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Entry version 198 (16 Oct 2019)
Sequence version 3 (23 Jan 2007)
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Protein

Keratin, type II cytoskeletal 6A

Gene

KRT6A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Epidermis-specific type I keratin involved in wound healing. Involved in the activation of follicular keratinocytes after wounding, while it does not play a major role in keratinocyte proliferation or migration. Participates in the regulation of epithelial migration by inhibiting the activity of SRC during wound repair.By similarity

Miscellaneous

There are at least six isoforms of human type II keratin-6 (K6), K6A being the most abundant representing about 77% of all forms found in epithelia.
There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa, respectively).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei414Stutter1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6805567 Keratinization
R-HSA-6809371 Formation of the cornified envelope

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Keratin, type II cytoskeletal 6A
Alternative name(s):
Cytokeratin-6A
Short name:
CK-6A
Cytokeratin-6D
Short name:
CK-6D
Keratin-6A
Short name:
K6A
Type-II keratin Kb6
Allergen: Hom s 5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KRT6A
Synonyms:K6A, KRT6D
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:6443 KRT6A

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
148041 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P02538

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Intermediate filament, Keratin

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Pachyonychia congenita 3 (PC3)12 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal dominant genodermatosis characterized by hypertrophic nail dystrophy, painful and highly debilitating plantar keratoderma, oral leukokeratosis, and a variety of epidermal cysts.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_072446164R → P in PC3. 1 PublicationCorresponds to variant dbSNP:rs62635293EnsemblClinVar.1
Natural variantiVAR_072447166Q → P in PC3. 1 PublicationCorresponds to variant dbSNP:rs267607460EnsemblClinVar.1
Natural variantiVAR_072448167I → N in PC3. 1 PublicationCorresponds to variant dbSNP:rs57126929EnsemblClinVar.1
Natural variantiVAR_072449170L → F in PC3. 1 PublicationCorresponds to variant dbSNP:rs57448541EnsemblClinVar.1
Natural variantiVAR_072450171N → D in PC3. 2 PublicationsCorresponds to variant dbSNP:rs62635294EnsemblClinVar.1
Natural variantiVAR_072451171N → K in PC3. 4 PublicationsCorresponds to variant dbSNP:rs59685571EnsemblClinVar.1
Natural variantiVAR_072452171N → S in PC3. 3 PublicationsCorresponds to variant dbSNP:rs58556099EnsemblClinVar.1
Natural variantiVAR_072453171N → Y in PC3. 1 PublicationCorresponds to variant dbSNP:rs62635294EnsemblClinVar.1
Natural variantiVAR_003878171Missing in PC3. 2 Publications1
Natural variantiVAR_072454172Missing in PC3. 3 Publications1
Natural variantiVAR_072455174F → C in PC3. 1 PublicationCorresponds to variant dbSNP:rs61145796EnsemblClinVar.1
Natural variantiVAR_072456174F → S in PC3. 3 PublicationsCorresponds to variant dbSNP:rs61145796EnsemblClinVar.1
Natural variantiVAR_017075174F → V in PC3. 1 PublicationCorresponds to variant dbSNP:rs28933087EnsemblClinVar.1
Natural variantiVAR_072457176S → P in PC3. 1 PublicationCorresponds to variant dbSNP:rs59642296EnsemblClinVar.1
Natural variantiVAR_072458178I → N in PC3. 1 PublicationCorresponds to variant dbSNP:rs267607461EnsemblClinVar.1
Natural variantiVAR_072459462I → N in PC3. 1 PublicationCorresponds to variant dbSNP:rs57629991EnsemblClinVar.1
Natural variantiVAR_072460462I → S in PC3. 1 PublicationCorresponds to variant dbSNP:rs57629991EnsemblClinVar.1
Natural variantiVAR_072461463A → P in PC3. 1 PublicationCorresponds to variant dbSNP:rs267607462EnsemblClinVar.1
Natural variantiVAR_072462464T → P in PC3. 1 PublicationCorresponds to variant dbSNP:rs61293647EnsemblClinVar.1
Natural variantiVAR_072463465Y → H in PC3. 1 PublicationCorresponds to variant dbSNP:rs267607463EnsemblClinVar.1
Natural variantiVAR_072464465Y → S in PC3. 1 Publication1
Natural variantiVAR_072465468L → P in PC3. 2 PublicationsCorresponds to variant dbSNP:rs59018888EnsemblClinVar.1
Natural variantiVAR_072466468L → Q in PC3. 1 PublicationCorresponds to variant dbSNP:rs59018888EnsemblClinVar.1
Natural variantiVAR_072467469L → P in PC3. 2 PublicationsCorresponds to variant dbSNP:rs57052654EnsemblClinVar.1
Natural variantiVAR_017076469L → R in PC3. 2 PublicationsCorresponds to variant dbSNP:rs57052654EnsemblClinVar.1
Natural variantiVAR_017077472E → K in PC3. 2 PublicationsCorresponds to variant dbSNP:rs60554162EnsemblClinVar.1

