CSN1S1

Functionⁱ

Important role in the capacity of milk to transport calcium phosphate.1 Publication

Antioxidant peptide has 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity.1 Publication

Miscellaneous

The B variant sequence is shown.

GO - Molecular functionⁱ

amyloid-beta binding
Source: CAFA
Inferred from direct assayⁱ
- 22155633
antioxidant activity Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

negative regulation of apoptotic process
Source: AgBase
Inferred from mutant phenotypeⁱ
- 24399684
negative regulation of gene expression
Source: AgBase
Inferred from mutant phenotypeⁱ
- 24399684
negative regulation of supramolecular fiber organization
Source: CAFA
Inferred from direct assayⁱ
- 22155633
positive regulation of androst-4-ene-3,17-dione biosynthetic process
Source: AgBase
Inferred from mutant phenotypeⁱ
- 24399684
positive regulation of androstenedione secretion
Source: AgBase
Inferred from mutant phenotypeⁱ
- 24399684
positive regulation of progesterone biosynthetic process
Source: AgBase
Inferred from mutant phenotypeⁱ
- 24399684
positive regulation of progesterone secretion
Source: AgBase
Inferred from mutant phenotypeⁱ
- 24399684
protein stabilization
Source: CAFA
Inferred from direct assayⁱ
- 22155633
response to 11-deoxycorticosterone
Source: AgBase
Inferred from direct assayⁱ
- 3585228
response to dehydroepiandrosterone
Source: AgBase
Inferred from direct assayⁱ
- 3585228
response to estradiol
Source: AgBase
Inferred from direct assayⁱ
- 3585228
response to growth hormone
Source: AgBase
Inferred from direct assayⁱ
- 16174355
response to progesterone
Source: AgBase
Inferred from direct assayⁱ
- 3585228

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Antioxidant, Milk protein

Molecular function

Antioxidant, Milk protein

Enzyme and pathway databases

Reactomeⁱ	R-BTA-5223345 Miscellaneous transport and binding events

Reactomeⁱ

R-BTA-5223345 Miscellaneous transport and binding events

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Alpha-S1-casein Alternative name(s): Allergen: Bos d 8 Cleaved into the following chain: Antioxidant peptide
Gene namesⁱ	Name:CSN1S1
Organismⁱ	Bos taurus (Bovine)
Taxonomic identifierⁱ	9913 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos
Proteomesⁱ	UP000009136 Componentⁱ: Chromosome 6

Organism-specific databases

VGNCⁱ	VGNC:27763 CSN1S1

VGNCⁱ

VGNC:27763 CSN1S1

Keywords - Cellular componentⁱ

Secreted

Pathology & Biotechⁱ

Allergenic propertiesⁱ

Causes an allergic reaction in human. Has six major and 3 minor IgE-binding regions and 5 major and 1 minor IgG-binding regions. Is a cause of cow's milk allergy (CMA).2 Publications

Keywords - Diseaseⁱ

Allergen

Protein family/group databases

Allergomeⁱ	10197 Bos d 9.0101 167 Bos d 8 2734 Bos d 9

Allergomeⁱ

10197 Bos d 9.0101
167 Bos d 8
2734 Bos d 9

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
Signal peptideⁱ	1 – 15	2 PublicationsAdd BLAST	15
ChainⁱPRO_0000004446	16 – 214	Alpha-S1-caseinAdd BLAST	199
PeptideⁱPRO_0000331578	95 – 105	Antioxidant peptideAdd BLAST	11

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	56	Phosphoserine2 Publications	1
Modified residueⁱ	61	Phosphoserine1 Publication	1
Modified residueⁱ	63	Phosphoserine1 Publication	1
Modified residueⁱ	79	Phosphoserine1 Publication	1
Modified residueⁱ	81	Phosphoserine1 Publication	1
Modified residueⁱ	82	Phosphoserine1 Publication	1
Modified residueⁱ	83	Phosphoserine1 Publication	1
Modified residueⁱ	90	Phosphoserine1 Publication	1
Modified residueⁱ	130	Phosphoserine1 Publication	1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

PaxDbⁱ	P02662
PeptideAtlas More...PeptideAtlasⁱ	P02662
PRIDEⁱ	P02662

PTM databases

CarbonylDBⁱ	P02662
iPTMnetⁱ	P02662

Miscellaneous databases

PMAP-CutDBⁱ

P02662

Expressionⁱ

Tissue specificityⁱ

Mammary gland specific. Secreted in milk.

