Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 224 (08 May 2019)
Sequence version 5 (05 Oct 2010)
Previous versions | rss
Other tutorials and videosHelp videoFeedback
Protein

Spectrin alpha chain, erythrocytic 1

Gene

SPTA1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane.

Miscellaneous

This complex is anchored to the cytoplasmic face of the plasma membrane via another protein, ankyrin, which binds to beta-spectrin and mediates the binding of the whole complex to a transmembrane protein band 3. The interaction of erythrocyte spectrin with other proteins through specific binding domains lead to the formation of an extensive subplasmalemmal meshwork which is thought to be responsible for the maintenance of the biconcave shape of human erythrocytes, for the regulation of plasma membrane components and for the maintenance of the lipid asymmetry of the plasma membrane.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) of the calcium-binding region(s) within the protein. One common calcium-binding motif is the EF-hand, but other calcium-binding motifs also exist.<p><a href='/help/ca_bind' target='_top'>More...</a></p>Calcium bindingi2284 – 22951PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi2327 – 23382PROSITE-ProRule annotationAdd BLAST12

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin capping, Actin-binding
Biological processCell shape
LigandCalcium, Metal-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-375165 NCAM signaling for neurite out-growth
R-HSA-445095 Interaction between L1 and Ankyrins
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-6807878 COPI-mediated anterograde transport

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P02549

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Spectrin alpha chain, erythrocytic 1
Alternative name(s):
Erythroid alpha-spectrin
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SPTA1
Synonyms:SPTA
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:11272 SPTA1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
182860 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P02549

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Elliptocytosis 2 (EL2)12 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA Rhesus-unlinked form of hereditary elliptocytosis, a genetically heterogeneous, autosomal dominant hematologic disorder. It is characterized by variable hemolytic anemia and elliptical or oval red cell shape.
See also OMIM:130600
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_00132424I → S in EL2; Lograno. 1 Publication1
Natural variantiVAR_00132828R → C in EL2. 1 PublicationCorresponds to variant dbSNP:rs121918642EnsemblClinVar.1
Natural variantiVAR_00132528R → H in EL2; Corbeil. 1 PublicationCorresponds to variant dbSNP:rs121918641EnsemblClinVar.1
Natural variantiVAR_00132628R → L in EL2. 1 PublicationCorresponds to variant dbSNP:rs121918641EnsemblClinVar.1
Natural variantiVAR_00132728R → S in EL2. 2 PublicationsCorresponds to variant dbSNP:rs121918642EnsemblClinVar.1
Natural variantiVAR_00132931V → A in EL2; Marseille. Corresponds to variant dbSNP:rs773826036Ensembl.1
Natural variantiVAR_00133034R → W in EL2; Genova. 1 PublicationCorresponds to variant dbSNP:rs201568233Ensembl.1
Natural variantiVAR_00133141R → W in EL2; Tunis. 1 PublicationCorresponds to variant dbSNP:rs121918640EnsemblClinVar.1
Natural variantiVAR_00133245R → S in EL2; Clichy. 1 PublicationCorresponds to variant dbSNP:rs121918637EnsemblClinVar.1
Natural variantiVAR_00133345R → T in EL2; Anastasia. 1 Publication1
Natural variantiVAR_00133446G → V in EL2; Culoz. 1 PublicationCorresponds to variant dbSNP:rs121918638EnsemblClinVar.1
Natural variantiVAR_00133649L → F in EL2; Lyon. 1 PublicationCorresponds to variant dbSNP:rs121918639EnsemblClinVar.1
Natural variantiVAR_001337151G → D in EL2; Ponte de Sor. Corresponds to variant dbSNP:rs199725919EnsemblClinVar.1
Natural variantiVAR_001338154L → LL in EL2. 1
Natural variantiVAR_001339207L → P in EL2 and HPP; Saint-Louis. 1 PublicationCorresponds to variant dbSNP:rs121918643EnsemblClinVar.1
Natural variantiVAR_001340260L → P in EL2; Nigerian. 1 PublicationCorresponds to variant dbSNP:rs121918634EnsemblClinVar.1
Natural variantiVAR_001341261S → P in EL2. 1 PublicationCorresponds to variant dbSNP:rs121918636EnsemblClinVar.1
Natural variantiVAR_001342469H → P in EL2; Barcelona. 1 Publication1
Natural variantiVAR_001343469Missing in EL2; Alexandria. 1
Natural variantiVAR_001344471Q → P in EL2. 1 PublicationCorresponds to variant dbSNP:rs121918635EnsemblClinVar.1
Natural variantiVAR_001346791D → E in EL2; Jendouba. 1 PublicationCorresponds to variant dbSNP:rs7418956EnsemblClinVar.1
Hereditary pyropoikilocytosis (HPP)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAutosomal recessive hematologic disorder characterized by hemolytic anemia, microspherocytosis, poikilocytosis, and an unusual thermal sensitivity of red cells.
See also OMIM:266140
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_00133548K → R in HPP. 1 PublicationCorresponds to variant dbSNP:rs121918644EnsemblClinVar.1
Natural variantiVAR_001339207L → P in EL2 and HPP; Saint-Louis. 1 PublicationCorresponds to variant dbSNP:rs121918643EnsemblClinVar.1
Spherocytosis 3 (SPH3)
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionSpherocytosis is a hematologic disorder leading to chronic hemolytic anemia and characterized by numerous abnormally shaped erythrocytes which are generally spheroidal. SPH3 is characterized by severe hemolytic anemia. Inheritance is autosomal recessive.
See also OMIM:270970

