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Protein

Apolipoprotein C-II

Gene

APOC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of chylomicrons, very low-density lipoproteins (VLDL), low-density lipoproteins (LDL), and high-density lipoproteins (HDL) in plasma. Plays an important role in lipoprotein metabolism as an activator of lipoprotein lipase. Both proapolipoprotein C-II and apolipoprotein C-II can activate lipoprotein lipase. In normolipidemic individuals, it is mainly distributed in the HDL, whereas in hypertriglyceridemic individuals, predominantly found in the VLDL and LDL.1 Publication1 Publication

GO - Molecular functioni

  • lipase inhibitor activity Source: BHF-UCL
  • lipid binding Source: BHF-UCL
  • lipoprotein lipase activator activity Source: BHF-UCL
  • phospholipase activator activity Source: BHF-UCL
  • phospholipase binding Source: BHF-UCL
  • protein homodimerization activity Source: BHF-UCL

GO - Biological processi

Keywordsi

Biological processLipid degradation, Lipid metabolism, Lipid transport, Transport
LigandSialic acid

Enzyme and pathway databases

ReactomeiR-HSA-8963888 Chylomicron assembly
R-HSA-8963889 Assembly of active LPL and LIPC lipase complexes
R-HSA-8963901 Chylomicron remodeling
R-HSA-8964058 HDL remodeling
R-HSA-975634 Retinoid metabolism and transport
SIGNORiP02655

Names & Taxonomyi

Protein namesi
Recommended name:
Apolipoprotein C-II
Short name:
Apo-CII
Short name:
ApoC-II
Alternative name(s):
Apolipoprotein C2
Cleaved into the following chain:
Proapolipoprotein C-II
Short name:
ProapoC-II
Gene namesi
Name:APOC2
Synonyms:APC2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000234906.8
HGNCiHGNC:609 APOC2
MIMi608083 gene
neXtProtiNX_P02655

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chylomicron, HDL, LDL, Secreted, VLDL

Pathology & Biotechi

Involvement in diseasei

Hyperlipoproteinemia 1B (HLPP1B)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAutosomal recessive trait characterized by hypertriglyceridemia, xanthomas, and increased risk of pancreatitis and early atherosclerosis.
See also OMIM:207750
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_00064048W → R in HLPP1B; variant Wakayama. 1 PublicationCorresponds to variant dbSNP:rs120074115EnsemblClinVar.1

Keywords - Diseasei

Disease mutation, Hyperlipidemia

Organism-specific databases

DisGeNETi344
MalaCardsiAPOC2
MIMi207750 phenotype
OpenTargetsiENSG00000234906
Orphaneti309020 Familial apolipoprotein C-II deficiency
PharmGKBiPA52

Polymorphism and mutation databases

BioMutaiAPOC2
DMDMi114022

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 222 PublicationsAdd BLAST22
ChainiPRO_000000202423 – 101Proapolipoprotein C-II2 PublicationsAdd BLAST79
ChainiPRO_000043083929 – 101Apolipoprotein C-II1 PublicationAdd BLAST73

Post-translational modificationi

Proapolipoprotein C-II is synthesized as a sialic acid containing glycoprotein which is subsequently desialylated prior to its proteolytic processing.1 Publication
Proapolipoprotein C-II, the major form found in plasma undergoes proteolytic cleavage of its N-terminal hexapeptide to generate apolipoprotein C-II, which occurs as the minor form in plasma.1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiP02655
MaxQBiP02655
PaxDbiP02655
PeptideAtlasiP02655
PRIDEiP02655
ProteomicsDBi51540
TopDownProteomicsiP02655

2D gel databases

DOSAC-COBS-2DPAGEiP02655
SWISS-2DPAGEiP02655

PTM databases

iPTMnetiP02655
PhosphoSitePlusiP02655

Miscellaneous databases

PMAP-CutDBiP02655

Expressioni

Tissue specificityi

Liver and intestine.1 Publication

Gene expression databases

BgeeiENSG00000234906 Expressed in 87 organ(s), highest expression level in liver
CleanExiHS_APC2
HS_APOC2
ExpressionAtlasiP02655 baseline and differential
GenevisibleiP02655 HS

