APOA2

Functionⁱ

May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism.

Caution

The PDB entries that describe the 3D-structure of this protein have been obsoleted in response to US Office of Research Integrity Notice 2018-07782.1 Publication

GO - Molecular functionⁱ

apolipoprotein receptor binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 11162594
cholesterol binding
Source: BHF-UCL
Inferred from direct assayⁱ
- 218942
cholesterol transporter activity Source: Ensembl
heat shock protein binding
Source: CAFA
Inferred from physical interactionⁱ
- 11027668
high-density lipoprotein particle binding Source: GO_Central
high-density lipoprotein particle receptor binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 10764676
lipase inhibitor activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 14967812
lipid binding
Source: BHF-UCL
Inferred from direct assayⁱ
- 14967812
lipid transporter activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 1606170
phosphatidylcholine binding
Source: BHF-UCL
Inferred from direct assayⁱ
- 17264082
phosphatidylcholine-sterol O-acyltransferase activator activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 14967812
phospholipid binding
Source: BHF-UCL
Inferred from direct assayⁱ
- 218942
protein heterodimerization activity
Source: UniProtKB
Inferred from physical interactionⁱ
- 7918467
protein homodimerization activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 17264082

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

acute inflammatory response Source: Ensembl
animal organ regeneration Source: Ensembl
cellular protein metabolic process Source: Reactome
cholesterol efflux
Source: BHF-UCL
Inferred from direct assayⁱ
- 11162594
cholesterol homeostasis
Source: BHF-UCL
Inferred from direct assayⁱ
- 14967812
cholesterol metabolic process Source: GO_Central
chylomicron assembly Source: Reactome
chylomicron remodeling Source: Reactome
diacylglycerol catabolic process
Source: BHF-UCL
Inferred from direct assayⁱ
- 14967812
high-density lipoprotein particle assembly
Source: BHF-UCL
Inferred from direct assayⁱ
- 218942
high-density lipoprotein particle clearance
Source: BHF-UCL
Inferred from direct assayⁱ
- 10764676
high-density lipoprotein particle remodeling
Source: BHF-UCL
Inferred from direct assayⁱ
- 14967812
- 8106353
lipoprotein metabolic process Source: GO_Central
low-density lipoprotein particle remodeling
Source: BHF-UCL
Inferred from direct assayⁱ
- 8106353
negative regulation of cholesterol import
Source: BHF-UCL
Inferred from direct assayⁱ
- 10764676
negative regulation of cholesterol transport
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 8636092
negative regulation of cholesterol transporter activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 8106353
negative regulation of cytokine secretion involved in immune response
Source: BHF-UCL
Inferred from direct assayⁱ
- 12458630
negative regulation of lipase activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 14967812
negative regulation of lipid catabolic process
Source: BHF-UCL
Inferred from direct assayⁱ
- 14967812
negative regulation of very-low-density lipoprotein particle remodeling
Source: BHF-UCL
Inferred from direct assayⁱ
- 14967812
peptidyl-methionine modification
Source: UniProtKB
Inferred from direct assayⁱ
- 12576517
phosphatidylcholine biosynthetic process
Source: BHF-UCL
Inferred from direct assayⁱ
- 14967812
phospholipid catabolic process
Source: BHF-UCL
Inferred from direct assayⁱ
- 14967812
phospholipid efflux
Source: BHF-UCL
Inferred from direct assayⁱ
- 11162594
positive regulation of cholesterol esterification
Source: BHF-UCL
Inferred from direct assayⁱ
- 14967812
positive regulation of interleukin-8 biosynthetic process
Source: UniProtKB
Inferred from direct assayⁱ
- 11591715
positive regulation of lipid catabolic process
Source: BHF-UCL
Inferred from direct assayⁱ
- 8640403
post-translational protein modification Source: Reactome
protein oxidation
Source: UniProtKB
Inferred from direct assayⁱ
- 12576517
regulation of intestinal cholesterol absorption Source: Ensembl
regulation of lipid metabolic process Source: Reactome
regulation of protein stability
Source: BHF-UCL
Inferred from direct assayⁱ
- 14967812
response to drug Source: Ensembl
response to estrogen Source: Ensembl
response to glucocorticoid Source: Ensembl
response to glucose
Source: BHF-UCL
Inferred from direct assayⁱ
- 14988251
retinoid metabolic process Source: Reactome
reverse cholesterol transport
Source: BHF-UCL
Inferred from direct assayⁱ
- 14967812
triglyceride metabolic process
Source: BHF-UCL
Traceable author statementⁱ
- 11551871
triglyceride-rich lipoprotein particle remodeling
Source: BHF-UCL
Inferred from direct assayⁱ
- 14967812
viral process Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Host-virus interaction, Lipid transport, Transport