Keywords - Diseasei

Disease mutation, Elliptocytosis, Hereditary hemolytic anemia, Pyropoikilocytosis

Organism-specific databases

DisGeNET

More...
DisGeNETi
6708

MalaCards human disease database

More...
MalaCardsi
SPTA1
MIMi130600 phenotype
266140 phenotype
270970 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000163554

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
288 Hereditary elliptocytosis
822 Hereditary spherocytosis

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA36101

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SPTA1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
308153675

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000734521 – 2419Spectrin alpha chain, erythrocytic 1Add BLAST2419

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei992PhosphoserineCombined sources1
Modified residuei1976PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P02549

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P02549

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P02549

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P02549

PeptideAtlas

More...
PeptideAtlasi
P02549

PRoteomics IDEntifications database

More...
PRIDEi
P02549

ProteomicsDB human proteome resource

More...
ProteomicsDBi
51533
51534 [P02549-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P02549

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P02549

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000163554 Expressed in 79 organ(s), highest expression level in trabecular bone tissue

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P02549 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB016193
CAB037246
HPA028048
HPA028253

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Composed of non-homologous chains, alpha and beta, which aggregate side-to-side in an antiparallel fashion to form dimers, tetramers, and higher polymers. Interacts with FASLG.2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
112586, 56 interactors

Database of interacting proteins

More...
DIPi
DIP-17031N

Protein interaction database and analysis system

More...
IntActi
P02549, 27 interactors

Molecular INTeraction database

More...
MINTi
P02549

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000357129

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

12419
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1OWANMR-A1-156[»]
3LBXX-ray2.80A1-158[»]
5J4OX-ray1.54A1599-1826[»]

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P02549

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P02549

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati53 – 155Spectrin 1Sequence analysisAdd BLAST103
Repeati159 – 261Spectrin 2Sequence analysisAdd BLAST103
Repeati265 – 367Spectrin 3Sequence analysisAdd BLAST103
Repeati371 – 474Spectrin 4Sequence analysisAdd BLAST104
Repeati477 – 580Spectrin 5Sequence analysisAdd BLAST104
Repeati583 – 685Spectrin 6Sequence analysisAdd BLAST103
Repeati688 – 790Spectrin 7Sequence analysisAdd BLAST103
Repeati794 – 896Spectrin 8Sequence analysisAdd BLAST103
Repeati900 – 969Spectrin 9Sequence analysisAdd BLAST70
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini977 – 1036SH3PROSITE-ProRule annotationAdd BLAST60
Repeati1087 – 1179Spectrin 10Sequence analysisAdd BLAST93
Repeati1185 – 1287Spectrin 11Sequence analysisAdd BLAST103
Repeati1290 – 1392Spectrin 12Sequence analysisAdd BLAST103
Repeati1396 – 1497Spectrin 13Sequence analysisAdd BLAST102
Repeati1501 – 1605Spectrin 14Sequence analysisAdd BLAST105
Repeati1608 – 1711Spectrin 15Sequence analysisAdd BLAST104
Repeati1714 – 1817Spectrin 16Sequence analysisAdd BLAST104
Repeati1820 – 1926Spectrin 17Sequence analysisAdd BLAST107
Repeati1929 – 2033Spectrin 18Sequence analysisAdd BLAST105
Repeati2044 – 2146Spectrin 19Sequence analysisAdd BLAST103
Repeati2158 – 2258Spectrin 20Sequence analysisAdd BLAST101
Domaini2271 – 2306EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini2314 – 2349EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini2352 – 2386EF-hand 3PROSITE-ProRule annotationAdd BLAST35

