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Protein

Alpha-crystallin B chain

Gene

CRYAB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei48Susceptible to oxidation1
Sitei60Susceptible to oxidation1
Sitei68Susceptible to oxidation1
Metal bindingi83Zinc 1By similarity1
Metal bindingi104Zinc 2Curated1
Metal bindingi106Zinc 2By similarity1
Metal bindingi111Zinc 1Curated1
Metal bindingi119Zinc 1Curated1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone, Eye lens protein
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-3371571 HSF1-dependent transactivation
SIGNORiP02511

Protein family/group databases

MoonDBiP02511 Curated

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-crystallin B chain
Alternative name(s):
Alpha(B)-crystallin
Heat shock protein beta-5
Short name:
HspB5
Renal carcinoma antigen NY-REN-27
Rosenthal fiber component
Gene namesi
Name:CRYAB
Synonyms:CRYA2, HSPB5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000109846.7
HGNCiHGNC:2389 CRYAB
MIMi123590 gene
neXtProtiNX_P02511

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Involvement in diseasei

Myopathy, myofibrillar, 2 (MFM2)4 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of myofibrillar myopathy, a group of chronic neuromuscular disorders characterized at ultrastructural level by disintegration of the sarcomeric Z disk and myofibrils, and replacement of the normal myofibrillar markings by small dense granules, or larger hyaline masses, or amorphous material. MFM2 is characterized by weakness of the proximal and distal limb muscles, weakness of the neck, velopharynx and trunk muscles, hypertrophic cardiomyopathy, and cataract in a subset of patients.
See also OMIM:608810
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_069528109D → H in MFM2. 1 PublicationCorresponds to variant dbSNP:rs387907339EnsemblClinVar.1
Natural variantiVAR_007899120R → G in MFM2; decreased interactions with wild-type CRYAA and CRYAB but increased interactions with wild-type CRYBB2 and CRYGC; cytoplasmic aggregation. 3 PublicationsCorresponds to variant dbSNP:rs104894201EnsemblClinVar.1
Cataract 16, multiple types (CTRCT16)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn opacification of the crystalline lens of the eye that frequently results in visual impairment or blindness. Opacities vary in morphology, are often confined to a portion of the lens, and may be static or progressive. In general, the more posteriorly located and dense an opacity, the greater the impact on visual function. CTRCT16 includes posterior polar cataract, among others. Posterior polar cataract is a subcapsular opacity, usually disk-shaped, located at the back of the lens.
See also OMIM:613763
CRYAB mutations may be involved in restrictive cardiomyopathy (RCM), a rare non-ischemic myocardial disease. RCM is characterized by restrictive ventricular-filling physiology in the presence of normal or reduced diastolic and/or systolic volumes (of 1 or both ventricles), biatrial enlargement, and normal ventricular wall thickness.1 Publication
Myopathy, myofibrillar, fatal infantile hypertonic, alpha-B crystallin-related (MFMFIH-CRYAB)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of myofibrillar myopathy, a group of chronic neuromuscular disorders characterized at ultrastructural level by disintegration of the sarcomeric Z disk and myofibrils, and replacement of the normal myofibrillar markings by small dense granules, or larger hyaline masses, or amorphous material. MFMFIH-CRYAB has onset in the first weeks of life after a normal neonatal period. Affected infants show rapidly progressive muscular rigidity of the trunk and limbs associated with increasing respiratory difficulty resulting in death before age 3 years.
See also OMIM:613869
Cardiomyopathy, dilated 1II (CMD1II)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
See also OMIM:615184
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_070035154G → S in CMD1II. 1 PublicationCorresponds to variant dbSNP:rs150516929EnsemblClinVar.1
Natural variantiVAR_070036157R → H in CMD1II. 1 PublicationCorresponds to variant dbSNP:rs141638421EnsemblClinVar.1

