APOC3

Functionⁱ

Component of triglyceride-rich very low density lipoproteins (VLDL) and high density lipoproteins (HDL) in plasma (PubMed:18201179, PubMed:22510806). Plays a multifaceted role in triglyceride homeostasis (PubMed:18201179, PubMed:22510806). Intracellularly, promotes hepatic very low density lipoprotein 1 (VLDL1) assembly and secretion; extracellularly, attenuates hydrolysis and clearance of triglyceride-rich lipoproteins (TRLs) (PubMed:18201179, PubMed:22510806). Impairs the lipolysis of TRLs by inhibiting lipoprotein lipase and the hepatic uptake of TRLs by remnant receptors (PubMed:18201179, PubMed:22510806). Formed of several curved helices connected via semiflexible hinges, so that it can wrap tightly around the curved micelle surface and easily adapt to the different diameters of its natural binding partners (PubMed:18408013).2 Publications1 Publication

Sites

Feature key	Position(s)	DescriptionActions	Length
Siteⁱ	37	May interact with the LDL receptor1 Publication	1
Siteⁱ	41	May interact with the LDL receptor1 Publication	1
Siteⁱ	44	May interact with the LDL receptor1 Publication	1

GO - Molecular functionⁱ

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cholesterol efflux
Source: BHF-UCL
Inferred from direct assayⁱ
- 11162594
- 16443932
cholesterol homeostasis
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 18767813
chylomicron assembly Source: Reactome
chylomicron remnant clearance
Source: BHF-UCL
Inferred from direct assayⁱ
- 4020294
chylomicron remodeling Source: Reactome
G protein-coupled receptor signaling pathway
Source: BHF-UCL
Inferred from direct assayⁱ
- 16443932
high-density lipoprotein particle remodeling
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 17438339
lipoprotein metabolic process Source: InterPro
negative regulation of cholesterol import
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 15778093
negative regulation of fatty acid biosynthetic process
Source: BHF-UCL
Inferred from direct assayⁱ
- 11060345
- 18635818
negative regulation of high-density lipoprotein particle clearance
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 15778093
negative regulation of lipid catabolic process
Source: BHF-UCL
Inferred from direct assayⁱ
- 15576844
negative regulation of lipid metabolic process
Source: BHF-UCL
Inferred from direct assayⁱ
- 182536
negative regulation of lipoprotein lipase activity
Source: BHF-UCL
Inferred from direct assayⁱ
negative regulation of low-density lipoprotein particle clearance
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 15778093
negative regulation of receptor-mediated endocytosis
Source: BHF-UCL
Inferred from direct assayⁱ
- 1917954
negative regulation of triglyceride catabolic process
Source: BHF-UCL
Inferred from direct assayⁱ
- 18635818
- 3973011
negative regulation of very-low-density lipoprotein particle clearance
Source: BHF-UCL
Inferred from direct assayⁱ
- 1917954
negative regulation of very-low-density lipoprotein particle remodeling
Source: BHF-UCL
Inferred from direct assayⁱ
- 3973011
phospholipid efflux
Source: BHF-UCL
Inferred from direct assayⁱ
- 11162594
regulation of Cdc42 protein signal transduction
Source: BHF-UCL
Inferred from direct assayⁱ
- 16443932
retinoid metabolic process Source: Reactome
reverse cholesterol transport
Source: BHF-UCL
Inferred by curatorⁱ
- 17438339
triglyceride catabolic process
Source: BHF-UCL
Inferred from direct assayⁱ
- 11060345
triglyceride homeostasis
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 18767813
triglyceride metabolic process
Source: HGNC
Inferred from mutant phenotypeⁱ
- 17142127
very-low-density lipoprotein particle assembly
Source: BHF-UCL
Traceable author statementⁱ
- 18399797

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Lipid degradation, Lipid metabolism, Lipid transport, Transport
Ligand	Sialic acid

Enzyme and pathway databases

Reactomeⁱ	R-HSA-8963888 Chylomicron assembly R-HSA-8963901 Chylomicron remodeling R-HSA-8964058 HDL remodeling R-HSA-975634 Retinoid metabolism and transport
SIGNORⁱ	P02656

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Apolipoprotein C-III Short name: Apo-CIII Short name: ApoC-III Alternative name(s): Apolipoprotein C3
Gene namesⁱ	Name:APOC3
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 11

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000110245.11
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:610 APOC3
MIMⁱ	107720 gene
neXtProtⁱ	NX_P02656

Keywords - Cellular componentⁱ

Chylomicron, Secreted, VLDL

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Hyperalphalipoproteinemia 2 (HALP2)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA condition characterized by high levels of high density lipoprotein (HDL) and increased HDL cholesterol levels.

