UniProtKB - P02654 (APOC1_HUMAN)
Protein
Apolipoprotein C-I
Gene
APOC1
Organism
Homo sapiens (Human)
Status
Functioni
Inhibitor of lipoprotein binding to the low density lipoprotein (LDL) receptor, LDL receptor-related protein, and very low density lipoprotein (VLDL) receptor. Associates with high density lipoproteins (HDL) and the triacylglycerol-rich lipoproteins in the plasma and makes up about 10% of the protein of the VLDL and 2% of that of HDL. Appears to interfere directly with fatty acid uptake and is also the major plasma inhibitor of cholesteryl ester transfer protein (CETP). Binds free fatty acids and reduces their intracellular esterification. Modulates the interaction of APOE with beta-migrating VLDL and inhibits binding of beta-VLDL to the LDL receptor-related protein.1 Publication1 Publication
Miscellaneous
Apolipoprotein C-I is present in acidic (APOC1A) and basic (APOC1B) forms in P.paniscus, P.abelii and P.troglodytes and perhaps also in baboons and macaques. The two genes for ApoC-I arose through a duplication process that occurred after the divergence of New World monkeys from the human lineage. In human, the acidic form has become a pseudogene sometime between the divergence of bonobos and chimpanzees from the human lineage and the appearance of the Denisovans. Pseudogenization resulted when the codon for the penultimate amino acid in the signal sequence was changed to a stop codon.1 Publication
GO - Molecular functioni
- fatty acid binding Source: BHF-UCL
- lipase inhibitor activity Source: BHF-UCL
- phosphatidylcholine binding Source: BHF-UCL
- phosphatidylcholine-sterol O-acyltransferase activator activity Source: BHF-UCL
- phospholipase inhibitor activity Source: BHF-UCL
GO - Biological processi
- cholesterol efflux Source: BHF-UCL
- cholesterol metabolic process Source: Ensembl
- chylomicron remnant clearance Source: BHF-UCL
- high-density lipoprotein particle remodeling Source: BHF-UCL
- lipid metabolic process Source: ProtInc
- lipoprotein metabolic process Source: InterPro
- negative regulation of cholesterol transport Source: BHF-UCL
- negative regulation of fatty acid biosynthetic process Source: BHF-UCL
- negative regulation of lipid catabolic process Source: BHF-UCL
- negative regulation of lipid metabolic process Source: BHF-UCL
- negative regulation of lipoprotein lipase activity Source: BHF-UCL
- negative regulation of phosphatidylcholine catabolic process Source: BHF-UCL
- negative regulation of receptor-mediated endocytosis Source: BHF-UCL
- negative regulation of very-low-density lipoprotein particle clearance Source: BHF-UCL
- phospholipid efflux Source: BHF-UCL
- plasma lipoprotein particle remodeling Source: BHF-UCL
- positive regulation of cholesterol esterification Source: BHF-UCL
- regulation of cholesterol transport Source: BHF-UCL
- triglyceride metabolic process Source: GO_Central
- very-low-density lipoprotein particle assembly Source: BHF-UCL
- very-low-density lipoprotein particle clearance Source: BHF-UCL
Keywordsi
Biological process | Lipid transport, Transport |
Enzyme and pathway databases
PathwayCommonsi | P02654 |
Reactomei | R-HSA-8866423, VLDL assembly R-HSA-8964046, VLDL clearance R-HSA-9029569, NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux |
Names & Taxonomyi
Protein namesi | Recommended name: Apolipoprotein C-IShort name: Apo-CI Short name: ApoC-I Alternative name(s): Apolipoprotein C1 Cleaved into the following chain: |
Gene namesi | Name:APOC1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000130208.9 |
HGNCi | HGNC:607, APOC1 |
MIMi | 107710, gene |
neXtProti | NX_P02654 |
Subcellular locationi
Extracellular region or secreted
- Secreted 1 Publication
Endoplasmic reticulum
- endoplasmic reticulum Source: LIFEdb
Extracellular region or secreted
- chylomicron Source: BHF-UCL
- extracellular region Source: Reactome
- high-density lipoprotein particle Source: BHF-UCL
- very-low-density lipoprotein particle Source: BHF-UCL
Keywords - Cellular componenti
Secreted, VLDLPathology & Biotechi
Organism-specific databases
