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Protein

Alpha-S1-casein

Gene

Csn1s1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Important role in the capacity of milk to transport calcium phosphate.

Keywordsi

Molecular functionMilk protein

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-S1-casein
Short name:
Alpha-casein
Gene namesi
Name:Csn1s1
Synonyms:Csna
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2430 Csn1s1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Protein family/group databases

Allergomei2151 Rat n 8

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 15By similarityAdd BLAST15
ChainiPRO_000000445816 – 284Alpha-S1-caseinAdd BLAST269

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei79PhosphoserineBy similarity1
Modified residuei93PhosphoserineBy similarity1
Modified residuei94PhosphoserineBy similarity1
Modified residuei95PhosphoserineBy similarity1
Modified residuei96PhosphoserineBy similarity1
Modified residuei97PhosphoserineBy similarity1
Modified residuei98PhosphoserineBy similarity1
Modified residuei99PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP02661
PRIDEiP02661

PTM databases

iPTMnetiP02661
PhosphoSitePlusiP02661

Expressioni

Tissue specificityi

Mammary gland specific. Secreted in milk.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000056956

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati138 – 14316
Repeati144 – 14926
Repeati150 – 15536
Repeati156 – 16146
Repeati162 – 16756
Repeati168 – 17366
Repeati174 – 17976
Repeati180 – 18586
Repeati186 – 19196
Repeati192 – 197106

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni138 – 19710 X 6 AA tandem repeatsAdd BLAST60

Sequence similaritiesi

Belongs to the alpha-casein family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410J2MD Eukaryota
ENOG41114JX LUCA
HOGENOMiHOG000214193
HOVERGENiHBG098347
InParanoidiP02661

Family and domain databases

InterProiView protein in InterPro
IPR026999 Alpha-s1_casein
IPR001588 Casein
IPR031305 Casein_CS
PANTHERiPTHR10240 PTHR10240, 1 hit
PfamiView protein in Pfam
PF00363 Casein, 1 hit
PROSITEiView protein in PROSITE
PS00306 CASEIN_ALPHA_BETA, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02661-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLLILTCLV AAALALPRAH RRNAVSSQTQ QENSSSEEQE IVKQPKYLSL
60 70 80 90 100
NEEFVNNLNR QRELLTEQDN EIKITMDSSA EEQATASAQE DSSSSSSSSE
110 120 130 140 150
ESKDAIPSAT EQKNIANKEI LNRCTLEQLQ RQIKYSQLLQ QASLAQQASL
160 170 180 190 200
AQQASLAQQA LLAQQPSLAQ QAALAQQASL AQQASLAQQA SLAQKHHPRL
210 220 230 240 250
SQVYYPNMEQ PYRMNAYSQV QMRHPMSVVD QAQFSVQSFP QLSQYGAYPL
260 270 280
WLYFPQDMQY LTPEAVLNTF KPIAPKDAEN TNVW
Length:284
Mass (Da):31,802
Last modified:July 21, 1986 - v1
Checksum:iFB3D34DA46417CD5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00710 mRNA No translation available.
X03585 Genomic DNA Translation: CAA27261.1
X03586 Genomic DNA Translation: CAA27262.1
X03587 Genomic DNA Translation: CAA27263.1
X03588 Genomic DNA Translation: CAA27264.1
PIRiA03105 KART
RefSeqiNP_620229.2, NM_138874.2
UniGeneiRn.10744

Genome annotation databases

GeneIDi24284
KEGGirno:24284
UCSCiRGD:2430 rat

Similar proteinsi

Entry informationi

Entry nameiCASA1_RAT
AccessioniPrimary (citable) accession number: P02661
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: May 23, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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