Gene expression databases

Bgeeⁱ	ENSBTAG00000007695 Expressed in 1 organ(s), highest expression level in adult mammalian kidney

Bgeeⁱ

ENSBTAG00000007695 Expressed in 1 organ(s), highest expression level in adult mammalian kidney

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	159482, 3 interactors
Database of interacting proteins More...DIPⁱ	DIP-29917N
IntActⁱ	P02662, 3 interactors
Molecular INTeraction database More...MINTⁱ	P02662
STRINGⁱ	9913.ENSBTAP00000010119

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P02662
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Repeatⁱ	85 – 99	Add BLAST		15
Repeatⁱ	125 – 140	Add BLAST		16

Sequence similaritiesⁱ

Belongs to the alpha-casein family.Curated

Keywords - Domainⁱ

Repeat, Signal

Phylogenomic databases

eggNOGⁱ	ENOG410J2MD Eukaryota ENOG41114JX LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000017378
HOVERGENⁱ	HBG005242
InParanoidⁱ	P02662
KEGG Orthology (KO) More...KOⁱ	K17281
OMAⁱ	SKCAEQF
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0XI1
TreeFamⁱ	TF340763

Family and domain databases

InterProⁱ	View protein in InterPro IPR026999 Alpha-s1_casein IPR001588 Casein IPR031305 Casein_CS
PANTHERⁱ	PTHR10240 PTHR10240, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00363 Casein, 1 hit
PROSITEⁱ	View protein in PROSITE PS00306 CASEIN_ALPHA_BETA, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P02662-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MKLLILTCLV AVALARPKHP IKHQGLPQEV LNENLLRFFV APFPEVFGKE 
        60         70         80         90        100
KVNELSKDIG SESTEDQAME DIKQMEAESI SSSEEIVPNS VEQKHIQKED 
       110        120        130        140        150
VPSERYLGYL EQLLRLKKYK VPQLEIVPNS AEERLHSMKE GIHAQQKEPM 
       160        170        180        190        200
IGVNQELAYF YPELFRQFYQ LDAYPSGAWY YVPLGTQYTD APSFSDIPNP 
       210 
IGSENSEKTT MPLW

Length:214

Mass (Da):24,529

Last modified:November 1, 1990 - v2

Checksum:ⁱF066B5C8AE55828B

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	11 – 12	AV → SA in ABW98943 (PubMed:19454699).Curated	2
Sequence conflictⁱ	42	P → L in AAA30429 (PubMed:3022833).Curated	1
Sequence conflictⁱ	44	P → S in ABW98945 (PubMed:19454699).Curated	1
Sequence conflictⁱ	95	H → Q in AAA30478 (PubMed:6897774).Curated	1
Sequence conflictⁱ	99	E → D in ABQ88318 (Ref. 14) Curated	1
Sequence conflictⁱ	143	H → D in AAA30429 (PubMed:3022833).Curated	1
Sequence conflictⁱ	171	L → P in ABW98953 (PubMed:19454699).Curated	1
Sequence conflictⁱ	203	S → L in AAA62707 (PubMed:3838718).Curated	1
Sequence conflictⁱ	211 – 212	MP → IS in AAA30429 (PubMed:3022833).Curated	2

