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Protein

Apolipoprotein A-I

Gene

APOA1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCholesterol metabolism, Lipid metabolism, Lipid transport, Steroid metabolism, Sterol metabolism, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-114608 Platelet degranulation
R-HSA-1369062 ABC transporters in lipid homeostasis
R-HSA-1989781 PPARA activates gene expression
R-HSA-2168880 Scavenging of heme from plasma
R-HSA-3000471 Scavenging by Class B Receptors
R-HSA-3000480 Scavenging by Class A Receptors
R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-8957275 Post-translational protein phosphorylation
R-HSA-8963888 Chylomicron assembly
R-HSA-8963896 HDL assembly
R-HSA-8963901 Chylomicron remodeling
R-HSA-8964011 HDL clearance
R-HSA-8964058 HDL remodeling
R-HSA-975634 Retinoid metabolism and transport
R-HSA-977225 Amyloid fiber formation

SIGNOR Signaling Network Open Resource

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SIGNORi
P02647

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Apolipoprotein A-I
Short name:
Apo-AI
Short name:
ApoA-I
Alternative name(s):
Apolipoprotein A1
Cleaved into the following 2 chains:
Proapolipoprotein A-I
Short name:
ProapoA-I
Alternative name(s):
Apolipoprotein A-I(1-242)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:APOA1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000118137.9

Human Gene Nomenclature Database

More...
HGNCi
HGNC:600 APOA1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
107680 gene+phenotype

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P02647

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Amyloid, HDL, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

High density lipoprotein deficiency 2 (HDLD2)
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionInherited as autosomal dominant trait. It is characterized by moderately low HDL cholesterol, predilection toward premature coronary artery disease (CAD) and a reduction in cellular cholesterol efflux.
See also OMIM:604091
High density lipoprotein deficiency 1 (HDLD1)
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionRecessive disorder characterized by absence of high density lipoprotein (HDL) cholesterol from plasma, accumulation of cholesteryl esters, premature coronary artery disease (CAD), hepatosplenomegaly, recurrent peripheral neuropathy and progressive muscle wasting and weakness.
See also OMIM:205400
APOA1 mutations may be involved in the pathogenesis of amyloid polyneuropathy-nephropathy Iowa type, also known as amyloidosis van Allen type or familial amyloid polyneuropathy type III (PubMed:3142462 and PubMed:2123470). The clinical picture is dominated by neuropathy in the early stages of the disease and nephropathy late in the course. Death is due in most cases to renal amyloidosis.
Amyloidosis 8 (AMYL8)4 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of hereditary generalized amyloidosis. Clinical features include extensive visceral amyloid deposits, renal amyloidosis resulting in nephrotic syndrome, arterial hypertension, hepatosplenomegaly, cholestasis, petechial skin rash. There is no involvement of the nervous system.
See also OMIM:105200
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_00060950G → R in AMYL8; also found in a family with amyloid polyneuropathy-nephropathy Iowa. 3 PublicationsCorresponds to variant dbSNP:rs28931574EnsemblClinVar.1
Natural variantiVAR_00061084L → R in AMYL8. 1 PublicationCorresponds to variant dbSNP:rs121912724EnsemblClinVar.1

Keywords - Diseasei

Amyloidosis, Atherosclerosis, Disease mutation, Neuropathy

Organism-specific databases

DisGeNET

More...
DisGeNETi
335

MalaCards human disease database

More...
MalaCardsi
APOA1
MIMi105200 phenotype
107680 gene+phenotype
205400 phenotype
604091 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000118137

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
93560 AApoAI amyloidosis
425 Apolipoprotein A-I deficiency

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA49

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

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ChEMBLi
CHEMBL5984

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
APOA1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
113992

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 182 PublicationsAdd BLAST18
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000042532319 – 267Proapolipoprotein A-IAdd BLAST249
ChainiPRO_000000193925 – 267Apolipoprotein A-IAdd BLAST243
ChainiPRO_000000194025 – 266Truncated apolipoprotein A-IAdd BLAST242

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei110Methionine sulfoxide1 Publication1
Modified residuei136Methionine sulfoxide1 Publication1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi263N-linked (Glc) (glycation) lysine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Glycosylated.By similarity
Palmitoylated.1 Publication
Phosphorylation sites are present in the extracellular medium.

