UniProtKB - P02647 (APOA1_HUMAN)
Apolipoprotein A-I
APOA1
Functioni
Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility.
1 PublicationGO - Molecular functioni
- amyloid-beta binding Source: BHF-UCL
- apolipoprotein A-I receptor binding Source: BHF-UCL
- apolipoprotein receptor binding Source: BHF-UCL
- chemorepellent activity Source: UniProtKB
- cholesterol binding Source: BHF-UCL
- cholesterol transfer activity Source: BHF-UCL
- enzyme binding Source: BHF-UCL
- heat shock protein binding Source: CAFA
- high-density lipoprotein particle binding Source: Ensembl
- high-density lipoprotein particle receptor binding Source: BHF-UCL
- identical protein binding Source: IntAct
- phosphatidylcholine binding Source: GO_Central
- phosphatidylcholine-sterol O-acyltransferase activator activity Source: BHF-UCL
- phospholipid binding Source: BHF-UCL
- protein homodimerization activity Source: UniProtKB
- signaling receptor binding Source: ARUK-UCL
GO - Biological processi
- adrenal gland development Source: Ensembl
- blood vessel endothelial cell migration Source: Ensembl
- cholesterol biosynthetic process Source: GO_Central
- cholesterol efflux Source: BHF-UCL
- cholesterol homeostasis Source: BHF-UCL
- cholesterol import Source: BHF-UCL
- cholesterol metabolic process Source: BHF-UCL
- cholesterol transport Source: MGI
- endothelial cell proliferation Source: Ensembl
- glucocorticoid metabolic process Source: Ensembl
- G protein-coupled receptor signaling pathway Source: BHF-UCL
- high-density lipoprotein particle assembly Source: BHF-UCL
- high-density lipoprotein particle clearance Source: BHF-UCL
- high-density lipoprotein particle remodeling Source: BHF-UCL
- integrin-mediated signaling pathway Source: UniProtKB
- lipid storage Source: Ensembl
- lipoprotein biosynthetic process Source: Ensembl
- lipoprotein metabolic process Source: GO_Central
- negative chemotaxis Source: UniProtKB
- negative regulation of cell adhesion molecule production Source: BHF-UCL
- negative regulation of cytokine production involved in immune response Source: BHF-UCL
- negative regulation of heterotypic cell-cell adhesion Source: BHF-UCL
- negative regulation of hydrolase activity Source: Ensembl
- negative regulation of inflammatory response Source: BHF-UCL
- negative regulation of interleukin-1 beta production Source: BHF-UCL
- negative regulation of response to cytokine stimulus Source: BHF-UCL
- negative regulation of tumor necrosis factor-mediated signaling pathway Source: BHF-UCL
- negative regulation of very-low-density lipoprotein particle remodeling Source: BHF-UCL
- peptidyl-methionine modification Source: UniProtKB
- phosphatidylcholine biosynthetic process Source: BHF-UCL
- phosphatidylcholine metabolic process Source: GO_Central
- phospholipid efflux Source: BHF-UCL
- phospholipid homeostasis Source: BHF-UCL
- positive regulation of cholesterol efflux Source: UniProtKB
- positive regulation of cholesterol esterification Source: BHF-UCL
- positive regulation of fatty acid biosynthetic process Source: GO_Central
- positive regulation of hydrolase activity Source: BHF-UCL
- positive regulation of lipid biosynthetic process Source: GO_Central
- positive regulation of lipoprotein lipase activity Source: GO_Central
- positive regulation of phagocytosis Source: UniProtKB
- positive regulation of phospholipid efflux Source: UniProtKB