Keywords - Diseaseⁱ

Disease mutation

Organism-specific databases

DisGeNET More...DisGeNETⁱ	345
MalaCards human disease database More...MalaCardsⁱ	APOC3
MIMⁱ	614028 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000110245
Orphanetⁱ	79506 Cholesterol-ester transfer protein deficiency 426 NON RARE IN EUROPE: Familial hypobetalipoproteinemia 33271 NON RARE IN EUROPE: Non-alcoholic fatty liver disease
PharmGKBⁱ	PA53

Polymorphism and mutation databases

BioMutaⁱ	APOC3
DMDMⁱ	114026

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 20	2 PublicationsAdd BLAST		20
ChainⁱPRO_0000002031	21 – 99	Apolipoprotein C-III1 PublicationAdd BLAST		79

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
GlycosylationⁱCAR_000168	94	O-linked (GalNAc...) threonine3 Publications		1

Post-translational modificationⁱ

The most abundant glycoforms are characterized by an O-linked disaccharide galactose linked to N-acetylgalactosamine (Gal-GalNAc), further modified with up to 3 sialic acid residues. Less abundant glycoforms are characterized by more complex and fucosylated glycan moieties. O-glycosylated on Thr-94 with a core 1 or possibly core 8 glycan.3 Publications

Keywords - PTMⁱ

Glycoprotein

Proteomic databases

EPDⁱ	P02656
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P02656
PaxDbⁱ	P02656
PeptideAtlas More...PeptideAtlasⁱ	P02656
PRIDEⁱ	P02656
ProteomicsDBⁱ	51541

2D gel databases

DOSAC-COBS 2D-PAGE database More...DOSAC-COBS-2DPAGEⁱ	P02656
SWISS-2DPAGEⁱ	P02656

PTM databases

CarbonylDBⁱ	P02656
GlyConnectⁱ	58
iPTMnetⁱ	P02656
PhosphoSitePlusⁱ	P02656
UniCarbKBⁱ	P02656

Expressionⁱ

Tissue specificityⁱ

Liver.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000110245 Expressed in 91 organ(s), highest expression level in liver
CleanExⁱ	HS_APOC3
ExpressionAtlasⁱ	P02656 baseline and differential
Genevisibleⁱ	P02656 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA065365

HPAⁱ

HPA065365

Interactionⁱ

GO - Molecular functionⁱ

high-density lipoprotein particle receptor binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 9254056

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	106842, 23 interactors
IntActⁱ	P02656, 6 interactors
STRINGⁱ	9606.ENSP00000227667

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	29 – 39	Combined sources	11
Helixⁱ	40 – 42	Combined sources	3
Helixⁱ	43 – 48	Combined sources	6
Helixⁱ	49 – 55	Combined sources	7
Helixⁱ	56 – 62	Combined sources	7
Turnⁱ	63 – 68	Combined sources	6
Helixⁱ	69 – 80	Combined sources	12
Helixⁱ	83 – 85	Combined sources	3
Helixⁱ	93 – 98	Combined sources	6

Show more details

3D structure databases

ProteinModelPortalⁱ	P02656
SMRⁱ	P02656
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P02656

EvolutionaryTraceⁱ

P02656

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	68 – 99	Lipid-bindingAdd BLAST		32

Sequence similaritiesⁱ

Belongs to the apolipoprotein C3 family.Curated

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	ENOG410JE3N Eukaryota ENOG4111APE LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000015395
HOGENOMⁱ	HOG000247042
HOVERGENⁱ	HBG050549
InParanoidⁱ	P02656
KEGG Orthology (KO) More...KOⁱ	K08759
PhylomeDBⁱ	P02656
TreeFamⁱ	TF338209

