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Protein

Parvalbumin alpha

Gene

PVALB

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions.

Miscellaneous

This parvalbumin has an isoelectric point of 5.50.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi52 – 631Add BLAST12
Calcium bindingi91 – 1022Add BLAST12

GO - Molecular functioni

Keywordsi

Molecular functionMuscle protein
LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Parvalbumin alpha
Gene namesi
Name:PVALB
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Chromosome 4

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved2 Publications
ChainiPRO_00000735912 – 110Parvalbumin alphaAdd BLAST109

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanine2 Publications1
Modified residuei24PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

PTM databases

iPTMnetiP02624

Expressioni

Gene expression databases

BgeeiENSOCUG00000027416 Expressed in 2 organ(s), highest expression level in prefrontal cortex

Structurei

3D structure databases

ProteinModelPortaliP02624
SMRiP02624
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini39 – 74EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini78 – 110EF-hand 2PROSITE-ProRule annotationAdd BLAST33

Sequence similaritiesi

Belongs to the parvalbumin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

GeneTreeiENSGT00390000008690
HOGENOMiHOG000037438
HOVERGENiHBG107490
InParanoidiP02624
OMAiAVDSFDH
OrthoDBiEOG091G0ZAO

Family and domain databases

InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR008080 Parvalbumin
PANTHERiPTHR11653 PTHR11653, 1 hit
PfamiView protein in Pfam
PF13499 EF-hand_7, 1 hit
SMARTiView protein in SMART
SM00054 EFh, 2 hits
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 2 hits
PS50222 EF_HAND_2, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02624-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAMTELLNAE DIKKAIGAFA AAESFDHKKF FQMVGLKKKS TEDVKKVFHI
60 70 80 90 100
LDKDKSGFIE EEELGFILKG FSPDARDLSV KETKTLMAAG DKDGDGKIGA
110
DEFSTLVSES
Length:110
Mass (Da):12,065
Last modified:January 23, 2007 - v2
Checksum:i8A1CFF36CDB3300E
GO

Sequence databases

PIRiA93795 PVRB
RefSeqiXP_002711455.1, XM_002711409.3
XP_008255298.1, XM_008257076.1

Genome annotation databases

EnsembliENSOCUT00000026448; ENSOCUP00000016160; ENSOCUG00000027416
GeneIDi100343964
KEGGiocu:100343964

Similar proteinsi

Cross-referencesi

Sequence databases

PIRiA93795 PVRB
RefSeqiXP_002711455.1, XM_002711409.3
XP_008255298.1, XM_008257076.1

3D structure databases

ProteinModelPortaliP02624
SMRiP02624
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiP02624

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSOCUT00000026448; ENSOCUP00000016160; ENSOCUG00000027416
GeneIDi100343964
KEGGiocu:100343964

Organism-specific databases

CTDi5816

Phylogenomic databases

GeneTreeiENSGT00390000008690
HOGENOMiHOG000037438
HOVERGENiHBG107490
InParanoidiP02624
OMAiAVDSFDH
OrthoDBiEOG091G0ZAO

Gene expression databases

BgeeiENSOCUG00000027416 Expressed in 2 organ(s), highest expression level in prefrontal cortex

Family and domain databases

InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR008080 Parvalbumin
PANTHERiPTHR11653 PTHR11653, 1 hit
PfamiView protein in Pfam
PF13499 EF-hand_7, 1 hit
SMARTiView protein in SMART
SM00054 EFh, 2 hits
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 2 hits
PS50222 EF_HAND_2, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiPRVA_RABIT
AccessioniPrimary (citable) accession number: P02624
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: September 12, 2018
This is version 107 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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