- positive regulation of Rho protein signal transduction Source: UniProtKB
- positive regulation of stress fiber assembly Source: UniProtKB
- positive regulation of substrate adhesion-dependent cell spreading Source: UniProtKB
- positive regulation of triglyceride catabolic process Source: GO_Central
- protein oxidation Source: UniProtKB
- protein stabilization Source: UniProtKB
- regulation of Cdc42 protein signal transduction Source: BHF-UCL
- regulation of intestinal cholesterol absorption Source: GO_Central
- regulation of protein phosphorylation Source: Ensembl
- reverse cholesterol transport Source: BHF-UCL
- triglyceride homeostasis Source: BHF-UCL
- very-low-density lipoprotein particle remodeling Source: GO_Central
- vitamin transport Source: AgBase
Keywordsi
Biological process | Cholesterol metabolism, Lipid metabolism, Lipid transport, Steroid metabolism, Sterol metabolism, Transport |
Enzyme and pathway databases
PathwayCommonsi | P02647 |
Reactomei | R-HSA-114608, Platelet degranulation R-HSA-1369062, ABC transporters in lipid homeostasis R-HSA-1989781, PPARA activates gene expression R-HSA-2168880, Scavenging of heme from plasma R-HSA-3000471, Scavenging by Class B Receptors R-HSA-3000480, Scavenging by Class A Receptors R-HSA-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-5682113, Defective ABCA1 causes TGD R-HSA-8957275, Post-translational protein phosphorylation R-HSA-8963888, Chylomicron assembly R-HSA-8963896, HDL assembly R-HSA-8963901, Chylomicron remodeling R-HSA-8964011, HDL clearance R-HSA-8964058, HDL remodeling R-HSA-9707616, Heme signaling R-HSA-975634, Retinoid metabolism and transport R-HSA-977225, Amyloid fiber formation |
SignaLinki | P02647 |
SIGNORi | P02647 |
Names & Taxonomyi
Protein namesi | Recommended name: Apolipoprotein A-ICuratedShort name: Apo-AI Short name: ApoA-I Alternative name(s): Apolipoprotein A1 Cleaved into the following 2 chains: Alternative name(s): Apolipoprotein A-I(1-242) |
Gene namesi | Name:APOA1Imported |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:600, APOA1 |
MIMi | 107680, gene |
neXtProti | NX_P02647 |
VEuPathDBi | HostDB:ENSG00000118137 |
Subcellular locationi
Extracellular region or secreted
Cytosol
- cytosol Source: Reactome
Endoplasmic reticulum
- endoplasmic reticulum lumen Source: Reactome
Endosome
- early endosome Source: Reactome
Extracellular region or secreted
- blood microparticle Source: UniProtKB
- chylomicron Source: GO_Central
- extracellular exosome Source: UniProtKB
- extracellular region Source: BHF-UCL
- extracellular space Source: MGI
- extracellular vesicle Source: UniProtKB
- high-density lipoprotein particle Source: BHF-UCL
- spherical high-density lipoprotein particle Source: BHF-UCL
- very-low-density lipoprotein particle Source: BHF-UCL
Plasma Membrane
- plasma membrane Source: Reactome
Other locations
- collagen-containing extracellular matrix Source: BHF-UCL
- cytoplasmic vesicle Source: BHF-UCL
- endocytic vesicle Source: BHF-UCL
- endocytic vesicle lumen Source: Reactome
- secretory granule lumen Source: Reactome
Keywords - Cellular componenti
Amyloid, HDL, SecretedPathology & Biotechi
Involvement in diseasei
Hypoalphalipoproteinemia, primary, 2 (FHA2)3 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_083307 | 23 – 267 | Missing in FHA2; no protein expression. 1 PublicationAdd BLAST | 245 | |