Keywords - Diseasei

Cardiomyopathy, Cataract, Disease mutation, Myofibrillar myopathy

Organism-specific databases

DisGeNETi1410
GeneReviewsiCRYAB
MalaCardsiCRYAB
MIMi608810 phenotype
613763 phenotype
613869 phenotype
615184 phenotype
OpenTargetsiENSG00000109846
Orphaneti399058 Alpha-B crystallin-related late-onset distal myopathy
441452 Early-onset lamellar cataract
98991 Early-onset nuclear cataract
98993 Early-onset posterior polar cataract
154 Familial isolated dilated cardiomyopathy
280553 Fatal infantile hypertonic myofibrillar myopathy
PharmGKBiPA26907

Chemistry databases

ChEMBLiCHEMBL3621022

Polymorphism and mutation databases

BioMutaiCRYAB
DMDMi117385

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001259071 – 175Alpha-crystallin B chainAdd BLAST175

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionine2 Publications1
Modified residuei19Phosphoserine1 Publication1
Modified residuei45Phosphoserine2 Publications1
Modified residuei59PhosphoserineCombined sources2 Publications1
Modified residuei92N6-acetyllysine; partial2 Publications1
Modified residuei166N6-acetyllysine1 Publication1
Glycosylationi170O-linked (GlcNAc) threonineBy similarity1

Keywords - PTMi

Acetylation, Glycoprotein, Oxidation, Phosphoprotein

Proteomic databases

EPDiP02511
PaxDbiP02511
PeptideAtlasiP02511
PRIDEiP02511
ProteomicsDBi51527

2D gel databases

REPRODUCTION-2DPAGEiIPI00021369
SWISS-2DPAGEiP02511
UCD-2DPAGEiP02511

PTM databases

GlyConnecti33
iPTMnetiP02511
PhosphoSitePlusiP02511
UniCarbKBiP02511

Miscellaneous databases

PMAP-CutDBiP02511

Expressioni

Tissue specificityi

Lens as well as other tissues (PubMed:838078, PubMed:2387586). Expressed in myocardial tissue (PubMed:28493373).3 Publications

Gene expression databases

BgeeiENSG00000109846 Expressed in 232 organ(s), highest expression level in heart left ventricle
CleanExiHS_CRYAB
ExpressionAtlasiP02511 baseline and differential
GenevisibleiP02511 HS

Organism-specific databases

HPAiCAB002053
CAB040560
HPA057100

Interactioni

Subunit structurei

Heteropolymer composed of three CRYAA and one CRYAB subunits (PubMed:20836128). Aggregates with homologous proteins, including the small heat shock protein HSPB1, to form large heteromeric complexes (PubMed:10751411). Inter-subunit bridging via zinc ions enhances stability, which is crucial as there is no protein turn over in the lens (PubMed:22890888). Interacts with HSPBAP1 and TTN/titin (PubMed:14676215). Interacts with TMEM109 (PubMed:23542032). Interacts with DES; binds rapidly during early stages of DES filament assembly and a reduced binding seen in the later stages (PubMed:28470624).6 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi107800, 114 interactors
CORUMiP02511
DIPiDIP-35017N
IntActiP02511, 27 interactors
MINTiP02511
STRINGi9606.ENSP00000227251

Structurei

Secondary structure

1175
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

DisProtiDP00445
ProteinModelPortaliP02511
SMRiP02511
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP02511

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini56 – 164sHSPPROSITE-ProRule annotationAdd BLAST109

Sequence similaritiesi

Belongs to the small heat shock protein (HSP20) family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3591 Eukaryota
ENOG410YERS LUCA
GeneTreeiENSGT00760000119238
HOVERGENiHBG054766
InParanoidiP02511
KOiK09542
OMAiITAPMKK
OrthoDBiEOG091G0USC
PhylomeDBiP02511
TreeFamiTF105049