Keywords - PTMi

Glycation, Glycoprotein, Lipoprotein, Oxidation, Palmitate, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P02647

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P02647

MaxQB - The MaxQuant DataBase

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MaxQBi
P02647

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P02647

PeptideAtlas

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PeptideAtlasi
P02647

PRoteomics IDEntifications database

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PRIDEi
P02647

ProteomicsDB human proteome resource

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ProteomicsDBi
51536

2D gel databases

DOSAC-COBS 2D-PAGE database

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DOSAC-COBS-2DPAGEi
P02647

USC-OGP 2-DE database

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OGPi
P02647

REPRODUCTION-2DPAGE

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REPRODUCTION-2DPAGEi
IPI00021841
P02647

Two-dimensional polyacrylamide gel electrophoresis database from the Geneva University Hospital

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SWISS-2DPAGEi
P02647

University College Dublin 2-DE Proteome Database

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UCD-2DPAGEi
P02647

PTM databases

CarbonylDB database of protein carbonylation sites

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CarbonylDBi
P02647

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P02647

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P02647

Miscellaneous databases

CutDB - Proteolytic event database

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PMAP-CutDBi
P02647

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Major protein of plasma HDL, also found in chylomicrons. Synthesized in the liver and small intestine. The oxidized form at Met-110 and Met-136 is increased in individuals with increased risk for coronary artery disease, such as in carrier of the eNOSa/b genotype and exposure to cigarette smoking. It is also present in increased levels in aortic lesions relative to native ApoA-I and increased levels are seen with increasing severity of disease.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000118137 Expressed in 106 organ(s), highest expression level in duodenum

CleanEx database of gene expression profiles

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CleanExi
HS_APOA1

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P02647 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P02647 HS

Organism-specific databases

Human Protein Atlas

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HPAi
CAB016778
HPA046715

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with APOA1BP and CLU (PubMed:1742316, PubMed:11991719). Component of a sperm activating protein complex (SPAP), consisting of APOA1, an immunoglobulin heavy chain, an immunoglobulin light chain and albumin (PubMed:1909888). Interacts with NDRG1 (PubMed:15922294). Interacts with SCGB3A2 (PubMed:12847263).5 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
106832, 90 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
P02647

Database of interacting proteins

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DIPi
DIP-29619N

Protein interaction database and analysis system

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IntActi
P02647, 71 interactors

Molecular INTeraction database

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MINTi
P02647

STRING: functional protein association networks

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STRINGi
9606.ENSP00000236850

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1267
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AV1X-ray4.00A/B/C/D68-267[»]
1GW3NMR-A166-211[»]
1GW4NMR-A166-211[»]
1ODPNMR-A190-209[»]
1ODQNMR-A190-209[»]
1ODRNMR-A190-209[»]
2MSCNMR-A/C68-265[»]
2MSDNMR-A/C68-265[»]
2MSENMR-A/C68-265[»]
2N5ENMR-A/B79-267[»]
3K2SX-ray-A/B25-267[»]
3R2PX-ray2.20A25-208[»]
4V6Melectron microscopy7.10A0/A168-267[»]
6CC9NMR-A/C68-265[»]
6CCHNMR-A/C68-265[»]
6CCXNMR-A/C68-265[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P02647

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P02647

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
P02647

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati68 – 891Add BLAST22
Repeati90 – 1112Add BLAST22
Repeati112 – 1223; half-lengthAdd BLAST11
Repeati123 – 1444Add BLAST22
Repeati145 – 1665Add BLAST22
Repeati167 – 1886Add BLAST22
Repeati189 – 2107Add BLAST22
Repeati211 – 2328Add BLAST22
Repeati233 – 2439; half-lengthAdd BLAST11
Repeati244 – 26710Add BLAST24

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni68 – 26710 X approximate tandem repeatsAdd BLAST200

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the apolipoprotein A1/A4/E family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IWKR Eukaryota
ENOG410YGQ6 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00530000063081

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000033998

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG105708

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P02647

KEGG Orthology (KO)

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KOi
K08757

Identification of Orthologs from Complete Genome Data

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OMAi
KDFATVY

Database of Orthologous Groups

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OrthoDBi
1553412at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P02647

