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Protein

Apolipoprotein A-II

Gene

APOA2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism.

Caution

The PDB entries that describe the 3D-structure of this protein have been obsoleted in response to US Office of Research Integrity Notice 2018-07782.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processHost-virus interaction, Lipid transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-1989781 PPARA activates gene expression
R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-8957275 Post-translational protein phosphorylation
R-HSA-8963888 Chylomicron assembly
R-HSA-8963901 Chylomicron remodeling
R-HSA-975634 Retinoid metabolism and transport

Names & Taxonomyi

Protein namesi
Recommended name:
Apolipoprotein A-II
Short name:
Apo-AII
Short name:
ApoA-II
Alternative name(s):
Apolipoprotein A2
Cleaved into the following 2 chains:
Proapolipoprotein A-II
Short name:
ProapoA-II
Alternative name(s):
Apolipoprotein A-II(1-76)
Gene namesi
Name:APOA2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000158874.11
HGNCiHGNC:601 APOA2
MIMi107670 gene+phenotype
neXtProtiNX_P02652

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

HDL, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi336
MalaCardsiAPOA2
MIMi107670 gene+phenotype
OpenTargetsiENSG00000158874
Orphaneti238269 AApoAII amyloidosis
PharmGKBiPA24886

Polymorphism and mutation databases

BioMutaiAPOA2
DMDMi114000

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 181 PublicationAdd BLAST18
ChainiPRO_000042535119 – 100Proapolipoprotein A-IIAdd BLAST82
ChainiPRO_000000200324 – 100Apolipoprotein A-II1 PublicationAdd BLAST77
ChainiPRO_000000200424 – 99Truncated apolipoprotein A-II1 PublicationAdd BLAST76

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei24Pyrrolidone carboxylic acid2 Publications1
Disulfide bondi29Interchain (with C-136 in APOD); in heterodimeric form1 Publication
Modified residuei49Methionine sulfoxide1 Publication1
Modified residuei54Phosphoserine; by FAM20C1 Publication1
Modified residuei68Phosphoserine; by FAM20CCombined sources1 Publication1

Post-translational modificationi

Phosphorylation sites are present in the extracellular medium.1 Publication
Apolipoprotein A-II is O-glycosylated.1 Publication

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Oxidation, Phosphoprotein, Pyrrolidone carboxylic acid

Proteomic databases

MaxQBiP02652
PaxDbiP02652
PeptideAtlasiP02652
PRIDEiP02652
ProteomicsDBi51538
TopDownProteomicsiP02652

2D gel databases

SWISS-2DPAGEiP02652

PTM databases

CarbonylDBiP02652
iPTMnetiP02652
PhosphoSitePlusiP02652

Miscellaneous databases

PMAP-CutDBiP02652

Expressioni

Tissue specificityi

Plasma; synthesized in the liver and intestine.

Gene expression databases

BgeeiENSG00000158874 Expressed in 98 organ(s), highest expression level in liver
CleanExiHS_APOA2
ExpressionAtlasiP02652 baseline and differential
GenevisibleiP02652 HS

Organism-specific databases

HPAiCAB025885

Interactioni

Subunit structurei

Monomer. Homodimer; disulfide-linked. Also forms a disulfide-linked heterodimer with APOD (PubMed:7918467).Interacts with APOA1BP and NDRG1.5 Publications
(Microbial infection) Interacts with HCV core protein.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
CATSPER1Q8NEC55EBI-1171525,EBI-744545

GO - Molecular functioni

Protein-protein interaction databases

BioGridi106833, 15 interactors
IntActiP02652, 23 interactors
MINTiP02652
STRINGi9606.ENSP00000356969

Structurei

3D structure databases

ProteinModelPortaliP02652
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP02652

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni32 – 43O-glycosylated at one siteAdd BLAST12

