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UniProtKB - P02654 (APOC1_HUMAN)

Entry version 193 (02 Dec 2020)
Sequence version 1 (23 Oct 1986)
Previous versions | rss
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Protein

Apolipoprotein C-I

Gene

APOC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Inhibitor of lipoprotein binding to the low density lipoprotein (LDL) receptor, LDL receptor-related protein, and very low density lipoprotein (VLDL) receptor. Associates with high density lipoproteins (HDL) and the triacylglycerol-rich lipoproteins in the plasma and makes up about 10% of the protein of the VLDL and 2% of that of HDL. Appears to interfere directly with fatty acid uptake and is also the major plasma inhibitor of cholesteryl ester transfer protein (CETP). Binds free fatty acids and reduces their intracellular esterification. Modulates the interaction of APOE with beta-migrating VLDL and inhibits binding of beta-VLDL to the LDL receptor-related protein.1 Publication1 Publication

Miscellaneous

Apolipoprotein C-I is present in acidic (APOC1A) and basic (APOC1B) forms in P.paniscus, P.abelii and P.troglodytes and perhaps also in baboons and macaques. The two genes for ApoC-I arose through a duplication process that occurred after the divergence of New World monkeys from the human lineage. In human, the acidic form has become a pseudogene sometime between the divergence of bonobos and chimpanzees from the human lineage and the appearance of the Denisovans. Pseudogenization resulted when the codon for the penultimate amino acid in the signal sequence was changed to a stop codon.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processLipid transport, Transport

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P02654

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-8866423, VLDL assembly
R-HSA-8964046, VLDL clearance
R-HSA-9029569, NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Apolipoprotein C-I
Short name:
Apo-CI
Short name:
ApoC-I
Alternative name(s):
Apolipoprotein C1
Cleaved into the following chain:
Truncated apolipoprotein C-I
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:APOC1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000130208.9

Human Gene Nomenclature Database

More...HGNCi		HGNC:607, APOC1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		107710, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P02654

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted, VLDL

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		341

Open Targets

More...OpenTargetsi		ENSG00000130208

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA51

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P02654, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		APOC1

Domain mapping of disease mutations (DMDM)

More...DMDMi		114016

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 262 PublicationsAdd BLAST26
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000201427 – 83Apolipoprotein C-IAdd BLAST57
ChainiPRO_000039184329 – 83Truncated apolipoprotein C-IBy similarityAdd BLAST55

Proteomic databases

The CPTAC Assay portal

More...CPTACi		non-CPTAC-1085
non-CPTAC-2623

Encyclopedia of Proteome Dynamics

More...EPDi		P02654

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P02654

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P02654

MaxQB - The MaxQuant DataBase

More...MaxQBi		P02654

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P02654

PeptideAtlas

More...PeptideAtlasi		P02654

PRoteomics IDEntifications database

More...PRIDEi		P02654

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		51539

Consortium for Top Down Proteomics

More...TopDownProteomicsi		P02654

PTM databases

CarbonylDB database of protein carbonylation sites

More...CarbonylDBi		P02654

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P02654

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Synthesized mainly in liver and to a minor degree in intestine. Also found in the lung and spleen.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000130208, Expressed in liver and 217 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P02654, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P02654, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000130208, Tissue enriched (liver)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		106838, 31 interactors

Protein interaction database and analysis system

More...IntActi		P02654, 30 interactors

Molecular INTeraction database

More...MINTi		P02654

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000465356

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P02654, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

183
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P02654

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P02654

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the apolipoprotein C1 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502SEU4, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000011584

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P02654

Database of Orthologous Groups

More...OrthoDBi		1558708at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P02654

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		4.10.260.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR043081, ApoC-1_sf
IPR006781, ApoC-I

The PANTHER Classification System

More...PANTHERi		PTHR16565, PTHR16565, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF04691, ApoC-I, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All

P02654-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRLFLSLPVL VVVLSIVLEG PAPAQGTPDV SSALDKLKEF GNTLEDKARE 
        60         70         80 
LISRIKQSEL SAKMREWFSE TFQKVKEKLK IDS
Length:83
Mass (Da):9,332
Last modified:October 23, 1986 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4A3614626624AE6A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EJI9K7EJI9_HUMAN
Apolipoprotein C-I
APOC1
83Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ELM9K7ELM9_HUMAN
Apolipoprotein C-I
APOC1
92Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EKP1K7EKP1_HUMAN
Apolipoprotein C-I
APOC1
53Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EPF9K7EPF9_HUMAN
Apolipoprotein C-I
APOC1
129Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ERI9K7ERI9_HUMAN
Apolipoprotein C-I
APOC1
77Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ELU7K7ELU7_HUMAN
Apolipoprotein C-I
APOC1
39Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EPR9K7EPR9_HUMAN
Apolipoprotein C-I
APOC1
29Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01418316I → M1 PublicationCorresponds to variant dbSNP:rs5112Ensembl.1
Natural variantiVAR_02901171T → S Polymorphism found only in persons of American Indian or Mexican ancestry; more susceptible to N-terminal truncation and shows greater distribution to the VLDL than the protein with T-71. 1 PublicationCorresponds to variant dbSNP:rs142372275Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X00570 mRNA Translation: CAA25235.1
M20843 Genomic DNA Translation: AAA51763.1
AF050154 Genomic DNA Translation: AAD02506.1
AY422954 Genomic DNA Translation: AAQ91813.1
BT007142 mRNA Translation: AAP35806.1
AK312036 mRNA Translation: BAG34973.1
CR456907 mRNA Translation: CAG33188.1
AM392727 mRNA Translation: CAL37605.1
FJ525874 Genomic DNA Translation: ACN81312.1
CH471126 Genomic DNA Translation: EAW57307.1
BC009698 mRNA Translation: AAH09698.1
BC055093 mRNA Translation: AAH55093.1
M20902 Genomic DNA Translation: AAA88018.1
M27359 mRNA Translation: AAA51762.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS12648.1

