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Protein

Parvalbumin alpha

Gene
N/A
Organism
Esox lucius (Northern pike)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions.

Miscellaneous

This is the major component, having an isoelectric point of 5.0.

Caution

This protein is more closely related to beta-type parvalbumins then to alpha-type.Curated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi50 – 611PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi89 – 1002PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

  • calcium ion binding Source: CAFA

Keywordsi

Molecular functionMuscle protein
LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Parvalbumin alpha
Alternative name(s):
Parvalbumin III
Parvalbumin pI 5.0
Parvalbumin-3
OrganismiEsox lucius (Northern pike)
Taxonomic identifieri8010 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiProtacanthopterygiiEsociformesEsocidaeEsox

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000735951 – 108Parvalbumin alphaAdd BLAST108

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylalanine1

Keywords - PTMi

Acetylation

Structurei

Secondary structure

1108
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

DisProtiDP00550
ProteinModelPortaliP02628
SMRiP02628
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP02628

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini37 – 72EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini76 – 108EF-hand 2PROSITE-ProRule annotationAdd BLAST33

Sequence similaritiesi

Belongs to the parvalbumin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

HOVERGENiHBG107490

Family and domain databases

InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR008080 Parvalbumin
PANTHERiPTHR11653 PTHR11653, 1 hit
PfamiView protein in Pfam
PF13499 EF-hand_7, 1 hit
SMARTiView protein in SMART
SM00054 EFh, 2 hits
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 2 hits
PS50222 EF_HAND_2, 2 hits

Sequencei

Sequence statusi: Complete.

P02628-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
AKDLLKADDI KKALDAVKAE GSFNHKKFFA LVGLKAMSAN DVKKVFKAID
60 70 80 90 100
ADASGFIEEE ELKFVLKSFA ADGRDLTDAE TKAFLKAADK DGDGKIGIDE

FETLVHEA
Length:108
Mass (Da):11,707
Last modified:July 21, 1986 - v1
Checksum:i8737BD351BA4ABC3
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti11K → KL in alpha-2. 1 Publication1
Natural varianti27K → A in alpha-2. 1 Publication1
Natural varianti31L → K in alpha-2. 1 Publication1

Sequence databases

PIRiA67143 PVPK

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

PIRiA67143 PVPK

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1PVAX-ray1.65A/B1-108[»]
2PASNMR-A1-108[»]
3PATNMR-A1-108[»]
DisProtiDP00550
ProteinModelPortaliP02628
SMRiP02628
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG107490

Miscellaneous databases

EvolutionaryTraceiP02628

Family and domain databases

InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR008080 Parvalbumin
PANTHERiPTHR11653 PTHR11653, 1 hit
PfamiView protein in Pfam
PF13499 EF-hand_7, 1 hit
SMARTiView protein in SMART
SM00054 EFh, 2 hits
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 2 hits
PS50222 EF_HAND_2, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiPRVA_ESOLU
AccessioniPrimary (citable) accession number: P02628
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: August 30, 2017
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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