Family and domain databases

CDDicd06498 ACD_alphaB-crystallin_HspB5, 1 hit
Gene3Di2.60.40.790, 1 hit
InterProiView protein in InterPro
IPR002068 A-crystallin/Hsp20_dom
IPR037882 ACD_alphaB-crystallin
IPR001436 Alpha-crystallin/HSP
IPR003090 Alpha-crystallin_N
IPR031107 HSP20
IPR008978 HSP20-like_chaperone
PANTHERiPTHR11527 PTHR11527, 1 hit
PfamiView protein in Pfam
PF00525 Crystallin, 1 hit
PF00011 HSP20, 1 hit
PIRSFiPIRSF036514 Sm_HSP_B1, 1 hit
PRINTSiPR00299 ACRYSTALLIN
SUPFAMiSSF49764 SSF49764, 1 hit
PROSITEiView protein in PROSITE
PS01031 SHSP, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All

P02511-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDIAIHHPWI RRPFFPFHSP SRLFDQFFGE HLLESDLFPT STSLSPFYLR
60 70 80 90 100
PPSFLRAPSW FDTGLSEMRL EKDRFSVNLD VKHFSPEELK VKVLGDVIEV
110 120 130 140 150
HGKHEERQDE HGFISREFHR KYRIPADVDP LTITSSLSSD GVLTVNGPRK
160 170
QVSGPERTIP ITREEKPAVT AAPKK
Length:175
Mass (Da):20,159
Last modified:January 1, 1990 - v2
Checksum:iAE08BED46B7849CB
GO

Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PR44E9PR44_HUMAN
Alpha-crystallin B chain
CRYAB
174Annotation score:
E9PJL7E9PJL7_HUMAN
Alpha-crystallin B chain
CRYAB
129Annotation score:
E9PRA8E9PRA8_HUMAN
Alpha-crystallin B chain
CRYAB
155Annotation score:
A0A024R3B9A0A024R3B9_HUMAN
Alpha-crystallin B chain
CRYAB hCG_1730741
108Annotation score:
H0YCW8H0YCW8_HUMAN
Alpha-crystallin B chain
CRYAB
106Annotation score:
E9PNH7E9PNH7_HUMAN
Alpha-crystallin B chain
CRYAB
106Annotation score:
E9PS12E9PS12_HUMAN
Alpha-crystallin B chain
CRYAB
77Annotation score:
E9PRS4E9PRS4_HUMAN
Alpha-crystallin B chain
CRYAB
68Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti165E → K in AAC19161 (Ref. 4) Curated1
Sequence conflicti175K → KKMPFLELHFLKQESFPTSE in AAC19161 (Ref. 4) Curated1

Mass spectrometryi

Molecular mass is 20201 Da from positions 1 - 175. Determined by ESI. 2 Publications
Molecular mass is 20281 Da from positions 1 - 175. Determined by ESI. With 1 phosphate group.2 Publications
Molecular mass is 20360 Da from positions 1 - 175. Determined by ESI. With 2 phosphate groups.1 Publication
Molecular mass is 20199 Da from positions 1 - 175. Determined by ESI. 2 Publications
Molecular mass is 20278 Da from positions 1 - 175. Determined by ESI. With 1 phosphate group.2 Publications