TreeFam database of animal gene trees

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TreeFami
TF334458

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR000074 ApoA_E

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01442 Apolipoprotein, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P02647-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKAAVLTLAV LFLTGSQARH FWQQDEPPQS PWDRVKDLAT VYVDVLKDSG
60 70 80 90 100
RDYVSQFEGS ALGKQLNLKL LDNWDSVTST FSKLREQLGP VTQEFWDNLE
110 120 130 140 150
KETEGLRQEM SKDLEEVKAK VQPYLDDFQK KWQEEMELYR QKVEPLRAEL
160 170 180 190 200
QEGARQKLHE LQEKLSPLGE EMRDRARAHV DALRTHLAPY SDELRQRLAA
210 220 230 240 250
RLEALKENGG ARLAEYHAKA TEHLSTLSEK AKPALEDLRQ GLLPVLESFK
260
VSFLSALEEY TKKLNTQ
Length:267
Mass (Da):30,778
Last modified:July 21, 1986 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1A28B8366E620310
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8W696F8W696_HUMAN
Apolipoprotein A-I
APOA1
245Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti32W → P AA sequence (PubMed:1742316).Curated1

<p>This subsection of the ‘Sequence’ section reports information derived from mass spectrometry experiments done on the entire protein or on biologically active derived peptide(s).<p><a href='/help/mass_spectrometry' target='_top'>More...</a></p>Mass spectrometryi

Molecular mass is 28081 Da from positions 25 - 267. Determined by ESI. Without methionine sulfoxide.1 Publication
Molecular mass is 28098 Da from positions 25 - 267. Determined by ESI. With 1 methionine sulfoxide, oxidation at Met-110.1 Publication
Molecular mass is 28095 Da from positions 25 - 267. Determined by ESI. With 1 methionine sulfoxide, oxidation at Met-136.1 Publication
Molecular mass is 28114 Da from positions 25 - 267. Determined by ESI. With 2 methionine sulfoxides, oxidation at Met-110 and Met-136.1 Publication

<p>This subsection of the ‘Sequence’ section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement_in_disease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

Genetic variations in APOA1 can result in APOA1 deficiency and are associated with low levels of HDL cholesterol [MIMi:107680].Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_00060527P → H in Munster-3C. Corresponds to variant dbSNP:rs121912720EnsemblClinVar.1
Natural variantiVAR_00060627P → R1 PublicationCorresponds to variant dbSNP:rs121912720EnsemblClinVar.1
Natural variantiVAR_00060728P → R in Munster-3B. 1 PublicationCorresponds to variant dbSNP:rs121912721EnsemblClinVar.1
Natural variantiVAR_00060834R → L in Baltimore. 1 PublicationCorresponds to variant dbSNP:rs28929476EnsemblClinVar.1
Natural variantiVAR_00060950G → R in AMYL8; also found in a family with amyloid polyneuropathy-nephropathy Iowa. 3 PublicationsCorresponds to variant dbSNP:rs28931574EnsemblClinVar.1
Natural variantiVAR_02544561A → T1 PublicationCorresponds to variant dbSNP:rs12718465EnsemblClinVar.1
Natural variantiVAR_00061084L → R in AMYL8. 1 PublicationCorresponds to variant dbSNP:rs121912724EnsemblClinVar.1
Natural variantiVAR_01701792T → I Polymorphism; confirmed at protein level. 2 PublicationsCorresponds to variant dbSNP:rs766422306Ensembl.1
Natural variantiVAR_000611113D → E1 PublicationCorresponds to variant dbSNP:rs150243849Ensembl.1
Natural variantiVAR_000612119A → D in Hita. 1
Natural variantiVAR_016189126D → H. Corresponds to variant dbSNP:rs5077Ensembl.1
Natural variantiVAR_000613127D → N in Munster-3A. Corresponds to variant dbSNP:rs921646982Ensembl.1
Natural variantiVAR_000615131K → M1 PublicationCorresponds to variant dbSNP:rs4882Ensembl.1
Natural variantiVAR_000614131Missing in Marburg/Munster-2. 1
Natural variantiVAR_000616132W → R in Tsushima. 1
Natural variantiVAR_000617134E → K in Fukuoka. 1 Publication1
Natural variantiVAR_000618160E → K in Norway. 1 PublicationCorresponds to variant dbSNP:rs121912718EnsemblClinVar.1
Natural variantiVAR_000619163E → G1 PublicationCorresponds to variant dbSNP:rs758509542Ensembl.1
Natural variantiVAR_000620167P → R in Giessen. 1 PublicationCorresponds to variant dbSNP:rs121912719EnsemblClinVar.1
Natural variantiVAR_000621168L → R in Zaragoza. 1 Publication1
Natural variantiVAR_000622171E → V1 PublicationCorresponds to variant dbSNP:rs1015066427Ensembl.1
Natural variantiVAR_074073173R → S in Boston; no evidence of association with premature coronary heart disease; associated with decreased levels of HDL cholesterol; associated with decreased serum cellular cholesterol efflux; associated with decreased lecithin-cholesterol acyltransferase (LCAT) activity. 1 Publication1
Natural variantiVAR_021362180V → E in Oita; 60% of normal apoA-I and normal HDL cholesterol levels; rapidly cleared from plasma. 1 PublicationCorresponds to variant dbSNP:rs121912727EnsemblClinVar.1
Natural variantiVAR_014609184R → P. Corresponds to variant dbSNP:rs5078Ensembl.1
Natural variantiVAR_000623189P → R1 PublicationCorresponds to variant dbSNP:rs121912722EnsemblClinVar.1
Natural variantiVAR_000624197R → C in Milano; no evidence of association with premature vascular disease; associated with decreased HDL levels and moderate increase in triglycerides; allows the formation of disulfide-linked homodimers via the introduced cysteine; assembles properly in HDL; alters protein structure; has no tendency to form fibrils and aggregates. 2 PublicationsCorresponds to variant dbSNP:rs28931573EnsemblClinVar.1
Natural variantiVAR_000625222E → K in Munster-4. 1 PublicationCorresponds to variant dbSNP:rs121912717EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
J00098 Genomic DNA Translation: AAB59514.1
X01038 Genomic DNA Translation: CAA25519.1
X02162 mRNA Translation: CAA26097.1
X00566 mRNA Translation: CAA25232.1
M11791 mRNA Translation: AAA35545.1
X07496 Genomic DNA Translation: CAA30377.1
M27875 mRNA Translation: AAA62829.1
M29068 mRNA Translation: AAA51747.1
AY422952 Genomic DNA Translation: AAQ91811.1
AY555191 Genomic DNA Translation: AAS68227.1
A14829 mRNA Translation: CAA01198.1
AK292231 mRNA Translation: BAF84920.1
EF444948 Genomic DNA Translation: ACA05932.1
EF444948 Genomic DNA Translation: ACA05933.1
EF444948 Genomic DNA Translation: ACA05934.1
EF444948 Genomic DNA Translation: ACA05935.1
EF444948 Genomic DNA Translation: ACA05936.1
CH471065 Genomic DNA Translation: EAW67274.1
BC005380 mRNA Translation: AAH05380.1
BC110286 mRNA Translation: AAI10287.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS8378.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A90947 LPHUA1

