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Protein

Apolipoprotein C-I

Gene

APOC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inhibitor of lipoprotein binding to the low density lipoprotein (LDL) receptor, LDL receptor-related protein, and very low density lipoprotein (VLDL) receptor. Associates with high density lipoproteins (HDL) and the triacylglycerol-rich lipoproteins in the plasma and makes up about 10% of the protein of the VLDL and 2% of that of HDL. Appears to interfere directly with fatty acid uptake and is also the major plasma inhibitor of cholesteryl ester transfer protein (CETP). Binds free fatty acids and reduces their intracellular esterification. Modulates the interaction of APOE with beta-migrating VLDL and inhibits binding of beta-VLDL to the LDL receptor-related protein.1 Publication1 Publication

Miscellaneous

Apolipoprotein C-I is present in acidic (APOC1A) and basic (APOC1B) forms in P.paniscus, P.abelii and P.troglodytes and perhaps also in baboons and macaques. The two genes for ApoC-I arose through a duplication process that occurred after the divergence of New World monkeys from the human lineage. In human, the acidic form has become a pseudogene sometime between the divergence of bonobos and chimpanzees from the human lineage and the appearance of the Denisovans. Pseudogenization resulted when the codon for the penultimate amino acid in the signal sequence was changed to a stop codon.1 Publication

GO - Molecular functioni

  • fatty acid binding Source: BHF-UCL
  • lipase inhibitor activity Source: BHF-UCL
  • phosphatidylcholine binding Source: BHF-UCL
  • phosphatidylcholine-sterol O-acyltransferase activator activity Source: BHF-UCL
  • phospholipase inhibitor activity Source: BHF-UCL

GO - Biological processi

  • cholesterol efflux Source: BHF-UCL
  • cholesterol metabolic process Source: Ensembl
  • chylomicron remnant clearance Source: BHF-UCL
  • high-density lipoprotein particle remodeling Source: BHF-UCL
  • lipid metabolic process Source: ProtInc
  • lipoprotein metabolic process Source: InterPro
  • negative regulation of cholesterol transport Source: BHF-UCL
  • negative regulation of fatty acid biosynthetic process Source: BHF-UCL
  • negative regulation of lipid catabolic process Source: BHF-UCL
  • negative regulation of lipid metabolic process Source: BHF-UCL
  • negative regulation of lipoprotein lipase activity Source: BHF-UCL
  • negative regulation of phosphatidylcholine catabolic process Source: BHF-UCL
  • negative regulation of receptor-mediated endocytosis Source: BHF-UCL
  • negative regulation of very-low-density lipoprotein particle clearance Source: BHF-UCL
  • phospholipid efflux Source: BHF-UCL
  • plasma lipoprotein particle remodeling Source: BHF-UCL
  • positive regulation of cholesterol esterification Source: BHF-UCL
  • regulation of cholesterol transport Source: BHF-UCL
  • triglyceride metabolic process Source: Ensembl
  • very-low-density lipoprotein particle assembly Source: BHF-UCL
  • very-low-density lipoprotein particle clearance Source: BHF-UCL

Keywordsi

Biological processLipid transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-8866423 VLDL assembly
R-HSA-8964046 VLDL clearance

Names & Taxonomyi

Protein namesi
Recommended name:
Apolipoprotein C-I
Short name:
Apo-CI
Short name:
ApoC-I
Alternative name(s):
Apolipoprotein C1
Cleaved into the following chain:
Gene namesi
Name:APOC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000130208.9
HGNCiHGNC:607 APOC1
MIMi107710 gene
neXtProtiNX_P02654

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted, VLDL

Pathology & Biotechi

Organism-specific databases

DisGeNETi341
OpenTargetsiENSG00000130208
PharmGKBiPA51

Polymorphism and mutation databases

BioMutaiAPOC1
DMDMi114016

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 262 PublicationsAdd BLAST26
ChainiPRO_000000201427 – 83Apolipoprotein C-IAdd BLAST57
ChainiPRO_000039184329 – 83Truncated apolipoprotein C-IBy similarityAdd BLAST55