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the spectrin family.Curated

Keywords - Domaini

Repeat, SH3 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0035 Eukaryota
COG5069 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161240

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000246965

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P02549

KEGG Orthology (KO)

More...
KOi
K06114

Identification of Orthologs from Complete Genome Data

More...
OMAi
HFAHEDT

Database of Orthologous Groups

More...
OrthoDBi
1376537at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P02549

TreeFam database of animal gene trees

More...
TreeFami
TF343803

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011992 EF-hand-dom_pair
IPR014837 EF-hand_Ca_insen
IPR002048 EF_hand_dom
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR018159 Spectrin/alpha-actinin
IPR002017 Spectrin_repeat

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08726 EFhand_Ca_insen, 1 hit
PF00018 SH3_1, 1 hit
PF00435 Spectrin, 20 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00326 SH3, 1 hit
SM00150 SPEC, 20 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47473 SSF47473, 1 hit
SSF50044 SSF50044, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50222 EF_HAND_2, 3 hits
PS50002 SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: P02549-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEQFPKETVV ESSGPKVLET AEEIQERRQE VLTRYQSFKE RVAERGQKLE
60 70 80 90 100
DSYHLQVFKR DADDLGKWIM EKVNILTDKS YEDPTNIQGK YQKHQSLEAE
110 120 130 140 150
VQTKSRLMSE LEKTREERFT MGHSAHEETK AHIEELRHLW DLLLELTLEK
160 170 180 190 200
GDQLLRALKF QQYVQECADI LEWIGDKEAI ATSVELGEDW ERTEVLHKKF
210 220 230 240 250
EDFQVELVAK EGRVVEVNQY ANECAEENHP DLPLIQSKQN EVNAAWERLR
260 270 280 290 300
GLALQRQKAL SNAANLQRFK RDVTEAIQWI KEKEPVLTSE DYGKDLVASE
310 320 330 340 350
GLFHSHKGLE RNLAVMSDKV KELCAKAEKL TLSHPSDAPQ IQEMKEDLVS
360 370 380 390 400
SWEHIRALAT SRYEKLQATY WYHRFSSDFD ELSGWMNEKT AAINADELPT
410 420 430 440 450
DVAGGEVLLD RHQQHKHEID SYDDRFQSAD ETGQDLVNAN HEASDEVREK
460 470 480 490 500
MEILDNNWTA LLELWDERHR QYEQCLDFHL FYRDSEQVDS WMSRQEAFLE
510 520 530 540 550
NEDLGNSLGS AEALLQKHED FEEAFTAQEE KIITVDKTAT KLIGDDHYDS
560 570 580 590 600
ENIKAIRDGL LARRDALREK AATRRRLLKE SLLLQKLYED SDDLKNWINK
610 620 630 640 650
KKKLADDEDY KDIQNLKSRV QKQQVFEKEL AVNKTQLENI QKTGQEMIEG
660 670 680 690 700
GHYASDNVTT RLSEVASLWE ELLEATKQKG TQLHEANQQL QFENNAEDLQ
710 720 730 740 750
RWLEDVEWQV TSEDYGKGLA EVQNRLRKHG LLESAVAARQ DQVDILTDLA
760 770 780 790 800
AYFEEIGHPD SKDIRARQES LVCRFEALKE PLATRKKKLL DLLHLQLICR
810 820 830 840 850
DTEDEEAWIQ ETEPSATSTY LGKDLIASKK LLNRHRVILE NIASHEPRIQ
860 870 880 890 900
