UniProtKB - P02564 (MYH7_RAT)
Myosin-7
Myh7
Functioni
Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle.
1 PublicationMiscellaneous
Caution
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 178 – 185 | ATP | 8 |
GO - Molecular functioni
- actin filament binding Source: InterPro
- ATP binding Source: RGD
- ATP hydrolysis activity Source: RGD
- calmodulin binding Source: UniProtKB-KW
- identical protein binding Source: RGD
- microfilament motor activity Source: RGD
- protein-containing complex binding Source: RGD
GO - Biological processi
- adult heart development Source: RGD
- aging Source: RGD
- ATP metabolic process Source: RGD
- cardiac muscle contraction Source: RGD
- cardiac muscle hypertrophy in response to stress Source: RGD
- cellular response to 3,3',5-triiodo-L-thyronine Source: RGD
- cellular response to angiotensin Source: RGD
- muscle contraction Source: RGD
- muscle filament sliding Source: RGD
- regulation of heart rate Source: RGD
- regulation of slow-twitch skeletal muscle fiber contraction Source: RGD
- regulation of the force of heart contraction Source: RGD
- regulation of the force of skeletal muscle contraction Source: RGD
- skeletal muscle contraction Source: RGD
- striated muscle contraction Source: RGD
- transition between fast and slow fiber Source: RGD
- ventricular cardiac muscle tissue morphogenesis Source: RGD
Keywordsi
Molecular function | Actin-binding, Calmodulin-binding, Motor protein, Muscle protein, Myosin |
Ligand | ATP-binding, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Myosin-7Alternative name(s): Myosin heavy chain 7 Myosin heavy chain slow isoform Short name: MyHC-slow Myosin heavy chain, cardiac muscle beta isoform Short name: MyHC-beta |
Gene namesi | Name:Myh7 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 62030, Myh7 |
Subcellular locationi
Cytoskeleton
- muscle myosin complex Source: RGD
- myosin complex Source: RGD
- stress fiber Source: RGD
Other locations
- cytoplasm Source: RGD
- myofibril Source: UniProtKB
- myosin filament Source: UniProtKB
- sarcomere Source: UniProtKB
- Z disc Source: RGD
Keywords - Cellular componenti
Cytoplasm, Thick filamentPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 1188 | Missing : No effect on myosin incorporation into sarcomeres. 1 Publication | 1 | |
Mutagenesisi | 1385 | Missing : No effect on myosin incorporation into sarcomeres. 1 Publication | 1 | |
Mutagenesisi | 1582 | Missing : No effect on myosin incorporation into sarcomeres. Causes myosin cytoplasmic aggregates that show a sponge-like structure. 1 Publication | 1 | |
Mutagenesisi | 1807 | Missing : No effect on myosin incorporation into sarcomeres. Disrupts location on the sarcomere bare zone. 1 Publication | 1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000123411 | 1 – 1935 | Myosin-7Add BLAST | 1935 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 129 | N6,N6,N6-trimethyllysineSequence analysis | 1 | |
Modified residuei | 378 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 1137 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1269 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1282 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 1308 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 1309 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 1510 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1513 | PhosphothreonineBy similarity | 1 |
Keywords - PTMi
Methylation, PhosphoproteinProteomic databases
jPOSTi | P02564 |
PaxDbi | P02564 |
PRIDEi | P02564 |
PTM databases
iPTMneti | P02564 |
PhosphoSitePlusi | P02564 |
Interactioni
Subunit structurei
Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2).
Interacts with ECPAS.
Interacts (via C-terminus) with LRRC39.
