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Protein

Troponin C, skeletal muscle

Gene

TNNC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments.

Miscellaneous

Skeletal muscle troponin C binds four calcium ions.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi28 – 391Add BLAST12
Calcium bindingi64 – 752Add BLAST12
Calcium bindingi104 – 1153Add BLAST12
Calcium bindingi140 – 1514Add BLAST12

GO - Molecular functioni

  • actin filament binding Source: GO_Central
  • calcium-dependent protein binding Source: GO_Central
  • calcium ion binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionMuscle protein
LigandCalcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-HSA-390522 Striated Muscle Contraction
SIGNORiP02585

Names & Taxonomyi

Protein namesi
Recommended name:
Troponin C, skeletal muscle
Gene namesi
Name:TNNC2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000101470.9
HGNCiHGNC:11944 TNNC2
MIMi191039 gene
neXtProtiNX_P02585

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000101470
PharmGKBiPA36633

Chemistry databases

ChEMBLiCHEMBL3831282
DrugBankiDB01373 Calcium
DB01023 Felodipine
DB04682 Octylphenoxy polyethoxyethanol

Polymorphism and mutation databases

BioMutaiTNNC2
DMDMi136043

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000737032 – 160Troponin C, skeletal muscleAdd BLAST159

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylthreonine1 Publication1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP02585
PeptideAtlasiP02585
PRIDEiP02585
ProteomicsDBi51535

PTM databases

iPTMnetiP02585
PhosphoSitePlusiP02585

Expressioni

Gene expression databases

BgeeiENSG00000101470 Expressed in 125 organ(s), highest expression level in skeletal muscle tissue of rectus abdominis
CleanExiHS_TNNC2
ExpressionAtlasiP02585 baseline and differential
GenevisibleiP02585 HS

Organism-specific databases

HPAiHPA043174
HPA058481

Interactioni

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi112980, 39 interactors
IntActiP02585, 5 interactors
STRINGi9606.ENSP00000361636

Structurei

3D structure databases

ProteinModelPortaliP02585
SMRiP02585
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini15 – 50EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini51 – 86EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini91 – 126EF-hand 3PROSITE-ProRule annotationAdd BLAST36
Domaini127 – 160EF-hand 4PROSITE-ProRule annotationAdd BLAST34

Sequence similaritiesi

Belongs to the troponin C family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0027 Eukaryota
COG5126 LUCA
GeneTreeiENSGT00760000118901
HOGENOMiHOG000233018
HOVERGENiHBG012180
InParanoidiP02585
KOiK12042
OMAiVETWEVD
OrthoDBiEOG091G0QHM
PhylomeDBiP02585
TreeFamiTF318191

Family and domain databases

CDDicd00051 EFh, 2 hits
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
PfamiView protein in Pfam
PF13499 EF-hand_7, 1 hit
PF13833 EF-hand_8, 1 hit
SMARTiView protein in SMART
SM00054 EFh, 4 hits
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 4 hits
PS50222 EF_HAND_2, 4 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P02585-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTDQQAEARS YLSEEMIAEF KAAFDMFDAD GGGDISVKEL GTVMRMLGQT
60 70 80 90 100
PTKEELDAII EEVDEDGSGT IDFEEFLVMM VRQMKEDAKG KSEEELAECF
110 120 130 140 150
RIFDRNADGY IDPEELAEIF RASGEHVTDE EIESLMKDGD KNNDGRIDFD
160
EFLKMMEGVQ
Length:160
Mass (Da):18,122
Last modified:January 23, 2007 - v2
Checksum:iEA93729732A0F916
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9J7T9C9J7T9_HUMAN
Troponin C type 2 (Fast), isoform C...
TNNC2 hCG_38373
145Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti2 – 3TD → DT AA sequence (PubMed:978749).Curated2
Sequence conflicti114E → G in AAA91854 (Ref. 3) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X07898 mRNA Translation: CAA30737.1
M33772, M33771 Genomic DNA Translation: AAA61197.1
M22307 mRNA Translation: AAA91854.1
AK291323 mRNA Translation: BAF84012.1
CR541864 mRNA Translation: CAG46662.1
CR541884 mRNA Translation: CAG46682.1
CH471077 Genomic DNA Translation: EAW75803.1
AL050348 Genomic DNA No translation available.
BC005323 mRNA Translation: AAH05323.1
CCDSiCCDS13375.1
PIRiA36574 TPHUCS
RefSeqiNP_003270.1, NM_003279.2
UniGeneiHs.182421

