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Entry version 169 (05 Jun 2019)
Sequence version 2 (19 Feb 2014)
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Protein

Myosin-4

Gene

unc-54

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for muscle contraction.1 Publication

Miscellaneous

There are four different myosin heavy chains in C.elegans.
MHC A and MHC B are found exclusively in the body wall muscle. They co-assemble into body wall thick filament.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi174 – 181ATPBy similarity8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding, Motor protein, Muscle protein, Myosin
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Myosin-4
Alternative name(s):
Myosin heavy chain B
Short name:
MHC B
Uncoordinated protein 54
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:unc-54
Synonyms:myo-4
ORF Names:F11C3.3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome I

Organism-specific databases

WormBase

More...
WormBasei
F11C3.3 ; CE09349 ; WBGene00006789 ; unc-54

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Thick filament

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Viable, but paralyzed. Double knockout with madd-3 results in lethality. Triple knockout with madd-3, and either cebp-1, dlk-1, mak-2, pmk-3 or sek-3 results in paralysis (as in the unc-54 single knockout), and suppresses the lethality phenotype in the double madd-3 and unc-54 mutant.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001233831 – 1963Myosin-4Add BLAST1963

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei125N6,N6,N6-trimethyllysineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Unfolded unc-54 is poly-ubiquitinated by ufd-2.1 Publication

Keywords - PTMi

Methylation, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P02566

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P02566

PeptideAtlas

More...
PeptideAtlasi
P02566

PRoteomics IDEntifications database

More...
PRIDEi
P02566

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P02566

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00006789 Expressed in 7 organ(s), highest expression level in material anatomical entity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2). Forms a complex composed of chaperone unc-45, unc-54 and ubiquitin-protein ligase ufd-2; promotes poly-ubiquitination of unfolded unc-54 (PubMed:29396393). Within the complex interacts with unc-45 (via UCS domain) and ufd-2 (PubMed:29396393). Interacts with itr-1 (via c-terminal coiled coil domain) (PubMed:12062062).2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
unc-45G5EG623EBI-329238,EBI-6675165

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
56866, 5 interactors

Database of interacting proteins

More...
DIPi
DIP-26548N

Protein interaction database and analysis system

More...
IntActi
P02566, 6 interactors

Molecular INTeraction database

More...
MINTi
P02566

STRING: functional protein association networks

More...
STRINGi
6239.F11C3.3.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P02566

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini28 – 77Myosin N-terminal SH3-likePROSITE-ProRule annotationAdd BLAST50
Domaini81 – 787Myosin motorPROSITE-ProRule annotationAdd BLAST707

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni662 – 684Actin-bindingAdd BLAST23
Regioni766 – 780Actin-bindingAdd BLAST15
Regioni848 – 1161Alpha-helical tailpiece (S2)Add BLAST314
Regioni1162 – 1963Light meromyosin (LMM)Add BLAST802
Regioni1162 – 1173HingeAdd BLAST12

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili848 – 1963Sequence analysisAdd BLAST1116

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils.
Limited proteolysis of myosin heavy chain produces 1 light meromyosin (LMM) and 1 heavy meromyosin (HMM). HMM can be further cleaved into 2 globular subfragments (S1) and 1 rod-shaped subfragment (S2).Curated

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0161 Eukaryota
COG5022 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000173223

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000173959

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P02566

KEGG Orthology (KO)

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KOi
K10352

Identification of Orthologs from Complete Genome Data

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OMAi
VYPDFKM

Database of Orthologous Groups

More...
OrthoDBi
47111at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.30.360, 1 hit
3.40.850.10, 1 hit
4.10.270.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036961 Kinesin_motor_dom_sf
IPR001609 Myosin_head_motor_dom
IPR027401 Myosin_IQ_contain_sf
IPR004009 Myosin_N
IPR008989 Myosin_S1_N
IPR002928 Myosin_tail
IPR027417 P-loop_NTPase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00063 Myosin_head, 1 hit
PF02736 Myosin_N, 1 hit
PF01576 Myosin_tail_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00193 MYOSINHEAVY