Organism-specific databases

HPAiHPA055877

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi106841, 4 interactors
IntActiP02655, 5 interactors
STRINGi9606.ENSP00000466775

Structurei

Secondary structure

1101
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP02655
SMRiP02655
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP02655

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni23 – 38O-glycosylated at one siteAdd BLAST16
Regioni66 – 74Lipid binding1 Publication9
Regioni78 – 101Lipoprotein lipase cofactor2 PublicationsAdd BLAST24

Sequence similaritiesi

Belongs to the apolipoprotein C2 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J3QQ Eukaryota
ENOG4111AXD LUCA
GeneTreeiENSGT00390000007913
HOGENOMiHOG000034002
HOVERGENiHBG050548
InParanoidiP02655
KOiK22287
OrthoDBiEOG091G17WL
PhylomeDBiP02655

Family and domain databases

Gene3Di1.10.1440.10, 1 hit
InterProiView protein in InterPro
IPR008019 Apo-CII
IPR023121 ApoC-II_dom_sf
PANTHERiPTHR16566 PTHR16566, 1 hit
PfamiView protein in Pfam
PF05355 Apo-CII, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

P02655-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGTRLLPALF LVLLVLGFEV QGTQQPQQDE MPSPTFLTQV KESLSSYWES
60 70 80 90 100
AKTAAQNLYE KTYLPAVDEK LRDLYSKSTA AMSTYTGIFT DQVLSVLKGE

E
Length:101
Mass (Da):11,284
Last modified:July 21, 1986 - v1
Checksum:i51CB86FEDB174D84
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
V9GYJ8V9GYJ8_HUMAN
Apolipoprotein C-II
APOC2
87Annotation score:
Q6P163Q6P163_HUMAN
APOC2 protein
APOC2
72Annotation score:
V9GZ01V9GZ01_HUMAN
Apolipoprotein C-II
APOC2
47Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti36F → L in AAP35354 (Ref. 7) Curated1
Sequence conflicti36F → L in ACN81313 (Ref. 8) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_00063941K → T2 PublicationsCorresponds to variant dbSNP:rs120074114EnsemblClinVar.1
Natural variantiVAR_00064048W → R in HLPP1B; variant Wakayama. 1 PublicationCorresponds to variant dbSNP:rs120074115EnsemblClinVar.1
Natural variantiVAR_00064160E → K in San Francisco; found in hyperlipidemic patients. 1 PublicationCorresponds to variant dbSNP:rs5122EnsemblClinVar.1
Natural variantiVAR_00064277K → Q in Africa. 2 PublicationsCorresponds to variant dbSNP:rs5126EnsemblClinVar.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X05151 Genomic DNA Translation: CAA28798.1
X00568 mRNA Translation: CAA25234.1
J02698 Genomic DNA Translation: AAA98743.1
AY422955 Genomic DNA Translation: AAQ91814.1
BT006708 mRNA Translation: AAP35354.1
FJ525875 Genomic DNA Translation: ACN81313.1
CH471126 Genomic DNA Translation: EAW57311.1
BC005348 mRNA Translation: AAH05348.3
M29844 mRNA Translation: AAA51743.1
M10612 Genomic DNA Translation: AAB59380.1
AF113884 mRNA Translation: AAD28193.1
CCDSiCCDS12650.1
PIRiA24238 LPHUC2
RefSeqiNP_000474.2, NM_000483.4
UniGeneiHs.75615

