APOC1

Functionⁱ

Inhibitor of lipoprotein binding to the low density lipoprotein (LDL) receptor, LDL receptor-related protein, and very low density lipoprotein (VLDL) receptor. Associates with high density lipoproteins (HDL) and the triacylglycerol-rich lipoproteins in the plasma and makes up about 10% of the protein of the VLDL and 2% of that of HDL. Appears to interfere directly with fatty acid uptake and is also the major plasma inhibitor of cholesteryl ester transfer protein (CETP). Binds free fatty acids and reduces their intracellular esterification. Modulates the interaction of APOE with beta-migrating VLDL and inhibits binding of beta-VLDL to the LDL receptor-related protein.1 Publication1 Publication

Miscellaneous

Apolipoprotein C-I is present in acidic (APOC1A) and basic (APOC1B) forms in P.paniscus, P.abelii and P.troglodytes and perhaps also in baboons and macaques. The two genes for ApoC-I arose through a duplication process that occurred after the divergence of New World monkeys from the human lineage. In human, the acidic form has become a pseudogene sometime between the divergence of bonobos and chimpanzees from the human lineage and the appearance of the Denisovans. Pseudogenization resulted when the codon for the penultimate amino acid in the signal sequence was changed to a stop codon.1 Publication

GO - Molecular functionⁱ

fatty acid binding
Source: BHF-UCL
Inferred from direct assayⁱ
- 17339654
lipase inhibitor activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 15576844
- 182536
phosphatidylcholine binding
Source: BHF-UCL
Traceable author statementⁱ
- 2302419
phosphatidylcholine-sterol O-acyltransferase activator activity
Source: BHF-UCL
Traceable author statementⁱ
- 18992221
phospholipase inhibitor activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 2302419

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cholesterol efflux
Source: BHF-UCL
Inferred from direct assayⁱ
- 11162594
cholesterol metabolic process Source: Ensembl
chylomicron remnant clearance
Source: BHF-UCL
Inferred from direct assayⁱ
- 4020294
high-density lipoprotein particle remodeling
Source: BHF-UCL
Traceable author statementⁱ
- 18992221
lipid metabolic process
Source: ProtInc
Traceable author statementⁱ
- 2897845
lipoprotein metabolic process Source: InterPro
negative regulation of cholesterol transport
Source: BHF-UCL
Inferred from direct assayⁱ
- 10978346
negative regulation of fatty acid biosynthetic process
Source: BHF-UCL
Inferred from direct assayⁱ
- 15576844
negative regulation of lipid catabolic process
Source: BHF-UCL
Inferred from direct assayⁱ
- 15576844
negative regulation of lipid metabolic process
Source: BHF-UCL
Inferred from direct assayⁱ
- 182536
negative regulation of lipoprotein lipase activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 15576844
negative regulation of phosphatidylcholine catabolic process
Source: BHF-UCL
Inferred from direct assayⁱ
- 2302419
negative regulation of receptor-mediated endocytosis
Source: BHF-UCL
Inferred from direct assayⁱ
- 1917954
negative regulation of very-low-density lipoprotein particle clearance
Source: BHF-UCL
Inferred from direct assayⁱ
- 1917954
phospholipid efflux
Source: BHF-UCL
Inferred from direct assayⁱ
- 11162594
plasma lipoprotein particle remodeling
Source: BHF-UCL
Inferred from direct assayⁱ
- 10978346
positive regulation of cholesterol esterification
Source: BHF-UCL
Traceable author statementⁱ
- 18992221
regulation of cholesterol transport
Source: BHF-UCL
Inferred by curatorⁱ
- 15576844
triglyceride metabolic process Source: Ensembl
very-low-density lipoprotein particle assembly
Source: BHF-UCL
Traceable author statementⁱ
- 18992221
very-low-density lipoprotein particle clearance
Source: BHF-UCL
Inferred from genetic interactionⁱ
- 15576844

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Lipid transport, Transport

Biological process

Lipid transport, Transport

Enzyme and pathway databases

Reactomeⁱ	R-HSA-8866423 VLDL assembly R-HSA-8964046 VLDL clearance

Reactomeⁱ

R-HSA-8866423 VLDL assembly
R-HSA-8964046 VLDL clearance

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Apolipoprotein C-I Short name: Apo-CI Short name: ApoC-I Alternative name(s): Apolipoprotein C1 Cleaved into the following chain: Truncated apolipoprotein C-I
Gene namesⁱ	Name:APOC1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 19

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000130208.9
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:607 APOC1
MIMⁱ	107710 gene
neXtProtⁱ	NX_P02654

Keywords - Cellular componentⁱ

Secreted, VLDL

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	341
Open Targets More...OpenTargetsⁱ	ENSG00000130208
PharmGKBⁱ	PA51

Polymorphism and mutation databases

BioMutaⁱ	APOC1
DMDMⁱ	114016

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
Signal peptideⁱ	1 – 26	2 PublicationsAdd BLAST	26
ChainⁱPRO_0000002014	27 – 83	Apolipoprotein C-IAdd BLAST	57
ChainⁱPRO_0000391843	29 – 83	Truncated apolipoprotein C-IBy similarityAdd BLAST	55

Proteomic databases

EPDⁱ	P02654
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P02654
PaxDbⁱ	P02654
PeptideAtlas More...PeptideAtlasⁱ	P02654
PRIDEⁱ	P02654
ProteomicsDBⁱ	51539
TopDownProteomicsⁱ	P02654

PTM databases

CarbonylDBⁱ	P02654
PhosphoSitePlusⁱ	P02654

Expressionⁱ

Tissue specificityⁱ

Synthesized mainly in liver and to a minor degree in intestine. Also found in the lung and spleen.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000130208
CleanExⁱ	HS_APOC1
ExpressionAtlasⁱ	P02654 baseline and differential
Genevisibleⁱ	P02654 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA051518

HPAⁱ

HPA051518

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	106838, 4 interactors
IntActⁱ	P02654, 28 interactors
Molecular INTeraction database More...MINTⁱ	P02654
STRINGⁱ	9606.ENSP00000252491

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Show more details

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	31 – 33	Combined sources	3
Helixⁱ	35 – 48	Combined sources	14
Turnⁱ	52 – 54	Combined sources	3
Beta strandⁱ	56 – 62	Combined sources	7
Helixⁱ	65 – 78	Combined sources	14
Beta strandⁱ	79 – 81	Combined sources	3

3D structure databases

ProteinModelPortalⁱ	P02654
SMRⁱ	P02654
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P02654

EvolutionaryTraceⁱ

P02654

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the apolipoprotein C1 family.Curated

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	ENOG410J7EM Eukaryota ENOG410ZDUT LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000011584
HOGENOMⁱ	HOG000034001
HOVERGENⁱ	HBG050547
InParanoidⁱ	P02654
KEGG Orthology (KO) More...KOⁱ	K22286
PhylomeDBⁱ	P02654

Family and domain databases

InterProⁱ	View protein in InterPro IPR006781 ApoC-I
PANTHERⁱ	PTHR16565 PTHR16565, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF04691 ApoC-I, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P02654-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MRLFLSLPVL VVVLSIVLEG PAPAQGTPDV SSALDKLKEF GNTLEDKARE 
        60         70         80 
LISRIKQSEL SAKMREWFSE TFQKVKEKLK IDS

Length:83

Mass (Da):9,332

Last modified:October 23, 1986 - v1

Checksum:ⁱ4A3614626624AE6A

GO

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_014183	16	I → M1 PublicationCorresponds to variant dbSNP:rs5112Ensembl.		1
Natural variantⁱVAR_029011	71	T → S Polymorphism found only in persons of American Indian or Mexican ancestry; more susceptible to N-terminal truncation and shows greater distribution to the VLDL than the protein with T-71. 1 PublicationCorresponds to variant dbSNP:rs142372275Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X00570 mRNA Translation: CAA25235.1 M20843 Genomic DNA Translation: AAA51763.1 AF050154 Genomic DNA Translation: AAD02506.1 AY422954 Genomic DNA Translation: AAQ91813.1 BT007142 mRNA Translation: AAP35806.1 AK312036 mRNA Translation: BAG34973.1 CR456907 mRNA Translation: CAG33188.1 AM392727 mRNA Translation: CAL37605.1 FJ525874 Genomic DNA Translation: ACN81312.1 CH471126 Genomic DNA Translation: EAW57307.1 BC009698 mRNA Translation: AAH09698.1 BC055093 mRNA Translation: AAH55093.1 M20902 Genomic DNA Translation: AAA88018.1 M27359 mRNA Translation: AAA51762.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS12648.1
PIRⁱ	A28057 LPHUC1
NCBI Reference Sequences More...RefSeqⁱ	NP_001307994.1, NM_001321065.1 NP_001307995.1, NM_001321066.1 NP_001636.1, NM_001645.4
UniGeneⁱ	Hs.110675 Hs.737668

Genome annotation databases

Ensemblⁱ	ENST00000588750; ENSP00000465356; ENSG00000130208 ENST00000588802; ENSP00000468029; ENSG00000130208
GeneIDⁱ	341
KEGGⁱ	hsa:341
UCSC genome browser More...UCSCⁱ	uc002pac.2 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
P02654	Apolipoprotein C-I, isoform CRA_a		HUMAN		83
Apolipoprotein C-I (Fragment)		HUMAN		77
UPI0000111E0F		HUMAN		57

Protein	Similar proteins		Species	Score	Length
P02654	Apolipoprotein C-I, isoform CRA_a		HUMAN		83
Apolipoprotein C-I, basic form		PANTR		83
Uncharacterized protein		GORGO		83
Apolipoprotein C-I (Fragment)		HUMAN		77
UPI0000111E0F		HUMAN		57
+2

Protein	Similar proteins		Species	Score	Length
P02654	Apolipoprotein C-I, isoform CRA_a		HUMAN		83
Uncharacterized protein		GORGO		83
Apolipoprotein C-I, basic form		PANTR		83
UPI0004D0A404		GALVR		87
Apolipoprotein C-I		FUKDA		88
+52

Cross-referencesⁱ

Web resourcesⁱ

Wikipedia

Apolipoprotein C1 entry

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X00570 mRNA Translation: CAA25235.1 M20843 Genomic DNA Translation: AAA51763.1 AF050154 Genomic DNA Translation: AAD02506.1 AY422954 Genomic DNA Translation: AAQ91813.1 BT007142 mRNA Translation: AAP35806.1 AK312036 mRNA Translation: BAG34973.1 CR456907 mRNA Translation: CAG33188.1 AM392727 mRNA Translation: CAL37605.1 FJ525874 Genomic DNA Translation: ACN81312.1 CH471126 Genomic DNA Translation: EAW57307.1 BC009698 mRNA Translation: AAH09698.1 BC055093 mRNA Translation: AAH55093.1 M20902 Genomic DNA Translation: AAA88018.1 M27359 mRNA Translation: AAA51762.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS12648.1
PIRⁱ	A28057 LPHUC1
NCBI Reference Sequences More...RefSeqⁱ	NP_001307994.1, NM_001321065.1 NP_001307995.1, NM_001321066.1 NP_001636.1, NM_001645.4
UniGeneⁱ	Hs.110675 Hs.737668

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1ALE	NMR	-	A	33-50	[»]
	1ALF	NMR	-	A	61-79	[»]
	1IOJ	NMR	-	A	27-83	[»]
	1OPP	NMR	-	A	27-64	[»]
ProteinModelPortalⁱ	P02654
SMRⁱ	P02654
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	106838, 4 interactors
IntActⁱ	P02654, 28 interactors
Molecular INTeraction database More...MINTⁱ	P02654
STRINGⁱ	9606.ENSP00000252491

PTM databases

CarbonylDBⁱ	P02654
PhosphoSitePlusⁱ	P02654

Polymorphism and mutation databases

BioMutaⁱ	APOC1
DMDMⁱ	114016

Proteomic databases

EPDⁱ	P02654
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P02654
PaxDbⁱ	P02654
PeptideAtlas More...PeptideAtlasⁱ	P02654
PRIDEⁱ	P02654
ProteomicsDBⁱ	51539
TopDownProteomicsⁱ	P02654

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	341
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000588750; ENSP00000465356; ENSG00000130208 ENST00000588802; ENSP00000468029; ENSG00000130208
GeneIDⁱ	341
KEGGⁱ	hsa:341
UCSC genome browser More...UCSCⁱ	uc002pac.2 human

Organism-specific databases

CTDⁱ	341
DisGeNET More...DisGeNETⁱ	341
EuPathDBⁱ	HostDB:ENSG00000130208.9
GeneCardsⁱ	APOC1
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:607 APOC1
Human Protein Atlas More...HPAⁱ	HPA051518
MIMⁱ	107710 gene
neXtProtⁱ	NX_P02654
Open Targets More...OpenTargetsⁱ	ENSG00000130208
PharmGKBⁱ	PA51
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410J7EM Eukaryota ENOG410ZDUT LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000011584
HOGENOMⁱ	HOG000034001
HOVERGENⁱ	HBG050547
InParanoidⁱ	P02654
KEGG Orthology (KO) More...KOⁱ	K22286
PhylomeDBⁱ	P02654

Enzyme and pathway databases

Reactomeⁱ	R-HSA-8866423 VLDL assembly R-HSA-8964046 VLDL clearance

Reactomeⁱ

R-HSA-8866423 VLDL assembly
R-HSA-8964046 VLDL clearance

Miscellaneous databases

ChiTaRSⁱ	APOC1 human
EvolutionaryTraceⁱ	P02654
GeneWikiⁱ	Apolipoprotein_C1
GenomeRNAiⁱ	341
Protein Ontology More...PROⁱ	PR:P02654
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000130208
CleanExⁱ	HS_APOC1
ExpressionAtlasⁱ	P02654 baseline and differential
Genevisibleⁱ	P02654 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR006781 ApoC-I
PANTHERⁱ	PTHR16565 PTHR16565, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF04691 ApoC-I, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	APOC1_HUMAN
Accessionⁱ	P02654Primary (citable) accession number: P02654 Secondary accession number(s): B2R526, Q6IB97
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
	Last sequence update:	October 23, 1986
	Last modified:	July 18, 2018
	This is version 178 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families

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UniProtKB - P02654 (APOC1_HUMAN)

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Apolipoprotein C-I

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Endoplasmic reticulum

Extracellular region or secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Natural variant

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