Sequence similaritiesi

Belongs to the apolipoprotein A2 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410KCI2 Eukaryota
ENOG4110NY0 LUCA
GeneTreeiENSGT00390000003306
HOGENOMiHOG000033999
HOVERGENiHBG050544
InParanoidiP02652
KOiK08758
PhylomeDBiP02652
TreeFamiTF338165

Family and domain databases

InterProiView protein in InterPro
IPR006801 ApoA-II
IPR036172 ApoA-II_sf
PANTHERiPTHR11027 PTHR11027, 1 hit
PfamiView protein in Pfam
PF04711 ApoA-II, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD010397 ApoA-II, 1 hit
SUPFAMiSSF82936 SSF82936, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All

P02652-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKLLAATVLL LTICSLEGAL VRRQAKEPCV ESLVSQYFQT VTDYGKDLME
60 70 80 90 100
KVKSPELQAE AKSYFEKSKE QLTPLIKKAG TELVNFLSYF VELGTQPATQ
Length:100
Mass (Da):11,175
Last modified:August 13, 1987 - v1
Checksum:i1247868A25EC3AF2
GO

Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
V9GYS1V9GYS1_HUMAN
Apolipoprotein A-II
APOA2
82Annotation score:
V9GYG9V9GYG9_HUMAN
Apolipoprotein A-II
APOA2
95Annotation score:
V9GYC1V9GYC1_HUMAN
Apolipoprotein A-II
APOA2
66Annotation score:
V9GYM3V9GYM3_HUMAN
Apolipoprotein A-II
APOA2
133Annotation score:
V9GYE3V9GYE3_HUMAN
Apolipoprotein A-II
APOA2
52Annotation score:
D3DVG8D3DVG8_HUMAN
Apolipoprotein A-II, isoform CRA_a
APOA2 hCG_1766509
72Annotation score:
Q76EI7Q76EI7_HUMAN
Apolipoprotein A-II
APOA2
27Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti96Q → H in CAA28583 (PubMed:6428397).Curated1

Mass spectrometryi

Molecular mass is 17252 Da from positions 24 - 100. Determined by ESI. Homodimer, without methionine sulfoxide.1 Publication
Molecular mass is 17269 Da from positions 24 - 100. Determined by ESI. Homodimer, with 1 methionine sulfoxide, oxidation at Met-49.1 Publication
Molecular mass is 8701.2 Da from positions 24 - 100. Determined by MALDI. Monomer.1 Publication
Molecular mass is 8823.4 Da from positions 24 - 100. Determined by MALDI. Cysteinylated ApoA-II monomer.1 Publication
Molecular mass is 17421.3 Da from positions 24 - 100. Determined by MALDI. Homodimer.1 Publication
Molecular mass is 17293.4 Da from positions 24 - 100. Determined by MALDI. Heterodimer with truncated apolipoprotein A-II.1 Publication
Molecular mass is 8578.3 Da from positions 24 - 99. Determined by MALDI. Monomer.1 Publication
Molecular mass is 17166.2 Da from positions 24 - 99. Determined by MALDI. Homodimer.1 Publication
Molecular mass is 17380 Da from positions 25 - 100. Determined by MALDI. Homodimer.1 Publication

Polymorphismi

A homozygous transition at position 1 of intron 3 of APOA2 results in deficiency of apolipoprotein A-II, without significant influence either on lipid and lipoprotein profiles or on the occurrence of coronary artery disease [MIMi:107670].1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04898 Genomic DNA Translation: CAA28583.1
X00955 mRNA Translation: CAA25467.1
X02905 Genomic DNA Translation: CAA26665.1
X02619 Genomic DNA Translation: CAA26474.1
M29882 mRNA Translation: AAA51701.1
AY100524 Genomic DNA Translation: AAM49807.1
AK312034 mRNA Translation: BAG34971.1
BT006786 mRNA Translation: AAP35432.1
AL590714 Genomic DNA No translation available.
BC005282 mRNA Translation: AAH05282.1
CCDSiCCDS1226.1
PIRiA93586 LPHUA2
RefSeqiNP_001634.1, NM_001643.1
UniGeneiHs.237658