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱ	29 – 41	Missing in variant A. Add BLAST	13
Natural variantⁱ	68	A → T in variant D.	1
Natural variantⁱ	207	E → G in variant C.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X00564 mRNA Translation: CAB57792.1 M33123 mRNA Translation: AAA30428.1 M38641 mRNA Translation: AAA30429.1 X59856 Genomic DNA Translation: CAA42516.1 EU221551 Genomic DNA Translation: ABW98936.1 EU221552 Genomic DNA Translation: ABW98937.1 EU221553 Genomic DNA Translation: ABW98938.1 EU221554 Genomic DNA Translation: ABW98939.1 EU221555 Genomic DNA Translation: ABW98940.1 EU221556 Genomic DNA Translation: ABW98941.1 EU221557 Genomic DNA Translation: ABW98942.1 EU221558 Genomic DNA Translation: ABW98943.1 EU221559 Genomic DNA Translation: ABW98944.1 EU221560 Genomic DNA Translation: ABW98945.1 EU221561 Genomic DNA Translation: ABW98946.1 EU221562 Genomic DNA Translation: ABW98947.1 EU221563 Genomic DNA Translation: ABW98948.1 EU221564 Genomic DNA Translation: ABW98949.1 EU221565 Genomic DNA Translation: ABW98950.1 EU221566 Genomic DNA Translation: ABW98951.1 EU221567 Genomic DNA Translation: ABW98952.1 EU221568 Genomic DNA Translation: ABW98953.1 EU221569 Genomic DNA Translation: ABW98954.1 EU221570 Genomic DNA Translation: ABW98955.1 EU221571 Genomic DNA Translation: ABW98956.1 EU221572 Genomic DNA Translation: ABW98957.1 EU221573 Genomic DNA Translation: ABW98958.1 EU221574 Genomic DNA Translation: ABW98959.1 EU221575 Genomic DNA Translation: ABW98960.1 EU221576 Genomic DNA Translation: ABW98961.1 EU221577 Genomic DNA Translation: ABW98962.1 EU221578 Genomic DNA Translation: ABW98963.1 EU221579 Genomic DNA Translation: ABW98964.1 EU221580 Genomic DNA Translation: ABW98965.1 EU221581 Genomic DNA Translation: ABW98966.1 BC109618 mRNA Translation: AAI09619.1 K01084 mRNA Translation: AAA30478.1 EF538766 Genomic DNA Translation: ABQ88318.1 M38658 mRNA Translation: AAA62707.1 AH007360 Genomic DNA Translation: AAD14099.1 D00412 mRNA Translation: BAA00313.1
PIRⁱ	S22575 KABOSB S72220
NCBI Reference Sequences More...RefSeqⁱ	NP_851372.1, NM_181029.2
UniGeneⁱ	Bt.59369

Genome annotation databases

Ensemblⁱ	ENSBTAT00000010119; ENSBTAP00000010119; ENSBTAG00000007695
GeneIDⁱ	282208
KEGGⁱ	bta:282208

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P02662	Alpha S1-casein (Fragment)		BUBBU		12	UniRef100_P02662
CSN1S1 (Fragment)		BOVIN		26
Alpha-S1-casein (Fragment)		BOSMU		26
CSN1S1 (Fragment)		BOSIN		26
CSN1S1 (Fragment)		BISBI		26
+14

Protein	Similar proteins		Species	Score	Length	Source
P02662	Alpha-S1-casein		BUBBU		214	UniRef90_P02662
CSN1S1 (Fragment)		BOVIN		26
Alpha-S1-casein (Fragment)		BOSMU		26
CSN1S1 (Fragment)		BOSIN		26
CSN1S1 (Fragment)		BISBI		26
+59

Protein	Similar proteins		Species	Score	Length	Source
P02662	Alpha-S1-casein		BUBBU		214	UniRef50_P02662
Alpha-S1-casein		CAPHI		214
Alpha-S1-casein		SHEEP		214
Alpha-S1-casein		CAMDR		230
Alpha-S1-casein		EQUAS		202
+108

