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UniProtKB - P02656 (APOC3_HUMAN)

Entry version 188 (13 Feb 2019)
Sequence version 1 (21 Jul 1986)
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Protein

Apolipoprotein C-III

Gene

APOC3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of triglyceride-rich very low density lipoproteins (VLDL) and high density lipoproteins (HDL) in plasma (PubMed:18201179, PubMed:22510806). Plays a multifaceted role in triglyceride homeostasis (PubMed:18201179, PubMed:22510806). Intracellularly, promotes hepatic very low density lipoprotein 1 (VLDL1) assembly and secretion; extracellularly, attenuates hydrolysis and clearance of triglyceride-rich lipoproteins (TRLs) (PubMed:18201179, PubMed:22510806). Impairs the lipolysis of TRLs by inhibiting lipoprotein lipase and the hepatic uptake of TRLs by remnant receptors (PubMed:18201179, PubMed:22510806). Formed of several curved helices connected via semiflexible hinges, so that it can wrap tightly around the curved micelle surface and easily adapt to the different diameters of its natural binding partners (PubMed:18408013).2 Publications1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei37May interact with the LDL receptor1 Publication1
Sitei41May interact with the LDL receptor1 Publication1
Sitei44May interact with the LDL receptor1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • cholesterol binding Source: BHF-UCL
  • enzyme regulator activity Source: BHF-UCL
  • high-density lipoprotein particle receptor binding Source: BHF-UCL
  • lipase inhibitor activity Source: BHF-UCL
  • phospholipid binding Source: BHF-UCL
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processLipid degradation, Lipid metabolism, Lipid transport, Transport
LigandSialic acid

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-8963888 Chylomicron assembly
R-HSA-8963901 Chylomicron remodeling
R-HSA-8964058 HDL remodeling
R-HSA-975634 Retinoid metabolism and transport

SIGNOR Signaling Network Open Resource

More...SIGNORi		P02656

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Apolipoprotein C-III
Short name:
Apo-CIII
Short name:
ApoC-III
Alternative name(s):
Apolipoprotein C3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:APOC3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000110245.11

Human Gene Nomenclature Database

More...HGNCi		HGNC:610 APOC3

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		107720 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P02656

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Chylomicron, Secreted, VLDL

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Hyperalphalipoproteinemia 2 (HALP2)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA condition characterized by high levels of high density lipoprotein (HDL) and increased HDL cholesterol levels.
See also OMIM:614028
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_00064378K → E in HALP2. 1 PublicationCorresponds to variant dbSNP:rs121918382EnsemblClinVar.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...DisGeNETi		345

MalaCards human disease database

More...MalaCardsi		APOC3
MIMi614028 phenotype

Open Targets

More...OpenTargetsi		ENSG00000110245

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		79506 Cholesterol-ester transfer protein deficiency
426 NON RARE IN EUROPE: Familial hypobetalipoproteinemia
33271 NON RARE IN EUROPE: Non-alcoholic fatty liver disease

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA53

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		APOC3

Domain mapping of disease mutations (DMDM)

More...DMDMi		114026

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 202 PublicationsAdd BLAST20
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000203121 – 99Apolipoprotein C-III1 PublicationAdd BLAST79

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>GlycosylationiCAR_00016894O-linked (GalNAc...) threonine3 Publications1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

The most abundant glycoforms are characterized by an O-linked disaccharide galactose linked to N-acetylgalactosamine (Gal-GalNAc), further modified with up to 3 sialic acid residues. Less abundant glycoforms are characterized by more complex and fucosylated glycan moieties. O-glycosylated on Thr-94 with a core 1 or possibly core 8 glycan.3 Publications

Keywords - PTMi

Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P02656

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P02656

MaxQB - The MaxQuant DataBase

More...MaxQBi		P02656

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P02656

PeptideAtlas

More...PeptideAtlasi		P02656

PRoteomics IDEntifications database

More...PRIDEi		P02656

ProteomicsDB human proteome resource

More...ProteomicsDBi		51541

2D gel databases

DOSAC-COBS 2D-PAGE database

More...DOSAC-COBS-2DPAGEi		P02656

Two-dimensional polyacrylamide gel electrophoresis database from the Geneva University Hospital