NCBI Reference Sequences

More...
RefSeqi
NP_000030.1, NM_000039.2
NP_001304946.1, NM_001318017.1
NP_001304947.1, NM_001318018.1
NP_001304950.1, NM_001318021.1

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.93194

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000236850; ENSP00000236850; ENSG00000118137
ENST00000359492; ENSP00000352471; ENSG00000118137
ENST00000375320; ENSP00000364469; ENSG00000118137
ENST00000375323; ENSP00000364472; ENSG00000118137

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
335

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:335

UCSC genome browser

More...
UCSCi
uc001ppv.2 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

SHMPD

The Singapore human mutation and polymorphism database

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00098 Genomic DNA Translation: AAB59514.1
X01038 Genomic DNA Translation: CAA25519.1
X02162 mRNA Translation: CAA26097.1
X00566 mRNA Translation: CAA25232.1
M11791 mRNA Translation: AAA35545.1
X07496 Genomic DNA Translation: CAA30377.1
M27875 mRNA Translation: AAA62829.1
M29068 mRNA Translation: AAA51747.1
AY422952 Genomic DNA Translation: AAQ91811.1
AY555191 Genomic DNA Translation: AAS68227.1
A14829 mRNA Translation: CAA01198.1
AK292231 mRNA Translation: BAF84920.1
EF444948 Genomic DNA Translation: ACA05932.1
EF444948 Genomic DNA Translation: ACA05933.1
EF444948 Genomic DNA Translation: ACA05934.1
EF444948 Genomic DNA Translation: ACA05935.1
EF444948 Genomic DNA Translation: ACA05936.1
CH471065 Genomic DNA Translation: EAW67274.1
BC005380 mRNA Translation: AAH05380.1
BC110286 mRNA Translation: AAI10287.1
CCDSiCCDS8378.1
PIRiA90947 LPHUA1
RefSeqiNP_000030.1, NM_000039.2
NP_001304946.1, NM_001318017.1
NP_001304947.1, NM_001318018.1
NP_001304950.1, NM_001318021.1
UniGeneiHs.93194