Cross-referencesⁱ

Web resourcesⁱ

Worthington enzyme manual

Protein Spotlight

Of buttons, digestion and glue - Issue 16 of November 2001

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X00564 mRNA Translation: CAB57792.1 M33123 mRNA Translation: AAA30428.1 M38641 mRNA Translation: AAA30429.1 X59856 Genomic DNA Translation: CAA42516.1 EU221551 Genomic DNA Translation: ABW98936.1 EU221552 Genomic DNA Translation: ABW98937.1 EU221553 Genomic DNA Translation: ABW98938.1 EU221554 Genomic DNA Translation: ABW98939.1 EU221555 Genomic DNA Translation: ABW98940.1 EU221556 Genomic DNA Translation: ABW98941.1 EU221557 Genomic DNA Translation: ABW98942.1 EU221558 Genomic DNA Translation: ABW98943.1 EU221559 Genomic DNA Translation: ABW98944.1 EU221560 Genomic DNA Translation: ABW98945.1 EU221561 Genomic DNA Translation: ABW98946.1 EU221562 Genomic DNA Translation: ABW98947.1 EU221563 Genomic DNA Translation: ABW98948.1 EU221564 Genomic DNA Translation: ABW98949.1 EU221565 Genomic DNA Translation: ABW98950.1 EU221566 Genomic DNA Translation: ABW98951.1 EU221567 Genomic DNA Translation: ABW98952.1 EU221568 Genomic DNA Translation: ABW98953.1 EU221569 Genomic DNA Translation: ABW98954.1 EU221570 Genomic DNA Translation: ABW98955.1 EU221571 Genomic DNA Translation: ABW98956.1 EU221572 Genomic DNA Translation: ABW98957.1 EU221573 Genomic DNA Translation: ABW98958.1 EU221574 Genomic DNA Translation: ABW98959.1 EU221575 Genomic DNA Translation: ABW98960.1 EU221576 Genomic DNA Translation: ABW98961.1 EU221577 Genomic DNA Translation: ABW98962.1 EU221578 Genomic DNA Translation: ABW98963.1 EU221579 Genomic DNA Translation: ABW98964.1 EU221580 Genomic DNA Translation: ABW98965.1 EU221581 Genomic DNA Translation: ABW98966.1 BC109618 mRNA Translation: AAI09619.1 K01084 mRNA Translation: AAA30478.1 EF538766 Genomic DNA Translation: ABQ88318.1 M38658 mRNA Translation: AAA62707.1 AH007360 Genomic DNA Translation: AAD14099.1 D00412 mRNA Translation: BAA00313.1
PIRⁱ	S22575 KABOSB S72220
RefSeqⁱ	NP_851372.1, NM_181029.2
UniGeneⁱ	Bt.59369

3D structure databases

ProteinModelPortalⁱ	P02662
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	159482, 3 interactors
DIPⁱ	DIP-29917N
IntActⁱ	P02662, 3 interactors
MINTⁱ	P02662
STRINGⁱ	9913.ENSBTAP00000010119

Protein family/group databases

Allergomeⁱ	10197 Bos d 9.0101 167 Bos d 8 2734 Bos d 9

Allergomeⁱ

10197 Bos d 9.0101
167 Bos d 8
2734 Bos d 9

PTM databases

CarbonylDBⁱ	P02662
iPTMnetⁱ	P02662

Proteomic databases

PaxDbⁱ	P02662
PeptideAtlasⁱ	P02662
PRIDEⁱ	P02662

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSBTAT00000010119; ENSBTAP00000010119; ENSBTAG00000007695
GeneIDⁱ	282208
KEGGⁱ	bta:282208

Organism-specific databases

CTDⁱ	1446
VGNCⁱ	VGNC:27763 CSN1S1

Phylogenomic databases

eggNOGⁱ	ENOG410J2MD Eukaryota ENOG41114JX LUCA
GeneTreeⁱ	ENSGT00390000017378
HOVERGENⁱ	HBG005242
InParanoidⁱ	P02662
KOⁱ	K17281
OMAⁱ	SKCAEQF
OrthoDBⁱ	EOG091G0XI1
TreeFamⁱ	TF340763

Enzyme and pathway databases

Reactomeⁱ	R-BTA-5223345 Miscellaneous transport and binding events

Reactomeⁱ

R-BTA-5223345 Miscellaneous transport and binding events

Miscellaneous databases

PMAP-CutDBⁱ	P02662
Protein Ontology More...PROⁱ	PR:P02662

Gene expression databases

Bgeeⁱ	ENSBTAG00000007695 Expressed in 1 organ(s), highest expression level in adult mammalian kidney

Bgeeⁱ

ENSBTAG00000007695 Expressed in 1 organ(s), highest expression level in adult mammalian kidney

Family and domain databases

InterProⁱ	View protein in InterPro IPR026999 Alpha-s1_casein IPR001588 Casein IPR031305 Casein_CS
PANTHERⁱ	PTHR10240 PTHR10240, 1 hit
Pfamⁱ	View protein in Pfam PF00363 Casein, 1 hit
PROSITEⁱ	View protein in PROSITE PS00306 CASEIN_ALPHA_BETA, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CASA1_BOVIN
Accessionⁱ	P02662Primary (citable) accession number: P02662 Secondary accession number(s): A5YK80 Q9TRH5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
	Last sequence update:	November 1, 1990
	Last modified:	September 12, 2018
	This is version 146 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Protein Spotlight
Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P02662 (CASA1_BOVIN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Alpha-S1-casein

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Extracellular region or secreted

Golgi apparatus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Protein family/group databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

Miscellaneous databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