Biological process

Host-virus interaction, Lipid transport, Transport

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1989781 PPARA activates gene expression R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-8957275 Post-translational protein phosphorylation R-HSA-8963888 Chylomicron assembly R-HSA-8963901 Chylomicron remodeling R-HSA-975634 Retinoid metabolism and transport

Reactomeⁱ

R-HSA-1989781 PPARA activates gene expression
R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-8957275 Post-translational protein phosphorylation
R-HSA-8963888 Chylomicron assembly
R-HSA-8963901 Chylomicron remodeling
R-HSA-975634 Retinoid metabolism and transport

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Apolipoprotein A-II Short name: Apo-AII Short name: ApoA-II Alternative name(s): Apolipoprotein A2 Cleaved into the following 2 chains: Proapolipoprotein A-II Short name: ProapoA-II Truncated apolipoprotein A-II Alternative name(s): Apolipoprotein A-II(1-76)
Gene namesⁱ	Name:APOA2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000158874.11
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:601 APOA2
MIMⁱ	107670 gene+phenotype
neXtProtⁱ	NX_P02652

Keywords - Cellular componentⁱ

HDL, Secreted

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	336
MalaCards human disease database More...MalaCardsⁱ	APOA2
MIMⁱ	107670 gene+phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000158874
Orphanetⁱ	238269 Familial renal amyloidosis due to Apolipoprotein AII variant
PharmGKBⁱ	PA24886

Polymorphism and mutation databases

BioMutaⁱ	APOA2
DMDMⁱ	114000

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
Signal peptideⁱ	1 – 18	1 PublicationAdd BLAST	18
ChainⁱPRO_0000425351	19 – 100	Proapolipoprotein A-IIAdd BLAST	82
ChainⁱPRO_0000002003	24 – 100	Apolipoprotein A-II1 PublicationAdd BLAST	77
ChainⁱPRO_0000002004	24 – 99	Truncated apolipoprotein A-II1 PublicationAdd BLAST	76

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	24	Pyrrolidone carboxylic acid2 Publications	1
Disulfide bondⁱ	29	Interchain (with C-136 in APOD); in heterodimeric form1 Publication
Modified residueⁱ	49	Methionine sulfoxide1 Publication	1
Modified residueⁱ	54	Phosphoserine; by FAM20C1 Publication	1
Modified residueⁱ	68	Phosphoserine; by FAM20CCombined sources1 Publication	1

Post-translational modificationⁱ

Phosphorylation sites are present in the extracellular medium.1 Publication

Apolipoprotein A-II is O-glycosylated.1 Publication

Keywords - PTMⁱ

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Oxidation, Phosphoprotein, Pyrrolidone carboxylic acid

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P02652
PaxDbⁱ	P02652
PeptideAtlas More...PeptideAtlasⁱ	P02652
PRIDEⁱ	P02652
ProteomicsDBⁱ	51538
TopDownProteomicsⁱ	P02652

2D gel databases

SWISS-2DPAGEⁱ	P02652

SWISS-2DPAGEⁱ

P02652

PTM databases

CarbonylDBⁱ	P02652
iPTMnetⁱ	P02652
PhosphoSitePlusⁱ	P02652

Miscellaneous databases

PMAP-CutDBⁱ	P02652

PMAP-CutDBⁱ

P02652

Expressionⁱ

Tissue specificityⁱ

Plasma; synthesized in the liver and intestine.

Gene expression databases

Bgeeⁱ	ENSG00000158874
CleanExⁱ	HS_APOA2
ExpressionAtlasⁱ	P02652 baseline and differential
Genevisibleⁱ	P02652 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB025885

HPAⁱ

CAB025885

Interactionⁱ

Subunit structureⁱ

Monomer. Homodimer; disulfide-linked. Also forms a disulfide-linked heterodimer with APOD (PubMed:7918467). Interacts with HCV core protein. Interacts with APOA1BP and NDRG1.5 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
CATSPER1	Q8NEC5	5	EBI-1171525,EBI-744545

With

Entry

#Exp.

IntAct

Notes

CATSPER1

Q8NEC5

5

EBI-1171525,EBI-744545

GO - Molecular functionⁱ

apolipoprotein receptor binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 11162594
heat shock protein binding
Source: CAFA
Inferred from physical interactionⁱ
- 11027668
high-density lipoprotein particle receptor binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 10764676
protein heterodimerization activity
Source: UniProtKB
Inferred from physical interactionⁱ
- 7918467
protein homodimerization activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 17264082

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	106833, 15 interactors
IntActⁱ	P02652, 9 interactors
Molecular INTeraction database More...MINTⁱ	P02652
STRINGⁱ	9606.ENSP00000356969

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P02652
SMRⁱ	P02652
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P02652

EvolutionaryTraceⁱ

P02652

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	32 – 43	O-glycosylated at one siteAdd BLAST		12