Natural variantiVAR_083309 | 108 – 267 | Missing in FHA2; missing protein expression. 1 PublicationAdd BLAST | 160 |
Amyloidosis 8 (AMYL8)7 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_000609 | 50 | G → R in AMYL8; also found in a family with amyloid polyneuropathy-nephropathy Iowa. 4 PublicationsCorresponds to variant dbSNP:rs28931574EnsemblClinVar. | 1 | |
Natural variantiVAR_000610 | 84 | L → R in AMYL8. 1 PublicationCorresponds to variant dbSNP:rs121912724EnsemblClinVar. | 1 | |
Natural variantiVAR_083310 | 173 | R → P in AMYL8; unknown pathological significance. 1 Publication | 1 | |
Natural variantiVAR_083311 | 198 | L → S in AMYL8; plasma level of HDL and apoA-I protein were significantly lower in the patient. 1 Publication | 1 | |
Natural variantiVAR_083312 | 199 | A → P in AMYL8; unknown pathological significance. 1 Publication | 1 |
Keywords - Diseasei
Amyloidosis, Atherosclerosis, Disease variant, NeuropathyOrganism-specific databases
DisGeNETi | 335 |
MalaCardsi | APOA1 |
MIMi | 105200, phenotype 618463, phenotype |
OpenTargetsi | ENSG00000118137 |
Orphaneti | 93560, AApoAI amyloidosis 425, Apolipoprotein A-I deficiency |
PharmGKBi | PA49 |
Miscellaneous databases
Pharosi | P02647, Tbio |
Chemistry databases
ChEMBLi | CHEMBL5984 |
DrugBanki | DB09130, Copper DB11886, Infigratinib DB00877, Sirolimus DB01593, Zinc DB14487, Zinc acetate DB14533, Zinc chloride DB14548, Zinc sulfate, unspecified form |
Genetic variation databases
BioMutai | APOA1 |
DMDMi | 113992 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 18 | 2 PublicationsAdd BLAST | 18 | |
ChainiPRO_0000425323 | 19 – 267 | Proapolipoprotein A-IAdd BLAST | 249 | |
ChainiPRO_0000001939 | 25 – 267 | Apolipoprotein A-IAdd BLAST | 243 | |
ChainiPRO_0000001940 | 25 – 266 | Truncated apolipoprotein A-IAdd BLAST | 242 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 110 | Methionine sulfoxide1 Publication | 1 | |
Modified residuei | 136 | Methionine sulfoxide1 Publication | 1 | |
Glycosylationi | 263 | N-linked (Glc) (glycation) lysine1 Publication | 1 |
Post-translational modificationi
Keywords - PTMi
Glycation, Glycoprotein, Lipoprotein, Oxidation, Palmitate, PhosphoproteinProteomic databases
CPTACi | non-CPTAC-1075 non-CPTAC-1076 |
EPDi | P02647 |
jPOSTi | P02647 |
MassIVEi | P02647 |
MaxQBi | P02647 |
PaxDbi | P02647 |
PeptideAtlasi | P02647 |
PRIDEi | P02647 |
ProteomicsDBi | 51536 |
TopDownProteomicsi | P02647 |
2D gel databases
DOSAC-COBS-2DPAGEi | P02647 |
OGPi | P02647 |
REPRODUCTION-2DPAGEi | IPI00021841 P02647 |
SWISS-2DPAGEi | P02647 |
UCD-2DPAGEi | P02647 |
PTM databases
CarbonylDBi | P02647 |
GlyGeni | P02647, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | P02647 |
MetOSitei | P02647 |
PhosphoSitePlusi | P02647 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000118137, Expressed in duodenum and 127 other tissues |
ExpressionAtlasi | P02647, baseline and differential |
Genevisiblei | P02647, HS |
Organism-specific databases
HPAi | ENSG00000118137, Tissue enriched (liver) |
Interactioni
Subunit structurei
Homodimer (By similarity).
Interacts with NAXE and CLU (PubMed:1742316, PubMed:11991719).
Component of a sperm activating protein complex (SPAP), consisting of APOA1, an immunoglobulin heavy chain, an immunoglobulin light chain and albumin (PubMed:1909888).
Interacts with NDRG1 (PubMed:15922294).
Interacts with SCGB3A2 (PubMed:12847263).
Interacts with NAXE and YJEFN3 (PubMed:23719382).
