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UniProtKB - P02662 (CASA1_BOVIN)
Protein
Alpha-S1-casein
Gene
CSN1S1
Organism
Bos taurus (Bovine)
Status
Functioni
Important role in the capacity of milk to transport calcium phosphate.
1 PublicationAntioxidant peptide has 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity.
1 PublicationMiscellaneous
The B variant sequence is shown.
GO - Molecular functioni
- amyloid-beta binding Source: CAFA
- antioxidant activity Source: UniProtKB-KW
GO - Biological processi
- negative regulation of apoptotic process Source: AgBase
- negative regulation of gene expression Source: WormBase
- negative regulation of supramolecular fiber organization Source: CAFA
- positive regulation of androst-4-ene-3,17-dione biosynthetic process Source: AgBase
- positive regulation of androstenedione secretion Source: AgBase
- positive regulation of progesterone biosynthetic process Source: AgBase
- positive regulation of progesterone secretion Source: AgBase
- protein stabilization Source: CAFA
- response to 11-deoxycorticosterone Source: AgBase
- response to dehydroepiandrosterone Source: AgBase
- response to estradiol Source: AgBase
- response to growth hormone Source: AgBase
- response to progesterone Source: AgBase
Keywordsi
Molecular function | Antioxidant, Milk protein |
Names & Taxonomyi
Protein namesi | Recommended name: Alpha-S1-caseinAlternative name(s): Allergen: Bos d 8 Cleaved into the following chain: |
Gene namesi | Name:CSN1S1 |
Organismi | Bos taurus (Bovine) |
Taxonomic identifieri | 9913 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Proteomesi |
|
Organism-specific databases
VEuPathDBi | HostDB:ENSBTAG00000007695 |
VGNCi | VGNC:27763, CSN1S1 |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular space Source: AgBase
Golgi apparatus
- Golgi apparatus Source: AgBase
- Golgi lumen Source: AgBase
Keywords - Cellular componenti
SecretedPathology & Biotechi
Allergenic propertiesi
Causes an allergic reaction in human. Has six major and 3 minor IgE-binding regions and 5 major and 1 minor IgG-binding regions. Is a cause of cow's milk allergy (CMA).2 Publications
Keywords - Diseasei
AllergenProtein family/group databases
Allergomei | 10197, Bos d 9.0101 167, Bos d 8 2734, Bos d 9 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 15 | 2 PublicationsAdd BLAST | 15 | |
ChainiPRO_0000004446 | 16 – 214 | Alpha-S1-caseinAdd BLAST | 199 | |
PeptideiPRO_0000331578 | 95 – 105 | Antioxidant peptideAdd BLAST | 11 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 56 | Phosphoserine2 Publications | 1 | |
Modified residuei | 61 | Phosphoserine1 Publication | 1 | |
Modified residuei | 63 | Phosphoserine1 Publication | 1 | |
Modified residuei | 79 | Phosphoserine1 Publication | 1 | |
Modified residuei | 81 | Phosphoserine1 Publication | 1 | |
Modified residuei | 82 | Phosphoserine1 Publication | 1 | |
Modified residuei | 83 | Phosphoserine1 Publication | 1 | |
Modified residuei | 90 | Phosphoserine1 Publication | 1 | |
Modified residuei | 130 | Phosphoserine1 Publication | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | P02662 |
PeptideAtlasi | P02662 |
PRIDEi | P02662 |
PTM databases
CarbonylDBi | P02662 |
iPTMneti | P02662 |
Expressioni
Tissue specificityi
Mammary gland specific. Secreted in milk.