By similarityGO - Molecular functioni
- actin filament binding Source: InterPro
- calmodulin binding Source: UniProtKB-KW
- identical protein binding Source: RGD
Protein-protein interaction databases
BioGRIDi | 248191, 2 interactors |
IntActi | P02564, 1 interactor |
STRINGi | 10116.ENSRNOP00000024186 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 32 – 81 | Myosin N-terminal SH3-likePROSITE-ProRule annotationAdd BLAST | 50 | |
Domaini | 85 – 778 | Myosin motorPROSITE-ProRule annotationAdd BLAST | 694 | |
Domaini | 781 – 810 | IQPROSITE-ProRule annotationAdd BLAST | 30 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 655 – 677 | Actin-bindingAdd BLAST | 23 | |
Regioni | 757 – 771 | Actin-bindingAdd BLAST | 15 | |
Regioni | 1915 – 1935 | DisorderedSequence analysisAdd BLAST | 21 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 840 – 1935 | Sequence analysisAdd BLAST | 1096 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG0161, Eukaryota |
InParanoidi | P02564 |
OrthoDBi | 47111at2759 |
PhylomeDBi | P02564 |
Family and domain databases
Gene3Di | 1.20.5.370, 4 hits 2.30.30.360, 1 hit 3.40.850.10, 1 hit |
InterProi | View protein in InterPro IPR000048, IQ_motif_EF-hand-BS IPR036961, Kinesin_motor_dom_sf IPR001609, Myosin_head_motor_dom IPR004009, Myosin_N IPR008989, Myosin_S1_N IPR002928, Myosin_tail IPR027417, P-loop_NTPase IPR014751, XRCC4-like_C |
Pfami | View protein in Pfam PF00063, Myosin_head, 1 hit PF02736, Myosin_N, 1 hit PF01576, Myosin_tail_1, 1 hit |
PRINTSi | PR00193, MYOSINHEAVY |
SMARTi | View protein in SMART SM00242, MYSc, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS50096, IQ, 1 hit PS51456, MYOSIN_MOTOR, 1 hit PS51844, SH3_LIKE, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
10 20 30 40 50
MADREMAAFG AGAPFLRKSE KERLEAQTRP FDLKKDVFVP DDKEEFVKAK
60 70 80 90 100
IVSREGGKVT AETENGKTVT VKEDQVMQQN PPKFDKIEDM AMLTFLHEPA
110 120 130 140 150
VLYNLKERYA SWMIYTYSGL FCVTVNPYKW LPVYNAQVVA AYRGKKRSEA
160 170 180 190 200
PPHIFSISDN AYQYMLTDRE NQSILITGES GAGKTVNTKR VIQYFAVIAA
210 220 230 240 250
IGDRSKKDQT PGKGTLEDQI IQANPALEAF GNAKTVRNDN SSRFGKFIRI
260 270 280 290 300
HFGATGKLAS ADIETYLLEK SRVIFQLKAE RDYHIFYQIL SNKKPELLDM
310 320 330 340 350
LLITNNPYDY AFFSQGETTV ASIDDSEEHM ATDSAFDVLG FTPEEKNSIY
360 370 380 390 400
KLTGAIMHFG NMKFKQKQRE EQAEPDGTEE ADKSAYLMGL NSADLLKGLC
410 420 430 440 450
HPRVKVGNEY VTKGQNVQQV AYAIGALAKS VYEKMFNWMV TRINATLETK
460 470 480 490 500
QPRQYFIGVL DIAGFEIFDF NSFEQLCINF TNEKLQQFFN HHMFVLEQEE
510 520 530 540 550
YKKEGIEWTF IDFGMDLQAC IDLIEKPMGI MSILEEECMF PKATDMTFKA
560 570 580 590 600
KLYDNHLGKS NNFQKPRNIK GKQEAHFSLI HYAGTVDYNI LGWLQKNKDP
610 620 630 640 650
LNETVVGLYQ KSSLKLLSNL FANYAGADAP VDKGKGKAKK GSSFQTVSAL
660 670 680 690 700
HRENLNKLMT NLRSTHPHFV RCIIPNETKS PGVMDNPLVM HQLRCNGVLE
710 720 730 740 750
GIRICRKGFP NRILYGDFRQ RYRILNPAAI PEGQFIDSRK GAEKLLGSLD
760 770 780 790 800
IDHNQYKFGH TKVFFKAGLL GLLEEMRDER LSRIITRIQA QSRGVLSRME
810 820 830 840 850
FKKLLERRDS LLIIQWNIRA FMGVKNWPWM KLYFKIKPLL KSAETEKEMA
860 870 880 890 900
NMKEEFGRVK DALEKSEARR KELEEKMVSL LQEKNDLQLQ VQAEQDNLAD
910 920 930 940 950
AEERCDQLIK NKIQLEAKVK EMTERLEDEE EMNAELTAKK RKLEDECSEL
960 970 980 990 1000
KRDIDDLELT LAKVEKEKHA TENKVKNLTE EMAGLDEIIV KLTKEKKALQ
1010 1020 1030 1040 1050
EAHQQALDDL QAEEDKVNTL TKAKVKLEQQ VDDLEGSLDQ DKKVRMDLER
1060 1070 1080 1090 1100
AKRKLEGDLK LTQESIMDLE NDKQQLDERL KKKDFELNAL NARIEDEQAL
1110 1120 1130 1140 1150
GSQLQKKLKE LQARIEELEE ELEAERTARA KVEKLRSDLS RELEEISERL
1160 1170 1180 1190 1200
EEAGGATSVQ IEMNKKREAE FQKMRRDLEE ATLQHEATAA ALRKKHADSV
1210 1220 1230 1240 1250
AELGEQIDNL QRVKQKLEKE KSEFKLELDD VTSNMEQIIK AKANLEKMCR
1260 1270 1280 1290 1300
TLEDQMNEHR SKAEETQRSV NDLTRQRAKL QTENGELSRQ LDEKEALISQ