EITERGNKMV EEGHFAAEDV ASRVKSLNQN MESLRARAAR RQNDLEANVQ
910 920 930 940 950
FQQYLADLHE AETWIREKEP IVDNTNYGAD EEAAGALLKK HEAFLLDLNS
960 970 980 990 1000
FGDSMKALRN QANACQQQQA APVEGVAGEQ RVMALYDFQA RSPREVTMKK
1010 1020 1030 1040 1050
GDVLTLLSSI NKDWWKVEAA DHQGIVPAVY VRRLAHDEFP MLPQRRREEP
1060 1070 1080 1090 1100
GNITQRQEQI ENQYRSLLDR AEERRRRLLQ RYNEFLLAYE AGDMLEWIQE
1110 1120 1130 1140 1150
KKAENTGVEL DDVWELQKKF DEFQKDLNTN EPRLRDINKV ADDLLFEGLL
1160 1170 1180 1190 1200
TPEGAQIRQE LNSRWGSLQR LADEQRQLLG SAHAVEVFHR EADDTKEQIE
1210 1220 1230 1240 1250
KKCQALSAAD PGSDLFSVQA LQRRHEGFER DLVPLGDKVT ILGETAERLS
1260 1270 1280 1290 1300
ESHPDATEDL QRQKMELNEA WEDLQGRTKD RKESLNEAQK FYLFLSKARD
1310 1320 1330 1340 1350
LQNWISSIGG MVSSQELAED LTGIEILLER HQEHRADMEA EAPTFQALED
1360 1370 1380 1390 1400
FSAELIDSGH HASPEIEKKL QAVKLERDDL EKAWEKRKKI LDQCLELQMF
1410 1420 1430 1440 1450
QGNCDQVESW MVARENSLRS DDKSSLDSLE ALMKKRDDLD KAITAQEGKI
1460 1470 1480 1490 1500
TDLEHFAESL IADEHYAKEE IATRLQRVLD RWKALKAQLI DERTKLGDYA
1510 1520 1530 1540 1550
NLKQFYRDLE ELEEWISEML PTACDESYKD ATNIQRKYLK HQTFAHEVDG
1560 1570 1580 1590 1600
RSEQVHGVIN LGNSLIECSA CDGNEEAMKE QLEQLKEHWD HLLERTNDKG
1610 1620 1630 1640 1650
KKLNEASRQQ RFNTSIRDFE FWLSEAETLL AMKDQARDLA SAGNLLKKHQ
1660 1670 1680 1690 1700
LLEREMLARE DALKDLNTLA EDLLSSGTFN VDQIVKKKDN VNKRFLNVQE
1710 1720 1730 1740 1750
LAAAHHEKLK EAYALFQFFQ DLDDEESWIE EKLIRVSSQD YGRDLQGVQN
1760 1770 1780 1790 1800
LLKKHKRLEG ELVAHEPAIQ NVLDMAEKLK DKAAVGQEEI QLRLAQFVEH
1810 1820 1830 1840 1850
WEKLKELAKA RGLKLEESLE YLQFMQNAEE EEAWINEKNA LAVRGDCGDT
1860 1870 1880 1890 1900
LAATQSLLMK HEALENDFAV HETRVQNVCA QGEDILNKVL QEESQNKEIS
1910 1920 1930 1940 1950
SKIEALNEKT PSLAKAIAAW KLQLEDDYAF QEFNWKADVV EAWIADKETS
1960 1970 1980 1990 2000
LKTNGNGADL GDFLTLLAKQ DTLDASLQSF QQERLPEITD LKDKLISAQH
2010 2020 2030 2040 2050
NQSKAIEERY AALLKRWEQL LEASAVHRQK LLEKQLPLQK AEDLFVEFAH
2060 2070 2080 2090 2100
KASALNNWCE KMEENLSEPV HCVSLNEIRQ LQKDHEDFLA SLARAQADFK
2110 2120 2130 2140 2150
CLLELDQQIK ALGVPSSPYT WLTVEVLERT WKHLSDIIEE REQELQKEEA
2160 2170 2180 2190 2200
RQVKNFEMCQ EFEQNASTFL QWILETRAYF LDGSLLKETG TLESQLEANK
2210 2220 2230 2240 2250
RKQKEIQAMK RQLTKIVDLG DNLEDALILD IKYSTIGLAQ QWDQLYQLGL
2260 2270 2280 2290 2300
RMQHNLEQQI QAKDIKGVSE ETLKEFSTIY KHFDENLTGR LTHKEFRSCL
2310 2320 2330 2340 2350
RGLNYYLPMV EEDEHEPKFE KFLDAVDPGR KGYVSLEDYT AFLIDKESEN
2360 2370 2380 2390 2400
IKSSDEIENA FQALAEGKSY ITKEDMKQAL TPEQVSFCAT HMQQYMDPRG
2410
RSHLSGYDYV GFTNSYFGN
Length:2,419
Mass (Da):280,014
Last modified:October 5, 2010 - v5
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB60680145C58DF55
GO
Isoform 2 (identifier: P02549-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1889-1891: Missing.