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01460741S → Y. Corresponds to variant dbSNP:rs2234703Ensembl.1
Natural variantiVAR_01460851P → L. Corresponds to variant dbSNP:rs2234704EnsemblClinVar.1
Natural variantiVAR_079841109D → G Probable disease-associated mutation found in patients with restrictive cardiomyopathy; reduces CRYAB and DES localization at the Z-bands and the intercalated disk in the myocardium; cytoplasmic aggregations of CRYAB and DES. 1 PublicationCorresponds to variant dbSNP:rs1114167341Ensembl.1
Natural variantiVAR_069528109D → H in MFM2. 1 PublicationCorresponds to variant dbSNP:rs387907339EnsemblClinVar.1
Natural variantiVAR_007899120R → G in MFM2; decreased interactions with wild-type CRYAA and CRYAB but increased interactions with wild-type CRYBB2 and CRYGC; cytoplasmic aggregation. 3 PublicationsCorresponds to variant dbSNP:rs104894201EnsemblClinVar.1
Natural variantiVAR_070035154G → S in CMD1II. 1 PublicationCorresponds to variant dbSNP:rs150516929EnsemblClinVar.1
Natural variantiVAR_070036157R → H in CMD1II. 1 PublicationCorresponds to variant dbSNP:rs141638421EnsemblClinVar.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M28638 Genomic DNA Translation: AAA52104.1
S45630 mRNA Translation: AAB23453.1
AF007162 mRNA Translation: AAC19161.1
AK314029 mRNA Translation: BAG36739.1
BT006770 mRNA Translation: AAP35416.1
EF444955 Genomic DNA Translation: ACA05949.1
CH471065 Genomic DNA Translation: EAW67162.1
BC007008 mRNA Translation: AAH07008.1
M24906 mRNA Translation: AAA60267.1
CCDSiCCDS8351.1
PIRiA35332 CYHUAB
RefSeqiNP_001276736.1, NM_001289807.1
NP_001276737.1, NM_001289808.1
NP_001876.1, NM_001885.2
XP_011540910.1, XM_011542608.1
UniGeneiHs.53454
Hs.703770

Genome annotation databases

EnsembliENST00000227251; ENSP00000227251; ENSG00000109846
ENST00000526180; ENSP00000436051; ENSG00000109846
ENST00000527950; ENSP00000437149; ENSG00000109846
ENST00000531198; ENSP00000434247; ENSG00000109846
ENST00000533475; ENSP00000433560; ENSG00000109846
ENST00000616970; ENSP00000483554; ENSG00000109846
GeneIDi1410
KEGGihsa:1410

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M28638 Genomic DNA Translation: AAA52104.1
S45630 mRNA Translation: AAB23453.1
AF007162 mRNA Translation: AAC19161.1
AK314029 mRNA Translation: BAG36739.1
BT006770 mRNA Translation: AAP35416.1
EF444955 Genomic DNA Translation: ACA05949.1
CH471065 Genomic DNA Translation: EAW67162.1
BC007008 mRNA Translation: AAH07008.1
M24906 mRNA Translation: AAA60267.1
CCDSiCCDS8351.1
PIRiA35332 CYHUAB
RefSeqiNP_001276736.1, NM_001289807.1
NP_001276737.1, NM_001289808.1
NP_001876.1, NM_001885.2
XP_011540910.1, XM_011542608.1
UniGeneiHs.53454
Hs.703770

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2KLRNMR-A/B1-175[»]
2N0KNMR-A/B64-152[»]
2WJ7X-ray2.63A/B/C/D/E67-157[»]
2Y1YX-ray2.00A71-157[»]
2Y1ZX-ray2.50A/B67-157[»]
2Y22X-ray3.70A/B/C/D/E/F67-157[»]
2YGDelectron microscopy9.40A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V/W/X1-175[»]
3J07Other-A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V/W/X1-175[»]
3L1GX-ray3.32A68-162[»]
3SGMX-ray1.70A/B/C/D90-100[»]
3SGNX-ray2.81A/B90-100[»]
3SGOX-ray2.56A90-100[»]
3SGPX-ray1.40A/B/C/D90-100[»]
3SGRX-ray2.17A/B/C/D/E/F90-100[»]
3SGSX-ray1.70A95-100[»]
4M5SX-ray1.37A68-153[»]
B156-164[»]
4M5TX-ray2.00A/C/E/G68-153[»]
B/D/F/H156-164[»]
5VVVX-ray2.80B/D38-50[»]
DisProtiDP00445
ProteinModelPortaliP02511
SMRiP02511
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107800, 114 interactors
CORUMiP02511
DIPiDIP-35017N
IntActiP02511, 27 interactors
MINTiP02511
STRINGi9606.ENSP00000227251