1310 1320 1330 1340 1350
LTRGKLTYTQ QLEDLKRQLE EEVKAKNALA HALQSARHDC DLLREQYEEE
1360 1370 1380 1390 1400
TEAKAELQRV LSKANSEVAQ WRTKYETDAI QRTEELEEAK KKLAQRLQDA
1410 1420 1430 1440 1450
EEAVEAVNAK CSSLEKTKHR LQNEIEDLMV DVERSNAAAA ALDKKQRNFD
1460 1470 1480 1490 1500
KILVEWKQKY EESQSELESS QKEARSLSTE LFKLKNAYEE SLEHLETFKR
1510 1520 1530 1540 1550
ENKNLQEEIS DLTEQLGSTG KSIHELEKIR KQLEAEKLEL QSALEEAEAS
1560 1570 1580 1590 1600
LEHEEGKILR AQLEFNQIKA EIERKLAEKD EEMEQAKRNH LRVVDSLQTS
1610 1620 1630 1640 1650
LDAETRSRNE ALRVKKKMEG DLNEMEIQLS HANRMAAEAQ KQVKSLQSLL
1660 1670 1680 1690 1700
KDTQIQLDDA VRANDDLKEN IAIVERRNNL LQAELEELRA VVEQTERSRK
1710 1720 1730 1740 1750
LAEQELIETS ERVQLLHSQN TSLINQKKKM DADLSQLQTE VEEAVQECRN
1760 1770 1780 1790 1800
AEEKAKKAIT DAAMMAEELK KEQDTSAHLE RMKNNMEQTI KDLQHRLDEA
1810 1820 1830 1840 1850
EQIALKGGKK QLQKLEARVR ELENELEAEQ KRNAESVKGM RKSERRIKEL
1860 1870 1880 1890 1900
TYQTEEDRKN LLRLQDLVDK LQLKVKAYKR QAEEAEEQAN TNLSKFRKVQ
1910 1920 1930
HELDEAEERA DIAESQVNKL RAKSRDIGAK GLNEE
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketG3V8B0 | G3V8B0_RAT | Myosin-7 | Myh7 rCG_23467 | 1,935 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 1529 – 1531 | IRK → VRR in AAA41654 (PubMed:7045682).Curated | 3 | |
Sequence conflicti | 1731 | D → H in AAA41654 (PubMed:7045682).Curated | 1 | |
Sequence conflicti | 1784 | N → K in AAA41654 (PubMed:7045682).Curated | 1 | |
Sequence conflicti | 1851 | T → N in AAA41654 (PubMed:7045682).Curated | 1 | |
Sequence conflicti | 1858 | R → K in AAA41654 (PubMed:7045682).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X15939 mRNA Translation: CAA34065.1 J00752 mRNA Translation: AAA41654.1 M32698 mRNA Translation: AAA41659.1 |
PIRi | S06006 |
RefSeqi | NP_058936.1, NM_017240.2 |
Genome annotation databases
GeneIDi | 29557 |
KEGGi | rno:29557 |
UCSCi | RGD:62030, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X15939 mRNA Translation: CAA34065.1 J00752 mRNA Translation: AAA41654.1 M32698 mRNA Translation: AAA41659.1 |
PIRi | S06006 |
RefSeqi | NP_058936.1, NM_017240.2 |
3D structure databases
SMRi | P02564 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 248191, 2 interactors |
IntActi | P02564, 1 interactor |
STRINGi | 10116.ENSRNOP00000024186 |
PTM databases
iPTMneti | P02564 |
PhosphoSitePlusi | P02564 |
Proteomic databases
jPOSTi | P02564 |
PaxDbi | P02564 |
PRIDEi | P02564 |
Genome annotation databases
GeneIDi | 29557 |
KEGGi | rno:29557 |
UCSCi | RGD:62030, rat |
Organism-specific databases
CTDi | 4625 |
RGDi | 62030, Myh7 |
Phylogenomic databases
eggNOGi | KOG0161, Eukaryota |
InParanoidi | P02564 |
OrthoDBi | 47111at2759 |
PhylomeDBi | P02564 |
Miscellaneous databases
PROi | PR:P02564 |
Family and domain databases
Gene3Di | 1.20.5.370, 4 hits 2.30.30.360, 1 hit 3.40.850.10, 1 hit |
InterProi | View protein in InterPro IPR000048, IQ_motif_EF-hand-BS IPR036961, Kinesin_motor_dom_sf IPR001609, Myosin_head_motor_dom IPR004009, Myosin_N IPR008989, Myosin_S1_N IPR002928, Myosin_tail IPR027417, P-loop_NTPase IPR014751, XRCC4-like_C |
Pfami | View protein in Pfam PF00063, Myosin_head, 1 hit PF02736, Myosin_N, 1 hit PF01576, Myosin_tail_1, 1 hit |
PRINTSi | PR00193, MYOSINHEAVY |
SMARTi | View protein in SMART SM00242, MYSc, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS50096, IQ, 1 hit PS51456, MYOSIN_MOTOR, 1 hit PS51844, SH3_LIKE, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | MYH7_RAT | |
Accessioni | P02564Primary (citable) accession number: P02564 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 21, 1986 |
Last sequence update: | October 1, 1989 | |
Last modified: | February 23, 2022 | |
This is version 176 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families