Note: Gene prediction based on EST data.
Show »
Length:2,416
Mass (Da):279,674
Checksum:iC3824332610EF99C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti119 – 130Missing in AAA60575 (PubMed:2794061).CuratedAdd BLAST12
Sequence conflicti395A → G in AAA60575 (PubMed:2794061).Curated1
Sequence conflicti1410W → R in AAA60577 (PubMed:1689726).Curated1
Sequence conflicti1410W → R in AAA60994 (PubMed:1689726).Curated1
Sequence conflicti1570Missing in AAA60577 (PubMed:1689726).Curated1
Sequence conflicti1570Missing in AAA60994 (PubMed:1689726).Curated1
Sequence conflicti1570Missing in AAA60569 (PubMed:3000887).Curated1
Sequence conflicti1891Q → H in AAA60577 (PubMed:1689726).Curated1
Sequence conflicti1891Q → H in AAA60994 (PubMed:1689726).Curated1
Sequence conflicti2400 – 2419GRSHL…SYFGN → VEAISLAMTTLASPIPTLAT NKQLLVDRRKS in AAA60577 (PubMed:1689726).CuratedAdd BLAST20
Sequence conflicti2400 – 2419GRSHL…SYFGN → VEAISLAMTTLASPIPTLAT NKQLLVDRRKS in AAA60994 (PubMed:1689726).CuratedAdd BLAST20

