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Protein

Alpha-S1-casein

Gene

CSN1S1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Important role in the capacity of milk to transport calcium phosphate.1 Publication
Antioxidant peptide has 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity.1 Publication

Miscellaneous

The B variant sequence is shown.

GO - Molecular functioni

  • amyloid-beta binding Source: CAFA
  • antioxidant activity Source: UniProtKB-KW

GO - Biological processi

Keywordsi

Molecular functionAntioxidant, Milk protein

Enzyme and pathway databases

ReactomeiR-BTA-5223345 Miscellaneous transport and binding events

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-S1-casein
Alternative name(s):
Allergen: Bos d 8
Cleaved into the following chain:
Gene namesi
Name:CSN1S1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 6

Organism-specific databases

VGNCiVGNC:27763 CSN1S1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human. Has six major and 3 minor IgE-binding regions and 5 major and 1 minor IgG-binding regions. Is a cause of cow's milk allergy (CMA).2 Publications

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei10197 Bos d 9.0101
167 Bos d 8
2734 Bos d 9

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 152 PublicationsAdd BLAST15
ChainiPRO_000000444616 – 214Alpha-S1-caseinAdd BLAST199
PeptideiPRO_000033157895 – 105Antioxidant peptideAdd BLAST11

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei56Phosphoserine2 Publications1
Modified residuei61Phosphoserine1 Publication1
Modified residuei63Phosphoserine1 Publication1
Modified residuei79Phosphoserine1 Publication1
Modified residuei81Phosphoserine1 Publication1
Modified residuei82Phosphoserine1 Publication1
Modified residuei83Phosphoserine1 Publication1
Modified residuei90Phosphoserine1 Publication1
Modified residuei130Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP02662
PeptideAtlasiP02662
PRIDEiP02662

PTM databases

CarbonylDBiP02662
iPTMnetiP02662

Miscellaneous databases

PMAP-CutDBiP02662

Expressioni

Tissue specificityi

Mammary gland specific. Secreted in milk.

Gene expression databases

BgeeiENSBTAG00000007695 Expressed in 1 organ(s), highest expression level in adult mammalian kidney

Interactioni

Protein-protein interaction databases

BioGridi159482, 3 interactors
DIPiDIP-29917N
IntActiP02662, 3 interactors
MINTiP02662
STRINGi9913.ENSBTAP00000010119

Structurei

3D structure databases

ProteinModelPortaliP02662
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati85 – 99Add BLAST15
Repeati125 – 140Add BLAST16

Sequence similaritiesi

Belongs to the alpha-casein family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410J2MD Eukaryota
ENOG41114JX LUCA
GeneTreeiENSGT00390000017378
HOVERGENiHBG005242
InParanoidiP02662
KOiK17281
OMAiSKCAEQF
OrthoDBiEOG091G0XI1
TreeFamiTF340763