<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section is used for proteins that cause an allergic reaction in mammals. We usually specify in which species the protein is allergenic.<p><a href='/help/allergenic_properties' target='_top'>More...</a></p>Allergenic propertiesi

Causes an allergic reaction in human. Binds to IgE from atopic dermatitis (AD) patients. Identified as an IgE autoantigen in atopic dermatitis (AD) patients with severe skin manifestations.

Keywords - Diseasei

Allergen, Disease mutation, Ectodermal dysplasia, Palmoplantar keratoderma

Organism-specific databases

DisGeNET

More...
DisGeNETi
3853

MalaCards human disease database

More...
MalaCardsi
KRT6A
MIMi615726 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000205420

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
2309 Pachyonychia congenita

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA30231

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P02538

Protein family/group databases

Allergome; a platform for allergen knowledge

More...
Allergomei
3326 Hom s 5.0101
415 Hom s 5

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB01593 Zinc
DB14487 Zinc acetate
DB14533 Zinc chloride

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
KRT6A

Domain mapping of disease mutations (DMDM)

More...
DMDMi
1346344

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved1 Publication
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000637312 – 564Keratin, type II cytoskeletal 6AAdd BLAST563

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanine1 Publication1

Keywords - PTMi

Acetylation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P02538

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P02538

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P02538

PeptideAtlas

More...
PeptideAtlasi
P02538

PRoteomics IDEntifications database

More...
PRIDEi
P02538

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
51529

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
P02538

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P02538

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P02538

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P02538

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Constitutively expressed in distinct types of epithelia such as those in oral mucosa, esophagus, papillae of tongue and hair follicle outer root sheath.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000205420 Expressed in 122 organ(s), highest expression level in ectocervix

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P02538 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P02538 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA045697
HPA061168

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer of a type I and a type II keratin. KRT6 isomers associate with KRT16 and/or KRT17 (By similarity).

Interacts with TCHP (PubMed:15731013).

By similarity1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
110051, 65 interactors

Database of interacting proteins

More...
DIPi
DIP-533N

Protein interaction database and analysis system

More...
IntActi
P02538, 55 interactors

Molecular INTeraction database

More...
MINTi
P02538

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000369317

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1564
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P02538

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini163 – 476IF rodPROSITE-ProRule annotationAdd BLAST314

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni2 – 162HeadAdd BLAST161
Regioni163 – 198Coil 1AAdd BLAST36
Regioni199 – 217Linker 1Add BLAST19
Regioni218 – 309Coil 1BAdd BLAST92
Regioni310 – 333Linker 12Add BLAST24
Regioni334 – 472Coil 2Add BLAST139
Regioni473 – 564TailAdd BLAST92

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the intermediate filament family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IG4R Eukaryota
ENOG410YY6B LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154600

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000230976

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P02538

KEGG Orthology (KO)