By similarity6 PublicationsBinary interactionsi
P02647
GO - Molecular functioni
- apolipoprotein A-I receptor binding Source: BHF-UCL
- apolipoprotein receptor binding Source: BHF-UCL
- chemorepellent activity Source: UniProtKB
- enzyme binding Source: BHF-UCL
- heat shock protein binding Source: CAFA
- high-density lipoprotein particle receptor binding Source: BHF-UCL
- identical protein binding Source: IntAct
- protein homodimerization activity Source: UniProtKB
- signaling receptor binding Source: ARUK-UCL
Protein-protein interaction databases
BioGRIDi | 106832, 172 interactors |
CORUMi | P02647 |
DIPi | DIP-29619N |
IntActi | P02647, 93 interactors |
MINTi | P02647 |
STRINGi | 9606.ENSP00000236850 |
Miscellaneous databases
RNActi | P02647, protein |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | P02647 |
BMRBi | P02647 |
SMRi | P02647 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P02647 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 68 – 89 | 1Add BLAST | 22 | |
Repeati | 90 – 111 | 2Add BLAST | 22 | |
Repeati | 112 – 122 | 3; half-lengthAdd BLAST | 11 | |
Repeati | 123 – 144 | 4Add BLAST | 22 | |
Repeati | 145 – 166 | 5Add BLAST | 22 | |
Repeati | 167 – 188 | 6Add BLAST | 22 | |
Repeati | 189 – 210 | 7Add BLAST | 22 | |
Repeati | 211 – 232 | 8Add BLAST | 22 | |
Repeati | 233 – 243 | 9; half-lengthAdd BLAST | 11 | |
Repeati | 244 – 267 | 10Add BLAST | 24 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 68 – 267 | 10 X approximate tandem repeatsAdd BLAST | 200 |
Sequence similaritiesi
Keywords - Domaini
Repeat, SignalPhylogenomic databases
eggNOGi | ENOG502S1XQ, Eukaryota |
GeneTreei | ENSGT00950000182929 |
HOGENOMi | CLU_058447_1_0_1 |
InParanoidi | P02647 |
OMAi | KEVREMW |
OrthoDBi | 1553412at2759 |
PhylomeDBi | P02647 |
TreeFami | TF334458 |
Family and domain databases
InterProi | View protein in InterPro IPR000074, ApoA_E |
Pfami | View protein in Pfam PF01442, Apolipoprotein, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
10 20 30 40 50
MKAAVLTLAV LFLTGSQARH FWQQDEPPQS PWDRVKDLAT VYVDVLKDSG
60 70 80 90 100
RDYVSQFEGS ALGKQLNLKL LDNWDSVTST FSKLREQLGP VTQEFWDNLE
110 120 130 140 150
KETEGLRQEM SKDLEEVKAK VQPYLDDFQK KWQEEMELYR QKVEPLRAEL
160 170 180 190 200
QEGARQKLHE LQEKLSPLGE EMRDRARAHV DALRTHLAPY SDELRQRLAA
210 220 230 240 250
RLEALKENGG ARLAEYHAKA TEHLSTLSEK AKPALEDLRQ GLLPVLESFK
260
VSFLSALEEY TKKLNTQ
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketF8W696 | F8W696_HUMAN | Apolipoprotein A-I | APOA1 | 245 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 32 | W → P AA sequence (PubMed:1742316).Curated | 1 |
Mass spectrometryi
Polymorphismi
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_083307 | 23 – 267 | Missing in FHA2; no protein expression. 1 PublicationAdd BLAST | 245 | |
Natural variantiVAR_000605 | 27 | P → H in Munster-3C. Corresponds to variant dbSNP:rs121912720EnsemblClinVar. | 1 | |
Natural variantiVAR_000606 | 27 | P → R1 PublicationCorresponds to variant dbSNP:rs121912720EnsemblClinVar. | 1 | |
