Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Beta-crystallin A1

Gene

Cryba1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Crystallins are the dominant structural components of the vertebrate eye lens.

GO - Molecular functioni

  • protein homodimerization activity Source: MGI
  • structural constituent of eye lens Source: MGI

GO - Biological processi

Keywordsi

Molecular functionEye lens protein

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-crystallin A1
Alternative name(s):
Beta-A1-crystallin
Gene namesi
Name:Cryba1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:88518 Cryba1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000575341 – 198Beta-crystallin A1Add BLAST198

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei65S-glutathionyl cysteine; alternateBy similarity1
Modified residuei65S-methylcysteine; alternateBy similarity1
Modified residuei100S-glutathionyl cysteine; alternateBy similarity1
Modified residuei100S-methylcysteine; alternateBy similarity1
Modified residuei120Omega-N-methylated arginineBy similarity1

Keywords - PTMi

Glutathionylation, Methylation

Proteomic databases

MaxQBiP02525
PaxDbiP02525
PRIDEiP02525

PTM databases

PhosphoSitePlusiP02525

Expressioni

Gene expression databases

CleanExiMM_CRYBA1

Interactioni

Subunit structurei

Homo/heterodimer, or complexes of higher-order. The structure of beta-crystallin oligomers seems to be stabilized through interactions between the N-terminal arms (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000077693

Structurei

3D structure databases

ProteinModelPortaliP02525
SMRiP02525
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 53Beta/gamma crystallin 'Greek key' 1PROSITE-ProRule annotationAdd BLAST40
Domaini54 – 100Beta/gamma crystallin 'Greek key' 2PROSITE-ProRule annotationAdd BLAST47
Domaini107 – 148Beta/gamma crystallin 'Greek key' 3PROSITE-ProRule annotationAdd BLAST42
Domaini149 – 197Beta/gamma crystallin 'Greek key' 4PROSITE-ProRule annotationAdd BLAST49

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 13N-terminal armAdd BLAST13
Regioni101 – 106Connecting peptide6

Domaini

Has a two-domain beta-structure, folded into four very similar Greek key motifs.

Sequence similaritiesi

Belongs to the beta/gamma-crystallin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IGDN Eukaryota
ENOG410ZGPB LUCA
HOVERGENiHBG003364
InParanoidiP02525

Family and domain databases

InterProiView protein in InterPro
IPR001064 Beta/gamma_crystallin
IPR011024 G_crystallin-like
PfamiView protein in Pfam
PF00030 Crystall, 2 hits
PRINTSiPR01367 BGCRYSTALLIN
SMARTiView protein in SMART
SM00247 XTALbg, 2 hits
SUPFAMiSSF49695 SSF49695, 1 hit
PROSITEiView protein in PROSITE
PS50915 CRYSTALLIN_BETA_GAMMA, 4 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P02525-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLYLVLFLVP FNSIQITIYD QENFQGKRME FTSSCPNVSE RNFDNVRSLK
60 70 80 90 100
VECGAWIGYE HTSFCGQQFI LERGEYPRWD AWSGSNAYHI ERLMSFRPIC
110 120 130 140 150
SANHKESKIT IFEKENFIGR QWEICDDYPS LQAMGWFNNE VGSMKIQCGA
160 170 180 190
WVCYQYPGYR GYQYILECDH HGGDYKHWPE WGSHAQTSQI QSIRRIQQ
Length:198
Mass (Da):23,401
Last modified:October 3, 2012 - v2
Checksum:iF7EBDD750402FEC5
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9QXC6Q9QXC6_MOUSE
Beta-A3/A1 crystallin protein
Cryba1 mCG_10833
215Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti111I → N in CAA24106 (PubMed:6896514).Curated1
Sequence conflicti111I → N in AAA51629 (PubMed:6896514).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL591136 Genomic DNA No translation available.
V00729 Genomic DNA Translation: CAA24107.1
V00728 mRNA Translation: CAA24106.1
J00378 mRNA Translation: AAA51629.1
PIRiA02927 CYMSB
UniGeneiMm.22830

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL591136 Genomic DNA No translation available.
V00729 Genomic DNA Translation: CAA24107.1
V00728 mRNA Translation: CAA24106.1
J00378 mRNA Translation: AAA51629.1
PIRiA02927 CYMSB
UniGeneiMm.22830

3D structure databases

ProteinModelPortaliP02525
SMRiP02525
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000077693

PTM databases

PhosphoSitePlusiP02525

Proteomic databases

MaxQBiP02525
PaxDbiP02525
PRIDEiP02525

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:88518 Cryba1

Phylogenomic databases

eggNOGiENOG410IGDN Eukaryota
ENOG410ZGPB LUCA
HOVERGENiHBG003364
InParanoidiP02525

Miscellaneous databases

ChiTaRSiCryba1 mouse
PROiPR:P02525
SOURCEiSearch...

Gene expression databases

CleanExiMM_CRYBA1

Family and domain databases

InterProiView protein in InterPro
IPR001064 Beta/gamma_crystallin
IPR011024 G_crystallin-like
PfamiView protein in Pfam
PF00030 Crystall, 2 hits
PRINTSiPR01367 BGCRYSTALLIN
SMARTiView protein in SMART
SM00247 XTALbg, 2 hits
SUPFAMiSSF49695 SSF49695, 1 hit
PROSITEiView protein in PROSITE
PS50915 CRYSTALLIN_BETA_GAMMA, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiCRBA1_MOUSE
AccessioniPrimary (citable) accession number: P02525
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: October 3, 2012
Last modified: June 20, 2018
This is version 109 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again