Genome annotation databases

EnsembliENST00000252490; ENSP00000252490; ENSG00000234906
ENST00000590360; ENSP00000466775; ENSG00000234906
GeneIDi344
KEGGihsa:344
UCSCiuc060zuu.1 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X05151 Genomic DNA Translation: CAA28798.1
X00568 mRNA Translation: CAA25234.1
J02698 Genomic DNA Translation: AAA98743.1
AY422955 Genomic DNA Translation: AAQ91814.1
BT006708 mRNA Translation: AAP35354.1
FJ525875 Genomic DNA Translation: ACN81313.1
CH471126 Genomic DNA Translation: EAW57311.1
BC005348 mRNA Translation: AAH05348.3
M29844 mRNA Translation: AAA51743.1
M10612 Genomic DNA Translation: AAB59380.1
AF113884 mRNA Translation: AAD28193.1
CCDSiCCDS12650.1
PIRiA24238 LPHUC2
RefSeqiNP_000474.2, NM_000483.4
UniGeneiHs.75615

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BY6NMR-A66-101[»]
1I5JNMR-A23-101[»]
1O8TNMR-A23-101[»]
1SOHNMR-A23-101[»]
ProteinModelPortaliP02655
SMRiP02655
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106841, 4 interactors
IntActiP02655, 5 interactors
STRINGi9606.ENSP00000466775

PTM databases

iPTMnetiP02655
PhosphoSitePlusiP02655

Polymorphism and mutation databases

BioMutaiAPOC2
DMDMi114022

2D gel databases

DOSAC-COBS-2DPAGEiP02655
SWISS-2DPAGEiP02655

Proteomic databases

EPDiP02655
MaxQBiP02655
PaxDbiP02655
PeptideAtlasiP02655
PRIDEiP02655
ProteomicsDBi51540
TopDownProteomicsiP02655

Protocols and materials databases

DNASUi344
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000252490; ENSP00000252490; ENSG00000234906
ENST00000590360; ENSP00000466775; ENSG00000234906
GeneIDi344
KEGGihsa:344
UCSCiuc060zuu.1 human

Organism-specific databases

CTDi344
DisGeNETi344
EuPathDBiHostDB:ENSG00000234906.8
GeneCardsiAPOC2
HGNCiHGNC:609 APOC2
HPAiHPA055877
MalaCardsiAPOC2
MIMi207750 phenotype
608083 gene
neXtProtiNX_P02655
OpenTargetsiENSG00000234906
Orphaneti309020 Familial apolipoprotein C-II deficiency
PharmGKBiPA52
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J3QQ Eukaryota
ENOG4111AXD LUCA
GeneTreeiENSGT00390000007913
HOGENOMiHOG000034002
HOVERGENiHBG050548
InParanoidiP02655
KOiK22287
OrthoDBiEOG091G17WL
PhylomeDBiP02655

Enzyme and pathway databases

ReactomeiR-HSA-8963888 Chylomicron assembly
R-HSA-8963889 Assembly of active LPL and LIPC lipase complexes
R-HSA-8963901 Chylomicron remodeling
R-HSA-8964058 HDL remodeling
R-HSA-975634 Retinoid metabolism and transport
SIGNORiP02655

Miscellaneous databases

EvolutionaryTraceiP02655
GeneWikiiApolipoprotein_C2
GenomeRNAii344
PMAP-CutDBiP02655
PROiPR:P02655
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000234906 Expressed in 87 organ(s), highest expression level in liver
CleanExiHS_APC2
HS_APOC2
ExpressionAtlasiP02655 baseline and differential
GenevisibleiP02655 HS

Family and domain databases

Gene3Di1.10.1440.10, 1 hit
InterProiView protein in InterPro
IPR008019 Apo-CII
IPR023121 ApoC-II_dom_sf
PANTHERiPTHR16566 PTHR16566, 1 hit
PfamiView protein in Pfam
PF05355 Apo-CII, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiAPOC2_HUMAN
AccessioniPrimary (citable) accession number: P02655
Secondary accession number(s): C0JYY4
, Q9BS39, Q9UDE3, Q9UNK3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: September 12, 2018
This is version 204 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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