More...SWISS-2DPAGEi		P02656

PTM databases

CarbonylDB database of protein carbonylation sites

More...CarbonylDBi		P02656

GlyConnect protein glycosylation platform

More...GlyConnecti		58

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P02656

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P02656

UniCarbKB; an annotated and curated database of glycan structures

More...UniCarbKBi		P02656

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Liver.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000110245 Expressed in 91 organ(s), highest expression level in liver

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P02656 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P02656 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA065365

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		106842, 23 interactors

Protein interaction database and analysis system

More...IntActi		P02656, 6 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000227667

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

199
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2JQ3NMR-A21-99[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...ProteinModelPortali		P02656

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P02656

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P02656

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni68 – 99Lipid-bindingAdd BLAST32

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the apolipoprotein C3 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG410JE3N Eukaryota
ENOG4111APE LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00390000015395

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000247042

The HOVERGEN Database of Homologous Vertebrate Genes

More...HOVERGENi		HBG050549

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P02656

KEGG Orthology (KO)

More...KOi		K08759

Database of Orthologous Groups

More...OrthoDBi		649708at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P02656

TreeFam database of animal gene trees

More...TreeFami		TF338209

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.225.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR008403 Apo-CIII
IPR038195 Apo_CIII_sf

The PANTHER Classification System

More...PANTHERi		PTHR14225 PTHR14225, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF05778 Apo-CIII, 1 hit

ProDom; a protein domain database

More...ProDomi		View protein in ProDom or Entries sharing at least one domain
PD010414 Apo-CIII, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P02656-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQPRVLLVVA LLALLASARA SEAEDASLLS FMQGYMKHAT KTAKDALSSV 
        60         70         80         90 
QESQVAQQAR GWVTDGFSSL KDYWSTVKDK FSEFWDLDPE VRPTSAVAA
Length:99
Mass (Da):10,852
Last modified:July 21, 1986 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD4E806339FAE4DA7
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B0YIW2B0YIW2_HUMAN
Apolipoprotein C-III variant 1
APOC3
117Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J2Q0C9J2Q0_HUMAN
Apolipoprotein C-III
APOC3
55Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti52 – 53ES → SQ AA sequence (PubMed:4846755).Curated2
Sequence conflicti57 – 59QQA → AQQ AA sequence (PubMed:4846755).Curated3

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_00064378K → E in HALP2. 1 PublicationCorresponds to variant dbSNP:rs121918382EnsemblClinVar.1
Natural variantiVAR_00064494T → A in C-III-0; unglycosylated. 1 PublicationCorresponds to variant dbSNP:rs121918381EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
J00098 Genomic DNA Translation: AAB59515.1
M33043, M33041, M33042 Genomic DNA Translation: AAB59372.1
X01392 Genomic DNA Translation: CAA25648.1
X01388 mRNA Translation: CAA25644.1
X03120 Genomic DNA Translation: CAA26895.1
V01513 mRNA Translation: CAA24757.1
M28613 mRNA Translation: AAA51760.1
M28614 mRNA Translation: AAA51761.1
X00567 mRNA Translation: CAA25233.1
AY422951 Genomic DNA Translation: AAQ91810.1
AY555191 Genomic DNA Translation: AAS68230.1
BC027977 mRNA Translation: AAH27977.1
BC121081 mRNA Translation: AAI21082.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS8377.1

Protein sequence database of the Protein Information Resource

More...PIRi		A90950 LPHUC3

NCBI Reference Sequences

More...RefSeqi		NP_000031.1, NM_000040.1

UniGene gene-oriented nucleotide sequence clusters

More...UniGenei		Hs.73849

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000227667; ENSP00000227667; ENSG00000110245