Natural variantiVAR_000607 | 28 | P → R in Munster-3B. 1 PublicationCorresponds to variant dbSNP:rs121912721EnsemblClinVar. | 1 | |
Natural variantiVAR_000608 | 34 | R → L in Baltimore. 1 PublicationCorresponds to variant dbSNP:rs28929476EnsemblClinVar. | 1 | |
Natural variantiVAR_000609 | 50 | G → R in AMYL8; also found in a family with amyloid polyneuropathy-nephropathy Iowa. 4 PublicationsCorresponds to variant dbSNP:rs28931574EnsemblClinVar. | 1 | |
Natural variantiVAR_083308 | 56 – 267 | Missing in HDL deficiency; with periorbital xanthelasmas; decreased protein abundance. 1 PublicationAdd BLAST | 212 | |
Natural variantiVAR_025445 | 61 | A → T2 PublicationsCorresponds to variant dbSNP:rs12718465EnsemblClinVar. | 1 | |
Natural variantiVAR_000610 | 84 | L → R in AMYL8. 1 PublicationCorresponds to variant dbSNP:rs121912724EnsemblClinVar. | 1 | |
Natural variantiVAR_017017 | 92 | T → I Confirmed at protein level. 2 PublicationsCorresponds to variant dbSNP:rs766422306Ensembl. | 1 | |
Natural variantiVAR_083309 | 108 – 267 | Missing in FHA2; missing protein expression. 1 PublicationAdd BLAST | 160 | |
Natural variantiVAR_000611 | 113 | D → E1 PublicationCorresponds to variant dbSNP:rs150243849Ensembl. | 1 | |
Natural variantiVAR_000612 | 119 | A → D in Hita. | 1 | |
Natural variantiVAR_016189 | 126 | D → H. Corresponds to variant dbSNP:rs5077Ensembl. | 1 | |
Natural variantiVAR_000613 | 127 | D → N in Munster-3A. Corresponds to variant dbSNP:rs921646982Ensembl. | 1 | |
Natural variantiVAR_000615 | 131 | K → M1 PublicationCorresponds to variant dbSNP:rs4882Ensembl. | 1 | |
Natural variantiVAR_000614 | 131 | Missing in Marburg/Munster-2. | 1 | |
Natural variantiVAR_000616 | 132 | W → R in Tsushima. | 1 | |
Natural variantiVAR_000617 | 134 | E → K in Fukuoka. 1 Publication | 1 | |
Natural variantiVAR_000618 | 160 | E → K in Norway. 1 PublicationCorresponds to variant dbSNP:rs121912718EnsemblClinVar. | 1 | |
Natural variantiVAR_000619 | 163 | E → G1 PublicationCorresponds to variant dbSNP:rs758509542Ensembl. | 1 | |
Natural variantiVAR_000620 | 167 | P → R in Giessen. 1 PublicationCorresponds to variant dbSNP:rs121912719EnsemblClinVar. | 1 | |
Natural variantiVAR_000621 | 168 | L → R in Zaragoza. 1 Publication | 1 | |
Natural variantiVAR_000622 | 171 | E → V1 PublicationCorresponds to variant dbSNP:rs1015066427Ensembl. | 1 | |
Natural variantiVAR_083310 | 173 | R → P in AMYL8; unknown pathological significance. 1 Publication | 1 | |
Natural variantiVAR_074073 | 173 | R → S in Boston; no evidence of association with premature coronary heart disease; associated with decreased levels of HDL cholesterol; associated with decreased serum cellular cholesterol efflux; associated with decreased lecithin-cholesterol acyltransferase (LCAT) activity. 1 Publication | 1 | |
Natural variantiVAR_021362 | 180 | V → E in Oita; 60% of normal apoA-I and normal HDL cholesterol levels; rapidly cleared from plasma. 1 PublicationCorresponds to variant dbSNP:rs121912727EnsemblClinVar. | 1 | |