DisGeNETi | 341 |
OpenTargetsi | ENSG00000130208 |
PharmGKBi | PA51 |
Miscellaneous databases
Pharosi | P02654, Tbio |
Polymorphism and mutation databases
BioMutai | APOC1 |
DMDMi | 114016 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 26 | 2 PublicationsAdd BLAST | 26 | |
ChainiPRO_0000002014 | 27 – 83 | Apolipoprotein C-IAdd BLAST | 57 | |
ChainiPRO_0000391843 | 29 – 83 | Truncated apolipoprotein C-IBy similarityAdd BLAST | 55 |
Proteomic databases
CPTACi | non-CPTAC-1085 non-CPTAC-2623 |
EPDi | P02654 |
jPOSTi | P02654 |
MassIVEi | P02654 |
MaxQBi | P02654 |
PaxDbi | P02654 |
PeptideAtlasi | P02654 |
PRIDEi | P02654 |
ProteomicsDBi | 51539 |
TopDownProteomicsi | P02654 |
PTM databases
CarbonylDBi | P02654 |
PhosphoSitePlusi | P02654 |
Expressioni
Tissue specificityi
Synthesized mainly in liver and to a minor degree in intestine. Also found in the lung and spleen.1 Publication
Gene expression databases
Bgeei | ENSG00000130208, Expressed in liver and 217 other tissues |
ExpressionAtlasi | P02654, baseline and differential |
Genevisiblei | P02654, HS |
Organism-specific databases
HPAi | ENSG00000130208, Tissue enriched (liver) |
Interactioni
Binary interactionsi
Hide detailsP02654
Protein-protein interaction databases
BioGRIDi | 106838, 31 interactors |
IntActi | P02654, 30 interactors |
MINTi | P02654 |
STRINGi | 9606.ENSP00000465356 |
Miscellaneous databases
RNActi | P02654, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P02654 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P02654 |
Family & Domainsi
Sequence similaritiesi
Belongs to the apolipoprotein C1 family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502SEU4, Eukaryota |
GeneTreei | ENSGT00390000011584 |
InParanoidi | P02654 |
OrthoDBi | 1558708at2759 |
PhylomeDBi | P02654 |
Family and domain databases
Gene3Di | 4.10.260.30, 1 hit |
InterProi | View protein in InterPro IPR043081, ApoC-1_sf IPR006781, ApoC-I |
PANTHERi | PTHR16565, PTHR16565, 1 hit |
Pfami | View protein in Pfam PF04691, ApoC-I, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All
P02654-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRLFLSLPVL VVVLSIVLEG PAPAQGTPDV SSALDKLKEF GNTLEDKARE
60 70 80
LISRIKQSEL SAKMREWFSE TFQKVKEKLK IDS
Computationally mapped potential isoform sequencesi
There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketK7EJI9 | K7EJI9_HUMAN | Apolipoprotein C-I | APOC1 | 83 | Annotation score: | ||
K7ELM9 | K7ELM9_HUMAN | Apolipoprotein C-I | APOC1 | 92 | Annotation score: | ||
K7EKP1 | K7EKP1_HUMAN | Apolipoprotein C-I | APOC1 | 53 | Annotation score: | ||
K7EPF9 | K7EPF9_HUMAN | Apolipoprotein C-I | APOC1 | 129 | Annotation score: | ||
K7ERI9 | K7ERI9_HUMAN | Apolipoprotein C-I | APOC1 | 77 | Annotation score: | ||
K7ELU7 | K7ELU7_HUMAN | Apolipoprotein C-I | APOC1 | 39 | Annotation score: | ||
K7EPR9 | K7EPR9_HUMAN | Apolipoprotein C-I | APOC1 | 29 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_014183 | 16 | I → M1 PublicationCorresponds to variant dbSNP:rs5112Ensembl. | 1 | |
Natural variantiVAR_029011 | 71 | T → S Polymorphism found only in persons of American Indian or Mexican ancestry; more susceptible to N-terminal truncation and shows greater distribution to the VLDL than the protein with T-71. 1 PublicationCorresponds to variant dbSNP:rs142372275Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X00570 mRNA Translation: CAA25235.1 M20843 Genomic DNA Translation: AAA51763.1 AF050154 Genomic DNA Translation: AAD02506.1 AY422954 Genomic DNA Translation: AAQ91813.1 BT007142 mRNA Translation: AAP35806.1 AK312036 mRNA Translation: BAG34973.1 CR456907 mRNA Translation: CAG33188.1 AM392727 mRNA Translation: CAL37605.1 FJ525874 Genomic DNA Translation: ACN81312.1 CH471126 Genomic DNA Translation: EAW57307.1 BC009698 mRNA Translation: AAH09698.1 BC055093 mRNA Translation: AAH55093.1 M20902 Genomic DNA Translation: AAA88018.1 M27359 mRNA Translation: AAA51762.1 |
CCDSi | CCDS12648.1 |
PIRi | A28057, LPHUC1 |
RefSeqi | NP_001307994.1, NM_001321065.1 NP_001307995.1, NM_001321066.1 NP_001636.1, NM_001645.4 |