Family and domain databases

Gene3Dⁱ	1.10.225.30, 1 hit
InterProⁱ	View protein in InterPro IPR008403 Apo-CIII IPR038195 Apo_CIII_sf
PANTHERⁱ	PTHR14225 PTHR14225, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF05778 Apo-CIII, 1 hit
ProDomⁱ	View protein in ProDom or Entries sharing at least one domain PD010414 Apo-CIII, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show all Align All

P02656-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MQPRVLLVVA LLALLASARA SEAEDASLLS FMQGYMKHAT KTAKDALSSV 
        60         70         80         90 
QESQVAQQAR GWVTDGFSSL KDYWSTVKDK FSEFWDLDPE VRPTSAVAA

Length:99

Mass (Da):10,852

Last modified:July 21, 1986 - v1

Checksum:ⁱD4E806339FAE4DA7

GO

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

B0YIW2	B0YIW2_HUMAN	Apolipoprotein C-III variant 1 Apolipoprotein C-III variant 1	APOC3	117	Annotation score:
C9J2Q0	C9J2Q0_HUMAN	Apolipoprotein C-III Apolipoprotein C-III	APOC3	55	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	52 – 53	ES → SQ AA sequence (PubMed:4846755).Curated		2
Sequence conflictⁱ	57 – 59	QQA → AQQ AA sequence (PubMed:4846755).Curated		3

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_000643	78	K → E in HALP2. 1 PublicationCorresponds to variant dbSNP:rs121918382EnsemblClinVar.		1
Natural variantⁱVAR_000644	94	T → A in C-III-0; unglycosylated. 1 PublicationCorresponds to variant dbSNP:rs121918381EnsemblClinVar.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	J00098 Genomic DNA Translation: AAB59515.1 M33043, M33041, M33042 Genomic DNA Translation: AAB59372.1 X01392 Genomic DNA Translation: CAA25648.1 X01388 mRNA Translation: CAA25644.1 X03120 Genomic DNA Translation: CAA26895.1 V01513 mRNA Translation: CAA24757.1 M28613 mRNA Translation: AAA51760.1 M28614 mRNA Translation: AAA51761.1 X00567 mRNA Translation: CAA25233.1 AY422951 Genomic DNA Translation: AAQ91810.1 AY555191 Genomic DNA Translation: AAS68230.1 BC027977 mRNA Translation: AAH27977.1 BC121081 mRNA Translation: AAI21082.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS8377.1
PIRⁱ	A90950 LPHUC3
NCBI Reference Sequences More...RefSeqⁱ	NP_000031.1, NM_000040.1
UniGeneⁱ	Hs.73849

Genome annotation databases

Ensemblⁱ	ENST00000227667; ENSP00000227667; ENSG00000110245
GeneIDⁱ	345
KEGGⁱ	hsa:345
UCSC genome browser More...UCSCⁱ	uc001ppt.2 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P02656	Apolipoprotein C-III variant 1		HUMAN		117	UniRef100_P02656
Apolipoprotein C-III		HUMAN		99
Apolipoprotein C-III (Fragment)		HUMAN		55
UPI000004139E		HUMAN		79

Protein	Similar proteins		Species	Score	Length	Source
P02656	Apolipoprotein C-III variant 1		HUMAN		117	UniRef90_P02656
APOC3 isoform 2		PANTR		117
Uncharacterized protein		PANPA		99
APOC3 isoform 1		PONAB		99
Apolipoprotein C3		GORGO		99
+6

Protein	Similar proteins		Species	Score	Length	Source
P02656	Apolipoprotein C-III variant 1		HUMAN		117	UniRef50_P02656
APOC3 isoform 2		PANTR		117
Uncharacterized protein		PANPA		99
Apolipoprotein C3		GORGO		99
APOC3 isoform 1		PONAB		99
+27

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	J00098 Genomic DNA Translation: AAB59515.1 M33043, M33041, M33042 Genomic DNA Translation: AAB59372.1 X01392 Genomic DNA Translation: CAA25648.1 X01388 mRNA Translation: CAA25644.1 X03120 Genomic DNA Translation: CAA26895.1 V01513 mRNA Translation: CAA24757.1 M28613 mRNA Translation: AAA51760.1 M28614 mRNA Translation: AAA51761.1 X00567 mRNA Translation: CAA25233.1 AY422951 Genomic DNA Translation: AAQ91810.1 AY555191 Genomic DNA Translation: AAS68230.1 BC027977 mRNA Translation: AAH27977.1 BC121081 mRNA Translation: AAI21082.1
CCDSⁱ	CCDS8377.1
PIRⁱ	A90950 LPHUC3
RefSeqⁱ	NP_000031.1, NM_000040.1
UniGeneⁱ	Hs.73849

