Protein

Collagen alpha-1(III) chain

Gene

COL3A1

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Collagen type III occurs in most soft connective tissues along with type I collagen. Involved in regulation of cortical development. Is the major ligand of ADGRG1 in the developing brain and binding to ADGRG1 inhibits neuronal migration and activates the RhoA pathway by coupling ADGRG1 to GNA13 and possibly GNA12.

Sites

Feature key	Position(s)	DescriptionActions	Length
Metal bindingⁱ	1280	Calcium	1
Metal bindingⁱ	1282	Calcium	1
Metal bindingⁱ	1283	Calcium; via carbonyl oxygen	1
Metal bindingⁱ	1285	Calcium; via carbonyl oxygen	1
Metal bindingⁱ	1288	Calcium	1

GO - Molecular functionⁱ

extracellular matrix structural constituent
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 7487954
- 9036918
extracellular matrix structural constituent conferring tensile strength
Source: BHF-UCL
Inferred from high throughput direct assayⁱ
- 27559042
- 28675934
integrin binding
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 9573018
metal ion binding Source: UniProtKB-KW
platelet-derived growth factor binding
Source: MGI
Inferred from direct assayⁱ
- 8900172
protease binding
Source: CAFA
Inferred from physical interactionⁱ
- 19932771
SMAD binding Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

aorta smooth muscle tissue morphogenesis Source: Ensembl
cell-matrix adhesion
Source: UniProtKB
Inferred from direct assayⁱ
- 16912226
cellular response to amino acid stimulus Source: Ensembl
cerebral cortex development Source: UniProtKB
collagen fibril organization
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 7546986
- 9036918
digestive tract development Source: Ensembl
extracellular matrix organization Source: Reactome
heart development
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 7546986
integrin-mediated signaling pathway
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 14970208
negative regulation of immune response
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 16754721
negative regulation of neuron migration Source: UniProtKB
peptide cross-linking
Source: UniProtKB
Inferred from direct assayⁱ
- 16754721
platelet activation
Source: UniProtKB
Non-traceable author statementⁱ
- 9573018
positive regulation of Rho protein signal transduction Source: UniProtKB
regulation of immune response Source: Reactome
response to cytokine
Source: UniProtKB
Inferred from direct assayⁱ
- 16360482
- 9076960
response to mechanical stimulus Source: Ensembl
response to radiation
Source: UniProtKB
Inferred from direct assayⁱ
- 14736764
skeletal system development Source: Ensembl
skin development
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 9036918
supramolecular fiber organization
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 14970208
transforming growth factor beta receptor signaling pathway
Source: UniProtKB
Inferred from direct assayⁱ
- 16360482
wound healing
Source: UniProtKB
Inferred from direct assayⁱ
- 1466622

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Ligand	Calcium, Metal-binding

Ligand

Calcium, Metal-binding

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1442490 Collagen degradation R-HSA-1474244 Extracellular matrix organization R-HSA-1650814 Collagen biosynthesis and modifying enzymes R-HSA-186797 Signaling by PDGF R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-2022090 Assembly of collagen fibrils and other multimeric structures R-HSA-216083 Integrin cell surface interactions R-HSA-3000170 Syndecan interactions R-HSA-3000171 Non-integrin membrane-ECM interactions R-HSA-3000178 ECM proteoglycans R-HSA-3000480 Scavenging by Class A Receptors R-HSA-419037 NCAM1 interactions R-HSA-8874081 MET activates PTK2 signaling R-HSA-8948216 Collagen chain trimerization
SIGNORⁱ	P02461

Reactomeⁱ

R-HSA-1442490 Collagen degradation
R-HSA-1474244 Extracellular matrix organization
R-HSA-1650814 Collagen biosynthesis and modifying enzymes
R-HSA-186797 Signaling by PDGF
R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-2022090 Assembly of collagen fibrils and other multimeric structures
R-HSA-216083 Integrin cell surface interactions
R-HSA-3000170 Syndecan interactions
R-HSA-3000171 Non-integrin membrane-ECM interactions
R-HSA-3000178 ECM proteoglycans
R-HSA-3000480 Scavenging by Class A Receptors
R-HSA-419037 NCAM1 interactions
R-HSA-8874081 MET activates PTK2 signaling
R-HSA-8948216 Collagen chain trimerization

SIGNORⁱ

P02461

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Collagen alpha-1(III) chain
Gene namesⁱ	Name:COL3A1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 2

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000168542.12
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:2201 COL3A1
MIMⁱ	120180 gene
neXtProtⁱ	NX_P02461

Keywords - Cellular componentⁱ

Extracellular matrix, Secreted

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Ehlers-Danlos syndrome, vascular type (EDSVASC)30 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA severe form of Ehlers-Danlos syndrome, a group of connective tissue disorders characterized by skin hyperextensibility, articular hypermobility, and tissue fragility. EDSVASC is an autosomal dominant disease characterized by joint and dermal manifestations as in other forms of the syndrome, and by proneness to spontaneous rupture of bowel and large arteries. The vascular complications may affect all anatomical areas.