Database of genes from NCBI RefSeq genomes

More...GeneIDi		345

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:345

UCSC genome browser

More...UCSCi		uc001ppt.2 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00098 Genomic DNA Translation: AAB59515.1
M33043, M33041, M33042 Genomic DNA Translation: AAB59372.1
X01392 Genomic DNA Translation: CAA25648.1
X01388 mRNA Translation: CAA25644.1
X03120 Genomic DNA Translation: CAA26895.1
V01513 mRNA Translation: CAA24757.1
M28613 mRNA Translation: AAA51760.1
M28614 mRNA Translation: AAA51761.1
X00567 mRNA Translation: CAA25233.1
AY422951 Genomic DNA Translation: AAQ91810.1
AY555191 Genomic DNA Translation: AAS68230.1
BC027977 mRNA Translation: AAH27977.1
BC121081 mRNA Translation: AAI21082.1
CCDSiCCDS8377.1
PIRiA90950 LPHUC3
RefSeqiNP_000031.1, NM_000040.1
UniGeneiHs.73849

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2JQ3NMR-A21-99[»]
ProteinModelPortaliP02656
SMRiP02656
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106842, 23 interactors
IntActiP02656, 6 interactors
STRINGi9606.ENSP00000227667

PTM databases

CarbonylDBiP02656
GlyConnecti58
iPTMnetiP02656
PhosphoSitePlusiP02656
UniCarbKBiP02656

Polymorphism and mutation databases

BioMutaiAPOC3
DMDMi114026

2D gel databases

DOSAC-COBS-2DPAGEiP02656
SWISS-2DPAGEiP02656

Proteomic databases

EPDiP02656
jPOSTiP02656
MaxQBiP02656
PaxDbiP02656
PeptideAtlasiP02656
PRIDEiP02656
ProteomicsDBi51541

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		345
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000227667; ENSP00000227667; ENSG00000110245
GeneIDi345
KEGGihsa:345
UCSCiuc001ppt.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		345
DisGeNETi345
EuPathDBiHostDB:ENSG00000110245.11

GeneCards: human genes, protein and diseases

More...GeneCardsi		APOC3
HGNCiHGNC:610 APOC3
HPAiHPA065365
MalaCardsiAPOC3
MIMi107720 gene
614028 phenotype
neXtProtiNX_P02656
OpenTargetsiENSG00000110245
Orphaneti79506 Cholesterol-ester transfer protein deficiency
426 NON RARE IN EUROPE: Familial hypobetalipoproteinemia
33271 NON RARE IN EUROPE: Non-alcoholic fatty liver disease
PharmGKBiPA53

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG410JE3N Eukaryota
ENOG4111APE LUCA
GeneTreeiENSGT00390000015395
HOGENOMiHOG000247042
HOVERGENiHBG050549
InParanoidiP02656
KOiK08759
OrthoDBi649708at2759
PhylomeDBiP02656
TreeFamiTF338209

Enzyme and pathway databases

ReactomeiR-HSA-8963888 Chylomicron assembly
R-HSA-8963901 Chylomicron remodeling
R-HSA-8964058 HDL remodeling
R-HSA-975634 Retinoid metabolism and transport
SIGNORiP02656

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		APOC3 human
EvolutionaryTraceiP02656

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Apolipoprotein_C3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		345

Protein Ontology

More...PROi		PR:P02656

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000110245 Expressed in 91 organ(s), highest expression level in liver
ExpressionAtlasiP02656 baseline and differential
GenevisibleiP02656 HS

Family and domain databases

Gene3Di1.10.225.30, 1 hit
InterProiView protein in InterPro
IPR008403 Apo-CIII
IPR038195 Apo_CIII_sf
PANTHERiPTHR14225 PTHR14225, 1 hit
PfamiView protein in Pfam
PF05778 Apo-CIII, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD010414 Apo-CIII, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAPOC3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P02656
Secondary accession number(s): Q08E83, Q6Q786
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: February 13, 2019
This is version 188 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
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