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_00132424I → S in EL2; Lograno. 1 Publication1
Natural variantiVAR_00132828R → C in EL2. 1 PublicationCorresponds to variant dbSNP:rs121918642EnsemblClinVar.1
Natural variantiVAR_00132528R → H in EL2; Corbeil. 1 PublicationCorresponds to variant dbSNP:rs121918641EnsemblClinVar.1
Natural variantiVAR_00132628R → L in EL2. 1 PublicationCorresponds to variant dbSNP:rs121918641EnsemblClinVar.1
Natural variantiVAR_00132728R → S in EL2. 2 PublicationsCorresponds to variant dbSNP:rs121918642EnsemblClinVar.1
Natural variantiVAR_00132931V → A in EL2; Marseille. Corresponds to variant dbSNP:rs773826036Ensembl.1
Natural variantiVAR_00133034R → W in EL2; Genova. 1 PublicationCorresponds to variant dbSNP:rs201568233Ensembl.1
Natural variantiVAR_00133141R → W in EL2; Tunis. 1 PublicationCorresponds to variant dbSNP:rs121918640EnsemblClinVar.1
Natural variantiVAR_00133245R → S in EL2; Clichy. 1 PublicationCorresponds to variant dbSNP:rs121918637EnsemblClinVar.1
Natural variantiVAR_00133345R → T in EL2; Anastasia. 1 Publication1
Natural variantiVAR_00133446G → V in EL2; Culoz. 1 PublicationCorresponds to variant dbSNP:rs121918638EnsemblClinVar.1
Natural variantiVAR_00133548K → R in HPP. 1 PublicationCorresponds to variant dbSNP:rs121918644EnsemblClinVar.1
Natural variantiVAR_00133649L → F in EL2; Lyon. 1 PublicationCorresponds to variant dbSNP:rs121918639EnsemblClinVar.1
Natural variantiVAR_038506109S → F. Corresponds to variant dbSNP:rs3737521Ensembl.1
Natural variantiVAR_001337151G → D in EL2; Ponte de Sor. Corresponds to variant dbSNP:rs199725919EnsemblClinVar.1
Natural variantiVAR_038507152D → N. Corresponds to variant dbSNP:rs16840544EnsemblClinVar.1
Natural variantiVAR_001338154L → LL in EL2. 1
Natural variantiVAR_001339207L → P in EL2 and HPP; Saint-Louis. 1 PublicationCorresponds to variant dbSNP:rs121918643EnsemblClinVar.1
Natural variantiVAR_001340260L → P in EL2; Nigerian. 1 PublicationCorresponds to variant dbSNP:rs121918634EnsemblClinVar.1
Natural variantiVAR_001341261S → P in EL2. 1 PublicationCorresponds to variant dbSNP:rs121918636EnsemblClinVar.1
Natural variantiVAR_001342469H → P in EL2; Barcelona. 1 Publication1
Natural variantiVAR_001343469Missing in EL2; Alexandria. 1
Natural variantiVAR_001344471Q → P in EL2. 1 PublicationCorresponds to variant dbSNP:rs121918635EnsemblClinVar.1
Natural variantiVAR_001345701R → H. Corresponds to variant dbSNP:rs12090314EnsemblClinVar.1
Natural variantiVAR_038508766A → T. Corresponds to variant dbSNP:rs11265047Ensembl.1
Natural variantiVAR_001346791D → E in EL2; Jendouba. 1 PublicationCorresponds to variant dbSNP:rs7418956EnsemblClinVar.1
Natural variantiVAR_001347809I → V. Corresponds to variant dbSNP:rs7547313EnsemblClinVar.1
Natural variantiVAR_001348853T → R. Corresponds to variant dbSNP:rs35121052EnsemblClinVar.1
Natural variantiVAR_038509957A → V. Corresponds to variant dbSNP:rs34706737EnsemblClinVar.1
Natural variantiVAR_001349970A → D. Corresponds to variant dbSNP:rs35948326EnsemblClinVar.1
Natural variantiVAR_0385101163S → A1 PublicationCorresponds to variant dbSNP:rs2482965EnsemblClinVar.1
Natural variantiVAR_0385111330R → I. Corresponds to variant dbSNP:rs34214405EnsemblClinVar.1
Natural variantiVAR_0385121568C → R2 PublicationsCorresponds to variant dbSNP:rs863931EnsemblClinVar.1
Natural variantiVAR_0591991693K → Q. Corresponds to variant dbSNP:rs857725EnsemblClinVar.1
Natural variantiVAR_0592001836N → S. Corresponds to variant dbSNP:rs16830483EnsemblClinVar.1
Natural variantiVAR_0013501858L → V1 PublicationCorresponds to variant dbSNP:rs3737515EnsemblClinVar.1
Natural variantiVAR_0013512025A → G in Cagliari. 1 Publication1
Natural variantiVAR_0592012265I → T. Corresponds to variant dbSNP:rs952094EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0376621889 – 1891Missing in isoform 2. Curated3

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M61826
, M61776, M61777, M61778, M61779, M61780, M61781, M61782, M61783, M61852, M61784, M61785, M61787, M61788, M61789, M61791, M61792, M61793, M61794, M61795, M61796, M61797, M61798, M61799, M61800, M61801, M61802, M61803, M61804, M61805, M61806, M61807, M61808, M61809, M61810, M61811, M61812, M61814, M61815, M61816, M61817, M61818, M61819, M61820, M61821, M61822, M61823, M61824, M61825 Genomic DNA Translation: AAA60994.1
M61877 mRNA Translation: AAA60577.1
AL353894 Genomic DNA No translation available.
M29994
, M29983, M29984, M29985, M29986, M29987, M29988, M29989, M29990, M29991, M29992, M29993 Genomic DNA Translation: AAA60575.1
M13233 Genomic DNA Translation: AAA53103.1
M11049 mRNA Translation: AAA60569.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS41423.1 [P02549-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
A35716 SJHUA

NCBI Reference Sequences

More...
RefSeqi
NP_003117.2, NM_003126.2 [P02549-1]
XP_011508218.1, XM_011509916.2 [P02549-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000368147; ENSP00000357129; ENSG00000163554 [P02549-1]
ENST00000643759; ENSP00000495214; ENSG00000163554 [P02549-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
6708