Family and domain databases

InterProiView protein in InterPro
IPR026999 Alpha-s1_casein
IPR001588 Casein
IPR031305 Casein_CS
PANTHERiPTHR10240 PTHR10240, 1 hit
PfamiView protein in Pfam
PF00363 Casein, 1 hit
PROSITEiView protein in PROSITE
PS00306 CASEIN_ALPHA_BETA, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02662-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKLLILTCLV AVALARPKHP IKHQGLPQEV LNENLLRFFV APFPEVFGKE
60 70 80 90 100
KVNELSKDIG SESTEDQAME DIKQMEAESI SSSEEIVPNS VEQKHIQKED
110 120 130 140 150
VPSERYLGYL EQLLRLKKYK VPQLEIVPNS AEERLHSMKE GIHAQQKEPM
160 170 180 190 200
IGVNQELAYF YPELFRQFYQ LDAYPSGAWY YVPLGTQYTD APSFSDIPNP
210
IGSENSEKTT MPLW
Length:214
Mass (Da):24,529
Last modified:November 1, 1990 - v2
Checksum:iF066B5C8AE55828B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti11 – 12AV → SA in ABW98943 (PubMed:19454699).Curated2
Sequence conflicti42P → L in AAA30429 (PubMed:3022833).Curated1
Sequence conflicti44P → S in ABW98945 (PubMed:19454699).Curated1
Sequence conflicti95H → Q in AAA30478 (PubMed:6897774).Curated1
Sequence conflicti99E → D in ABQ88318 (Ref. 14) Curated1
Sequence conflicti143H → D in AAA30429 (PubMed:3022833).Curated1
Sequence conflicti171L → P in ABW98953 (PubMed:19454699).Curated1
Sequence conflicti203S → L in AAA62707 (PubMed:3838718).Curated1
Sequence conflicti211 – 212MP → IS in AAA30429 (PubMed:3022833).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti29 – 41Missing in variant A. Add BLAST13
Natural varianti68A → T in variant D. 1
Natural varianti207E → G in variant C. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X00564 mRNA Translation: CAB57792.1
M33123 mRNA Translation: AAA30428.1
M38641 mRNA Translation: AAA30429.1
X59856 Genomic DNA Translation: CAA42516.1
EU221551 Genomic DNA Translation: ABW98936.1
EU221552 Genomic DNA Translation: ABW98937.1
EU221553 Genomic DNA Translation: ABW98938.1
EU221554 Genomic DNA Translation: ABW98939.1
EU221555 Genomic DNA Translation: ABW98940.1
EU221556 Genomic DNA Translation: ABW98941.1
EU221557 Genomic DNA Translation: ABW98942.1
EU221558 Genomic DNA Translation: ABW98943.1
EU221559 Genomic DNA Translation: ABW98944.1
EU221560 Genomic DNA Translation: ABW98945.1
EU221561 Genomic DNA Translation: ABW98946.1
EU221562 Genomic DNA Translation: ABW98947.1
EU221563 Genomic DNA Translation: ABW98948.1
EU221564 Genomic DNA Translation: ABW98949.1
EU221565 Genomic DNA Translation: ABW98950.1
EU221566 Genomic DNA Translation: ABW98951.1
EU221567 Genomic DNA Translation: ABW98952.1
EU221568 Genomic DNA Translation: ABW98953.1
EU221569 Genomic DNA Translation: ABW98954.1
EU221570 Genomic DNA Translation: ABW98955.1
EU221571 Genomic DNA Translation: ABW98956.1
EU221572 Genomic DNA Translation: ABW98957.1
EU221573 Genomic DNA Translation: ABW98958.1
EU221574 Genomic DNA Translation: ABW98959.1
EU221575 Genomic DNA Translation: ABW98960.1
EU221576 Genomic DNA Translation: ABW98961.1
EU221577 Genomic DNA Translation: ABW98962.1
EU221578 Genomic DNA Translation: ABW98963.1
EU221579 Genomic DNA Translation: ABW98964.1
EU221580 Genomic DNA Translation: ABW98965.1
EU221581 Genomic DNA Translation: ABW98966.1
BC109618 mRNA Translation: AAI09619.1
K01084 mRNA Translation: AAA30478.1
EF538766 Genomic DNA Translation: ABQ88318.1
M38658 mRNA Translation: AAA62707.1
AH007360 Genomic DNA Translation: AAD14099.1
D00412 mRNA Translation: BAA00313.1
PIRiS22575 KABOSB
S72220
RefSeqiNP_851372.1, NM_181029.2
UniGeneiBt.59369

Genome annotation databases

EnsembliENSBTAT00000010119; ENSBTAP00000010119; ENSBTAG00000007695
GeneIDi282208
KEGGibta:282208

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Worthington enzyme manual
Protein Spotlight