Gene expression databases
Bgeei | ENSBTAG00000007695, Expressed in milk and 34 other tissues |
ExpressionAtlasi | P02662, baseline |
Interactioni
Protein-protein interaction databases
BioGRIDi | 159482, 3 interactors |
DIPi | DIP-29917N |
IntActi | P02662, 3 interactors |
MINTi | P02662 |
STRINGi | 9913.ENSBTAP00000010119 |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 85 – 99 | Add BLAST | 15 | |
Repeati | 125 – 140 | Add BLAST | 16 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 195 – 214 | DisorderedSequence analysisAdd BLAST | 20 |
Sequence similaritiesi
Belongs to the alpha-casein family.Curated
Keywords - Domaini
Repeat, SignalPhylogenomic databases
eggNOGi | ENOG502TEWT, Eukaryota |
GeneTreei | ENSGT00390000017378 |
HOGENOMi | CLU_126070_0_0_1 |
InParanoidi | P02662 |
OMAi | WYYPPQV |
OrthoDBi | 1478191at2759 |
TreeFami | TF340763 |
Family and domain databases
InterProi | View protein in InterPro IPR026999, Alpha-s1_casein IPR001588, Casein IPR031305, Casein_CS |
PANTHERi | PTHR10240, PTHR10240, 1 hit |
Pfami | View protein in Pfam PF00363, Casein, 1 hit |
PROSITEi | View protein in PROSITE PS00306, CASEIN_ALPHA_BETA, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
P02662-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKLLILTCLV AVALARPKHP IKHQGLPQEV LNENLLRFFV APFPEVFGKE
60 70 80 90 100
KVNELSKDIG SESTEDQAME DIKQMEAESI SSSEEIVPNS VEQKHIQKED
110 120 130 140 150
VPSERYLGYL EQLLRLKKYK VPQLEIVPNS AEERLHSMKE GIHAQQKEPM
160 170 180 190 200
IGVNQELAYF YPELFRQFYQ LDAYPSGAWY YVPLGTQYTD APSFSDIPNP
210
IGSENSEKTT MPLW
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A3Q1MJE5 | A0A3Q1MJE5_BOVIN | Alpha-S1-casein | CSN1S1 | 200 | Annotation score: | ||
A0A3Q1NG86 | A0A3Q1NG86_BOVIN | Alpha-S1-casein | CSN1S1 | 206 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 11 – 12 | AV → SA in ABW98943 (PubMed:19454699).Curated | 2 | |
Sequence conflicti | 42 | P → L in AAA30429 (PubMed:3022833).Curated | 1 | |
Sequence conflicti | 44 | P → S in ABW98945 (PubMed:19454699).Curated | 1 | |
Sequence conflicti | 95 | H → Q in AAA30478 (PubMed:6897774).Curated | 1 | |
Sequence conflicti | 99 | E → D in ABQ88318 (Ref. 14) Curated | 1 | |
Sequence conflicti | 143 | H → D in AAA30429 (PubMed:3022833).Curated | 1 | |
Sequence conflicti | 171 | L → P in ABW98953 (PubMed:19454699).Curated | 1 | |
Sequence conflicti | 203 | S → L in AAA62707 (PubMed:3838718).Curated | 1 | |
Sequence conflicti | 211 – 212 | MP → IS in AAA30429 (PubMed:3022833).Curated | 2 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural varianti | 29 – 41 | Missing in variant A. Add BLAST | 13 | |
Natural varianti | 68 | A → T in variant D. | 1 | |
Natural varianti | 207 | E → G in variant C. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X00564 mRNA Translation: CAB57792.1 M33123 mRNA Translation: AAA30428.1 M38641 mRNA Translation: AAA30429.1 X59856 Genomic DNA Translation: CAA42516.1 EU221551 Genomic DNA Translation: ABW98936.1 EU221552 Genomic DNA Translation: ABW98937.1 EU221553 Genomic DNA Translation: ABW98938.1 EU221554 Genomic DNA Translation: ABW98939.1 EU221555 Genomic DNA Translation: ABW98940.1 EU221556 Genomic DNA Translation: ABW98941.1 EU221557 Genomic DNA Translation: ABW98942.1 EU221558 Genomic DNA Translation: ABW98943.1 EU221559 Genomic DNA Translation: ABW98944.1 EU221560 Genomic DNA Translation: ABW98945.1 EU221561 Genomic DNA Translation: ABW98946.1 EU221562 Genomic DNA Translation: ABW98947.1 EU221563 Genomic DNA Translation: ABW98948.1 EU221564 Genomic DNA Translation: ABW98949.1 EU221565 Genomic DNA Translation: ABW98950.1 EU221566 Genomic DNA Translation: ABW98951.1 EU221567 Genomic DNA Translation: ABW98952.1 EU221568 Genomic DNA Translation: ABW98953.1 EU221569 Genomic DNA Translation: ABW98954.1 EU221570 Genomic DNA Translation: ABW98955.1 EU221571 Genomic DNA Translation: ABW98956.1 EU221572 Genomic DNA Translation: ABW98957.1 EU221573 Genomic DNA Translation: ABW98958.1 EU221574 Genomic DNA Translation: ABW98959.1 EU221575 Genomic DNA Translation: ABW98960.1 EU221576 Genomic DNA Translation: ABW98961.1 EU221577 Genomic DNA Translation: ABW98962.1 EU221578 Genomic DNA Translation: ABW98963.1 EU221579 Genomic DNA Translation: ABW98964.1 EU221580 Genomic DNA Translation: ABW98965.1 EU221581 Genomic DNA Translation: ABW98966.1 BC109618 mRNA Translation: AAI09619.1 K01084 mRNA Translation: AAA30478.1 EF538766 Genomic DNA Translation: ABQ88318.1 M38658 mRNA Translation: AAA62707.1 AH007360 Genomic DNA Translation: AAD14099.1 D00412 mRNA Translation: BAA00313.1 |