More...
KOi
K07605

Identification of Orthologs from Complete Genome Data

More...
OMAi
IFEAYIN

Database of Orthologous Groups

More...
OrthoDBi
924636at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P02538

TreeFam database of animal gene trees

More...
TreeFami
TF317854

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.5.1160, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR018039 IF_conserved
IPR039008 IF_rod_dom
IPR042180 IF_rod_dom_coil1B
IPR032444 Keratin_2_head
IPR003054 Keratin_II

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00038 Filament, 1 hit
PF16208 Keratin_2_head, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01276 TYPE2KERATIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01391 Filament, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00226 IF_ROD_1, 1 hit
PS51842 IF_ROD_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P02538-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASTSTTIRS HSSSRRGFSA NSARLPGVSR SGFSSVSVSR SRGSGGLGGA
60 70 80 90 100
CGGAGFGSRS LYGLGGSKRI SIGGGSCAIS GGYGSRAGGS YGFGGAGSGF
110 120 130 140 150
GFGGGAGIGF GLGGGAGLAG GFGGPGFPVC PPGGIQEVTV NQSLLTPLNL
160 170 180 190 200
QIDPTIQRVR AEEREQIKTL NNKFASFIDK VRFLEQQNKV LETKWTLLQE
210 220 230 240 250
QGTKTVRQNL EPLFEQYINN LRRQLDSIVG ERGRLDSELR GMQDLVEDFK
260 270 280 290 300
NKYEDEINKR TAAENEFVTL KKDVDAAYMN KVELQAKADT LTDEINFLRA
310 320 330 340 350
LYDAELSQMQ THISDTSVVL SMDNNRNLDL DSIIAEVKAQ YEEIAQRSRA
360 370 380 390 400
EAESWYQTKY EELQVTAGRH GDDLRNTKQE IAEINRMIQR LRSEIDHVKK
410 420 430 440 450
QCANLQAAIA DAEQRGEMAL KDAKNKLEGL EDALQKAKQD LARLLKEYQE
460 470 480 490 500
LMNVKLALDV EIATYRKLLE GEECRLNGEG VGQVNISVVQ STVSSGYGGA
510 520 530 540 550
SGVGSGLGLG GGSSYSYGSG LGVGGGFSSS SGRAIGGGLS SVGGGSSTIK
560
YTTTSSSSRK SYKH
Length:564
Mass (Da):60,045
Last modified:January 23, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i26708916C7DC923A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti192E → D in AAB60696 (PubMed:7543104).Curated1
Sequence conflicti241G → N in AAB60696 (PubMed:7543104).Curated1
Sequence conflicti249F → L in AAB60696 (PubMed:7543104).Curated1
Sequence conflicti395I → S in CAA24760 (PubMed:6191871).Curated1
Sequence conflicti404N → S in AAB60696 (PubMed:7543104).Curated1
Sequence conflicti443R → W in AAH69269 (PubMed:15489334).Curated1
Sequence conflicti486I → V in AAB60696 (PubMed:7543104).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02126421N → S1 PublicationCorresponds to variant dbSNP:rs17845411Ensembl.1
Natural variantiVAR_035030111G → D. Corresponds to variant dbSNP:rs681063Ensembl.1
Natural variantiVAR_072446164R → P in PC3. 1 PublicationCorresponds to variant dbSNP:rs62635293EnsemblClinVar.1
Natural variantiVAR_072447166Q → P in PC3. 1 PublicationCorresponds to variant dbSNP:rs267607460EnsemblClinVar.1
Natural variantiVAR_072448167I → N in PC3. 1 PublicationCorresponds to variant dbSNP:rs57126929EnsemblClinVar.1
Natural variantiVAR_072449170L → F in PC3. 1 PublicationCorresponds to variant dbSNP:rs57448541EnsemblClinVar.1
Natural variantiVAR_072450171N → D in PC3. 2 PublicationsCorresponds to variant dbSNP:rs62635294EnsemblClinVar.1
Natural variantiVAR_072451171N → K in PC3. 4 PublicationsCorresponds to variant dbSNP:rs59685571EnsemblClinVar.1