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:6708

UCSC genome browser

More...
UCSCi
uc001fst.2 human [P02549-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M61826
, M61776, M61777, M61778, M61779, M61780, M61781, M61782, M61783, M61852, M61784, M61785, M61787, M61788, M61789, M61791, M61792, M61793, M61794, M61795, M61796, M61797, M61798, M61799, M61800, M61801, M61802, M61803, M61804, M61805, M61806, M61807, M61808, M61809, M61810, M61811, M61812, M61814, M61815, M61816, M61817, M61818, M61819, M61820, M61821, M61822, M61823, M61824, M61825 Genomic DNA Translation: AAA60994.1
M61877 mRNA Translation: AAA60577.1
AL353894 Genomic DNA No translation available.
M29994
, M29983, M29984, M29985, M29986, M29987, M29988, M29989, M29990, M29991, M29992, M29993 Genomic DNA Translation: AAA60575.1
M13233 Genomic DNA Translation: AAA53103.1
M11049 mRNA Translation: AAA60569.1
CCDSiCCDS41423.1 [P02549-1]
PIRiA35716 SJHUA
RefSeqiNP_003117.2, NM_003126.2 [P02549-1]
XP_011508218.1, XM_011509916.2 [P02549-1]

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1OWANMR-A1-156[»]
3LBXX-ray2.80A1-158[»]
5J4OX-ray1.54A1599-1826[»]
SMRiP02549
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112586, 56 interactors
DIPiDIP-17031N
IntActiP02549, 27 interactors
MINTiP02549
STRINGi9606.ENSP00000357129

PTM databases

iPTMnetiP02549
PhosphoSitePlusiP02549

Polymorphism and mutation databases

BioMutaiSPTA1
DMDMi308153675

Proteomic databases

EPDiP02549
jPOSTiP02549
MaxQBiP02549
PaxDbiP02549
PeptideAtlasiP02549
PRIDEiP02549
ProteomicsDBi51533
51534 [P02549-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
6708
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000368147; ENSP00000357129; ENSG00000163554 [P02549-1]
ENST00000643759; ENSP00000495214; ENSG00000163554 [P02549-1]
GeneIDi6708
KEGGihsa:6708
UCSCiuc001fst.2 human [P02549-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6708
DisGeNETi6708

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SPTA1

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0028529
HGNCiHGNC:11272 SPTA1
HPAiCAB016193
CAB037246
HPA028048
HPA028253
MalaCardsiSPTA1
MIMi130600 phenotype
182860 gene
266140 phenotype
270970 phenotype
neXtProtiNX_P02549
OpenTargetsiENSG00000163554
Orphaneti288 Hereditary elliptocytosis
822 Hereditary spherocytosis
PharmGKBiPA36101

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0035 Eukaryota
COG5069 LUCA
GeneTreeiENSGT00940000161240
HOGENOMiHOG000246965
InParanoidiP02549
KOiK06114
OMAiHFAHEDT
OrthoDBi1376537at2759
PhylomeDBiP02549
TreeFamiTF343803

Enzyme and pathway databases

ReactomeiR-HSA-375165 NCAM signaling for neurite out-growth
R-HSA-445095 Interaction between L1 and Ankyrins
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-6807878 COPI-mediated anterograde transport
SIGNORiP02549

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
SPTA1 human
EvolutionaryTraceiP02549

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Spectrin,_alpha_1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
6708

Protein Ontology

More...
PROi
PR:P02549

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000163554 Expressed in 79 organ(s), highest expression level in trabecular bone tissue
GenevisibleiP02549 HS

Family and domain databases

InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR014837 EF-hand_Ca_insen
IPR002048 EF_hand_dom
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR018159 Spectrin/alpha-actinin
IPR002017 Spectrin_repeat
PfamiView protein in Pfam
PF08726 EFhand_Ca_insen, 1 hit
PF00018 SH3_1, 1 hit
PF00435 Spectrin, 20 hits
SMARTiView protein in SMART
SM00326 SH3, 1 hit
SM00150 SPEC, 20 hits
SUPFAMiSSF47473 SSF47473, 1 hit
SSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS50222 EF_HAND_2, 3 hits
PS50002 SH3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSPTA1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P02549
Secondary accession number(s): Q15514
, Q5VYL1, Q5VYL2, Q6LDY5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: October 5, 2010
Last modified: May 8, 2019
This is version 224 of the entry and version 5 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again