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Protein

Troponin C, skeletal muscle

Gene

TNNC2

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments.

Miscellaneous

Skeletal muscle troponin C binds four calcium ions.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi27 – 381Add BLAST12
Calcium bindingi63 – 742Add BLAST12
Calcium bindingi103 – 1143Add BLAST12
Calcium bindingi139 – 1504Add BLAST12

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMuscle protein
LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Troponin C, skeletal muscle
Gene namesi
Name:TNNC2
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000737051 – 159Troponin C, skeletal muscleAdd BLAST159

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylthreonineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP02587
PeptideAtlasiP02587
PRIDEiP02587

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000007911

Structurei

3D structure databases

ProteinModelPortaliP02587
SMRiP02587
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 49EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini50 – 85EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini90 – 125EF-hand 3PROSITE-ProRule annotationAdd BLAST36
Domaini126 – 159EF-hand 4PROSITE-ProRule annotationAdd BLAST34

Sequence similaritiesi

Belongs to the troponin C family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0027 Eukaryota
COG5126 LUCA
HOVERGENiHBG012180
InParanoidiP02587

Family and domain databases

CDDicd00051 EFh, 1 hit
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
PfamiView protein in Pfam
PF13499 EF-hand_7, 1 hit
PF13833 EF-hand_8, 1 hit
SMARTiView protein in SMART
SM00054 EFh, 4 hits
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 4 hits
PS50222 EF_HAND_2, 4 hits

Sequencei

Sequence statusi: Complete.

P02587-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
TDQQAEARSY LSEEMIAEFK AAFDMFDADG GGDISVKELG TVMRMLGQTP
60 70 80 90 100
TKEELDAIIE EVDEDGSGTI DFEEFLVMMV RQMKEDAKGK SEEELAECFR
110 120 130 140 150
IFDRNMDGYI DAEELAEIFR ASGEHVTDEE IESIMKDGDK NNDGRIDFDE

FLKMMEGVQ
Length:159
Mass (Da):18,025
Last modified:November 1, 1997 - v2
Checksum:iD2A249BBC2C94D94
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1 – 2TD → DT AA sequence (PubMed:6825863).Curated2

Sequence databases

PIRiA03014 TPPGCS
UniGeneiSsc.54139

Similar proteinsi

Entry informationi

Entry nameiTNNC2_PIG
AccessioniPrimary (citable) accession number: P02587
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: November 1, 1997
Last modified: August 30, 2017
This is version 99 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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