Natural variantiVAR_014609 | 184 | R → P. Corresponds to variant dbSNP:rs5078Ensembl. | 1 | |
Natural variantiVAR_000623 | 189 | P → R1 PublicationCorresponds to variant dbSNP:rs121912722EnsemblClinVar. | 1 | |
Natural variantiVAR_000624 | 197 | R → C in Milano; no evidence of association with premature vascular disease; associated with decreased HDL levels and moderate increase in triglycerides; allows the formation of disulfide-linked homodimers via the introduced cysteine; assembles properly in HDL; alters protein structure; has no tendency to form fibrils and aggregates. 2 PublicationsCorresponds to variant dbSNP:rs28931573EnsemblClinVar. | 1 | |
Natural variantiVAR_083311 | 198 | L → S in AMYL8; plasma level of HDL and apoA-I protein were significantly lower in the patient. 1 Publication | 1 | |
Natural variantiVAR_083312 | 199 | A → P in AMYL8; unknown pathological significance. 1 Publication | 1 | |
Natural variantiVAR_000625 | 222 | E → K in Munster-4. 1 PublicationCorresponds to variant dbSNP:rs121912717EnsemblClinVar. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J00098 Genomic DNA Translation: AAB59514.1 X01038 Genomic DNA Translation: CAA25519.1 X02162 mRNA Translation: CAA26097.1 X00566 mRNA Translation: CAA25232.1 M11791 mRNA Translation: AAA35545.1 X07496 Genomic DNA Translation: CAA30377.1 M27875 mRNA Translation: AAA62829.1 M29068 mRNA Translation: AAA51747.1 AY422952 Genomic DNA Translation: AAQ91811.1 AY555191 Genomic DNA Translation: AAS68227.1 A14829 mRNA Translation: CAA01198.1 AK292231 mRNA Translation: BAF84920.1 EF444948 Genomic DNA Translation: ACA05932.1 EF444948 Genomic DNA Translation: ACA05933.1 EF444948 Genomic DNA Translation: ACA05934.1 EF444948 Genomic DNA Translation: ACA05935.1 EF444948 Genomic DNA Translation: ACA05936.1 CH471065 Genomic DNA Translation: EAW67274.1 BC005380 mRNA Translation: AAH05380.1 BC110286 mRNA Translation: AAI10287.1 |
CCDSi | CCDS8378.1 |
PIRi | A90947, LPHUA1 |
RefSeqi | NP_000030.1, NM_000039.2 NP_001304946.1, NM_001318017.1 NP_001304947.1, NM_001318018.1 NP_001304950.1, NM_001318021.1 |
Genome annotation databases
Ensembli | ENST00000236850.5; ENSP00000236850.3; ENSG00000118137.10 ENST00000359492.6; ENSP00000352471.2; ENSG00000118137.10 ENST00000375320.5; ENSP00000364469.1; ENSG00000118137.10 ENST00000375323.5; ENSP00000364472.1; ENSG00000118137.10 |
GeneIDi | 335 |
KEGGi | hsa:335 |
MANE-Selecti | ENST00000236850.5; ENSP00000236850.3; NM_000039.3; NP_000030.1 |
UCSCi | uc001ppv.2, human |
Similar proteinsi
Cross-referencesi
Web resourcesi
