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Protein

Parvalbumin alpha

Gene

Pvalb

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi52 – 631Add BLAST12
Calcium bindingi91 – 1022Add BLAST12

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMuscle protein
LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Parvalbumin alpha
Gene namesi
Name:Pvalb
Synonyms:Pva
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi3457 Pvalb

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved3 Publications
ChainiPRO_00000735922 – 110Parvalbumin alphaAdd BLAST109

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserine3 Publications1
Modified residuei2PhosphoserineCombined sources1
Modified residuei8PhosphoserineCombined sources1
Modified residuei24PhosphoserineCombined sources1
Modified residuei66PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP02625
PRIDEiP02625

PTM databases

iPTMnetiP02625
PhosphoSitePlusiP02625

Expressioni

Gene expression databases

BgeeiENSRNOG00000006471 Expressed in 8 organ(s), highest expression level in skeletal muscle tissue
GenevisibleiP02625 RN

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000058825

Structurei

Secondary structure

1110
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP02625
SMRiP02625
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP02625

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini39 – 74EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini78 – 110EF-hand 2PROSITE-ProRule annotationAdd BLAST33

Sequence similaritiesi

Belongs to the parvalbumin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0027 Eukaryota
COG5126 LUCA
GeneTreeiENSGT00390000008690
HOGENOMiHOG000037438
HOVERGENiHBG107490
InParanoidiP02625
OMAiAVDSFDH
OrthoDBiEOG091G0ZAO
PhylomeDBiP02625
TreeFamiTF332342

Family and domain databases

InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR008080 Parvalbumin
PANTHERiPTHR11653 PTHR11653, 1 hit
PfamiView protein in Pfam
PF13499 EF-hand_7, 1 hit
SMARTiView protein in SMART
SM00054 EFh, 2 hits
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 2 hits
PS50222 EF_HAND_2, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02625-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSMTDLLSAE DIKKAIGAFT AADSFDHKKF FQMVGLKKKS ADDVKKVFHI
60 70 80 90 100
LDKDKSGFIE EDELGSILKG FSSDARDLSA KETKTLMAAG DKDGDGKIGV
110
EEFSTLVAES
Length:110
Mass (Da):11,926
Last modified:January 23, 2007 - v2
Checksum:i6A1509AC8F012B3D
GO

Mass spectrometryi

Molecular mass is 11836.88±1.57 Da from positions 2 - 110. Determined by ESI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M12725 mRNA Translation: AAA41799.1
M15457
, M15453, M15454, M15455 Genomic DNA Translation: AAA41800.1
BC126090 mRNA Translation: AAI26091.1
M10764 mRNA Translation: AAA41797.1
M10765 mRNA Translation: AAA41798.1
PIRiA29308 PVRTA
RefSeqiNP_071944.1, NM_022499.2
XP_006241991.1, XM_006241929.3
UniGeneiRn.2005

Genome annotation databases

EnsembliENSRNOT00000067635; ENSRNOP00000058825; ENSRNOG00000006471
GeneIDi25269
KEGGirno:25269
UCSCiRGD:3457 rat

Similar proteinsi

Entry informationi

Entry nameiPRVA_RAT
AccessioniPrimary (citable) accession number: P02625
Secondary accession number(s): A0JN21
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: September 12, 2018
This is version 159 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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