See also OMIM:130050

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_001768	183	G → C in EDSVASC. 2 PublicationsCorresponds to variant dbSNP:rs121912926EnsemblClinVar.	1
Natural variantⁱVAR_011095	183	G → D in EDSVASC. Corresponds to variant dbSNP:rs587779420EnsemblClinVar.	1
Natural variantⁱVAR_011096	183	G → S in EDSVASC. Corresponds to variant dbSNP:rs121912926EnsemblClinVar.	1
Natural variantⁱVAR_011097	192	G → V in EDSVASC. Corresponds to variant dbSNP:rs587779710EnsemblClinVar.	1
Natural variantⁱVAR_001769	201	G → R in EDSVASC. 2 PublicationsCorresponds to variant dbSNP:rs587779436EnsemblClinVar.	1
Natural variantⁱVAR_011098	204	G → D in EDSVASC. 1 PublicationCorresponds to variant dbSNP:rs587779626EnsemblClinVar.	1
Natural variantⁱVAR_011099	204	G → S in EDSVASC. Corresponds to variant dbSNP:rs587779711EnsemblClinVar.	1
Natural variantⁱVAR_011100	210	G → D in EDSVASC. 1 Publication	1
Natural variantⁱVAR_011101	219	G → C in EDSVASC. Corresponds to variant dbSNP:rs587779624EnsemblClinVar.	1
Natural variantⁱVAR_011102	225	G → V in EDSVASC. Corresponds to variant dbSNP:rs587779533EnsemblClinVar.	1
Natural variantⁱVAR_001770	228	G → E in EDSVASC. 2 PublicationsCorresponds to variant dbSNP:rs587779555EnsemblClinVar.	1
Natural variantⁱVAR_011103	240	G → R in EDSVASC. Corresponds to variant dbSNP:rs587779468EnsemblClinVar.	1
Natural variantⁱVAR_011104	243	G → V in EDSVASC. Corresponds to variant dbSNP:rs587779629EnsemblClinVar.	1
Natural variantⁱVAR_011105	249	G → D in EDSVASC. Corresponds to variant dbSNP:rs121912927EnsemblClinVar.	1
Natural variantⁱVAR_011106	249	G → V in EDSVASC. Corresponds to variant dbSNP:rs121912927EnsemblClinVar.	1
Natural variantⁱVAR_011107	252	G → D in EDSVASC. Corresponds to variant dbSNP:rs587779464EnsemblClinVar.	1
Natural variantⁱVAR_011108	252	G → R in EDSVASC. Corresponds to variant dbSNP:rs587779705EnsemblClinVar.	1
Natural variantⁱVAR_011109	252	G → V in EDSVASC. Corresponds to variant dbSNP:rs587779464EnsemblClinVar.	1
Natural variantⁱVAR_011110	255	G → V in EDSVASC. Corresponds to variant dbSNP:rs587779605EnsemblClinVar.	1
Natural variantⁱVAR_011111	264	G → R in EDSVASC. 1 Publication	1
Natural variantⁱVAR_011112	267	G → V in EDSVASC. Corresponds to variant dbSNP:rs587779427EnsemblClinVar.	1
Natural variantⁱVAR_037007	297	G → R in EDSVASC. 1 Publication	1
Natural variantⁱVAR_001771	303	G → R in EDSVASC. 1 PublicationCorresponds to variant dbSNP:rs121912919EnsemblClinVar.	1
Natural variantⁱVAR_011113	321	G → V in EDSVASC. Corresponds to variant dbSNP:rs587779588EnsemblClinVar.	1
Natural variantⁱVAR_011114	327	G → D in EDSVASC. 1 Publication	1
Natural variantⁱVAR_011115	345	G → R in EDSVASC. Corresponds to variant dbSNP:rs587779419EnsemblClinVar.	1
Natural variantⁱVAR_011116	417	G → R in EDSVASC. Corresponds to variant dbSNP:rs587779637EnsemblClinVar.	1
Natural variantⁱVAR_011117	444	G → R in EDSVASC. Corresponds to variant dbSNP:rs587779489EnsemblClinVar.	1
Natural variantⁱVAR_011118	489	G → E in EDSVASC. Corresponds to variant dbSNP:rs587779476EnsemblClinVar.	1
Natural variantⁱVAR_011119	501	G → R in EDSVASC. Corresponds to variant dbSNP:rs587779523EnsemblClinVar.	1
Natural variantⁱVAR_011120	519	G → V in EDSVASC.	1
Natural variantⁱVAR_001772	540	G → R in EDSVASC. 2 PublicationsCorresponds to variant dbSNP:rs587779584EnsemblClinVar.	1
Natural variantⁱVAR_011121	549	G → E in EDSVASC. Corresponds to variant dbSNP:rs587779679EnsemblClinVar.	1
Natural variantⁱVAR_011122	552	G → E in EDSVASC. Corresponds to variant dbSNP:rs121912928EnsemblClinVar.	1
Natural variantⁱVAR_001773	567	G → E in EDSVASC. 1 Publication	1
Natural variantⁱVAR_001774	582	G → S in EDSVASC. 1 PublicationCorresponds to variant dbSNP:rs121912923EnsemblClinVar.	1
Natural variantⁱVAR_011123	588	G → D in EDSVASC. Corresponds to variant dbSNP:rs587779691EnsemblClinVar.	1
Natural variantⁱVAR_011124	636	G → R in EDSVASC. Corresponds to variant dbSNP:rs587779522EnsemblClinVar.	1
Natural variantⁱVAR_011125	657	G → E in EDSVASC. Corresponds to variant dbSNP:rs587779699EnsemblClinVar.	1
Natural variantⁱVAR_011126	660	G → D in EDSVASC. Corresponds to variant dbSNP:rs587779493EnsemblClinVar.	1
Natural variantⁱVAR_001777	666	G → D in EDSVASC. 1 PublicationCorresponds to variant dbSNP:rs121912921EnsemblClinVar.	1
Natural variantⁱVAR_011128	699	G → R in EDSVASC. Corresponds to variant dbSNP:rs587779668EnsemblClinVar.	1
Natural variantⁱVAR_001779	726	G → R in EDSVASC. 2 PublicationsCorresponds to variant dbSNP:rs587779638EnsemblClinVar.	1
Natural variantⁱVAR_011129	738	G → S in EDSVASC. Corresponds to variant dbSNP:rs121912925EnsemblClinVar.	1
Natural variantⁱVAR_011130	738	G → V in EDSVASC. Corresponds to variant dbSNP:rs587779615EnsemblClinVar.	1
Natural variantⁱVAR_011131	744	G → V in EDSVASC. Corresponds to variant dbSNP:rs587779697EnsemblClinVar.	1
Natural variantⁱVAR_001780	756	G → E in EDSVASC. 1 Publication	1
Natural variantⁱVAR_001781	762	G → C in EDSVASC. 1 Publication	1
Natural variantⁱVAR_001782	786	G → R in EDSVASC. 1 PublicationCorresponds to variant dbSNP:rs113485686EnsemblClinVar.	1
Natural variantⁱVAR_001783	804	G → S in EDSVASC. 1 PublicationCorresponds to variant dbSNP:rs121912920EnsemblClinVar.	1
Natural variantⁱVAR_001784	828	G → R in EDSVASC. 1 Publication	1
Natural variantⁱVAR_011132	828	G → W in EDSVASC. Corresponds to variant dbSNP:rs587779486EnsemblClinVar.	1