SHMPD The Singapore human mutation and polymorphism database |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J00098 Genomic DNA Translation: AAB59514.1 X01038 Genomic DNA Translation: CAA25519.1 X02162 mRNA Translation: CAA26097.1 X00566 mRNA Translation: CAA25232.1 M11791 mRNA Translation: AAA35545.1 X07496 Genomic DNA Translation: CAA30377.1 M27875 mRNA Translation: AAA62829.1 M29068 mRNA Translation: AAA51747.1 AY422952 Genomic DNA Translation: AAQ91811.1 AY555191 Genomic DNA Translation: AAS68227.1 A14829 mRNA Translation: CAA01198.1 AK292231 mRNA Translation: BAF84920.1 EF444948 Genomic DNA Translation: ACA05932.1 EF444948 Genomic DNA Translation: ACA05933.1 EF444948 Genomic DNA Translation: ACA05934.1 EF444948 Genomic DNA Translation: ACA05935.1 EF444948 Genomic DNA Translation: ACA05936.1 CH471065 Genomic DNA Translation: EAW67274.1 BC005380 mRNA Translation: AAH05380.1 BC110286 mRNA Translation: AAI10287.1 |
CCDSi | CCDS8378.1 |
PIRi | A90947, LPHUA1 |
RefSeqi | NP_000030.1, NM_000039.2 NP_001304946.1, NM_001318017.1 NP_001304947.1, NM_001318018.1 NP_001304950.1, NM_001318021.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1AV1 | X-ray | 4.00 | A/B/C/D | 68-267 | [»] | |
1GW3 | NMR | - | A | 166-211 | [»] | |
1GW4 | NMR | - | A | 166-211 | [»] | |
1ODP | NMR | - | A | 190-209 | [»] | |
1ODQ | NMR | - | A | 190-209 | [»] | |
1ODR | NMR | - | A | 190-209 | [»] | |
2MSC | NMR | - | A/C | 68-265 | [»] | |
2MSD | NMR | - | A/C | 68-265 | [»] | |
2MSE | NMR | - | A/C | 68-265 | [»] | |
2N5E | NMR | - | A/B | 79-267 | [»] | |
3K2S | X-ray | - | A/B | 25-267 | [»] | |
3R2P | X-ray | 2.20 | A | 25-208 | [»] | |
4V6M | electron microscopy | 7.10 | A0/A1 | 68-267 | [»] | |
6CC9 | NMR | - | A/C | 68-265 | [»] | |
6CCH | NMR | - | A/C | 68-265 | [»] | |
6CCX | NMR | - | A/C | 68-265 | [»] | |
6CLZ | NMR | - | B/C | 79-267 | [»] | |
6CM1 | NMR | - | B/C | 79-267 | [»] | |
6PTS | NMR | - | A/C | 68-265 | [»] | |
6PTW | NMR | - | A/C | 68-265 | [»] | |
6W4E | NMR | - | A/D | 68-265 | [»] | |
6W4F | NMR | - | A/D | 68-265 | [»] | |
7KJR | electron microscopy | 2.08 | C/D | 79-267 | [»] | |
7RSC | NMR | - | D/E | 68-265 | [»] | |
7RSE | NMR | - | D/E | 68-265 | [»] | |
AlphaFoldDBi | P02647 | |||||
BMRBi | P02647 | |||||
SMRi | P02647 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 106832, 172 interactors |
CORUMi | P02647 |
DIPi | DIP-29619N |
IntActi | P02647, 93 interactors |
MINTi | P02647 |
STRINGi | 9606.ENSP00000236850 |
Chemistry databases
ChEMBLi | CHEMBL5984 |
DrugBanki | DB09130, Copper DB11886, Infigratinib DB00877, Sirolimus DB01593, Zinc DB14487, Zinc acetate DB14533, Zinc chloride DB14548, Zinc sulfate, unspecified form |
PTM databases
CarbonylDBi | P02647 |
GlyGeni | P02647, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | P02647 |
MetOSitei | P02647 |
PhosphoSitePlusi | P02647 |
Genetic variation databases
BioMutai | APOA1 |
DMDMi | 113992 |
2D gel databases
DOSAC-COBS-2DPAGEi | P02647 |
OGPi | P02647 |
REPRODUCTION-2DPAGEi | IPI00021841 P02647 |
SWISS-2DPAGEi | P02647 |
UCD-2DPAGEi | P02647 |
Proteomic databases
CPTACi | non-CPTAC-1075 non-CPTAC-1076 |
EPDi | P02647 |
jPOSTi | P02647 |
MassIVEi | P02647 |
MaxQBi | P02647 |
PaxDbi | P02647 |
PeptideAtlasi | P02647 |
PRIDEi | P02647 |
ProteomicsDBi | 51536 |
TopDownProteomicsi | P02647 |
Protocols and materials databases