Of buttons, digestion and glue - Issue 16 of November 2001

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X00564 mRNA Translation: CAB57792.1
M33123 mRNA Translation: AAA30428.1
M38641 mRNA Translation: AAA30429.1
X59856 Genomic DNA Translation: CAA42516.1
EU221551 Genomic DNA Translation: ABW98936.1
EU221552 Genomic DNA Translation: ABW98937.1
EU221553 Genomic DNA Translation: ABW98938.1
EU221554 Genomic DNA Translation: ABW98939.1
EU221555 Genomic DNA Translation: ABW98940.1
EU221556 Genomic DNA Translation: ABW98941.1
EU221557 Genomic DNA Translation: ABW98942.1
EU221558 Genomic DNA Translation: ABW98943.1
EU221559 Genomic DNA Translation: ABW98944.1
EU221560 Genomic DNA Translation: ABW98945.1
EU221561 Genomic DNA Translation: ABW98946.1
EU221562 Genomic DNA Translation: ABW98947.1
EU221563 Genomic DNA Translation: ABW98948.1
EU221564 Genomic DNA Translation: ABW98949.1
EU221565 Genomic DNA Translation: ABW98950.1
EU221566 Genomic DNA Translation: ABW98951.1
EU221567 Genomic DNA Translation: ABW98952.1
EU221568 Genomic DNA Translation: ABW98953.1
EU221569 Genomic DNA Translation: ABW98954.1
EU221570 Genomic DNA Translation: ABW98955.1
EU221571 Genomic DNA Translation: ABW98956.1
EU221572 Genomic DNA Translation: ABW98957.1
EU221573 Genomic DNA Translation: ABW98958.1
EU221574 Genomic DNA Translation: ABW98959.1
EU221575 Genomic DNA Translation: ABW98960.1
EU221576 Genomic DNA Translation: ABW98961.1
EU221577 Genomic DNA Translation: ABW98962.1
EU221578 Genomic DNA Translation: ABW98963.1
EU221579 Genomic DNA Translation: ABW98964.1
EU221580 Genomic DNA Translation: ABW98965.1
EU221581 Genomic DNA Translation: ABW98966.1
BC109618 mRNA Translation: AAI09619.1
K01084 mRNA Translation: AAA30478.1
EF538766 Genomic DNA Translation: ABQ88318.1
M38658 mRNA Translation: AAA62707.1
AH007360 Genomic DNA Translation: AAD14099.1
D00412 mRNA Translation: BAA00313.1
PIRiS22575 KABOSB
S72220
RefSeqiNP_851372.1, NM_181029.2
UniGeneiBt.59369

3D structure databases

ProteinModelPortaliP02662
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi159482, 3 interactors
DIPiDIP-29917N
IntActiP02662, 3 interactors
MINTiP02662
STRINGi9913.ENSBTAP00000010119

Protein family/group databases

Allergomei10197 Bos d 9.0101
167 Bos d 8
2734 Bos d 9

PTM databases

CarbonylDBiP02662
iPTMnetiP02662

Proteomic databases

PaxDbiP02662
PeptideAtlasiP02662
PRIDEiP02662

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000010119; ENSBTAP00000010119; ENSBTAG00000007695
GeneIDi282208
KEGGibta:282208

Organism-specific databases

CTDi1446
VGNCiVGNC:27763 CSN1S1

Phylogenomic databases

eggNOGiENOG410J2MD Eukaryota
ENOG41114JX LUCA
GeneTreeiENSGT00390000017378
HOVERGENiHBG005242
InParanoidiP02662
KOiK17281
OMAiSKCAEQF
OrthoDBiEOG091G0XI1
TreeFamiTF340763

Enzyme and pathway databases

ReactomeiR-BTA-5223345 Miscellaneous transport and binding events

Miscellaneous databases

PMAP-CutDBiP02662
PROiPR:P02662

Gene expression databases

BgeeiENSBTAG00000007695 Expressed in 1 organ(s), highest expression level in adult mammalian kidney

Family and domain databases

InterProiView protein in InterPro
IPR026999 Alpha-s1_casein
IPR001588 Casein
IPR031305 Casein_CS
PANTHERiPTHR10240 PTHR10240, 1 hit
PfamiView protein in Pfam
PF00363 Casein, 1 hit
PROSITEiView protein in PROSITE
PS00306 CASEIN_ALPHA_BETA, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCASA1_BOVIN
AccessioniPrimary (citable) accession number: P02662
Secondary accession number(s): A5YK80
, A8WCP1, A8WCP2, A8WCP3, A8WCP4, A8WCP5, A8WCP6, A8WCP7, A8WCP8, A8WCP9, A8WCQ0, A8WCQ1, A8WCQ2, A8WCQ3, A8WCQ4, A8WCQ5, A8WCQ6, A8WCQ7, A8WCQ8, A8WCQ9, A8WCR0, A8WCR1, A8WCR2, A8WCR3, A8WCR4, A8WCR5, A8WCR6, A8WCR7, A8WCR8, A8WCR9, A8WCS0, A8WCS1, Q28048, Q28069, Q32LE8, Q7M2U6, Q9TRH5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: November 1, 1990
Last modified: September 12, 2018
This is version 146 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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