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AV1X-ray4.00A/B/C/D68-267[»]
1GW3NMR-A166-211[»]
1GW4NMR-A166-211[»]
1ODPNMR-A190-209[»]
1ODQNMR-A190-209[»]
1ODRNMR-A190-209[»]
2MSCNMR-A/C68-265[»]
2MSDNMR-A/C68-265[»]
2MSENMR-A/C68-265[»]
2N5ENMR-A/B79-267[»]
3K2SX-ray-A/B25-267[»]
3R2PX-ray2.20A25-208[»]
4V6Melectron microscopy7.10A0/A168-267[»]
6CC9NMR-A/C68-265[»]
6CCHNMR-A/C68-265[»]
6CCXNMR-A/C68-265[»]
ProteinModelPortaliP02647
SMRiP02647
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106832, 90 interactors
CORUMiP02647
DIPiDIP-29619N
IntActiP02647, 71 interactors
MINTiP02647
STRINGi9606.ENSP00000236850

Chemistry databases

ChEMBLiCHEMBL5984

PTM databases

CarbonylDBiP02647
iPTMnetiP02647
PhosphoSitePlusiP02647

Polymorphism and mutation databases

BioMutaiAPOA1
DMDMi113992

2D gel databases

DOSAC-COBS-2DPAGEiP02647
OGPiP02647
REPRODUCTION-2DPAGEiIPI00021841
P02647
SWISS-2DPAGEiP02647
UCD-2DPAGEiP02647

Proteomic databases

EPDiP02647
jPOSTiP02647
MaxQBiP02647
PaxDbiP02647
PeptideAtlasiP02647
PRIDEiP02647
ProteomicsDBi51536

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
335
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000236850; ENSP00000236850; ENSG00000118137
ENST00000359492; ENSP00000352471; ENSG00000118137
ENST00000375320; ENSP00000364469; ENSG00000118137
ENST00000375323; ENSP00000364472; ENSG00000118137
GeneIDi335
KEGGihsa:335
UCSCiuc001ppv.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
335
DisGeNETi335
EuPathDBiHostDB:ENSG00000118137.9

GeneCards: human genes, protein and diseases

More...
GeneCardsi
APOA1
HGNCiHGNC:600 APOA1
HPAiCAB016778
HPA046715
MalaCardsiAPOA1
MIMi105200 phenotype
107680 gene+phenotype
205400 phenotype
604091 phenotype
neXtProtiNX_P02647
OpenTargetsiENSG00000118137
Orphaneti93560 AApoAI amyloidosis
425 Apolipoprotein A-I deficiency
PharmGKBiPA49

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IWKR Eukaryota
ENOG410YGQ6 LUCA
GeneTreeiENSGT00530000063081
HOGENOMiHOG000033998
HOVERGENiHBG105708
InParanoidiP02647
KOiK08757
OMAiKDFATVY
OrthoDBi1553412at2759
PhylomeDBiP02647
TreeFamiTF334458

Enzyme and pathway databases

ReactomeiR-HSA-114608 Platelet degranulation
R-HSA-1369062 ABC transporters in lipid homeostasis
R-HSA-1989781 PPARA activates gene expression
R-HSA-2168880 Scavenging of heme from plasma
R-HSA-3000471 Scavenging by Class B Receptors
R-HSA-3000480 Scavenging by Class A Receptors
R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-8957275 Post-translational protein phosphorylation
R-HSA-8963888 Chylomicron assembly
R-HSA-8963896 HDL assembly
R-HSA-8963901 Chylomicron remodeling
R-HSA-8964011 HDL clearance
R-HSA-8964058 HDL remodeling
R-HSA-975634 Retinoid metabolism and transport
R-HSA-977225 Amyloid fiber formation
SIGNORiP02647

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
APOA1 human
EvolutionaryTraceiP02647

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Apolipoprotein_A1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
335
PMAP-CutDBiP02647

Protein Ontology

More...
PROi
PR:P02647

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000118137 Expressed in 106 organ(s), highest expression level in duodenum
CleanExiHS_APOA1
ExpressionAtlasiP02647 baseline and differential
GenevisibleiP02647 HS

Family and domain databases

InterProiView protein in InterPro
IPR000074 ApoA_E
PfamiView protein in Pfam
PF01442 Apolipoprotein, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAPOA1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P02647
Secondary accession number(s): A8K866
, Q6LDN9, Q6Q785, Q9UCS8, Q9UCT8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: January 16, 2019
This is version 239 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
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