Protein sequence database of the Protein Information Resource

More...PIRi		A28057, LPHUC1

NCBI Reference Sequences

More...RefSeqi		NP_001307994.1, NM_001321065.1
NP_001307995.1, NM_001321066.1
NP_001636.1, NM_001645.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000588750; ENSP00000465356; ENSG00000130208
ENST00000588802; ENSP00000468029; ENSG00000130208

Database of genes from NCBI RefSeq genomes

More...GeneIDi		341

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:341

UCSC genome browser

More...UCSCi		uc002pac.2, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Wikipedia

Apolipoprotein C1 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X00570 mRNA Translation: CAA25235.1
M20843 Genomic DNA Translation: AAA51763.1
AF050154 Genomic DNA Translation: AAD02506.1
AY422954 Genomic DNA Translation: AAQ91813.1
BT007142 mRNA Translation: AAP35806.1
AK312036 mRNA Translation: BAG34973.1
CR456907 mRNA Translation: CAG33188.1
AM392727 mRNA Translation: CAL37605.1
FJ525874 Genomic DNA Translation: ACN81312.1
CH471126 Genomic DNA Translation: EAW57307.1
BC009698 mRNA Translation: AAH09698.1
BC055093 mRNA Translation: AAH55093.1
M20902 Genomic DNA Translation: AAA88018.1
M27359 mRNA Translation: AAA51762.1
CCDSiCCDS12648.1
PIRiA28057, LPHUC1
RefSeqiNP_001307994.1, NM_001321065.1
NP_001307995.1, NM_001321066.1
NP_001636.1, NM_001645.4

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ALENMR-A33-50[»]
1ALFNMR-A61-79[»]
1IOJNMR-A27-83[»]
1OPPNMR-A27-64[»]
6DVUX-ray1.80A/B1-83[»]
6DXRX-ray2.00A/B1-83[»]
6DZ6X-ray3.00A/B1-83[»]
6NF3X-ray2.33A/B1-83[»]
SMRiP02654
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi106838, 31 interactors
IntActiP02654, 30 interactors
MINTiP02654
STRINGi9606.ENSP00000465356

PTM databases

CarbonylDBiP02654
PhosphoSitePlusiP02654

Polymorphism and mutation databases

BioMutaiAPOC1
DMDMi114016

Proteomic databases

CPTACinon-CPTAC-1085
non-CPTAC-2623
EPDiP02654
jPOSTiP02654
MassIVEiP02654
MaxQBiP02654
PaxDbiP02654
PeptideAtlasiP02654
PRIDEiP02654
ProteomicsDBi51539
TopDownProteomicsiP02654

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		17780, 355 antibodies

The DNASU plasmid repository

More...DNASUi		341

Genome annotation databases

EnsembliENST00000588750; ENSP00000465356; ENSG00000130208
ENST00000588802; ENSP00000468029; ENSG00000130208
GeneIDi341
KEGGihsa:341
UCSCiuc002pac.2, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		341
DisGeNETi341
EuPathDBiHostDB:ENSG00000130208.9

GeneCards: human genes, protein and diseases

More...GeneCardsi		APOC1
HGNCiHGNC:607, APOC1
HPAiENSG00000130208, Tissue enriched (liver)
MIMi107710, gene
neXtProtiNX_P02654
OpenTargetsiENSG00000130208
PharmGKBiPA51

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502SEU4, Eukaryota
GeneTreeiENSGT00390000011584
InParanoidiP02654
OrthoDBi1558708at2759
PhylomeDBiP02654

Enzyme and pathway databases

PathwayCommonsiP02654
ReactomeiR-HSA-8866423, VLDL assembly
R-HSA-8964046, VLDL clearance
R-HSA-9029569, NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		341, 14 hits in 843 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		APOC1, human
EvolutionaryTraceiP02654

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Apolipoprotein_C1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		341
PharosiP02654, Tbio

Protein Ontology

More...PROi		PR:P02654
RNActiP02654, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000130208, Expressed in liver and 217 other tissues
ExpressionAtlasiP02654, baseline and differential
GenevisibleiP02654, HS

Family and domain databases

Gene3Di4.10.260.30, 1 hit
InterProiView protein in InterPro
IPR043081, ApoC-1_sf
IPR006781, ApoC-I
PANTHERiPTHR16565, PTHR16565, 1 hit
PfamiView protein in Pfam
PF04691, ApoC-I, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAPOC1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P02654
Secondary accession number(s): B2R526, Q6IB97
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: October 23, 1986
Last modified: December 2, 2020
This is version 193 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
  5. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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