Genome annotation databases
Ensembli | ENST00000588750; ENSP00000465356; ENSG00000130208 ENST00000588802; ENSP00000468029; ENSG00000130208 |
GeneIDi | 341 |
KEGGi | hsa:341 |
UCSCi | uc002pac.2, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Web resourcesi
Wikipedia Apolipoprotein C1 entry |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X00570 mRNA Translation: CAA25235.1 M20843 Genomic DNA Translation: AAA51763.1 AF050154 Genomic DNA Translation: AAD02506.1 AY422954 Genomic DNA Translation: AAQ91813.1 BT007142 mRNA Translation: AAP35806.1 AK312036 mRNA Translation: BAG34973.1 CR456907 mRNA Translation: CAG33188.1 AM392727 mRNA Translation: CAL37605.1 FJ525874 Genomic DNA Translation: ACN81312.1 CH471126 Genomic DNA Translation: EAW57307.1 BC009698 mRNA Translation: AAH09698.1 BC055093 mRNA Translation: AAH55093.1 M20902 Genomic DNA Translation: AAA88018.1 M27359 mRNA Translation: AAA51762.1 |
CCDSi | CCDS12648.1 |
PIRi | A28057, LPHUC1 |
RefSeqi | NP_001307994.1, NM_001321065.1 NP_001307995.1, NM_001321066.1 NP_001636.1, NM_001645.4 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1ALE | NMR | - | A | 33-50 | [»] | |
1ALF | NMR | - | A | 61-79 | [»] | |
1IOJ | NMR | - | A | 27-83 | [»] | |
1OPP | NMR | - | A | 27-64 | [»] | |
6DVU | X-ray | 1.80 | A/B | 1-83 | [»] | |
6DXR | X-ray | 2.00 | A/B | 1-83 | [»] | |
6DZ6 | X-ray | 3.00 | A/B | 1-83 | [»] | |
6NF3 | X-ray | 2.33 | A/B | 1-83 | [»] | |
SMRi | P02654 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 106838, 31 interactors |
IntActi | P02654, 30 interactors |
MINTi | P02654 |
STRINGi | 9606.ENSP00000465356 |
PTM databases
CarbonylDBi | P02654 |
PhosphoSitePlusi | P02654 |
Polymorphism and mutation databases
BioMutai | APOC1 |
DMDMi | 114016 |
Proteomic databases
CPTACi | non-CPTAC-1085 non-CPTAC-2623 |
EPDi | P02654 |
jPOSTi | P02654 |
MassIVEi | P02654 |
MaxQBi | P02654 |
PaxDbi | P02654 |
PeptideAtlasi | P02654 |
PRIDEi | P02654 |
ProteomicsDBi | 51539 |
TopDownProteomicsi | P02654 |
Protocols and materials databases
Antibodypediai | 17780, 355 antibodies |
DNASUi | 341 |
Genome annotation databases
Ensembli | ENST00000588750; ENSP00000465356; ENSG00000130208 ENST00000588802; ENSP00000468029; ENSG00000130208 |
GeneIDi | 341 |
KEGGi | hsa:341 |
UCSCi | uc002pac.2, human |
Organism-specific databases
CTDi | 341 |
DisGeNETi | 341 |
EuPathDBi | HostDB:ENSG00000130208.9 |
GeneCardsi | APOC1 |
HGNCi | HGNC:607, APOC1 |
HPAi | ENSG00000130208, Tissue enriched (liver) |
MIMi | 107710, gene |
neXtProti | NX_P02654 |
OpenTargetsi | ENSG00000130208 |
PharmGKBi | PA51 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502SEU4, Eukaryota |
GeneTreei | ENSGT00390000011584 |
InParanoidi | P02654 |
OrthoDBi | 1558708at2759 |
PhylomeDBi | P02654 |
Enzyme and pathway databases
PathwayCommonsi | P02654 |
Reactomei | R-HSA-8866423, VLDL assembly R-HSA-8964046, VLDL clearance R-HSA-9029569, NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux |
Miscellaneous databases
BioGRID-ORCSi | 341, 14 hits in 843 CRISPR screens |
ChiTaRSi | APOC1, human |
EvolutionaryTracei | P02654 |
GeneWikii | Apolipoprotein_C1 |
GenomeRNAii | 341 |
Pharosi | P02654, Tbio |
PROi | PR:P02654 |
RNActi | P02654, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000130208, Expressed in liver and 217 other tissues |
ExpressionAtlasi | P02654, baseline and differential |
Genevisiblei | P02654, HS |
Family and domain databases
Gene3Di | 4.10.260.30, 1 hit |
InterProi | View protein in InterPro IPR043081, ApoC-1_sf IPR006781, ApoC-I |
PANTHERi | PTHR16565, PTHR16565, 1 hit |
Pfami | View protein in Pfam PF04691, ApoC-I, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | APOC1_HUMAN | |
Accessioni | P02654Primary (citable) accession number: P02654 Secondary accession number(s): B2R526, Q6IB97 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 21, 1986 |
Last sequence update: | October 23, 1986 | |
Last modified: | December 2, 2020 | |
This is version 193 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations