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Protein

Collagen alpha-2(I) chain

Gene

COL1A2

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Type I collagen is a member of group I collagen (fibrillar forming collagen).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi1176CalciumBy similarity1
Metal bindingi1178CalciumBy similarity1
Metal bindingi1179Calcium; via carbonyl oxygenBy similarity1
Metal bindingi1181Calcium; via carbonyl oxygenBy similarity1
Metal bindingi1184CalciumBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandCalcium, Metal-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-GGA-1442490 Collagen degradation
R-GGA-1474244 Extracellular matrix organization
R-GGA-1650814 Collagen biosynthesis and modifying enzymes
R-GGA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-GGA-2022090 Assembly of collagen fibrils and other multimeric structures
R-GGA-216083 Integrin cell surface interactions
R-GGA-2243919 Crosslinking of collagen fibrils
R-GGA-3000171 Non-integrin membrane-ECM interactions
R-GGA-3000178 ECM proteoglycans
R-GGA-430116 GP1b-IX-V activation signalling
R-GGA-75892 Platelet Adhesion to exposed collagen
R-GGA-76009 Platelet Aggregation (Plug Formation)
R-GGA-8874081 MET activates PTK2 signaling
R-GGA-8948216 Collagen chain trimerization

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Collagen alpha-2(I) chain
Alternative name(s):
Alpha-2 type I collagen
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:COL1A2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiGallus gallus (Chicken)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9031 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000539 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 22By similarityAdd BLAST22
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_000000581523 – 77N-terminal propeptideBy similarityAdd BLAST55
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000581678 – 1117Collagen alpha-2(I) chainAdd BLAST1040
PropeptideiPRO_00000058171118 – 1363C-terminal propeptideBy similarityAdd BLAST246

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei23Pyrrolidone carboxylic acidBy similarity1
Modified residuei78Pyrrolidone carboxylic acid2 Publications1 Publication1
Modified residuei83Allysine1 Publication1
Modified residuei1765-hydroxylysine; alternateBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi176O-linked (Gal...) hydroxylysine; alternateBy similarity1
Modified residuei4404-hydroxyproline1 Publication1
Modified residuei4434-hydroxyproline1 Publication1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi1158 ↔ 1190PROSITE-ProRule annotation
Disulfide bondi1198 ↔ 1361PROSITE-ProRule annotation
Glycosylationi1264N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1269 ↔ 1314PROSITE-ProRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.1 Publication
The N-terminus of the mature protein is blocked.

Keywords - PTMi

Disulfide bond, Glycoprotein, Hydroxylation, Pyrrolidone carboxylic acid

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P02467

PRoteomics IDEntifications database

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PRIDEi
P02467

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
P02467

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Forms the fibrils of tendon, ligaments and bones. In bones the fibrils are mineralized with calcium hydroxyapatite.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSGALG00000009641 Expressed in 10 organ(s), highest expression level in colon

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P02467 baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Trimers of one alpha 2(I) and two alpha 1(I) chains.

GO - Molecular functioni

Protein-protein interaction databases

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-3102 Collagen type I trimer

STRING: functional protein association networks

More...
STRINGi
9031.ENSGALP00000015687

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P02467

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1128 – 1363Fibrillar collagen NC1PROSITE-ProRule annotationAdd BLAST236

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The C-terminal propeptide, also known as COLFI domain, have crucial roles in tissue growth and repair by controlling both the intracellular assembly of procollagen molecules and the extracellular assembly of collagen fibrils. It binds a calcium ion which is essential for its function.By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the fibrillar collagen family.PROSITE-ProRule annotation

Keywords - Domaini

Collagen, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3544 Eukaryota
ENOG410XNMM LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155639

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG004933

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P02467

Database of Orthologous Groups

More...
OrthoDBi
EOG091G03LV

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P02467

TreeFam database of animal gene trees

More...
TreeFami
TF344135

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008160 Collagen
IPR000885 Fib_collagen_C

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01410 COLFI, 1 hit
PF01391 Collagen, 5 hits

ProDom; a protein domain database

More...
ProDomi
View protein in ProDom or Entries sharing at least one domain
PD002078 Fib_collagen_C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00038 COLFI, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51461 NC1_FIB, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P02467-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLSFVDTRIL LLLAVTSYLA TSQHLFQASA GRKGPRGDKG PQGERGPPGP
60 70 80 90 100
PGRDGEDGPP GPPGPPGPPG LGGNFAAQYD PSKAADFGPG PMGLMGPRGP
110 120 130 140 150
PGASGPPGPP GFQGVPGEPG EPGQTGPQGP RGPPGPPGKA GEDGHPGKPG
160 170 180 190 200
RPGERGVAGP QGARGFPGTP GLPGFKGIRG HNGLDGQKGQ PGTPGTKGEP
210 220 230 240 250
GAPGENGTPG QPGARGLPGE RGRIGAPGPA GARGSDGSAG PTGPAGPIGA
260 270 280 290 300
AGPPGFPGAP GAKGEIGPAG NVGPTGPAGP RGEIGLPGSS GPVGPPGNPG
310 320 330 340 350
ANGLPGAKGA AGLPGVAGAP GLPGPRGIPG PPGPAGPSGA RGLVGEPGPA
360 370 380 390 400
GAKGESGNKG EPGAAGPPGP PGPSGEEGKR GSNGEPGSAG PPGPAGLRGV
410 420 430 440 450
PGSRGLPGAD GRAGVMGPAG NRGASGPVGA KGPNGDAGRP GEPGLMGPRG
460 470 480 490 500
LPGQPGSPGP AGKEGPVGFP GADGRVGPIG PAGNRGEPGN IGFPGPKGPT
510 520 530 540 550
GEPGKPGEKG NVGLAGPRGA PGPEGNNGAQ GPPGVTGNQG AKGETGPAGP
560 570 580 590 600
PGFQGLPGPS GPAGEAGKPG ERGLHGEFGV PGPAGPRGER GLPGESGAVG
610 620 630 640 650
PAGPIGSRGP SGPPGPDGNK GEPGNVGPAG APGPAGPGGI PGERGVAGVP
660 670 680 690 700
GGKGEKGAPG LRGDTGATGR DGARGLPGAI GAPGPAGGAG DRGEGGPAGP
710 720 730 740 750
AGPAGARGIP GERGEPGPVG PSGFAGPPGA AGQPGAKGER GPKGPKGETG
760 770 780 790 800
PTGAIGPIGA SGPPGPVGAA GPAGPRGDAG PPGMTGFPGA AGRVGPPGPA
810 820 830 840 850
GITGPPGPPG PAGKDGPRGL RGDVGPVGRT GEQGIAGPPG FAGEKGPSGE
860 870 880 890 900
AGAAGPPGTP GPQGILGAPG ILGLPGSRGE RGLPGIAGAT GEPGPLGVSG
910 920 930 940 950
PPGARGPSGP VGSPGPNGAP GEAGRDGNPG NDGPPGRDGA PGFKGERGAP
960 970 980 990 1000
GNPGPSGALG APGPHGQVGP SGKPGNRGDP GPVGPVGPAG AFGPRGLAGP
1010 1020 1030 1040 1050
QGPRGEKGEP GDKGHRGLPG LKGHNGLQGL PGLAGQHGDQ GPPGNNGPAG
1060 1070 1080 1090 1100
PRGPPGPSGP PGKDGRNGLP GPIGPAGVRG SHGSQGPAGP PGPPGPPGPP
1110 1120 1130 1140 1150
GPNGGGYEVG FDAEYYRADQ PSLRPKDYEV DATLKTLNNQ IETLLTPEGS
1160 1170 1180 1190 1200
KKNPARTCRD LRLSHPEWSS GFYWIDPNQG CTADAIRAYC DFATGETCIH
1210 1220 1230 1240 1250
ASLEDIPTKT WYVSKNPKDK KHIWFGETIN GGTQFEYNGE GVTTKDMATQ
1260 1270 1280 1290 1300
LAFMRLLANH ASQNITYHCK NSIAYMDEET GNLKKAVILQ GSNDVELRAE
1310 1320 1330 1340 1350
GNSRFTFSVL VDGCSKKNNK WGKTIIEYRT NKPSRLPILD IAPLDIGGAD
1360
QEFGLHIGPV CFK
Length:1,363
Mass (Da):128,995
Last modified:May 10, 2017 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i41FFEE5077B428B4
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1L1RMY1A0A1L1RMY1_CHICK
Collagen alpha-2(I) chain
COL1A2
71Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti428 – 430VGA → AGV AA sequence (PubMed:5544653).Curated3
Sequence conflicti974P → L in AAA48638 (PubMed:6159982).Curated1
Sequence conflicti1010P → H in AAA51615 (PubMed:6267043).Curated1
Sequence conflicti1055P → H in AAA51615 (PubMed:6267043).Curated1
Sequence conflicti1061P → H in AAA51615 (PubMed:6267043).Curated1
Sequence conflicti1262S → P in AAA51615 (PubMed:6267043).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AADN04000096 Genomic DNA No translation available.
M25963
, M25956, M25959, M25961, M25962 Genomic DNA Translation: AAA69960.1
M25965, M25964 Genomic DNA Translation: AAA69961.1
M25984
, M25957, M25966, M25967, M25969, M25970, M25971, M25972, M25973, M25974, M25976, M25977, M25978, M25979, M25980, M25981, M25982, M25983 Genomic DNA Translation: AAA69962.1
J00826, J00821, K00792 Genomic DNA Translation: AAA51611.1
J00830, J00829 Genomic DNA Translation: AAA51613.1
J00837 Genomic DNA Translation: AAA51614.1
J00812
, J00811, J00814, J00815 Genomic DNA Translation: AAA51615.1
X02657 mRNA Translation: CAA26493.1
K00794 Genomic DNA No translation available.
V00390 mRNA Translation: CAA23688.1
M17608 mRNA Translation: AAA48673.1
M10581 Genomic DNA Translation: AAA48637.1
M10540 Genomic DNA Translation: AAA48638.1
J00828, J00827 Genomic DNA Translation: AAA51612.1
J00832, J00831 Genomic DNA Translation: AAD22117.1
J00833 Genomic DNA No translation available.
J00822 Genomic DNA No translation available.

Protein sequence database of the Protein Information Resource

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PIRi
I50173
I50206 CGCH2S
S10847

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Gga.5097

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSGALT00000015703; ENSGALP00000015687; ENSGALG00000009641

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AADN04000096 Genomic DNA No translation available.
M25963
, M25956, M25959, M25961, M25962 Genomic DNA Translation: AAA69960.1
M25965, M25964 Genomic DNA Translation: AAA69961.1
M25984
, M25957, M25966, M25967, M25969, M25970, M25971, M25972, M25973, M25974, M25976, M25977, M25978, M25979, M25980, M25981, M25982, M25983 Genomic DNA Translation: AAA69962.1
J00826, J00821, K00792 Genomic DNA Translation: AAA51611.1
J00830, J00829 Genomic DNA Translation: AAA51613.1
J00837 Genomic DNA Translation: AAA51614.1
J00812
, J00811, J00814, J00815 Genomic DNA Translation: AAA51615.1
X02657 mRNA Translation: CAA26493.1
K00794 Genomic DNA No translation available.
V00390 mRNA Translation: CAA23688.1
M17608 mRNA Translation: AAA48673.1
M10581 Genomic DNA Translation: AAA48637.1
M10540 Genomic DNA Translation: AAA48638.1
J00828, J00827 Genomic DNA Translation: AAA51612.1
J00832, J00831 Genomic DNA Translation: AAD22117.1
J00833 Genomic DNA No translation available.
J00822 Genomic DNA No translation available.
PIRiI50173
I50206 CGCH2S
S10847
UniGeneiGga.5097

3D structure databases

SMRiP02467
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

ComplexPortaliCPX-3102 Collagen type I trimer
STRINGi9031.ENSGALP00000015687

Proteomic databases

PaxDbiP02467
PRIDEiP02467

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000015703; ENSGALP00000015687; ENSGALG00000009641

Phylogenomic databases

eggNOGiKOG3544 Eukaryota
ENOG410XNMM LUCA
GeneTreeiENSGT00940000155639
HOVERGENiHBG004933
InParanoidiP02467
OrthoDBiEOG091G03LV
PhylomeDBiP02467
TreeFamiTF344135

Enzyme and pathway databases

ReactomeiR-GGA-1442490 Collagen degradation
R-GGA-1474244 Extracellular matrix organization
R-GGA-1650814 Collagen biosynthesis and modifying enzymes
R-GGA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-GGA-2022090 Assembly of collagen fibrils and other multimeric structures
R-GGA-216083 Integrin cell surface interactions
R-GGA-2243919 Crosslinking of collagen fibrils
R-GGA-3000171 Non-integrin membrane-ECM interactions
R-GGA-3000178 ECM proteoglycans
R-GGA-430116 GP1b-IX-V activation signalling
R-GGA-75892 Platelet Adhesion to exposed collagen
R-GGA-76009 Platelet Aggregation (Plug Formation)
R-GGA-8874081 MET activates PTK2 signaling
R-GGA-8948216 Collagen chain trimerization

Miscellaneous databases

PMAP-CutDBiP02467

Protein Ontology

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PROi
PR:P02467

Gene expression databases

BgeeiENSGALG00000009641 Expressed in 10 organ(s), highest expression level in colon
ExpressionAtlasiP02467 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR008160 Collagen
IPR000885 Fib_collagen_C
PfamiView protein in Pfam
PF01410 COLFI, 1 hit
PF01391 Collagen, 5 hits
ProDomiView protein in ProDom or Entries sharing at least one domain
PD002078 Fib_collagen_C, 1 hit
SMARTiView protein in SMART
SM00038 COLFI, 1 hit
PROSITEiView protein in PROSITE
PS51461 NC1_FIB, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCO1A2_CHICK
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P02467
Secondary accession number(s): F1P0H9
, P87491, P87492, Q90758, Q90792, Q90795, Q90797, Q92014
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: May 10, 2017
Last modified: December 5, 2018
This is version 138 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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