Genome annotation databases

EnsembliENST00000372555; ENSP00000361636; ENSG00000101470
GeneIDi7125
KEGGihsa:7125
UCSCiuc002xpr.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X07898 mRNA Translation: CAA30737.1
M33772, M33771 Genomic DNA Translation: AAA61197.1
M22307 mRNA Translation: AAA91854.1
AK291323 mRNA Translation: BAF84012.1
CR541864 mRNA Translation: CAG46662.1
CR541884 mRNA Translation: CAG46682.1
CH471077 Genomic DNA Translation: EAW75803.1
AL050348 Genomic DNA No translation available.
BC005323 mRNA Translation: AAH05323.1
CCDSiCCDS13375.1
PIRiA36574 TPHUCS
RefSeqiNP_003270.1, NM_003279.2
UniGeneiHs.182421

3D structure databases

ProteinModelPortaliP02585
SMRiP02585
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112980, 39 interactors
IntActiP02585, 5 interactors
STRINGi9606.ENSP00000361636

Chemistry databases

ChEMBLiCHEMBL3831282
DrugBankiDB01373 Calcium
DB01023 Felodipine
DB04682 Octylphenoxy polyethoxyethanol

PTM databases

iPTMnetiP02585
PhosphoSitePlusiP02585

Polymorphism and mutation databases

BioMutaiTNNC2
DMDMi136043

Proteomic databases

PaxDbiP02585
PeptideAtlasiP02585
PRIDEiP02585
ProteomicsDBi51535

Protocols and materials databases

DNASUi7125
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000372555; ENSP00000361636; ENSG00000101470
GeneIDi7125
KEGGihsa:7125
UCSCiuc002xpr.4 human

Organism-specific databases

CTDi7125
EuPathDBiHostDB:ENSG00000101470.9
GeneCardsiTNNC2
HGNCiHGNC:11944 TNNC2
HPAiHPA043174
HPA058481
MIMi191039 gene
neXtProtiNX_P02585
OpenTargetsiENSG00000101470
PharmGKBiPA36633
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0027 Eukaryota
COG5126 LUCA
GeneTreeiENSGT00760000118901
HOGENOMiHOG000233018
HOVERGENiHBG012180
InParanoidiP02585
KOiK12042
OMAiVETWEVD
OrthoDBiEOG091G0QHM
PhylomeDBiP02585
TreeFamiTF318191

Enzyme and pathway databases

ReactomeiR-HSA-390522 Striated Muscle Contraction
SIGNORiP02585

Miscellaneous databases

ChiTaRSiTNNC2 human
GeneWikiiTNNC2
GenomeRNAii7125
PROiPR:P02585
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000101470 Expressed in 125 organ(s), highest expression level in skeletal muscle tissue of rectus abdominis
CleanExiHS_TNNC2
ExpressionAtlasiP02585 baseline and differential
GenevisibleiP02585 HS

Family and domain databases

CDDicd00051 EFh, 2 hits
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
PfamiView protein in Pfam
PF13499 EF-hand_7, 1 hit
PF13833 EF-hand_8, 1 hit
SMARTiView protein in SMART
SM00054 EFh, 4 hits
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 4 hits
PS50222 EF_HAND_2, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiTNNC2_HUMAN
AccessioniPrimary (citable) accession number: P02585
Secondary accession number(s): Q6FH92
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 171 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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