PIRi | S22575, KABOSB S72220 |
RefSeqi | NP_851372.1, NM_181029.2 |
Genome annotation databases
Ensembli | ENSBTAT00000010119; ENSBTAP00000010119; ENSBTAG00000007695 ENSBTAT00000084279; ENSBTAP00000071217; ENSBTAG00000007695 |
GeneIDi | 282208 |
KEGGi | bta:282208 |
Similar proteinsi
Cross-referencesi
Web resourcesi
Worthington enzyme manual |
Protein Spotlight Of buttons, digestion and glue - Issue 16 of November 2001 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X00564 mRNA Translation: CAB57792.1 M33123 mRNA Translation: AAA30428.1 M38641 mRNA Translation: AAA30429.1 X59856 Genomic DNA Translation: CAA42516.1 EU221551 Genomic DNA Translation: ABW98936.1 EU221552 Genomic DNA Translation: ABW98937.1 EU221553 Genomic DNA Translation: ABW98938.1 EU221554 Genomic DNA Translation: ABW98939.1 EU221555 Genomic DNA Translation: ABW98940.1 EU221556 Genomic DNA Translation: ABW98941.1 EU221557 Genomic DNA Translation: ABW98942.1 EU221558 Genomic DNA Translation: ABW98943.1 EU221559 Genomic DNA Translation: ABW98944.1 EU221560 Genomic DNA Translation: ABW98945.1 EU221561 Genomic DNA Translation: ABW98946.1 EU221562 Genomic DNA Translation: ABW98947.1 EU221563 Genomic DNA Translation: ABW98948.1 EU221564 Genomic DNA Translation: ABW98949.1 EU221565 Genomic DNA Translation: ABW98950.1 EU221566 Genomic DNA Translation: ABW98951.1 EU221567 Genomic DNA Translation: ABW98952.1 EU221568 Genomic DNA Translation: ABW98953.1 EU221569 Genomic DNA Translation: ABW98954.1 EU221570 Genomic DNA Translation: ABW98955.1 EU221571 Genomic DNA Translation: ABW98956.1 EU221572 Genomic DNA Translation: ABW98957.1 EU221573 Genomic DNA Translation: ABW98958.1 EU221574 Genomic DNA Translation: ABW98959.1 EU221575 Genomic DNA Translation: ABW98960.1 EU221576 Genomic DNA Translation: ABW98961.1 EU221577 Genomic DNA Translation: ABW98962.1 EU221578 Genomic DNA Translation: ABW98963.1 EU221579 Genomic DNA Translation: ABW98964.1 EU221580 Genomic DNA Translation: ABW98965.1 EU221581 Genomic DNA Translation: ABW98966.1 BC109618 mRNA Translation: AAI09619.1 K01084 mRNA Translation: AAA30478.1 EF538766 Genomic DNA Translation: ABQ88318.1 M38658 mRNA Translation: AAA62707.1 AH007360 Genomic DNA Translation: AAD14099.1 D00412 mRNA Translation: BAA00313.1 |
PIRi | S22575, KABOSB S72220 |
RefSeqi | NP_851372.1, NM_181029.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 159482, 3 interactors |
DIPi | DIP-29917N |
IntActi | P02662, 3 interactors |
MINTi | P02662 |
STRINGi | 9913.ENSBTAP00000010119 |
Protein family/group databases
Allergomei | 10197, Bos d 9.0101 167, Bos d 8 2734, Bos d 9 |
PTM databases
CarbonylDBi | P02662 |
iPTMneti | P02662 |
Proteomic databases
PaxDbi | P02662 |
PeptideAtlasi | P02662 |
PRIDEi | P02662 |
Genome annotation databases
Ensembli | ENSBTAT00000010119; ENSBTAP00000010119; ENSBTAG00000007695 ENSBTAT00000084279; ENSBTAP00000071217; ENSBTAG00000007695 |
GeneIDi | 282208 |
KEGGi | bta:282208 |
Organism-specific databases
CTDi | 1446 |
VEuPathDBi | HostDB:ENSBTAG00000007695 |
VGNCi | VGNC:27763, CSN1S1 |
Phylogenomic databases
eggNOGi | ENOG502TEWT, Eukaryota |
GeneTreei | ENSGT00390000017378 |
HOGENOMi | CLU_126070_0_0_1 |
InParanoidi | P02662 |
OMAi | WYYPPQV |
OrthoDBi | 1478191at2759 |
TreeFami | TF340763 |
Miscellaneous databases
PROi | PR:P02662 |
Gene expression databases
Bgeei | ENSBTAG00000007695, Expressed in milk and 34 other tissues |
ExpressionAtlasi | P02662, baseline |
Family and domain databases
InterProi | View protein in InterPro IPR026999, Alpha-s1_casein IPR001588, Casein IPR031305, Casein_CS |
PANTHERi | PTHR10240, PTHR10240, 1 hit |
Pfami | View protein in Pfam PF00363, Casein, 1 hit |
PROSITEi | View protein in PROSITE PS00306, CASEIN_ALPHA_BETA, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CASA1_BOVIN | |
Accessioni | P02662Primary (citable) accession number: P02662 Secondary accession number(s): A5YK80 Q9TRH5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 21, 1986 |
Last sequence update: | November 1, 1990 | |
Last modified: | February 23, 2022 | |
This is version 161 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Protein Spotlight
Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries