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Entry version 152 (08 May 2019)
Sequence version 2 (30 May 2000)
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Protein

Collagen alpha-2(I) chain

Gene

COL1A2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Type I collagen is a member of group I collagen (fibrillar forming collagen).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi1179CalciumBy similarity1
Metal bindingi1181CalciumBy similarity1
Metal bindingi1182Calcium; via carbonyl oxygenBy similarity1
Metal bindingi1184Calcium; via carbonyl oxygenBy similarity1
Metal bindingi1187CalciumBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandCalcium, Metal-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-BTA-114604 GPVI-mediated activation cascade
R-BTA-1442490 Collagen degradation
R-BTA-1650814 Collagen biosynthesis and modifying enzymes
R-BTA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-BTA-2022090 Assembly of collagen fibrils and other multimeric structures
R-BTA-202733 Cell surface interactions at the vascular wall
R-BTA-216083 Integrin cell surface interactions
R-BTA-2214320 Anchoring fibril formation
R-BTA-2243919 Crosslinking of collagen fibrils
R-BTA-3000171 Non-integrin membrane-ECM interactions
R-BTA-3000178 ECM proteoglycans
R-BTA-430116 GP1b-IX-V activation signalling
R-BTA-75892 Platelet Adhesion to exposed collagen
R-BTA-8948216 Collagen chain trimerization

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Collagen alpha-2(I) chain
Alternative name(s):
Alpha-2 type I collagen
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:COL1A2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBos taurus (Bovine)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9913 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000009136 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Vertebrate Gene Nomenclature Database

More...
VGNCi
VGNC:27561 COL1A2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Protein family/group databases

Allergome; a platform for allergen knowledge

More...
Allergomei
3550 Bos d alpha2I.0101
896 Bos d alpha2I

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 22By similarityAdd BLAST22
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_000000579823 – 79N-terminal propeptide1 PublicationAdd BLAST57
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000579980 – 1117Collagen alpha-2(I) chainAdd BLAST1038
PropeptideiPRO_00000058001118 – 1364C-terminal propeptideBy similarityAdd BLAST247

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei23Pyrrolidone carboxylic acidBy similarity1
Modified residuei80Pyrrolidone carboxylic acid1 Publication1
Modified residuei84Allysine1 Publication1
Modified residuei1004-hydroxyproline1 Publication1
Modified residuei1064-hydroxyproline1 Publication1
Modified residuei1154-hydroxyproline1 Publication1
Modified residuei1184-hydroxyproline1 Publication1
Modified residuei1214-hydroxyproline1 Publication1
Modified residuei1334-hydroxyproline1 Publication1
Modified residuei1364-hydroxyproline1 Publication1
Modified residuei1454-hydroxyproline1 Publication1
Modified residuei1514-hydroxyproline1 Publication1
Modified residuei1664-hydroxyproline1 Publication1
Modified residuei1694-hydroxyproline1 Publication1
Modified residuei1724-hydroxyproline1 Publication1
Modified residuei1755-hydroxylysine; alternate1 Publication1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi175O-linked (Gal...) hydroxylysine; alternateBy similarity1
Modified residuei1904-hydroxyproline1 Publication1
Modified residuei1934-hydroxyproline1 Publication1
Modified residuei1965-hydroxylysine1 Publication1
Modified residuei1994-hydroxyproline1 Publication1
Modified residuei2024-hydroxyproline1 Publication1
Modified residuei2084-hydroxyproline1 Publication1
Modified residuei2174-hydroxyproline1 Publication1
Modified residuei2264-hydroxyproline1 Publication1
Modified residuei2534-hydroxyproline1 Publication1
Modified residuei2564-hydroxyproline1 Publication1
Modified residuei2594-hydroxyproline1 Publication1
Modified residuei2625-hydroxylysine1 Publication1
Modified residuei2714-hydroxyproline1 Publication1
Modified residuei2864-hydroxyproline1 Publication1
Modified residuei2954-hydroxyproline1 Publication1
Modified residuei3044-hydroxyproline1 Publication1
Modified residuei3075-hydroxylysine1 Publication1
Modified residuei3134-hydroxyproline1 Publication1
Modified residuei3194-hydroxyproline1 Publication1
Modified residuei3224-hydroxyproline1 Publication1
Modified residuei3284-hydroxyproline1 Publication1
Modified residuei3464-hydroxyproline1 Publication1
Modified residuei3525-hydroxylysine1 Publication1
Modified residuei3614-hydroxyproline1 Publication1
Modified residuei3674-hydroxyproline1 Publication1
Modified residuei3704-hydroxyproline1 Publication1
Modified residuei3914-hydroxyproline1 Publication1
Modified residuei3944-hydroxyproline1 Publication1
Modified residuei4004-hydroxyproline1 Publication1
Modified residuei4064-hydroxyproline1 Publication1
Modified residuei4394-hydroxyproline1 Publication1
Modified residuei4424-hydroxyproline1 Publication1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi1161 ↔ 1193PROSITE-ProRule annotation
Disulfide bondi1201 ↔ 1362PROSITE-ProRule annotation
Glycosylationi1265N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1270 ↔ 1315PROSITE-ProRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.

Keywords - PTMi

Disulfide bond, Glycoprotein, Hydroxylation, Pyrrolidone carboxylic acid

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P02465

PeptideAtlas

More...
PeptideAtlasi
P02465

PRoteomics IDEntifications database

More...
PRIDEi
P02465

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
P02465

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Forms the fibrils of tendon, ligaments and bones. In bones the fibrils are mineralized with calcium hydroxyapatite.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSBTAG00000013472 Expressed in 9 organ(s), highest expression level in colon

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Trimers of one alpha 2(I) and two alpha 1(I) chains.

GO - Molecular functioni

Protein-protein interaction databases

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-3101 Collagen type I trimer

Protein interaction database and analysis system

More...
IntActi
P02465, 1 interactor

Molecular INTeraction database

More...
MINTi
P02465

STRING: functional protein association networks

More...
STRINGi
9913.ENSBTAP00000033771

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P02465

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1131 – 1364Fibrillar collagen NC1PROSITE-ProRule annotationAdd BLAST234

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The C-terminal propeptide, also known as COLFI domain, have crucial roles in tissue growth and repair by controlling both the intracellular assembly of procollagen molecules and the extracellular assembly of collagen fibrils. It binds a calcium ion which is essential for its function (By similarity).By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the fibrillar collagen family.PROSITE-ProRule annotation

Keywords - Domaini

Collagen, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3544 Eukaryota
ENOG410XNMM LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155639

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000085654

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P02465

KEGG Orthology (KO)

More...
KOi
K06236

Identification of Orthologs from Complete Genome Data

More...
OMAi
PTGKHGN

Database of Orthologous Groups

More...
OrthoDBi
1406711at2759

TreeFam database of animal gene trees

More...
TreeFami
TF344135

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008160 Collagen
IPR000885 Fib_collagen_C

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01410 COLFI, 1 hit
PF01391 Collagen, 5 hits

ProDom; a protein domain database

More...
ProDomi
View protein in ProDom or Entries sharing at least one domain
PD002078 Fib_collagen_C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00038 COLFI, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51461 NC1_FIB, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P02465-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLSFVDTRTL LLLAVTSCLA TCQSLQEATA RKGPSGDRGP RGERGPPGPP
60 70 80 90 100
GRDGDDGIPG PPGPPGPPGP PGLGGNFAAQ FDAKGGGPGP MGLMGPRGPP
110 120 130 140 150
GASGAPGPQG FQGPPGEPGE PGQTGPAGAR GPPGPPGKAG EDGHPGKPGR
160 170 180 190 200
PGERGVVGPQ GARGFPGTPG LPGFKGIRGH NGLDGLKGQP GAPGVKGEPG
210 220 230 240 250
APGENGTPGQ TGARGLPGER GRVGAPGPAG ARGSDGSVGP VGPAGPIGSA
260 270 280 290 300
GPPGFPGAPG PKGELGPVGN PGPAGPAGPR GEVGLPGLSG PVGPPGNPGA
310 320 330 340 350
NGLPGAKGAA GLPGVAGAPG LPGPRGIPGP VGAAGATGAR GLVGEPGPAG
360 370 380 390 400
SKGESGNKGE PGAVGQPGPP GPSGEEGKRG STGEIGPAGP PGPPGLRGNP
410 420 430 440 450
GSRGLPGADG RAGVMGPAGS RGATGPAGVR GPNGDSGRPG EPGLMGPRGF
460 470 480 490 500
PGSPGNIGPA GKEGPVGLPG IDGRPGPIGP AGARGEPGNI GFPGPKGPSG
510 520 530 540 550
DPGKAGEKGH AGLAGARGAP GPDGNNGAQG PPGLQGVQGG KGEQGPAGPP
560 570 580 590 600
GFQGLPGPAG TAGEAGKPGE RGIPGEFGLP GPAGARGERG PPGESGAAGP
610 620 630 640 650
TGPIGSRGPS GPPGPDGNKG EPGVVGAPGT AGPSGPSGLP GERGAAGIPG
660 670 680 690 700
GKGEKGETGL RGDIGSPGRD GARGAPGAIG APGPAGANGD RGEAGPAGPA
710 720 730 740 750
GPAGPRGSPG ERGEVGPAGP NGFAGPAGAA GQPGAKGERG TKGPKGENGP
760 770 780 790 800
VGPTGPVGAA GPSGPNGPPG PAGSRGDGGP PGATGFPGAA GRTGPPGPSG
810 820 830 840 850
ISGPPGPPGP AGKEGLRGPR GDQGPVGRSG ETGASGPPGF VGEKGPSGEP
860 870 880 890 900
GTAGPPGTPG PQGLLGAPGF LGLPGSRGER GLPGVAGSVG EPGPLGIAGP
910 920 930 940 950
PGARGPPGNV GNPGVNGAPG EAGRDGNPGN DGPPGRDGQP GHKGERGYPG
960 970 980 990 1000
NAGPVGAAGA PGPQGPVGPV GKHGNRGEPG PAGAVGPAGA VGPRGPSGPQ
1010 1020 1030 1040 1050
GIRGDKGEPG DKGPRGLPGL KGHNGLQGLP GLAGHHGDQG APGAVGPAGP
1060 1070 1080 1090 1100
RGPAGPSGPA GKDGRIGQPG AVGPAGIRGS QGSQGPAGPP GPPGPPGPPG
1110 1120 1130 1140 1150
PSGGGYEFGF DGDFYRADQP RSPTSLRPKD YEVDATLKSL NNQIETLLTP
1160 1170 1180 1190 1200
EGSRKNPART CRDLRLSHPE WSSGYYWIDP NQGCTMDAIK VYCDFSTGET
1210 1220 1230 1240 1250
CIRAQPEDIP VKNWYRNSKA KKHVWVGETI NGGTQFEYNV EGVTTKEMAT
1260 1270 1280 1290 1300
QLAFMRLLAN HASQNITYHC KNSIAYMDEE TGNLKKAVIL QGSNDVELVA
1310 1320 1330 1340 1350
EGNSRFTYTV LVDGCSKKTN EWQKTIIEYK TNKPSRLPIL DIAPLDIGGA
1360
DQEIRLNIGP VCFK
Length:1,364
Mass (Da):129,064
Last modified:May 30, 2000 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5593F4D6B9ED119A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A3Q1LZN8A0A3Q1LZN8_BOVIN
Collagen alpha-2(I) chain
COL1A2
1,274Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q1NA44A0A3Q1NA44_BOVIN
Collagen alpha-2(I) chain
COL1A2
1,248Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti157V → P AA sequence (PubMed:173531).Curated1
Sequence conflicti187K → T AA sequence (PubMed:173531).Curated1
Sequence conflicti211T → K AA sequence (PubMed:173531).Curated1
Sequence conflicti298 – 300PGA → AGP AA sequence (PubMed:173531).Curated3
Sequence conflicti423 – 424AT → TA AA sequence (PubMed:4412529).Curated2

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB008683 mRNA Translation: BAA25171.1
BC149095 mRNA Translation: AAI49096.1

Protein sequence database of the Protein Information Resource

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PIRi
A90596 CGBO2S

NCBI Reference Sequences

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RefSeqi
NP_776945.1, NM_174520.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSBTAT00000033863; ENSBTAP00000033771; ENSBTAG00000013472

Database of genes from NCBI RefSeq genomes

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GeneIDi
282188

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
bta:282188

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB008683 mRNA Translation: BAA25171.1
BC149095 mRNA Translation: AAI49096.1
PIRiA90596 CGBO2S
RefSeqiNP_776945.1, NM_174520.2

3D structure databases

SMRiP02465
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

ComplexPortaliCPX-3101 Collagen type I trimer
IntActiP02465, 1 interactor
MINTiP02465
STRINGi9913.ENSBTAP00000033771

Protein family/group databases

Allergomei3550 Bos d alpha2I.0101
896 Bos d alpha2I

Proteomic databases

PaxDbiP02465
PeptideAtlasiP02465
PRIDEiP02465

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000033863; ENSBTAP00000033771; ENSBTAG00000013472
GeneIDi282188
KEGGibta:282188

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
1278
VGNCiVGNC:27561 COL1A2

Phylogenomic databases

eggNOGiKOG3544 Eukaryota
ENOG410XNMM LUCA
GeneTreeiENSGT00940000155639
HOGENOMiHOG000085654
InParanoidiP02465
KOiK06236
OMAiPTGKHGN
OrthoDBi1406711at2759
TreeFamiTF344135

Enzyme and pathway databases

ReactomeiR-BTA-114604 GPVI-mediated activation cascade
R-BTA-1442490 Collagen degradation
R-BTA-1650814 Collagen biosynthesis and modifying enzymes
R-BTA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-BTA-2022090 Assembly of collagen fibrils and other multimeric structures
R-BTA-202733 Cell surface interactions at the vascular wall
R-BTA-216083 Integrin cell surface interactions
R-BTA-2214320 Anchoring fibril formation
R-BTA-2243919 Crosslinking of collagen fibrils
R-BTA-3000171 Non-integrin membrane-ECM interactions
R-BTA-3000178 ECM proteoglycans
R-BTA-430116 GP1b-IX-V activation signalling
R-BTA-75892 Platelet Adhesion to exposed collagen
R-BTA-8948216 Collagen chain trimerization

Miscellaneous databases

PMAP-CutDBiP02465

Gene expression databases

BgeeiENSBTAG00000013472 Expressed in 9 organ(s), highest expression level in colon

Family and domain databases

InterProiView protein in InterPro
IPR008160 Collagen
IPR000885 Fib_collagen_C
PfamiView protein in Pfam
PF01410 COLFI, 1 hit
PF01391 Collagen, 5 hits
ProDomiView protein in ProDom or Entries sharing at least one domain
PD002078 Fib_collagen_C, 1 hit
SMARTiView protein in SMART
SM00038 COLFI, 1 hit
PROSITEiView protein in PROSITE
PS51461 NC1_FIB, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCO1A2_BOVIN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P02465
Secondary accession number(s): A6QP13, O62649
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: May 30, 2000
Last modified: May 8, 2019
This is version 152 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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