Genome annotation databases

EnsembliENST00000367990; ENSP00000356969; ENSG00000158874
GeneIDi336
KEGGihsa:336
UCSCiuc001fzc.2 human

Similar proteinsi

Cross-referencesi

Web resourcesi

SHMPD

The Singapore human mutation and polymorphism database

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04898 Genomic DNA Translation: CAA28583.1
X00955 mRNA Translation: CAA25467.1
X02905 Genomic DNA Translation: CAA26665.1
X02619 Genomic DNA Translation: CAA26474.1
M29882 mRNA Translation: AAA51701.1
AY100524 Genomic DNA Translation: AAM49807.1
AK312034 mRNA Translation: BAG34971.1
BT006786 mRNA Translation: AAP35432.1
AL590714 Genomic DNA No translation available.
BC005282 mRNA Translation: AAH05282.1
CCDSiCCDS1226.1
PIRiA93586 LPHUA2
RefSeqiNP_001634.1, NM_001643.1
UniGeneiHs.237658

3D structure databases

ProteinModelPortaliP02652
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106833, 15 interactors
IntActiP02652, 23 interactors
MINTiP02652
STRINGi9606.ENSP00000356969

PTM databases

CarbonylDBiP02652
iPTMnetiP02652
PhosphoSitePlusiP02652

Polymorphism and mutation databases

BioMutaiAPOA2
DMDMi114000

2D gel databases

SWISS-2DPAGEiP02652

Proteomic databases

MaxQBiP02652
PaxDbiP02652
PeptideAtlasiP02652
PRIDEiP02652
ProteomicsDBi51538
TopDownProteomicsiP02652

Protocols and materials databases

DNASUi336
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367990; ENSP00000356969; ENSG00000158874
GeneIDi336
KEGGihsa:336
UCSCiuc001fzc.2 human

Organism-specific databases

CTDi336
DisGeNETi336
EuPathDBiHostDB:ENSG00000158874.11
GeneCardsiAPOA2
HGNCiHGNC:601 APOA2
HPAiCAB025885
MalaCardsiAPOA2
MIMi107670 gene+phenotype
neXtProtiNX_P02652
OpenTargetsiENSG00000158874
Orphaneti238269 AApoAII amyloidosis
PharmGKBiPA24886
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410KCI2 Eukaryota
ENOG4110NY0 LUCA
GeneTreeiENSGT00390000003306
HOGENOMiHOG000033999
HOVERGENiHBG050544
InParanoidiP02652
KOiK08758
PhylomeDBiP02652
TreeFamiTF338165

Enzyme and pathway databases

ReactomeiR-HSA-1989781 PPARA activates gene expression
R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-8957275 Post-translational protein phosphorylation
R-HSA-8963888 Chylomicron assembly
R-HSA-8963901 Chylomicron remodeling
R-HSA-975634 Retinoid metabolism and transport

Miscellaneous databases

ChiTaRSiAPOA2 human
EvolutionaryTraceiP02652
GeneWikiiAPOA2
GenomeRNAii336
PMAP-CutDBiP02652
PROiPR:P02652
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000158874 Expressed in 98 organ(s), highest expression level in liver
CleanExiHS_APOA2
ExpressionAtlasiP02652 baseline and differential
GenevisibleiP02652 HS

Family and domain databases

InterProiView protein in InterPro
IPR006801 ApoA-II
IPR036172 ApoA-II_sf
PANTHERiPTHR11027 PTHR11027, 1 hit
PfamiView protein in Pfam
PF04711 ApoA-II, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD010397 ApoA-II, 1 hit
SUPFAMiSSF82936 SSF82936, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiAPOA2_HUMAN
AccessioniPrimary (citable) accession number: P02652
Secondary accession number(s): B2R524
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: August 13, 1987
Last modified: November 7, 2018
This is version 214 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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