Proteomic databases

EPDiP02654
MaxQBiP02654
PaxDbiP02654
PeptideAtlasiP02654
PRIDEiP02654
ProteomicsDBi51539
TopDownProteomicsiP02654

PTM databases

CarbonylDBiP02654
PhosphoSitePlusiP02654

Expressioni

Tissue specificityi

Synthesized mainly in liver and to a minor degree in intestine. Also found in the lung and spleen.1 Publication

Gene expression databases

BgeeiENSG00000130208
CleanExiHS_APOC1
ExpressionAtlasiP02654 baseline and differential
GenevisibleiP02654 HS

Organism-specific databases

HPAiHPA051518

Interactioni

Protein-protein interaction databases

BioGridi106838, 4 interactors
IntActiP02654, 28 interactors
MINTiP02654
STRINGi9606.ENSP00000252491

Structurei

Secondary structure

183
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi31 – 33Combined sources3
Helixi35 – 48Combined sources14
Turni52 – 54Combined sources3
Beta strandi56 – 62Combined sources7
Helixi65 – 78Combined sources14
Beta strandi79 – 81Combined sources3

3D structure databases

ProteinModelPortaliP02654
SMRiP02654
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP02654

Family & Domainsi

Sequence similaritiesi

Belongs to the apolipoprotein C1 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J7EM Eukaryota
ENOG410ZDUT LUCA
GeneTreeiENSGT00390000011584
HOGENOMiHOG000034001
HOVERGENiHBG050547
InParanoidiP02654
KOiK22286
PhylomeDBiP02654

Family and domain databases

InterProiView protein in InterPro
IPR006781 ApoC-I
PANTHERiPTHR16565 PTHR16565, 1 hit
PfamiView protein in Pfam
PF04691 ApoC-I, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02654-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLFLSLPVL VVVLSIVLEG PAPAQGTPDV SSALDKLKEF GNTLEDKARE
60 70 80
LISRIKQSEL SAKMREWFSE TFQKVKEKLK IDS
Length:83
Mass (Da):9,332
Last modified:October 23, 1986 - v1
Checksum:i4A3614626624AE6A
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01418316I → M1 PublicationCorresponds to variant dbSNP:rs5112Ensembl.1
Natural variantiVAR_02901171T → S Polymorphism found only in persons of American Indian or Mexican ancestry; more susceptible to N-terminal truncation and shows greater distribution to the VLDL than the protein with T-71. 1 PublicationCorresponds to variant dbSNP:rs142372275Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X00570 mRNA Translation: CAA25235.1
M20843 Genomic DNA Translation: AAA51763.1
AF050154 Genomic DNA Translation: AAD02506.1
AY422954 Genomic DNA Translation: AAQ91813.1
BT007142 mRNA Translation: AAP35806.1
AK312036 mRNA Translation: BAG34973.1
CR456907 mRNA Translation: CAG33188.1
AM392727 mRNA Translation: CAL37605.1
FJ525874 Genomic DNA Translation: ACN81312.1
CH471126 Genomic DNA Translation: EAW57307.1
BC009698 mRNA Translation: AAH09698.1
BC055093 mRNA Translation: AAH55093.1
M20902 Genomic DNA Translation: AAA88018.1
M27359 mRNA Translation: AAA51762.1
CCDSiCCDS12648.1
PIRiA28057 LPHUC1
RefSeqiNP_001307994.1, NM_001321065.1
NP_001307995.1, NM_001321066.1
NP_001636.1, NM_001645.4
UniGeneiHs.110675
Hs.737668

Genome annotation databases

EnsembliENST00000588750; ENSP00000465356; ENSG00000130208
ENST00000588802; ENSP00000468029; ENSG00000130208
GeneIDi341
KEGGihsa:341
UCSCiuc002pac.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiAPOC1_HUMAN
AccessioniPrimary (citable) accession number: P02654
Secondary accession number(s): B2R526, Q6IB97
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: October 23, 1986
Last modified: July 18, 2018
This is version 178 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

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