Natural variantⁱVAR_037008	830 – 838	Missing in EDSVASC. 1 Publication	9
Natural variantⁱVAR_011133	852	G → C in EDSVASC. Corresponds to variant dbSNP:rs587779690EnsemblClinVar.	1
Natural variantⁱVAR_011134	879	G → V in EDSVASC. Corresponds to variant dbSNP:rs587779645EnsemblClinVar.	1
Natural variantⁱVAR_011135	882	G → D in EDSVASC. Corresponds to variant dbSNP:rs587779622EnsemblClinVar.	1
Natural variantⁱVAR_011136	900	G → D in EDSVASC. Corresponds to variant dbSNP:rs587779599EnsemblClinVar.	1
Natural variantⁱVAR_011137	903	G → E in EDSVASC. Corresponds to variant dbSNP:rs587779505EnsemblClinVar.	1
Natural variantⁱVAR_001785	909	G → D in EDSVASC. 1 Publication	1
Natural variantⁱVAR_011138	909	G → V in EDSVASC. Corresponds to variant dbSNP:rs587779483EnsemblClinVar.	1
Natural variantⁱVAR_011139	918	G → E in EDSVASC. Corresponds to variant dbSNP:rs587779662EnsemblClinVar.	1
Natural variantⁱVAR_011140	924	G → C in EDSVASC. Corresponds to variant dbSNP:rs587779471EnsemblClinVar.	1
Natural variantⁱVAR_001786	936	G → R in EDSVASC. 2 PublicationsCorresponds to variant dbSNP:rs587779566EnsemblClinVar.	1
Natural variantⁱVAR_001787	936	G → S in EDSVASC.	1
Natural variantⁱVAR_001788	939	G → D in EDSVASC. 1 PublicationCorresponds to variant dbSNP:rs112978464Ensembl.	1
Natural variantⁱVAR_011141	942	G → E in EDSVASC. Corresponds to variant dbSNP:rs587779517EnsemblClinVar.	1
Natural variantⁱVAR_001789	957	G → S in EDSVASC; severe variant. 1 PublicationCorresponds to variant dbSNP:rs121912913Ensembl.	1
Natural variantⁱVAR_001790	960	G → V in EDSVASC; severe variant. 1 PublicationCorresponds to variant dbSNP:rs121912922EnsemblClinVar.	1
Natural variantⁱVAR_011142	966	G → V in EDSVASC. Corresponds to variant dbSNP:rs587779571EnsemblClinVar.	1
Natural variantⁱVAR_011143	972	G → A in EDSVASC. Corresponds to variant dbSNP:rs587779559EnsemblClinVar.	1
Natural variantⁱVAR_011144	984	G → T in EDSVASC; requires 2 nucleotide substitutions.	1
Natural variantⁱVAR_001791	996	G → E in EDSVASC. 1 PublicationCorresponds to variant dbSNP:rs587779576EnsemblClinVar.	1
Natural variantⁱVAR_011145	999	G → R in EDSVASC. Corresponds to variant dbSNP:rs587779548EnsemblClinVar.	1
Natural variantⁱVAR_011146	1011	G → E in EDSVASC. Corresponds to variant dbSNP:rs587779552EnsemblClinVar.	1
Natural variantⁱVAR_001792	1014	G → E in EDSVASC. 1 PublicationCorresponds to variant dbSNP:rs121912916EnsemblClinVar.	1
Natural variantⁱVAR_011147	1032	G → V in EDSVASC. Corresponds to variant dbSNP:rs587779428EnsemblClinVar.	1
Natural variantⁱVAR_011148	1035	G → C in EDSVASC. Corresponds to variant dbSNP:rs587779704EnsemblClinVar.	1
Natural variantⁱVAR_011149	1044	G → D in EDSVASC. 1 Publication	1
Natural variantⁱVAR_001793	1050	G → D in EDSVASC; mild variant. 1 PublicationCorresponds to variant dbSNP:rs121912914EnsemblClinVar.	1
Natural variantⁱVAR_011150	1050	G → V in EDSVASC. 1 PublicationCorresponds to variant dbSNP:rs121912914EnsemblClinVar.	1
Natural variantⁱVAR_001794	1071	G → V in EDSVASC. 1 PublicationCorresponds to variant dbSNP:rs587779709EnsemblClinVar.	1
Natural variantⁱVAR_001795	1077	G → V in EDSVASC. 1 PublicationCorresponds to variant dbSNP:rs121912915EnsemblClinVar.	1
Natural variantⁱVAR_011151	1089	G → D in EDSVASC. Corresponds to variant dbSNP:rs587779672EnsemblClinVar.	1
Natural variantⁱVAR_011152	1098	G → D in EDSVASC. 1 Publication	1
Natural variantⁱVAR_011153	1098	G → V in EDSVASC. Corresponds to variant dbSNP:rs587779614EnsemblClinVar.	1
Natural variantⁱVAR_001796	1101	G → E in EDSVASC. 1 PublicationCorresponds to variant dbSNP:rs121912924EnsemblClinVar.	1
Natural variantⁱVAR_001797	1104	G → A in EDSVASC. 1 Publication	1
Natural variantⁱVAR_011154	1161	G → V in EDSVASC. Corresponds to variant dbSNP:rs587779473EnsemblClinVar.	1
Natural variantⁱVAR_011155	1164	G → E in EDSVASC. Corresponds to variant dbSNP:rs587779431EnsemblClinVar.	1
Natural variantⁱVAR_011156	1164	G → R in EDSVASC. Corresponds to variant dbSNP:rs587779553EnsemblClinVar.	1
Natural variantⁱVAR_001799	1167	G → V in EDSVASC. 1 PublicationCorresponds to variant dbSNP:rs587779578EnsemblClinVar.	1
Natural variantⁱVAR_001800	1170	G → D in EDSVASC. 2 PublicationsCorresponds to variant dbSNP:rs587779465EnsemblClinVar.	1
Natural variantⁱVAR_011157	1170	G → V in EDSVASC. Corresponds to variant dbSNP:rs587779465EnsemblClinVar.	1
Natural variantⁱVAR_001801	1173	G → E in EDSVASC. 3 PublicationsCorresponds to variant dbSNP:rs121912918EnsemblClinVar.	1
Natural variantⁱVAR_011158	1173	G → R in EDSVASC; Gottron type acrogeria. 1 PublicationCorresponds to variant dbSNP:rs587779521EnsemblClinVar.	1
Natural variantⁱVAR_001802	1176	G → V in EDSVASC; severe. 1 Publication	1
Natural variantⁱVAR_011159	1179	G → R in EDSVASC. Corresponds to variant dbSNP:rs587779574EnsemblClinVar.	1
Natural variantⁱVAR_001803	1182	G → E in EDSVASC. 1 PublicationCorresponds to variant dbSNP:rs111505097EnsemblClinVar.	1
Natural variantⁱVAR_001804	1185	G → D in EDSVASC; severe variant. 1 PublicationCorresponds to variant dbSNP:rs121912917EnsemblClinVar.	1
Natural variantⁱVAR_001805	1185	G → V in EDSVASC. 1 PublicationCorresponds to variant dbSNP:rs121912917EnsemblClinVar.	1
Natural variantⁱVAR_001806	1188	G → E in EDSVASC; severe variant. 2 PublicationsCorresponds to variant dbSNP:rs112456072EnsemblClinVar.	1
Natural variantⁱVAR_001807	1188	G → R in EDSVASC. 1 PublicationCorresponds to variant dbSNP:rs587779504EnsemblClinVar.	1

Keywords - Diseaseⁱ

Aortic aneurysm, Disease mutation, Ehlers-Danlos syndrome

Organism-specific databases

DisGeNET More...DisGeNETⁱ	1281
GeneReviewsⁱ	COL3A1
MalaCards human disease database More...MalaCardsⁱ	COL3A1
MIMⁱ	130050 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000168542
Orphanetⁱ	2500 Acrogeria 286 Ehlers-Danlos syndrome, vascular type 86 Familial abdominal aortic aneurysm 231160 Familial cerebral saccular aneurysm
PharmGKBⁱ	PA26716

Chemistry databases

ChEMBLⁱ	CHEMBL2364188
Drug and drug target database More...DrugBankⁱ	DB00048 Collagenase clostridium histolyticum

Polymorphism and mutation databases

BioMutaⁱ	COL3A1
DMDMⁱ	124056490

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
Signal peptideⁱ	1 – 23	Add BLAST	23
PropeptideⁱPRO_0000005740	24 – 153	N-terminal propeptideAdd BLAST	130
ChainⁱPRO_0000005741	154 – 1221	Collagen alpha-1(III) chainAdd BLAST	1068
PropeptideⁱPRO_0000005742	1222 – 1466	C-terminal propeptideAdd BLAST	245

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	173	4-hydroxyproline1 Publication	1
Modified residueⁱ	179	4-hydroxyproline1 Publication	1
Modified residueⁱ	182	4-hydroxyproline1 Publication	1
Modified residueⁱ	185	4-hydroxyproline1 Publication	1
Modified residueⁱ	191	4-hydroxyproline1 Publication	1
Modified residueⁱ	194	4-hydroxyproline1 Publication	1
Modified residueⁱ	197	4-hydroxyproline1 Publication	1
Modified residueⁱ	203	4-hydroxyproline1 Publication	1
Modified residueⁱ	206	4-hydroxyproline1 Publication	1
Modified residueⁱ	215	4-hydroxyproline1 Publication	1
Modified residueⁱ	218	4-hydroxyproline1 Publication	1
Modified residueⁱ	236	4-hydroxyproline1 Publication	1
Modified residueⁱ	239	4-hydroxyproline1 Publication	1
Modified residueⁱ	245	4-hydroxyproline1 Publication	1
Modified residueⁱ	248	4-hydroxyproline1 Publication	1
Modified residueⁱ	257	4-hydroxyproline1 Publication	1
Modified residueⁱ	260	4-hydroxyproline1 Publication	1
Modified residueⁱ	263	5-hydroxylysine; alternate1 Publication	1
Glycosylationⁱ	263	O-linked (Gal...) hydroxylysine; alternate	1
Modified residueⁱ	281	4-hydroxyproline1 Publication	1
Modified residueⁱ	284	5-hydroxylysine1 Publication	1
Modified residueⁱ	290	4-hydroxyproline1 Publication	1
Modified residueⁱ	296	4-hydroxyproline1 Publication	1
Modified residueⁱ	305	4-hydroxyproline1 Publication	1
Modified residueⁱ	311	4-hydroxyproline1 Publication	1
Modified residueⁱ	314	4-hydroxyproline1 Publication	1
Modified residueⁱ	332	4-hydroxyproline1 Publication	1
Modified residueⁱ	335	4-hydroxyproline1 Publication	1
Modified residueⁱ	338	4-hydroxyproline1 Publication	1
Modified residueⁱ	344	4-hydroxyproline1 Publication	1
Modified residueⁱ	347	4-hydroxyproline1 Publication	1
Modified residueⁱ	359	4-hydroxyproline1 Publication	1
Modified residueⁱ	365	4-hydroxyproline1 Publication	1
Modified residueⁱ	371	4-hydroxyproline1 Publication	1
Modified residueⁱ	383	4-hydroxyproline1 Publication	1
Modified residueⁱ	386	4-hydroxyproline1 Publication	1
Modified residueⁱ	392	4-hydroxyproline1 Publication	1
Modified residueⁱ	404	4-hydroxyproline1 Publication	1
Modified residueⁱ	407	4-hydroxyproline1 Publication	1
Modified residueⁱ	416	4-hydroxyproline1 Publication	1
Modified residueⁱ	425	4-hydroxyproline1 Publication	1
Modified residueⁱ	434	4-hydroxyproline1 Publication	1
Modified residueⁱ	443	4-hydroxyproline1 Publication	1
Modified residueⁱ	455	4-hydroxyproline1 Publication	1
Modified residueⁱ	458	4-hydroxyproline1 Publication	1
Modified residueⁱ	470	4-hydroxyproline1 Publication	1
Modified residueⁱ	473	4-hydroxyproline1 Publication	1
Modified residueⁱ	479	4-hydroxyproline1 Publication	1
Modified residueⁱ	488	4-hydroxyproline1 Publication	1
Modified residueⁱ	500	4-hydroxyproline1 Publication	1
Modified residueⁱ	512	4-hydroxyproline1 Publication	1
Modified residueⁱ	524	4-hydroxyproline1 Publication	1
Modified residueⁱ	530	4-hydroxyproline1 Publication	1
Modified residueⁱ	533	4-hydroxyproline1 Publication	1
Modified residueⁱ	539	4-hydroxyproline1 Publication	1
Modified residueⁱ	542	4-hydroxyproline1 Publication	1
Modified residueⁱ	545	4-hydroxyproline1 Publication	1
Modified residueⁱ	551	4-hydroxyproline1 Publication	1
Modified residueⁱ	554	4-hydroxyproline1 Publication	1
Modified residueⁱ	563	4-hydroxyproline1 Publication	1
Modified residueⁱ	566	4-hydroxyproline1 Publication	1
Modified residueⁱ	575	4-hydroxyproline1 Publication	1
Modified residueⁱ	581	4-hydroxyproline1 Publication	1
Modified residueⁱ	590	4-hydroxyproline1 Publication	1
Modified residueⁱ	599	4-hydroxyproline1 Publication	1
Modified residueⁱ	602	4-hydroxyproline1 Publication	1
Modified residueⁱ	608	4-hydroxyproline1 Publication	1
Modified residueⁱ	620	4-hydroxyproline1 Publication	1
Modified residueⁱ	635	4-hydroxyproline1 Publication	1
Modified residueⁱ	644	4-hydroxyproline1 Publication	1
Modified residueⁱ	650	4-hydroxyproline1 Publication	1
Modified residueⁱ	656	4-hydroxyproline1 Publication	1
Modified residueⁱ	659	4-hydroxyproline1 Publication	1
Modified residueⁱ	661	4-hydroxyproline1 Publication	1
Modified residueⁱ	668	4-hydroxyproline1 Publication	1
Modified residueⁱ	671	4-hydroxyproline1 Publication	1
Modified residueⁱ	680	4-hydroxyproline1 Publication	1
Modified residueⁱ	686	4-hydroxyproline1 Publication	1
Modified residueⁱ	692	4-hydroxyproline1 Publication	1
Modified residueⁱ	701	4-hydroxyproline1 Publication	1
Modified residueⁱ	703	4-hydroxyproline1 Publication	1
Modified residueⁱ	713	4-hydroxyproline1 Publication	1
Modified residueⁱ	716	4-hydroxyproline1 Publication	1
Modified residueⁱ	722	4-hydroxyproline1 Publication	1
Modified residueⁱ	728	4-hydroxyproline1 Publication	1
Modified residueⁱ	737	4-hydroxyproline1 Publication	1
Modified residueⁱ	746	4-hydroxyproline1 Publication	1
Modified residueⁱ	749	4-hydroxyproline1 Publication	1
Modified residueⁱ	755	4-hydroxyproline1 Publication	1
Modified residueⁱ	770	4-hydroxyproline1 Publication	1
Modified residueⁱ	776	4-hydroxyproline1 Publication	1
Modified residueⁱ	785	4-hydroxyproline1 Publication	1
Modified residueⁱ	788	4-hydroxyproline1 Publication	1
Modified residueⁱ	797	4-hydroxyproline1 Publication	1
Modified residueⁱ	806	4-hydroxyproline1 Publication	1
Modified residueⁱ	812	4-hydroxyproline1 Publication	1
Modified residueⁱ	815	4-hydroxyproline1 Publication	1
Modified residueⁱ	821	4-hydroxyproline1 Publication	1
Modified residueⁱ	830	4-hydroxyproline1 Publication	1
Modified residueⁱ	839	4-hydroxyproline1 Publication	1
Modified residueⁱ	845	4-hydroxyproline1 Publication	1
Modified residueⁱ	854	4-hydroxyproline1 Publication	1
Modified residueⁱ	860	5-hydroxylysine1 Publication	1
Modified residueⁱ	866	4-hydroxyproline1 Publication	1
Modified residueⁱ	869	4-hydroxyproline1 Publication	1
Modified residueⁱ	875	4-hydroxyproline1 Publication	1
Modified residueⁱ	881	4-hydroxyproline1 Publication	1
Modified residueⁱ	884	4-hydroxyproline1 Publication	1
Modified residueⁱ	890	4-hydroxyproline1 Publication	1
Modified residueⁱ	892	4-hydroxyproline1 Publication	1
Modified residueⁱ	899	4-hydroxyproline1 Publication	1
Modified residueⁱ	905	4-hydroxyproline1 Publication	1
Modified residueⁱ	914	4-hydroxyproline1 Publication	1
Modified residueⁱ	917	4-hydroxyproline1 Publication	1
Modified residueⁱ	929	4-hydroxyproline1 Publication	1
Modified residueⁱ	935	4-hydroxyproline1 Publication	1
Modified residueⁱ	941	4-hydroxyproline1 Publication	1
Modified residueⁱ	944	4-hydroxyproline1 Publication	1
Modified residueⁱ	962	4-hydroxyproline1 Publication	1
Modified residueⁱ	965	4-hydroxyproline1 Publication	1
Modified residueⁱ	971	4-hydroxyproline1 Publication	1
Modified residueⁱ	977	5-hydroxylysine1 Publication	1
Modified residueⁱ	983	4-hydroxyproline1 Publication	1
Modified residueⁱ	995	4-hydroxyproline1 Publication	1
Modified residueⁱ	1001	4-hydroxyproline1 Publication	1
Modified residueⁱ	1010	4-hydroxyproline1 Publication	1
Modified residueⁱ	1016	4-hydroxyproline1 Publication	1
Modified residueⁱ	1022	4-hydroxyproline1 Publication	1
Modified residueⁱ	1028	4-hydroxyproline1 Publication	1
Modified residueⁱ	1040	4-hydroxyproline1 Publication	1
Modified residueⁱ	1043	4-hydroxyproline1 Publication	1
Modified residueⁱ	1046	4-hydroxyproline1 Publication	1
Modified residueⁱ	1049	4-hydroxyproline1 Publication	1
Modified residueⁱ	1052	4-hydroxyproline1 Publication	1
Modified residueⁱ	1076	4-hydroxyproline1 Publication	1
Modified residueⁱ	1085	4-hydroxyproline1 Publication	1
Modified residueⁱ	1106	5-hydroxylysine1 Publication	1
Modified residueⁱ	1112	4-hydroxyproline1 Publication	1
Modified residueⁱ	1115	4-hydroxyproline1 Publication	1
Modified residueⁱ	1118	4-hydroxyproline1 Publication	1
Modified residueⁱ	1121	4-hydroxyproline1 Publication	1
Modified residueⁱ	1133	4-hydroxyproline1 Publication	1
Modified residueⁱ	1148	4-hydroxyproline1 Publication	1
Modified residueⁱ	1157	4-hydroxyproline1 Publication	1
Modified residueⁱ	1163	4-hydroxyproline1 Publication	1
Modified residueⁱ	1178	4-hydroxyproline1 Publication	1
Modified residueⁱ	1181	4-hydroxyproline1 Publication	1
Modified residueⁱ	1184	4-hydroxyproline1 Publication	1
Modified residueⁱ	1187	4-hydroxyproline1 Publication	1
Modified residueⁱ	1190	4-hydroxyproline1 Publication	1
Modified residueⁱ	1193	4-hydroxyproline1 Publication	1
Disulfide bondⁱ	1196	InterchainPROSITE-ProRule annotation1 Publication
Disulfide bondⁱ	1197	InterchainPROSITE-ProRule annotation1 Publication
Disulfide bondⁱ	1262 ↔ 1294	PROSITE-ProRule annotation1 Publication
Disulfide bondⁱ	1268	Interchain (with C-1285)PROSITE-ProRule annotation1 Publication
Disulfide bondⁱ	1285	Interchain (with C-1268)PROSITE-ProRule annotation1 Publication
Disulfide bondⁱ	1302 ↔ 1464	PROSITE-ProRule annotation1 Publication
Disulfide bondⁱ	1372 ↔ 1417	PROSITE-ProRule annotation1 Publication

Post-translational modificationⁱ

Proline residues at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.2 Publications

O-linked glycan consists of a Glc-Gal disaccharide bound to the oxygen atom of a post-translationally added hydroxyl group.

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Hydroxylation

Proteomic databases

EPDⁱ	P02461
PaxDbⁱ	P02461
PeptideAtlas More...PeptideAtlasⁱ	P02461
PRIDEⁱ	P02461
ProteomicsDBⁱ	51522 51523 [P02461-2]

PTM databases

GlyConnectⁱ	1127
iPTMnetⁱ	P02461
PhosphoSitePlusⁱ	P02461

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000168542 Expressed in 229 organ(s), highest expression level in uterine cervix
ExpressionAtlasⁱ	P02461 baseline and differential
Genevisibleⁱ	P02461 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB016766 CAB059993 HPA007583

HPAⁱ

CAB016766
CAB059993
HPA007583

Interactionⁱ

Subunit structureⁱ

Trimers of identical alpha 1(III) chains. The chains are linked to each other by interchain disulfide bonds. Trimers are also cross-linked via hydroxylysines.

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
AAEL010235	O01949	2	EBI-2431491,EBI-7685554	From Aedes aegypti.
SPARC	P09486	4	EBI-15740444,EBI-2800983

GO - Molecular functionⁱ

integrin binding
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 9573018
platelet-derived growth factor binding
Source: MGI
Inferred from direct assayⁱ
- 8900172
protease binding
Source: CAFA
Inferred from physical interactionⁱ
- 19932771
SMAD binding Source: Ensembl

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	107678, 12 interactors
ComplexPortalⁱ	CPX-1714 Collagen type III trimer
Database of interacting proteins More...DIPⁱ	DIP-57177N
IntActⁱ	P02461, 23 interactors
Molecular INTeraction database More...MINTⁱ	P02461
STRINGⁱ	9606.ENSP00000304408