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00242 MYSc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51456 MYOSIN_MOTOR, 1 hit
PS51844 SH3_LIKE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P02566-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEHEKDPGWQ YLRRTREQVL EDQSKPYDSK KNVWIPDPEE GYLAGEITAT
60 70 80 90 100
KGDQVTIVTA RGNEVTLKKE LVQEMNPPKF EKTEDMSNLS FLNDASVLHN
110 120 130 140 150
LRSRYAAMLI YTYSGLFCVV INPYKRLPIY TDSCARMFMG KRKTEMPPHL
160 170 180 190 200
FAVSDEAYRN MLQDHENQSM LITGESGAGK TENTKKVICY FAAVGASQQE
210 220 230 240 250
GGAEVDPNKK KVTLEDQIVQ TNPVLEAFGN AKTVRNNNSS RFGKFIRIHF
260 270 280 290 300
NKHGRLASCD IEHYLLEKSR VIRQAPGERC YHIFYQIYSD FRPELKKELL
310 320 330 340 350
LDLPIKDYWF VAQAELIIDG IDDVEEFQLT DEAFDILNFS AVEKQDCYRL
360 370 380 390 400
MSAHMHMGNM KFKQRPREEQ AEPDGTDEAE KASNMYGIGC EEFLKALTKP
410 420 430 440 450
RVKVGTEWVS KGQNCEQVNW AVGAMAKGLY SRVFNWLVKK CNLTLDQKGI
460 470 480 490 500
DRDYFIGVLD IAGFEIFDFN SFEQLWINFV NEKLQQFFNH HMFVLEQEEY
510 520 530 540 550
AREGIQWVFI DFGLDLQACI ELIEKPLGII SMLDEECIVP KATDLTLASK
560 570 580 590 600
LVDQHLGKHP NFEKPKPPKG KQGEAHFAMR HYAGTVRYNC LNWLEKNKDP
610 620 630 640 650
LNDTVVSAMK QSKGNDLLVE IWQDYTTQEE AAAKAKEGGG GGKKKGKSGS
660 670 680 690 700
FMTVSMLYRE SLNNLMTMLN KTHPHFIRCI IPNEKKQSGM IDAALVLNQL
710 720 730 740 750
TCNGVLEGIR ICRKGFPNRT LHPDFVQRYA ILAAKEAKSD DDKKKCAEAI
760 770 780 790 800
MSKLVNDGSL SEEMFRIGLT KVFFKAGVLA HLEDIRDEKL ATILTGFQSQ
810 820 830 840 850
IRWHLGLKDR KRRMEQRAGL LIVQRNVRSW CTLRTWEWFK LYGKVKPMLK
860 870 880 890 900
AGKEAEELEK INDKVKALED SLAKEEKLRK ELEESSAKLV EEKTSLFTNL
910 920 930 940 950
ESTKTQLSDA EERLAKLEAQ QKDASKQLSE LNDQLADNED RTADVQRAKK
960 970 980 990 1000
KIEAEVEALK KQIQDLEMSL RKAESEKQSK DHQIRSLQDE MQQQDEAIAK
1010 1020 1030 1040 1050
LNKEKKHQEE INRKLMEDLQ SEEDKGNHQN KVKAKLEQTL DDLEDSLERE
1060 1070 1080 1090 1100
KRARADLDKQ KRKVEGELKI AQENIDESGR QRHDLENNLK KKESELHSVS
1110 1120 1130 1140 1150
SRLEDEQALV SKLQRQIKDG QSRISELEEE LENERQSRSK ADRAKSDLQR
1160 1170 1180 1190 1200
ELEELGEKLD EQGGATAAQV EVNKKREAEL AKLRRDLEEA NMNHENQLGG
1210 1220 1230 1240 1250
LRKKHTDAVA ELTDQLDQLN KAKAKVEKDK AQAVRDAEDL AAQLDQETSG
1260 1270 1280 1290 1300
KLNNEKLAKQ FELQLTELQS KADEQSRQLQ DFTSLKGRLH SENGDLVRQL
1310 1320 1330 1340 1350
EDAESQVNQL TRLKSQLTSQ LEEARRTADE EARERQTVAA QAKNYQHEAE
1360 1370 1380 1390 1400
QLQESLEEEI EGKNEILRQL SKANADIQQW KARFEGEGLL KADELEDAKR
1410 1420 1430 1440 1450
RQAQKINELQ EALDAANSKN ASLEKTKSRL VGDLDDAQVD VERANGVASA
1460 1470 1480 1490 1500
LEKKQKGFDK IIDEWRKKTD DLAAELDGAQ RDLRNTSTDL FKAKNAQEEL
1510 1520 1530 1540 1550
AEVVEGLRRE NKSLSQEIKD LTDQLGEGGR SVHEMQKIIR RLEIEKEELQ
1560 1570 1580 1590 1600
HALDEAEAAL EAEESKVLRA QVEVSQIRSE IEKRIQEKEE EFENTRKNHA
1610 1620 1630 1640 1650
RALESMQASL ETEAKGKAEL LRIKKKLEGD INELEIALDH ANKANADAQK
1660 1670 1680 1690 1700
NLKRYQEQVR ELQLQVEEEQ RNGADTREQF FNAEKRATLL QSEKEELLVA
1710 1720 1730 1740 1750
NEAAERARKQ AEYEAADARD QANEANAQVS SLTSAKRKLE GEIQAIHADL
1760 1770 1780 1790 1800
DETLNEYKAA EERSKKAIAD ATRLAEELRQ EQEHSQHVDR LRKGLEQQLK
1810 1820 1830 1840 1850
EIQVRLDEAE AAALKGGKKV IAKLEQRVRE LESELDGEQR RFQDANKNLG
1860 1870 1880 1890 1900
RADRRVRELQ FQVDEDKKNF ERLQDLIDKL QQKLKTQKKQ VEEAEELANL
1910 1920 1930 1940 1950
NLQKYKQLTH QLEDAEERAD QAENSLSKMR SKSRASASVA PGLQSSASAA
1960
VIRSPSRARA SDF
Length:1,963
Mass (Da):224,755
Last modified:February 19, 2014 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD653C86050E846C6
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA28124 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1334E → R (PubMed:7202124).Curated1
Sequence conflicti1877I → L (PubMed:7202124).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
J01050 Genomic DNA Translation: AAA28124.1 Sequence problems.
Z81499, Z83107 Genomic DNA Translation: CAB04089.1
V01494 Genomic DNA Translation: CAA24738.1

