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Protein

Oncomodulin

Gene

Ocm

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Has some calmodulin-like activity with respect to enzyme activation and growth regulation. Binds two calcium ions.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi52Calcium 1By similarity1
Metal bindingi56Calcium 1By similarity1
Metal bindingi58Calcium 1; via carbonyl oxygenBy similarity1
Metal bindingi63Calcium 1By similarity1
Metal bindingi91Calcium 1By similarity1
Metal bindingi93Calcium 2By similarity1
Metal bindingi95Calcium 2By similarity1
Metal bindingi97Calcium 2; via carbonyl oxygenBy similarity1
Metal bindingi102Calcium 2By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi52 – 631Add BLAST12
Calcium bindingi91 – 1022Add BLAST12

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Oncomodulin
Short name:
OM
Alternative name(s):
Parvalbumin beta
Gene namesi
Name:Ocm
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 12

Organism-specific databases

RGDi3222 Ocm

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000735842 – 109OncomodulinAdd BLAST108

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserine1 Publication1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP02631
PRIDEiP02631

PTM databases

iPTMnetiP02631

Expressioni

Tissue specificityi

Found in tumor tissues and not detected in normal tissues.

Gene expression databases

BgeeiENSRNOG00000001031 Expressed in 7 organ(s), highest expression level in colon
GenevisibleiP02631 RN

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000040755

Structurei

Secondary structure

1109
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

DisProtiDP00730
ProteinModelPortaliP02631
SMRiP02631
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP02631

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini39 – 74EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini78 – 109EF-hand 2PROSITE-ProRule annotationAdd BLAST32

Sequence similaritiesi

Belongs to the parvalbumin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0027 Eukaryota
COG5126 LUCA
GeneTreeiENSGT00390000008690
HOGENOMiHOG000037438
HOVERGENiHBG107490
InParanoidiP02631
OMAiQVKDIFR
OrthoDBiEOG091G0XK0
PhylomeDBiP02631
TreeFamiTF332342

Family and domain databases

InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR008080 Parvalbumin
PANTHERiPTHR11653 PTHR11653, 1 hit
PfamiView protein in Pfam
PF13499 EF-hand_7, 1 hit
SMARTiView protein in SMART
SM00054 EFh, 2 hits
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 2 hits
PS50222 EF_HAND_2, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02631-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSITDILSAE DIAAALQECQ DPDTFEPQKF FQTSGLSKMS ASQVKDIFRF
60 70 80 90 100
IDNDQSGYLD GDELKYFLQK FQSDARELTE SETKSLMDAA DNDGDGKIGA

DEFQEMVHS
Length:109
Mass (Da):12,188
Last modified:January 23, 2007 - v2
Checksum:i89A168BD30748514
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti26E → Q AA sequence (PubMed:6617664).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02705 mRNA Translation: AAA41756.1
X15836, X15837, X15838 Genomic DNA Translation: CAA33840.1
PIRiS04616 PVRTO
RefSeqiNP_037127.1, NM_012995.1
UniGeneiRn.9719

Genome annotation databases

EnsembliENSRNOT00000043439; ENSRNOP00000040755; ENSRNOG00000001031
ENSRNOT00000092601; ENSRNOP00000075788; ENSRNOG00000001031
GeneIDi25503
KEGGirno:25503

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02705 mRNA Translation: AAA41756.1
X15836, X15837, X15838 Genomic DNA Translation: CAA33840.1
PIRiS04616 PVRTO
RefSeqiNP_037127.1, NM_012995.1
UniGeneiRn.9719

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1OMDX-ray1.85A2-109[»]
1RROX-ray1.30A2-109[»]
2NLNNMR-A2-109[»]
DisProtiDP00730
ProteinModelPortaliP02631
SMRiP02631
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000040755

PTM databases

iPTMnetiP02631

Proteomic databases

PaxDbiP02631
PRIDEiP02631

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000043439; ENSRNOP00000040755; ENSRNOG00000001031
ENSRNOT00000092601; ENSRNOP00000075788; ENSRNOG00000001031
GeneIDi25503
KEGGirno:25503

Organism-specific databases

CTDi4951
RGDi3222 Ocm

Phylogenomic databases

eggNOGiKOG0027 Eukaryota
COG5126 LUCA
GeneTreeiENSGT00390000008690
HOGENOMiHOG000037438
HOVERGENiHBG107490
InParanoidiP02631
OMAiQVKDIFR
OrthoDBiEOG091G0XK0
PhylomeDBiP02631
TreeFamiTF332342

Miscellaneous databases

EvolutionaryTraceiP02631
PROiPR:P02631

Gene expression databases

BgeeiENSRNOG00000001031 Expressed in 7 organ(s), highest expression level in colon
GenevisibleiP02631 RN

Family and domain databases

InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR008080 Parvalbumin
PANTHERiPTHR11653 PTHR11653, 1 hit
PfamiView protein in Pfam
PF13499 EF-hand_7, 1 hit
SMARTiView protein in SMART
SM00054 EFh, 2 hits
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 2 hits
PS50222 EF_HAND_2, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiONCO_RAT
AccessioniPrimary (citable) accession number: P02631
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: September 12, 2018
This is version 153 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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