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Protein

Protein S100-B

Gene

S100B

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Could assist ATAD3A cytoplasmic processing, preventing aggregation and favoring mitochondrial localization. May mediate calcium-dependent regulation on many physiological processes by interacting with other proteins, such as TPR-containing proteins, and modulating their activity (By similarity).By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi19 – 321; low affinityAdd BLAST14
Calcium bindingi62 – 732; high affinityAdd BLAST12

GO - Molecular functioni

  • calcium-dependent protein binding Source: Ensembl
  • calcium ion binding Source: UniProtKB
  • kinase inhibitor activity Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB
  • RAGE receptor binding Source: Ensembl
  • S100 protein binding Source: UniProtKB
  • tau protein binding Source: UniProtKB
  • zinc ion binding Source: UniProtKB

GO - Biological processi

  • astrocyte activation Source: UniProtKB
  • axonogenesis Source: UniProtKB
  • learning or memory Source: UniProtKB
  • memory Source: Ensembl
  • negative regulation of monocyte chemotactic protein-1 production Source: GO_Central
  • phosphorylation Source: UniProtKB
  • positive regulation of complement activation Source: UniProtKB
  • positive regulation of I-kappaB kinase/NF-kappaB signaling Source: Ensembl
  • regulation of neuronal synaptic plasticity Source: Ensembl
  • regulation of translation Source: UniProtKB

Keywordsi

LigandCalcium, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-BTA-1810476 RIP-mediated NFkB activation via ZBP1
R-BTA-3134963 DEx/H-box helicases activate type I IFN and inflammatory cytokines production
R-BTA-445989 TAK1 activates NFkB by phosphorylation and activation of IKKs complex
R-BTA-879415 Advanced glycosylation endproduct receptor signaling
R-BTA-933542 TRAF6 mediated NF-kB activation
SABIO-RKiP02638

Names & Taxonomyi

Protein namesi
Recommended name:
Protein S100-B
Alternative name(s):
S-100 protein beta chain
S-100 protein subunit beta
S100 calcium-binding protein B
Gene namesi
Name:S100B
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 1

Organism-specific databases

VGNCiVGNC:34248 S100B

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved2 Publications
ChainiPRO_00001439652 – 92Protein S100-BAdd BLAST91

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserine1 Publication1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP02638
PeptideAtlasiP02638
PRIDEiP02638

PTM databases

iPTMnetiP02638

Expressioni

Tissue specificityi

Although predominant among the water-soluble brain proteins, S100 is also found in a variety of other tissues.

Gene expression databases

BgeeiENSBTAG00000004777

Interactioni

Subunit structurei

Dimer of either two alpha chains, or two beta chains, or one alpha and one beta chain. The S100B dimer binds two molecules of STK38. Interacts with CACYBP in a calcium-dependent manner. Interacts with ATAD3A; this interaction probably occurs in the cytosol prior to ATAD3A mitochondrial targeting. Interacts with S100A6. The S100B dimer interacts with two molecules of CAPZA1. Interacts with AGER. Interacts with PPP5C (via TPR repeats); the interaction is calcium-dependent and modulates PPP5C activity (By similarity).By similarity

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi182329, 3 interactors
IntActiP02638, 4 interactors
MINTiP02638
STRINGi9913.ENSBTAP00000006275

Structurei

Secondary structure

192
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi3 – 19Combined sources17
Beta strandi21 – 24Combined sources4
Beta strandi25 – 29Combined sources5
Helixi30 – 40Combined sources11
Turni42 – 44Combined sources3
Helixi48 – 50Combined sources3
Helixi51 – 61Combined sources11
Beta strandi66 – 69Combined sources4
Helixi71 – 88Combined sources18

3D structure databases

ProteinModelPortaliP02638
SMRiP02638
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP02638

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini13 – 48EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini49 – 84EF-hand 2PROSITE-ProRule annotationAdd BLAST36

Sequence similaritiesi

Belongs to the S-100 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IYFX Eukaryota
ENOG41127J0 LUCA
GeneTreeiENSGT00760000119034
HOGENOMiHOG000246968
HOVERGENiHBG001479
InParanoidiP02638
OMAiCCHEFFE
OrthoDBiEOG091G13Z2
TreeFamiTF332727

Family and domain databases

CDDicd05027 S-100B, 1 hit
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR028481 S100-B
IPR001751 S100/CaBP-9k_CS
IPR013787 S100_Ca-bd_sub
PANTHERiPTHR11639:SF17 PTHR11639:SF17, 1 hit
PfamiView protein in Pfam
PF00036 EF-hand_1, 1 hit
PF01023 S_100, 1 hit
SMARTiView protein in SMART
SM00054 EFh, 1 hit
SM01394 S_100, 1 hit
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 1 hit
PS50222 EF_HAND_2, 1 hit
PS00303 S100_CABP, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02638-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSELEKAVVA LIDVFHQYSG REGDKHKLKK SELKELINNE LSHFLEEIKE
60 70 80 90
QEVVDKVMET LDSDGDGECD FQEFMAFVAM ITTACHEFFE HE
Length:92
Mass (Da):10,668
Last modified:January 23, 2007 - v2
Checksum:i589BF1DAA0AF6DA7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ195377 mRNA Translation: ABA39829.1
BC103041 mRNA Translation: AAI03042.1
BC134727 mRNA Translation: AAI34728.1
PIRiA91254 BCBOIB
RefSeqiNP_001029727.1, NM_001034555.3
UniGeneiBt.49610

Genome annotation databases

EnsembliENSBTAT00000006275; ENSBTAP00000006275; ENSBTAG00000004777
GeneIDi525716
KEGGibta:525716

Similar proteinsi

Entry informationi

Entry nameiS100B_BOVIN
AccessioniPrimary (citable) accession number: P02638
Secondary accession number(s): A4IFR6, Q3ZBY1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: July 18, 2018
This is version 163 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

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