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	1236 – 1249	Combined sources	14
Beta strandⁱ	1253 – 1257	Combined sources	5
Helixⁱ	1262 – 1268	Combined sources	7
Beta strandⁱ	1274 – 1279	Combined sources	6
Helixⁱ	1286 – 1288	Combined sources	3
Beta strandⁱ	1290 – 1295	Combined sources	6
Turnⁱ	1296 – 1299	Combined sources	4
Beta strandⁱ	1300 – 1303	Combined sources	4
Beta strandⁱ	1305 – 1307	Combined sources	3
Beta strandⁱ	1309 – 1313	Combined sources	5
Beta strandⁱ	1320 – 1322	Combined sources	3
Helixⁱ	1328 – 1331	Combined sources	4
Beta strandⁱ	1339 – 1341	Combined sources	3
Beta strandⁱ	1343 – 1345	Combined sources	3
Helixⁱ	1347 – 1360	Combined sources	14
Beta strandⁱ	1364 – 1374	Combined sources	11
Turnⁱ	1381 – 1384	Combined sources	4
Beta strandⁱ	1391 – 1393	Combined sources	3
Beta strandⁱ	1395 – 1397	Combined sources	3
Beta strandⁱ	1399 – 1404	Combined sources	6
Helixⁱ	1406 – 1408	Combined sources	3
Beta strandⁱ	1411 – 1415	Combined sources	5
Beta strandⁱ	1422 – 1434	Combined sources	13
Helixⁱ	1436 – 1438	Combined sources	3
Beta strandⁱ	1443 – 1445	Combined sources	3
Beta strandⁱ	1455 – 1465	Combined sources	11

Show more details

3D structure databases

ProteinModelPortalⁱ	P02461
SMRⁱ	P02461
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P02461

EvolutionaryTraceⁱ

P02461

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	30 – 89	VWFCPROSITE-ProRule annotationAdd BLAST		60
Domainⁱ	1232 – 1466	Fibrillar collagen NC1PROSITE-ProRule annotationAdd BLAST		235

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	149 – 167	Nonhelical region (N-terminal)Add BLAST	19
Regionⁱ	168 – 1196	Triple-helical regionAdd BLAST	1029
Regionⁱ	1197 – 1205	Nonhelical region (C-terminal)	9

Domainⁱ

The C-terminal propeptide, also known as COLFI domain, have crucial roles in tissue growth and repair by controlling both the intracellular assembly of procollagen molecules and the extracellular assembly of collagen fibrils. It binds a calcium ion which is essential for its function.

Sequence similaritiesⁱ

Belongs to the fibrillar collagen family.PROSITE-ProRule annotation

Keywords - Domainⁱ

Collagen, Repeat, Signal

Phylogenomic databases

eggNOGⁱ	KOG3544 Eukaryota ENOG410XNMM LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00900000140789
HOVERGENⁱ	HBG004933
InParanoidⁱ	P02461
KEGG Orthology (KO) More...KOⁱ	K19720
OMAⁱ	CRDLKFC
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G03LV
PhylomeDBⁱ	P02461
TreeFamⁱ	TF344135

Family and domain databases

InterProⁱ	View protein in InterPro IPR008160 Collagen IPR000885 Fib_collagen_C IPR001007 VWF_dom
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01410 COLFI, 1 hit PF01391 Collagen, 8 hits PF00093 VWC, 1 hit
ProDomⁱ	View protein in ProDom or Entries sharing at least one domain PD002078 Fib_collagen_C, 1 hit
SMARTⁱ	View protein in SMART SM00038 COLFI, 1 hit SM00214 VWC, 1 hit
PROSITEⁱ	View protein in PROSITE PS51461 NC1_FIB, 1 hit PS01208 VWFC_1, 1 hit PS50184 VWFC_2, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform 1 (identifier: P02461-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMSFVQKGSW LLLALLHPTI ILAQQEAVEG GCSHLGQSYA DRDVWKPEPC 
        60         70         80         90        100
QICVCDSGSV LCDDIICDDQ ELDCPNPEIP FGECCAVCPQ PPTAPTRPPN 
       110        120        130        140        150
GQGPQGPKGD PGPPGIPGRN GDPGIPGQPG SPGSPGPPGI CESCPTGPQN 
       160        170        180        190        200
YSPQYDSYDV KSGVAVGGLA GYPGPAGPPG PPGPPGTSGH PGSPGSPGYQ 
       210        220        230        240        250
GPPGEPGQAG PSGPPGPPGA IGPSGPAGKD GESGRPGRPG ERGLPGPPGI 
       260        270        280        290        300
KGPAGIPGFP GMKGHRGFDG RNGEKGETGA PGLKGENGLP GENGAPGPMG 
       310        320        330        340        350
PRGAPGERGR PGLPGAAGAR GNDGARGSDG QPGPPGPPGT AGFPGSPGAK 
       360        370        380        390        400
GEVGPAGSPG SNGAPGQRGE PGPQGHAGAQ GPPGPPGING SPGGKGEMGP 
       410        420        430        440        450
AGIPGAPGLM GARGPPGPAG ANGAPGLRGG AGEPGKNGAK GEPGPRGERG 
       460        470        480        490        500
EAGIPGVPGA KGEDGKDGSP GEPGANGLPG AAGERGAPGF RGPAGPNGIP 
       510        520        530        540        550
GEKGPAGERG APGPAGPRGA AGEPGRDGVP GGPGMRGMPG SPGGPGSDGK 
       560        570        580        590        600
PGPPGSQGES GRPGPPGPSG PRGQPGVMGF PGPKGNDGAP GKNGERGGPG 
       610        620        630        640        650
GPGPQGPPGK NGETGPQGPP GPTGPGGDKG DTGPPGPQGL QGLPGTGGPP 
       660        670        680        690        700
GENGKPGEPG PKGDAGAPGA PGGKGDAGAP GERGPPGLAG APGLRGGAGP 
       710        720        730        740        750
PGPEGGKGAA GPPGPPGAAG TPGLQGMPGE RGGLGSPGPK GDKGEPGGPG 
       760        770        780        790        800
ADGVPGKDGP RGPTGPIGPP GPAGQPGDKG EGGAPGLPGI AGPRGSPGER 
       810        820        830        840        850
GETGPPGPAG FPGAPGQNGE PGGKGERGAP GEKGEGGPPG VAGPPGGSGP 
       860        870        880        890        900
AGPPGPQGVK GERGSPGGPG AAGFPGARGL PGPPGSNGNP GPPGPSGSPG 
       910        920        930        940        950
KDGPPGPAGN TGAPGSPGVS GPKGDAGQPG EKGSPGAQGP PGAPGPLGIA 
       960        970        980        990       1000
GITGARGLAG PPGMPGPRGS PGPQGVKGES GKPGANGLSG ERGPPGPQGL 
      1010       1020       1030       1040       1050
PGLAGTAGEP GRDGNPGSDG LPGRDGSPGG KGDRGENGSP GAPGAPGHPG 
      1060       1070       1080       1090       1100
PPGPVGPAGK SGDRGESGPA GPAGAPGPAG SRGAPGPQGP RGDKGETGER 
      1110       1120       1130       1140       1150
GAAGIKGHRG FPGNPGAPGS PGPAGQQGAI GSPGPAGPRG PVGPSGPPGK 
      1160       1170       1180       1190       1200
DGTSGHPGPI GPPGPRGNRG ERGSEGSPGH PGQPGPPGPP GAPGPCCGGV 
      1210       1220       1230       1240       1250
GAAAIAGIGG EKAGGFAPYY GDEPMDFKIN TDEIMTSLKS VNGQIESLIS 
      1260       1270       1280       1290       1300
PDGSRKNPAR NCRDLKFCHP ELKSGEYWVD PNQGCKLDAI KVFCNMETGE 
      1310       1320       1330       1340       1350
TCISANPLNV PRKHWWTDSS AEKKHVWFGE SMDGGFQFSY GNPELPEDVL 
      1360       1370       1380       1390       1400
DVHLAFLRLL SSRASQNITY HCKNSIAYMD QASGNVKKAL KLMGSNEGEF 
      1410       1420       1430       1440       1450
KAEGNSKFTY TVLEDGCTKH TGEWSKTVFE YRTRKAVRLP IVDIAPYDIG 
      1460 
GPDQEFGVDV GPVCFL

Length:1,466

Mass (Da):138,564

Last modified:January 23, 2007 - v4

Checksum:ⁱB904B4E05E17D339

Isoform 2 (identifier: P02461-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
847-1149: Missing.

