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Protein

Apovitellenin-1

Gene
N/A
Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Protein component of the very low density lipoprotein (VLDL) of egg-laying females. Potent lipoprotein lipase inhibitor, preventing the loss of triglycerides from VLDL on their way from the liver to the growing oocytes.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionStorage protein

Names & Taxonomyi

Protein namesi
Recommended name:
Apovitellenin-1
Alternative name(s):
Apo-VLDL-II
Short name:
Apo-II
Apovitellenin I
Very low density lipoprotein II
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

VLDL

Pathology & Biotechi

Protein family/group databases

Allergomei2740 Gal d Apo I

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 243 PublicationsAdd BLAST24
ChainiPRO_000000206425 – 106Apovitellenin-1Add BLAST82

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi99Interchain1 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP02659
PRIDEiP02659

Expressioni

Tissue specificityi

Produced by the liver, secreted into the blood and then sequestred by receptor mediated endocytosis into growing oocytes.

Developmental stagei

ApoII mRNA induction by estrogen in kidney at day 11 is at 10% of the level in the liver but estrogen-responsiveness decreases later in development and is low in the adult.

Inductioni

By steroids (estrogen).

Gene expression databases

BgeeiENSGALG00000015134 Expressed in 2 organ(s), highest expression level in liver

Interactioni

Subunit structurei

Homodimer; disulfide-linked.

Protein-protein interaction databases

STRINGi9031.ENSGALP00000024373

Family & Domainsi

Sequence similaritiesi

Belongs to the apovitellenin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410KEFA Eukaryota
ENOG4111ASP LUCA
GeneTreeiENSGT00530000066877
HOGENOMiHOG000034012
HOVERGENiHBG050554
InParanoidiP02659
OMAiRRDWLVI
OrthoDBiEOG091G0YX7
PhylomeDBiP02659

Family and domain databases

InterProiView protein in InterPro
IPR008404 Apo-VLDL-II
PfamiView protein in Pfam
PF05418 Apo-VLDL-II, 1 hit
PIRSFiPIRSF002369 Apo-VLDL-II, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD012358 Apo-VLDL-II, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02659-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVQYRALVIA VILLLSTTVP EVHSKSIIDR ERRDWLVIPD AAAAYIYEAV
60 70 80 90 100
NKVSPRAGQF LLDVSQTTVV SGIRNFLINE TARLTKLAEQ LMEKIKNLCY

TKVLGY
Length:106
Mass (Da):11,966
Last modified:July 21, 1986 - v1
Checksum:i8A17DA72F574AF67
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti2Missing AA sequence (PubMed:7430115).Curated1
Sequence conflicti23H → C AA sequence (PubMed:7430115).Curated1
Sequence conflicti68 – 69TV → NS in AAA48938 (PubMed:2703502).Curated2
Sequence conflicti71 – 73SGI → IGS AA sequence (PubMed:988817).Curated3
Sequence conflicti91 – 92LM → ML AA sequence (PubMed:988817).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00449 mRNA Translation: CAA23727.1
J00810 Genomic DNA Translation: AAA48596.1
M25774 mRNA Translation: AAA48938.1
PIRiA93464 VLCH1
I50374
RefSeqiNP_990814.2, NM_205483.2
XP_015151420.1, XM_015295934.1
UniGeneiGga.4123

Genome annotation databases

EnsembliENSGALT00000024419; ENSGALP00000024373; ENSGALG00000015134
GeneIDi396476
KEGGigga:396476

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00449 mRNA Translation: CAA23727.1
J00810 Genomic DNA Translation: AAA48596.1
M25774 mRNA Translation: AAA48938.1
PIRiA93464 VLCH1
I50374
RefSeqiNP_990814.2, NM_205483.2
XP_015151420.1, XM_015295934.1
UniGeneiGga.4123

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000024373

Protein family/group databases

Allergomei2740 Gal d Apo I

Proteomic databases

PaxDbiP02659
PRIDEiP02659

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000024419; ENSGALP00000024373; ENSGALG00000015134
GeneIDi396476
KEGGigga:396476

Organism-specific databases

CTDi396476

Phylogenomic databases

eggNOGiENOG410KEFA Eukaryota
ENOG4111ASP LUCA
GeneTreeiENSGT00530000066877
HOGENOMiHOG000034012
HOVERGENiHBG050554
InParanoidiP02659
OMAiRRDWLVI
OrthoDBiEOG091G0YX7
PhylomeDBiP02659

Miscellaneous databases

PROiPR:P02659

Gene expression databases

BgeeiENSGALG00000015134 Expressed in 2 organ(s), highest expression level in liver

Family and domain databases

InterProiView protein in InterPro
IPR008404 Apo-VLDL-II
PfamiView protein in Pfam
PF05418 Apo-VLDL-II, 1 hit
PIRSFiPIRSF002369 Apo-VLDL-II, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD012358 Apo-VLDL-II, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiAPOV1_CHICK
AccessioniPrimary (citable) accession number: P02659
Secondary accession number(s): Q90882
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: September 12, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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