Sequence similaritiesⁱ

Belongs to the apolipoprotein A2 family.Curated

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	ENOG410KCI2 Eukaryota ENOG4110NY0 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000003306
HOGENOMⁱ	HOG000033999
HOVERGENⁱ	HBG050544
InParanoidⁱ	P02652
KEGG Orthology (KO) More...KOⁱ	K08758
PhylomeDBⁱ	P02652
TreeFamⁱ	TF338165

Family and domain databases

InterProⁱ	View protein in InterPro IPR006801 ApoA-II IPR036172 ApoA-II_sf
PANTHERⁱ	PTHR11027 PTHR11027, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF04711 ApoA-II, 1 hit
ProDomⁱ	View protein in ProDom or Entries sharing at least one domain PD010397 ApoA-II, 1 hit
SUPFAMⁱ	SSF82936 SSF82936, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P02652-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
MKLLAATVLL LTICSLEGAL VRRQAKEPCV ESLVSQYFQT VTDYGKDLME 
        60         70         80         90        100
KVKSPELQAE AKSYFEKSKE QLTPLIKKAG TELVNFLSYF VELGTQPATQ

Length:100

Mass (Da):11,175

Last modified:August 13, 1987 - v1

Checksum:ⁱ1247868A25EC3AF2

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	96	Q → H in CAA28583 (PubMed:6428397).Curated		1

Mass spectrometryⁱ

Molecular mass is 17252 Da from positions 24 - 100. Determined by ESI. Homodimer, without methionine sulfoxide.1 Publication

Molecular mass is 17269 Da from positions 24 - 100. Determined by ESI. Homodimer, with 1 methionine sulfoxide, oxidation at Met-49.1 Publication

Molecular mass is 8701.2 Da from positions 24 - 100. Determined by MALDI. Monomer.1 Publication

Molecular mass is 8823.4 Da from positions 24 - 100. Determined by MALDI. Cysteinylated ApoA-II monomer.1 Publication

Molecular mass is 17421.3 Da from positions 24 - 100. Determined by MALDI. Homodimer.1 Publication

Molecular mass is 17293.4 Da from positions 24 - 100. Determined by MALDI. Heterodimer with truncated apolipoprotein A-II.1 Publication

Molecular mass is 8578.3 Da from positions 24 - 99. Determined by MALDI. Monomer.1 Publication

Molecular mass is 17166.2 Da from positions 24 - 99. Determined by MALDI. Homodimer.1 Publication

Molecular mass is 17380 Da from positions 25 - 100. Determined by MALDI. Homodimer.1 Publication

Polymorphismⁱ

A homozygous transition at position 1 of intron 3 of APOA2 results in deficiency of apolipoprotein A-II, without significant influence either on lipid and lipoprotein profiles or on the occurrence of coronary artery disease [MIMⁱ:107670].1 Publication

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X04898 Genomic DNA Translation: CAA28583.1 X00955 mRNA Translation: CAA25467.1 X02905 Genomic DNA Translation: CAA26665.1 X02619 Genomic DNA Translation: CAA26474.1 M29882 mRNA Translation: AAA51701.1 AY100524 Genomic DNA Translation: AAM49807.1 AK312034 mRNA Translation: BAG34971.1 BT006786 mRNA Translation: AAP35432.1 AL590714 Genomic DNA No translation available. BC005282 mRNA Translation: AAH05282.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS1226.1
PIRⁱ	A93586 LPHUA2
NCBI Reference Sequences More...RefSeqⁱ	NP_001634.1, NM_001643.1
UniGeneⁱ	Hs.237658

Genome annotation databases

Ensemblⁱ	ENST00000367990; ENSP00000356969; ENSG00000158874
GeneIDⁱ	336
KEGGⁱ	hsa:336
UCSC genome browser More...UCSCⁱ	uc001fzc.2 human

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
P02652	Apolipoprotein A-II		GORGO		100
Apolipoprotein A-II		HUMAN		133
APOA2 isoform 7		PANTR		133
Uncharacterized protein		NOMLE		133
Apolipoprotein A-II Proapolipoprotein A-II Truncated apolipoprotein A-II		RHIRO		132
+35

Protein	Similar proteins		Species	Score	Length
P02652	Apolipoprotein A-II		GORGO		100
Apolipoprotein A-II		HUMAN		133
APOA2 isoform 7		PANTR		133
Uncharacterized protein		NOMLE		133
Apolipoprotein A-II Proapolipoprotein A-II Truncated apolipoprotein A-II		RHIRO		132
+45