« Hide

        10         20         30         40         50
MMSFVQKGSW LLLALLHPTI ILAQQEAVEG GCSHLGQSYA DRDVWKPEPC 
        60         70         80         90        100
QICVCDSGSV LCDDIICDDQ ELDCPNPEIP FGECCAVCPQ PPTAPTRPPN 
       110        120        130        140        150
GQGPQGPKGD PGPPGIPGRN GDPGIPGQPG SPGSPGPPGI CESCPTGPQN 
       160        170        180        190        200
YSPQYDSYDV KSGVAVGGLA GYPGPAGPPG PPGPPGTSGH PGSPGSPGYQ 
       210        220        230        240        250
GPPGEPGQAG PSGPPGPPGA IGPSGPAGKD GESGRPGRPG ERGLPGPPGI 
       260        270        280        290        300
KGPAGIPGFP GMKGHRGFDG RNGEKGETGA PGLKGENGLP GENGAPGPMG 
       310        320        330        340        350
PRGAPGERGR PGLPGAAGAR GNDGARGSDG QPGPPGPPGT AGFPGSPGAK 
       360        370        380        390        400
GEVGPAGSPG SNGAPGQRGE PGPQGHAGAQ GPPGPPGING SPGGKGEMGP 
       410        420        430        440        450
AGIPGAPGLM GARGPPGPAG ANGAPGLRGG AGEPGKNGAK GEPGPRGERG 
       460        470        480        490        500
EAGIPGVPGA KGEDGKDGSP GEPGANGLPG AAGERGAPGF RGPAGPNGIP 
       510        520        530        540        550
GEKGPAGERG APGPAGPRGA AGEPGRDGVP GGPGMRGMPG SPGGPGSDGK 
       560        570        580        590        600
PGPPGSQGES GRPGPPGPSG PRGQPGVMGF PGPKGNDGAP GKNGERGGPG 
       610        620        630        640        650
GPGPQGPPGK NGETGPQGPP GPTGPGGDKG DTGPPGPQGL QGLPGTGGPP 
       660        670        680        690        700
GENGKPGEPG PKGDAGAPGA PGGKGDAGAP GERGPPGLAG APGLRGGAGP 
       710        720        730        740        750
PGPEGGKGAA GPPGPPGAAG TPGLQGMPGE RGGLGSPGPK GDKGEPGGPG 
       760        770        780        790        800
ADGVPGKDGP RGPTGPIGPP GPAGQPGDKG EGGAPGLPGI AGPRGSPGER 
       810        820        830        840        850
GETGPPGPAG FPGAPGQNGE PGGKGERGAP GEKGEGGPPG VAGPPGKDGT 
       860        870        880        890        900
SGHPGPIGPP GPRGNRGERG SEGSPGHPGQ PGPPGPPGAP GPCCGGVGAA 
       910        920        930        940        950
AIAGIGGEKA GGFAPYYGDE PMDFKINTDE IMTSLKSVNG QIESLISPDG 
       960        970        980        990       1000
SRKNPARNCR DLKFCHPELK SGEYWVDPNQ GCKLDAIKVF CNMETGETCI 
      1010       1020       1030       1040       1050
SANPLNVPRK HWWTDSSAEK KHVWFGESMD GGFQFSYGNP ELPEDVLDVH 
      1060       1070       1080       1090       1100
LAFLRLLSSR ASQNITYHCK NSIAYMDQAS GNVKKALKLM GSNEGEFKAE 
      1110       1120       1130       1140       1150
GNSKFTYTVL EDGCTKHTGE WSKTVFEYRT RKAVRLPIVD IAPYDIGGPD 
      1160 
QEFGVDVGPV CFL

Note: No experimental confirmation available.

Show »

