phosphoserine1 Publication1
Modified residuei144PhosphoserineBy similarity1
Modified residuei146PhosphoserineBy similarity1
Modified residuei150PhosphoserineBy similarity1
Modified residuei158Phosphoserine2 Publications1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP02663
PeptideAtlasiP02663
PRIDEiP02663

PTM databases

CarbonylDBiP02663
iPTMnetiP02663

Miscellaneous databases

PMAP-CutDBiP02663

Expressioni

Tissue specificityi

Mammary gland specific. Secreted in milk.

Interactioni

GO - Molecular functioni

  • protein homodimerization activity Source: AgBase
  • zymogen binding Source: AgBase

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000006590

Structurei

3D structure databases

ProteinModelPortaliP02663
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati76 – 140Add BLAST65
Repeati158 – 222Add BLAST65

Sequence similaritiesi

Belongs to the alpha-casein family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410JE87 Eukaryota
ENOG4111369 LUCA
GeneTreeiENSGT00530000065240
HOGENOMiHOG000111307
HOVERGENiHBG005244
InParanoidiP02663
OMAiVMNPWDQ
OrthoDBiEOG091G0QMQ
TreeFamiTF339561

Family and domain databases

InterProiView protein in InterPro
IPR011175 Alpha-s2_casein
IPR001588 Casein
IPR031305 Casein_CS
PANTHERiPTHR16656 PTHR16656, 1 hit
PfamiView protein in Pfam
PF00363 Casein, 2 hits
PIRSFiPIRSF002371 Alpha-s2-casein, 1 hit
PROSITEiView protein in PROSITE
PS00306 CASEIN_ALPHA_BETA, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02663-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFFIFTCLL AVALAKNTME HVSSSEESII SQETYKQEKN MAINPSKENL
60 70 80 90 100
CSTFCKEVVR NANEEEYSIG SSSEESAEVA TEEVKITVDD KHYQKALNEI
110 120 130 140 150
NQFYQKFPQY LQYLYQGPIV LNPWDQVKRN AVPITPTLNR EQLSTSEENS
160 170 180 190 200
KKTVDMESTE VFTKKTKLTE EEKNRLNFLK KISQRYQKFA LPQYLKTVYQ
210 220
HQKAMKPWIQ PKTKVIPYVR YL
Length:222
Mass (Da):26,019
Last modified:July 1, 1989 - v2
Checksum:i81E7408AF1C12F7C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti42A → D in AAI14774 (Ref. 2) Curated1
Sequence conflicti102Q → E AA sequence (PubMed:862906).Curated1
Sequence conflicti105Q → R in AAI14774 (Ref. 2) Curated1

Mass spectrometryi

Molecular mass is 4870 Da from positions 165 - 203. Determined by ESI. 1 Publication

Polymorphismi

At least two alleles exist. The sequence of the A allele is shown here. The D allele sequence differs from that shown in having a deletion of nine residues, which may be 49-58, 50-59, or 51-60.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M16644 mRNA Translation: AAA30479.1
BC114773 mRNA Translation: AAI14774.1
PIRiJQ2008 KABOS2
RefSeqiNP_776953.1, NM_174528.2
UniGeneiBt.57616

Genome annotation databases

EnsembliENSBTAT00000006590; ENSBTAP00000006590; ENSBTAG00000005005
GeneIDi282209
KEGGibta:282209

Similar proteinsi

Entry informationi

Entry nameiCASA2_BOVIN
AccessioniPrimary (citable) accession number: P02663
Secondary accession number(s): Q1RMQ6, Q9TR51
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 1, 1989
Last modified: February 28, 2018
This is version 135 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  2. SIMILARITY comments
    Index of protein domains and families

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