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2JQ3	NMR	-	A	21-99	[»]
ProteinModelPortalⁱ	P02656
SMRⁱ	P02656
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	106842, 23 interactors
IntActⁱ	P02656, 6 interactors
STRINGⁱ	9606.ENSP00000227667

PTM databases

CarbonylDBⁱ	P02656
GlyConnectⁱ	58
iPTMnetⁱ	P02656
PhosphoSitePlusⁱ	P02656
UniCarbKBⁱ	P02656

Polymorphism and mutation databases

BioMutaⁱ	APOC3
DMDMⁱ	114026

2D gel databases

DOSAC-COBS-2DPAGEⁱ	P02656
SWISS-2DPAGEⁱ	P02656

Proteomic databases

EPDⁱ	P02656
MaxQBⁱ	P02656
PaxDbⁱ	P02656
PeptideAtlasⁱ	P02656
PRIDEⁱ	P02656
ProteomicsDBⁱ	51541

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	345
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000227667; ENSP00000227667; ENSG00000110245
GeneIDⁱ	345
KEGGⁱ	hsa:345
UCSCⁱ	uc001ppt.2 human

Organism-specific databases

CTDⁱ	345
DisGeNETⁱ	345
EuPathDBⁱ	HostDB:ENSG00000110245.11
GeneCardsⁱ	APOC3
HGNCⁱ	HGNC:610 APOC3
HPAⁱ	HPA065365
MalaCardsⁱ	APOC3
MIMⁱ	107720 gene 614028 phenotype
neXtProtⁱ	NX_P02656
OpenTargetsⁱ	ENSG00000110245
Orphanetⁱ	79506 Cholesterol-ester transfer protein deficiency 426 NON RARE IN EUROPE: Familial hypobetalipoproteinemia 33271 NON RARE IN EUROPE: Non-alcoholic fatty liver disease
PharmGKBⁱ	PA53
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410JE3N Eukaryota ENOG4111APE LUCA
GeneTreeⁱ	ENSGT00390000015395
HOGENOMⁱ	HOG000247042
HOVERGENⁱ	HBG050549
InParanoidⁱ	P02656
KOⁱ	K08759
PhylomeDBⁱ	P02656
TreeFamⁱ	TF338209

Enzyme and pathway databases

Reactomeⁱ	R-HSA-8963888 Chylomicron assembly R-HSA-8963901 Chylomicron remodeling R-HSA-8964058 HDL remodeling R-HSA-975634 Retinoid metabolism and transport
SIGNORⁱ	P02656

Miscellaneous databases

ChiTaRSⁱ	APOC3 human
EvolutionaryTraceⁱ	P02656
GeneWikiⁱ	Apolipoprotein_C3
GenomeRNAiⁱ	345
Protein Ontology More...PROⁱ	PR:P02656
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000110245 Expressed in 91 organ(s), highest expression level in liver
CleanExⁱ	HS_APOC3
ExpressionAtlasⁱ	P02656 baseline and differential
Genevisibleⁱ	P02656 HS

Family and domain databases

Gene3Dⁱ	1.10.225.30, 1 hit
InterProⁱ	View protein in InterPro IPR008403 Apo-CIII IPR038195 Apo_CIII_sf
PANTHERⁱ	PTHR14225 PTHR14225, 1 hit
Pfamⁱ	View protein in Pfam PF05778 Apo-CIII, 1 hit
ProDomⁱ	View protein in ProDom or Entries sharing at least one domain PD010414 Apo-CIII, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	APOC3_HUMAN
Accessionⁱ	P02656Primary (citable) accession number: P02656 Secondary accession number(s): Q08E83, Q6Q786
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
	Last sequence update:	July 21, 1986
	Last modified:	November 7, 2018
	This is version 186 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM

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UniProtKB - P02656 (APOC3_HUMAN)

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Apolipoprotein C-III

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Endosome

Extracellular region or secreted

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

2D gel databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

2D gel databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