Chemistry databases

ChEMBLiCHEMBL3621022

Protein family/group databases

MoonDBiP02511 Curated

PTM databases

GlyConnecti33
iPTMnetiP02511
PhosphoSitePlusiP02511
UniCarbKBiP02511

Polymorphism and mutation databases

BioMutaiCRYAB
DMDMi117385

2D gel databases

REPRODUCTION-2DPAGEiIPI00021369
SWISS-2DPAGEiP02511
UCD-2DPAGEiP02511

Proteomic databases

EPDiP02511
PaxDbiP02511
PeptideAtlasiP02511
PRIDEiP02511
ProteomicsDBi51527

Protocols and materials databases

DNASUi1410
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000227251; ENSP00000227251; ENSG00000109846
ENST00000526180; ENSP00000436051; ENSG00000109846
ENST00000527950; ENSP00000437149; ENSG00000109846
ENST00000531198; ENSP00000434247; ENSG00000109846
ENST00000533475; ENSP00000433560; ENSG00000109846
ENST00000616970; ENSP00000483554; ENSG00000109846
GeneIDi1410
KEGGihsa:1410

Organism-specific databases

CTDi1410
DisGeNETi1410
EuPathDBiHostDB:ENSG00000109846.7
GeneCardsiCRYAB
GeneReviewsiCRYAB
HGNCiHGNC:2389 CRYAB
HPAiCAB002053
CAB040560
HPA057100
MalaCardsiCRYAB
MIMi123590 gene
608810 phenotype
613763 phenotype
613869 phenotype
615184 phenotype
neXtProtiNX_P02511
OpenTargetsiENSG00000109846
Orphaneti399058 Alpha-B crystallin-related late-onset distal myopathy
441452 Early-onset lamellar cataract
98991 Early-onset nuclear cataract
98993 Early-onset posterior polar cataract
154 Familial isolated dilated cardiomyopathy
280553 Fatal infantile hypertonic myofibrillar myopathy
PharmGKBiPA26907
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3591 Eukaryota
ENOG410YERS LUCA
GeneTreeiENSGT00760000119238
HOVERGENiHBG054766
InParanoidiP02511
KOiK09542
OMAiITAPMKK
OrthoDBiEOG091G0USC
PhylomeDBiP02511
TreeFamiTF105049

Enzyme and pathway databases

ReactomeiR-HSA-3371571 HSF1-dependent transactivation
SIGNORiP02511

Miscellaneous databases

ChiTaRSiCRYAB human
EvolutionaryTraceiP02511
GeneWikiiCRYAB
GenomeRNAii1410
PMAP-CutDBiP02511
PROiPR:P02511
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000109846 Expressed in 232 organ(s), highest expression level in heart left ventricle
CleanExiHS_CRYAB
ExpressionAtlasiP02511 baseline and differential
GenevisibleiP02511 HS

Family and domain databases

CDDicd06498 ACD_alphaB-crystallin_HspB5, 1 hit
Gene3Di2.60.40.790, 1 hit
InterProiView protein in InterPro
IPR002068 A-crystallin/Hsp20_dom
IPR037882 ACD_alphaB-crystallin
IPR001436 Alpha-crystallin/HSP
IPR003090 Alpha-crystallin_N
IPR031107 HSP20
IPR008978 HSP20-like_chaperone
PANTHERiPTHR11527 PTHR11527, 1 hit
PfamiView protein in Pfam
PF00525 Crystallin, 1 hit
PF00011 HSP20, 1 hit
PIRSFiPIRSF036514 Sm_HSP_B1, 1 hit
PRINTSiPR00299 ACRYSTALLIN
SUPFAMiSSF49764 SSF49764, 1 hit
PROSITEiView protein in PROSITE
PS01031 SHSP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCRYAB_HUMAN
AccessioniPrimary (citable) accession number: P02511
Secondary accession number(s): B0YIX0
, O43416, Q9UC37, Q9UC38, Q9UC39, Q9UC40, Q9UC41
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 1, 1990
Last modified: November 7, 2018
This is version 218 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
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