Protein sequence database of the Protein Information Resource

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PIRi
T20770 MWKW

NCBI Reference Sequences

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RefSeqi
NP_493596.1, NM_061195.4

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
F11C3.3.1; F11C3.3.1; WBGene00006789
F11C3.3.2; F11C3.3.2; WBGene00006789
F11C3.3.3; F11C3.3.3; WBGene00006789

Database of genes from NCBI RefSeq genomes

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GeneIDi
259839

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_F11C3.3

UCSC genome browser

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UCSCi
F11C3.3.1 c. elegans

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J01050 Genomic DNA Translation: AAA28124.1 Sequence problems.
Z81499, Z83107 Genomic DNA Translation: CAB04089.1
V01494 Genomic DNA Translation: CAA24738.1
PIRiT20770 MWKW
RefSeqiNP_493596.1, NM_061195.4

3D structure databases

SMRiP02566
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi56866, 5 interactors
DIPiDIP-26548N
IntActiP02566, 6 interactors
MINTiP02566
STRINGi6239.F11C3.3.1

PTM databases

iPTMnetiP02566

Proteomic databases

EPDiP02566
PaxDbiP02566
PeptideAtlasiP02566
PRIDEiP02566

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF11C3.3.1; F11C3.3.1; WBGene00006789
F11C3.3.2; F11C3.3.2; WBGene00006789
F11C3.3.3; F11C3.3.3; WBGene00006789
GeneIDi259839
KEGGicel:CELE_F11C3.3
UCSCiF11C3.3.1 c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
259839
WormBaseiF11C3.3 ; CE09349 ; WBGene00006789 ; unc-54

Phylogenomic databases

eggNOGiKOG0161 Eukaryota
COG5022 LUCA
GeneTreeiENSGT00940000173223
HOGENOMiHOG000173959
InParanoidiP02566
KOiK10352
OMAiVYPDFKM
OrthoDBi47111at2759

Miscellaneous databases

Protein Ontology

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PROi
PR:P02566

Gene expression databases

BgeeiWBGene00006789 Expressed in 7 organ(s), highest expression level in material anatomical entity

Family and domain databases

Gene3Di2.30.30.360, 1 hit
3.40.850.10, 1 hit
4.10.270.10, 1 hit
InterProiView protein in InterPro
IPR036961 Kinesin_motor_dom_sf
IPR001609 Myosin_head_motor_dom
IPR027401 Myosin_IQ_contain_sf
IPR004009 Myosin_N
IPR008989 Myosin_S1_N
IPR002928 Myosin_tail
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00063 Myosin_head, 1 hit
PF02736 Myosin_N, 1 hit
PF01576 Myosin_tail_1, 1 hit
PRINTSiPR00193 MYOSINHEAVY
SMARTiView protein in SMART
SM00242 MYSc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51456 MYOSIN_MOTOR, 1 hit
PS51844 SH3_LIKE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMYO4_CAEEL
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P02566
Secondary accession number(s): O02244
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: February 19, 2014
Last modified: June 5, 2019
This is version 169 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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