Cross-referencesⁱ

Web resourcesⁱ

SHMPD

The Singapore human mutation and polymorphism database

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X04898 Genomic DNA Translation: CAA28583.1 X00955 mRNA Translation: CAA25467.1 X02905 Genomic DNA Translation: CAA26665.1 X02619 Genomic DNA Translation: CAA26474.1 M29882 mRNA Translation: AAA51701.1 AY100524 Genomic DNA Translation: AAM49807.1 AK312034 mRNA Translation: BAG34971.1 BT006786 mRNA Translation: AAP35432.1 AL590714 Genomic DNA No translation available. BC005282 mRNA Translation: AAH05282.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS1226.1
PIRⁱ	A93586 LPHUA2
NCBI Reference Sequences More...RefSeqⁱ	NP_001634.1, NM_001643.1
UniGeneⁱ	Hs.237658

3D structure databases

ProteinModelPortalⁱ	P02652
SMRⁱ	P02652
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	106833, 15 interactors
IntActⁱ	P02652, 9 interactors
Molecular INTeraction database More...MINTⁱ	P02652
STRINGⁱ	9606.ENSP00000356969

PTM databases

CarbonylDBⁱ	P02652
iPTMnetⁱ	P02652
PhosphoSitePlusⁱ	P02652

Polymorphism and mutation databases

BioMutaⁱ	APOA2
DMDMⁱ	114000

2D gel databases

SWISS-2DPAGEⁱ	P02652

SWISS-2DPAGEⁱ

P02652

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P02652
PaxDbⁱ	P02652
PeptideAtlas More...PeptideAtlasⁱ	P02652
PRIDEⁱ	P02652
ProteomicsDBⁱ	51538
TopDownProteomicsⁱ	P02652

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	336
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000367990; ENSP00000356969; ENSG00000158874
GeneIDⁱ	336
KEGGⁱ	hsa:336
UCSC genome browser More...UCSCⁱ	uc001fzc.2 human

Organism-specific databases

CTDⁱ	336
DisGeNET More...DisGeNETⁱ	336
EuPathDBⁱ	HostDB:ENSG00000158874.11
GeneCardsⁱ	APOA2
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:601 APOA2
Human Protein Atlas More...HPAⁱ	CAB025885
MalaCards human disease database More...MalaCardsⁱ	APOA2
MIMⁱ	107670 gene+phenotype
neXtProtⁱ	NX_P02652
Open Targets More...OpenTargetsⁱ	ENSG00000158874
Orphanetⁱ	238269 Familial renal amyloidosis due to Apolipoprotein AII variant
PharmGKBⁱ	PA24886
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410KCI2 Eukaryota ENOG4110NY0 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000003306
HOGENOMⁱ	HOG000033999
HOVERGENⁱ	HBG050544
InParanoidⁱ	P02652
KEGG Orthology (KO) More...KOⁱ	K08758
PhylomeDBⁱ	P02652
TreeFamⁱ	TF338165

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1989781 PPARA activates gene expression R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-8957275 Post-translational protein phosphorylation R-HSA-8963888 Chylomicron assembly R-HSA-8963901 Chylomicron remodeling R-HSA-975634 Retinoid metabolism and transport

Reactomeⁱ

R-HSA-1989781 PPARA activates gene expression
R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-8957275 Post-translational protein phosphorylation
R-HSA-8963888 Chylomicron assembly
R-HSA-8963901 Chylomicron remodeling
R-HSA-975634 Retinoid metabolism and transport

Miscellaneous databases

ChiTaRSⁱ	APOA2 human
EvolutionaryTraceⁱ	P02652
GeneWikiⁱ	APOA2
GenomeRNAiⁱ	336
PMAP-CutDBⁱ	P02652
Protein Ontology More...PROⁱ	PR:P02652
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000158874
CleanExⁱ	HS_APOA2
ExpressionAtlasⁱ	P02652 baseline and differential
Genevisibleⁱ	P02652 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR006801 ApoA-II IPR036172 ApoA-II_sf
PANTHERⁱ	PTHR11027 PTHR11027, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF04711 ApoA-II, 1 hit
ProDomⁱ	View protein in ProDom or Entries sharing at least one domain PD010397 ApoA-II, 1 hit
SUPFAMⁱ	SSF82936 SSF82936, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	APOA2_HUMAN
Accessionⁱ	P02652Primary (citable) accession number: P02652 Secondary accession number(s): B2R524
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
	Last sequence update:	August 13, 1987
	Last modified:	June 20, 2018
	This is version 211 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

Documents

Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
SIMILARITY comments
Index of protein domains and families

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P02652 (APOA2_HUMAN)

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Apolipoprotein A-II

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Cytosol

Endoplasmic reticulum

Endosome

Extracellular region or secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

2D gel databases

PTM databases

Miscellaneous databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

<p>This subsection of the ‘Sequence’ section reports information derived from mass spectrometry experiments done on the entire protein or on biologically active derived peptide(s).<p><a href='/help/mass_spectrometry' target='_top'>More...</a></p>Mass spectrometryi

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

2D gel databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

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<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Mass spectrometryⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