Natural variantiVAR_072452171N → S in PC3. 3 PublicationsCorresponds to variant dbSNP:rs58556099EnsemblClinVar.1
Natural variantiVAR_072453171N → Y in PC3. 1 PublicationCorresponds to variant dbSNP:rs62635294EnsemblClinVar.1
Natural variantiVAR_003878171Missing in PC3. 2 Publications1
Natural variantiVAR_072454172Missing in PC3. 3 Publications1
Natural variantiVAR_072455174F → C in PC3. 1 PublicationCorresponds to variant dbSNP:rs61145796EnsemblClinVar.1
Natural variantiVAR_072456174F → S in PC3. 3 PublicationsCorresponds to variant dbSNP:rs61145796EnsemblClinVar.1
Natural variantiVAR_017075174F → V in PC3. 1 PublicationCorresponds to variant dbSNP:rs28933087EnsemblClinVar.1
Natural variantiVAR_072457176S → P in PC3. 1 PublicationCorresponds to variant dbSNP:rs59642296EnsemblClinVar.1
Natural variantiVAR_072458178I → N in PC3. 1 PublicationCorresponds to variant dbSNP:rs267607461EnsemblClinVar.1
Natural variantiVAR_072459462I → N in PC3. 1 PublicationCorresponds to variant dbSNP:rs57629991EnsemblClinVar.1
Natural variantiVAR_072460462I → S in PC3. 1 PublicationCorresponds to variant dbSNP:rs57629991EnsemblClinVar.1
Natural variantiVAR_072461463A → P in PC3. 1 PublicationCorresponds to variant dbSNP:rs267607462EnsemblClinVar.1
Natural variantiVAR_072462464T → P in PC3. 1 PublicationCorresponds to variant dbSNP:rs61293647EnsemblClinVar.1
Natural variantiVAR_072463465Y → H in PC3. 1 PublicationCorresponds to variant dbSNP:rs267607463EnsemblClinVar.1
Natural variantiVAR_072464465Y → S in PC3. 1 Publication1
Natural variantiVAR_072465468L → P in PC3. 2 PublicationsCorresponds to variant dbSNP:rs59018888EnsemblClinVar.1
Natural variantiVAR_072466468L → Q in PC3. 1 PublicationCorresponds to variant dbSNP:rs59018888EnsemblClinVar.1
Natural variantiVAR_072467469L → P in PC3. 2 PublicationsCorresponds to variant dbSNP:rs57052654EnsemblClinVar.1
Natural variantiVAR_017076469L → R in PC3. 2 PublicationsCorresponds to variant dbSNP:rs57052654EnsemblClinVar.1
Natural variantiVAR_017077472E → K in PC3. 2 PublicationsCorresponds to variant dbSNP:rs60554162EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
L42583
, L42575, L42576, L42577, L42578, L42579, L42580, L42581 Genomic DNA Translation: AAC41767.1
AH005420 Genomic DNA Translation: AAB60696.1
BT006899 mRNA Translation: AAP35545.1
BC008807 mRNA Translation: AAH08807.1
BC014152 mRNA Translation: AAH14152.1
BC069269 mRNA Translation: AAH69269.1
BC125058 mRNA Translation: AAI25059.1
BC139753 mRNA Translation: AAI39754.1
V01516 Genomic DNA Translation: CAA24760.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS41786.1

Protein sequence database of the Protein Information Resource

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PIRi
A57398 KRHUEA
I61769

NCBI Reference Sequences

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RefSeqi
NP_005545.1, NM_005554.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000330722; ENSP00000369317; ENSG00000205420

Database of genes from NCBI RefSeq genomes

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GeneIDi
3853

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:3853

UCSC genome browser

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UCSCi
uc001sam.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Human Intermediate Filament Mutation Database