ABCDi | P02647, 1 sequenced antibody |
Antibodypediai | 32291, 1601 antibodies from 48 providers |
DNASUi | 335 |
Genome annotation databases
Ensembli | ENST00000236850.5; ENSP00000236850.3; ENSG00000118137.10 ENST00000359492.6; ENSP00000352471.2; ENSG00000118137.10 ENST00000375320.5; ENSP00000364469.1; ENSG00000118137.10 ENST00000375323.5; ENSP00000364472.1; ENSG00000118137.10 |
GeneIDi | 335 |
KEGGi | hsa:335 |
MANE-Selecti | ENST00000236850.5; ENSP00000236850.3; NM_000039.3; NP_000030.1 |
UCSCi | uc001ppv.2, human |
Organism-specific databases
CTDi | 335 |
DisGeNETi | 335 |
GeneCardsi | APOA1 |
HGNCi | HGNC:600, APOA1 |
HPAi | ENSG00000118137, Tissue enriched (liver) |
MalaCardsi | APOA1 |
MIMi | 105200, phenotype 107680, gene 618463, phenotype |
neXtProti | NX_P02647 |
OpenTargetsi | ENSG00000118137 |
Orphaneti | 93560, AApoAI amyloidosis 425, Apolipoprotein A-I deficiency |
PharmGKBi | PA49 |
VEuPathDBi | HostDB:ENSG00000118137 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502S1XQ, Eukaryota |
GeneTreei | ENSGT00950000182929 |
HOGENOMi | CLU_058447_1_0_1 |
InParanoidi | P02647 |
OMAi | KEVREMW |
OrthoDBi | 1553412at2759 |
PhylomeDBi | P02647 |
TreeFami | TF334458 |
Enzyme and pathway databases
PathwayCommonsi | P02647 |
Reactomei | R-HSA-114608, Platelet degranulation R-HSA-1369062, ABC transporters in lipid homeostasis R-HSA-1989781, PPARA activates gene expression R-HSA-2168880, Scavenging of heme from plasma R-HSA-3000471, Scavenging by Class B Receptors R-HSA-3000480, Scavenging by Class A Receptors R-HSA-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-5682113, Defective ABCA1 causes TGD R-HSA-8957275, Post-translational protein phosphorylation R-HSA-8963888, Chylomicron assembly R-HSA-8963896, HDL assembly R-HSA-8963901, Chylomicron remodeling R-HSA-8964011, HDL clearance R-HSA-8964058, HDL remodeling R-HSA-9707616, Heme signaling R-HSA-975634, Retinoid metabolism and transport R-HSA-977225, Amyloid fiber formation |
SignaLinki | P02647 |
SIGNORi | P02647 |
Miscellaneous databases
BioGRID-ORCSi | 335, 12 hits in 1071 CRISPR screens |
ChiTaRSi | APOA1, human |
EvolutionaryTracei | P02647 |
GeneWikii | Apolipoprotein_A1 |
GenomeRNAii | 335 |
Pharosi | P02647, Tbio |
PROi | PR:P02647 |
RNActi | P02647, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000118137, Expressed in duodenum and 127 other tissues |
ExpressionAtlasi | P02647, baseline and differential |
Genevisiblei | P02647, HS |
Family and domain databases
InterProi | View protein in InterPro IPR000074, ApoA_E |
Pfami | View protein in Pfam PF01442, Apolipoprotein, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | APOA1_HUMAN | |
Accessioni | P02647Primary (citable) accession number: P02647 Secondary accession number(s): A8K866 Q9UCT8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 21, 1986 |
Last sequence update: | July 21, 1986 | |
Last modified: | May 25, 2022 | |
This is version 260 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families