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42583
, L42575, L42576, L42577, L42578, L42579, L42580, L42581 Genomic DNA Translation: AAC41767.1
AH005420 Genomic DNA Translation: AAB60696.1
BT006899 mRNA Translation: AAP35545.1
BC008807 mRNA Translation: AAH08807.1
BC014152 mRNA Translation: AAH14152.1
BC069269 mRNA Translation: AAH69269.1
BC125058 mRNA Translation: AAI25059.1
BC139753 mRNA Translation: AAI39754.1
V01516 Genomic DNA Translation: CAA24760.1
CCDSiCCDS41786.1
PIRiA57398 KRHUEA
I61769
RefSeqiNP_005545.1, NM_005554.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5KI0NMR-A533-551[»]
SMRiP02538
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi110051, 65 interactors
DIPiDIP-533N
IntActiP02538, 55 interactors
MINTiP02538
STRINGi9606.ENSP00000369317

Chemistry databases

DrugBankiDB01593 Zinc
DB14487 Zinc acetate
DB14533 Zinc chloride

Protein family/group databases

Allergomei3326 Hom s 5.0101
415 Hom s 5

PTM databases

iPTMnetiP02538
PhosphoSitePlusiP02538
SwissPalmiP02538

Polymorphism and mutation databases

BioMutaiKRT6A
DMDMi1346344

Proteomic databases

jPOSTiP02538
MassIVEiP02538
PaxDbiP02538
PeptideAtlasiP02538
PRIDEiP02538
ProteomicsDBi51529
TopDownProteomicsiP02538

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
3853

Genome annotation databases

EnsembliENST00000330722; ENSP00000369317; ENSG00000205420
GeneIDi3853
KEGGihsa:3853
UCSCiuc001sam.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3853
DisGeNETi3853

GeneCards: human genes, protein and diseases

More...
GeneCardsi
KRT6A
HGNCiHGNC:6443 KRT6A
HPAiHPA045697
HPA061168
MalaCardsiKRT6A
MIMi148041 gene
615726 phenotype
neXtProtiNX_P02538
OpenTargetsiENSG00000205420
Orphaneti2309 Pachyonychia congenita
PharmGKBiPA30231

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IG4R Eukaryota
ENOG410YY6B LUCA
GeneTreeiENSGT00940000154600
HOGENOMiHOG000230976
InParanoidiP02538
KOiK07605
OMAiIFEAYIN
OrthoDBi924636at2759
PhylomeDBiP02538
TreeFamiTF317854

Enzyme and pathway databases

ReactomeiR-HSA-6805567 Keratinization
R-HSA-6809371 Formation of the cornified envelope

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
KRT6A human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Keratin_6A

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
3853
PharosiP02538

Protein Ontology

More...
PROi
PR:P02538

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000205420 Expressed in 122 organ(s), highest expression level in ectocervix
ExpressionAtlasiP02538 baseline and differential
GenevisibleiP02538 HS

Family and domain databases

Gene3Di1.20.5.1160, 1 hit
InterProiView protein in InterPro
IPR018039 IF_conserved
IPR039008 IF_rod_dom
IPR042180 IF_rod_dom_coil1B
IPR032444 Keratin_2_head
IPR003054 Keratin_II
PfamiView protein in Pfam
PF00038 Filament, 1 hit
PF16208 Keratin_2_head, 1 hit
PRINTSiPR01276 TYPE2KERATIN
SMARTiView protein in SMART
SM01391 Filament, 1 hit
PROSITEiView protein in PROSITE
PS00226 IF_ROD_1, 1 hit
PS51842 IF_ROD_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiK2C6A_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P02538
Secondary accession number(s): A4QPC1
, P48667, Q08AR4, Q6NT67, Q96CL4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: October 16, 2019
This is version 198 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Allergens
    Nomenclature of allergens and list of entries
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  7. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
UniProt is an ELIXIR core data resource
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