Length:1,163

Mass (Da):111,907

Checksum:ⁱBE06E5CA84FBB829

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	H7C435	H7C435_HUMAN		Collagen alpha-1(III) chain Collagen alpha-1(III) chain	COL3A1	90	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	163	G → GG in CAA33387 (PubMed:2780304).Curated	1
Sequence conflictⁱ	168	G → V AA sequence (PubMed:557335).Curated	1
Sequence conflictⁱ	226 – 228	Missing AA sequence (PubMed:557335).Curated	3
Sequence conflictⁱ	241	E → D in CAA33387 (PubMed:2780304).Curated	1
Sequence conflictⁱ	278	T → A AA sequence (PubMed:557335).Curated	1
Sequence conflictⁱ	293 – 295	NGA → DGS AA sequence (PubMed:557335).Curated	3
Sequence conflictⁱ	401	A → L AA sequence (PubMed:7864881).Curated	1
Sequence conflictⁱ	409	L → P AA sequence (PubMed:7864881).Curated	1
Sequence conflictⁱ	472	E → D in CAA33387 (PubMed:2780304).Curated	1
Sequence conflictⁱ	488 – 490	PGF → LGS in CAA33387 (PubMed:2780304).Curated	3
Sequence conflictⁱ	589	A → E AA sequence (PubMed:7864881).Curated	1
Sequence conflictⁱ	614	T → Y in CAA33387 (PubMed:2780304).Curated	1
Sequence conflictⁱ	635	P → R in CAA33387 (PubMed:2780304).Curated	1
Sequence conflictⁱ	664	D → E in CAA33387 (PubMed:2780304).Curated	1
Sequence conflictⁱ	676	D → N AA sequence (PubMed:687591).Curated	1
Sequence conflictⁱ	803	T → P AA sequence (PubMed:7864881).Curated	1
Sequence conflictⁱ	896	S → A AA sequence (PubMed:6246925).Curated	1
Sequence conflictⁱ	980	S → A AA sequence (PubMed:7016180).Curated	1
Sequence conflictⁱ	985 – 989	ANGLS → PSGQN AA sequence (PubMed:7016180).Curated	5
Sequence conflictⁱ	1019	D → Y in CAA29886 (PubMed:3357782).Curated	1
Sequence conflictⁱ	1067	S → P AA sequence (PubMed:7864881).Curated	1
Sequence conflictⁱ	1070	A → P AA sequence (PubMed:7864881).Curated	1
Sequence conflictⁱ	1097	T → P AA sequence (PubMed:7016180).Curated	1
Sequence conflictⁱ	1153 – 1154	TS → AT AA sequence (PubMed:7016180).Curated	2
Sequence conflictⁱ	1156	H → S AA sequence (PubMed:7016180).Curated	1
Sequence conflictⁱ	1184	P → S in CAA33387 (PubMed:2780304).Curated	1
Sequence conflictⁱ	1203	A → P in CAA33387 (PubMed:2780304).Curated	1
Sequence conflictⁱ	1210	G → A in CAA33387 (PubMed:2780304).Curated	1
Sequence conflictⁱ	1222	D → P in AAA52002 (PubMed:2579949).Curated	1
Sequence conflictⁱ	1235	M → I in AAA52002 (PubMed:2579949).Curated	1
Sequence conflictⁱ	1241	V → A in CAA29886 (PubMed:3357782).Curated	1
Sequence conflictⁱ	1241	V → A in CAA25879 (PubMed:6096827).Curated	1
Sequence conflictⁱ	1274	S → T in AAA52002 (PubMed:2579949).Curated	1
Sequence conflictⁱ	1332	M → I in AAA52002 (PubMed:2579949).Curated	1
Sequence conflictⁱ	1357	L → P in AAA52002 (PubMed:2579949).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_001767	169	L → F. Corresponds to variant dbSNP:rs111391222EnsemblClinVar.	1
Natural variantⁱVAR_001768	183	G → C in EDSVASC. 2 PublicationsCorresponds to variant dbSNP:rs121912926EnsemblClinVar.	1
Natural variantⁱVAR_011095	183	G → D in EDSVASC. Corresponds to variant dbSNP:rs587779420EnsemblClinVar.	1
Natural variantⁱVAR_011096	183	G → S in EDSVASC. Corresponds to variant dbSNP:rs121912926EnsemblClinVar.	1
Natural variantⁱVAR_011097	192	G → V in EDSVASC. Corresponds to variant dbSNP:rs587779710EnsemblClinVar.	1
Natural variantⁱVAR_001769	201	G → R in EDSVASC. 2 PublicationsCorresponds to variant dbSNP:rs587779436EnsemblClinVar.	1
Natural variantⁱVAR_011098	204	G → D in EDSVASC. 1 PublicationCorresponds to variant dbSNP:rs587779626EnsemblClinVar.	1
Natural variantⁱVAR_011099	204	G → S in EDSVASC. Corresponds to variant dbSNP:rs587779711EnsemblClinVar.	1
Natural variantⁱVAR_011100	210	G → D in EDSVASC. 1 Publication	1
Natural variantⁱVAR_011101	219	G → C in EDSVASC. Corresponds to variant dbSNP:rs587779624EnsemblClinVar.	1
Natural variantⁱVAR_011102	225	G → V in EDSVASC. Corresponds to variant dbSNP:rs587779533EnsemblClinVar.	1
Natural variantⁱVAR_001770	228	G → E in EDSVASC. 2 PublicationsCorresponds to variant dbSNP:rs587779555EnsemblClinVar.	1
Natural variantⁱVAR_011103	240	G → R in EDSVASC. Corresponds to variant dbSNP:rs587779468EnsemblClinVar.	1
Natural variantⁱVAR_011104	243	G → V in EDSVASC. Corresponds to variant dbSNP:rs587779629EnsemblClinVar.	1
Natural variantⁱVAR_011105	249	G → D in EDSVASC. Corresponds to variant dbSNP:rs121912927EnsemblClinVar.	1
Natural variantⁱVAR_011106	249	G → V in EDSVASC. Corresponds to variant dbSNP:rs121912927EnsemblClinVar.	1
Natural variantⁱVAR_011107	252	G → D in EDSVASC. Corresponds to variant dbSNP:rs587779464EnsemblClinVar.	1
Natural variantⁱVAR_011108	252	G → R in EDSVASC. Corresponds to variant dbSNP:rs587779705EnsemblClinVar.	1
Natural variantⁱVAR_011109	252	G → V in EDSVASC. Corresponds to variant dbSNP:rs587779464EnsemblClinVar.	1
Natural variantⁱVAR_011110	255	G → V in EDSVASC. Corresponds to variant dbSNP:rs587779605EnsemblClinVar.	1
Natural variantⁱVAR_011111	264	G → R in EDSVASC. 1 Publication	1
Natural variantⁱVAR_011112	267	G → V in EDSVASC. Corresponds to variant dbSNP:rs587779427EnsemblClinVar.	1
Natural variantⁱVAR_037007	297	G → R in EDSVASC. 1 Publication	1
Natural variantⁱVAR_001771	303	G → R in EDSVASC. 1 PublicationCorresponds to variant dbSNP:rs121912919EnsemblClinVar.	1
Natural variantⁱVAR_011113	321	G → V in EDSVASC. Corresponds to variant dbSNP:rs587779588EnsemblClinVar.	1
Natural variantⁱVAR_011114	327	G → D in EDSVASC. 1 Publication	1
Natural variantⁱVAR_011115	345	G → R in EDSVASC. Corresponds to variant dbSNP:rs587779419EnsemblClinVar.	1
Natural variantⁱVAR_011116	417	G → R in EDSVASC. Corresponds to variant dbSNP:rs587779637EnsemblClinVar.	1
Natural variantⁱVAR_035738	420	G → S in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs587779692EnsemblClinVar.	1
Natural variantⁱVAR_011117	444	G → R in EDSVASC. Corresponds to variant dbSNP:rs587779489EnsemblClinVar.	1
Natural variantⁱVAR_011118	489	G → E in EDSVASC. Corresponds to variant dbSNP:rs587779476EnsemblClinVar.	1
Natural variantⁱVAR_011119	501	G → R in EDSVASC. Corresponds to variant dbSNP:rs587779523EnsemblClinVar.	1
Natural variantⁱVAR_011120	519	G → V in EDSVASC.	1
Natural variantⁱVAR_055665	534	G → E. Corresponds to variant dbSNP:rs41263744Ensembl.	1
Natural variantⁱVAR_001772	540	G → R in EDSVASC. 2 PublicationsCorresponds to variant dbSNP:rs587779584EnsemblClinVar.	1
Natural variantⁱVAR_011121	549	G → E in EDSVASC. Corresponds to variant dbSNP:rs587779679EnsemblClinVar.	1
Natural variantⁱVAR_011122	552	G → E in EDSVASC. Corresponds to variant dbSNP:rs121912928EnsemblClinVar.	1
Natural variantⁱVAR_001773	567	G → E in EDSVASC. 1 Publication	1
Natural variantⁱVAR_001774	582	G → S in EDSVASC. 1 PublicationCorresponds to variant dbSNP:rs121912923EnsemblClinVar.	1
Natural variantⁱVAR_011123	588	G → D in EDSVASC. Corresponds to variant dbSNP:rs587779691EnsemblClinVar.	1
Natural variantⁱVAR_001775	602	P → T1 PublicationCorresponds to variant dbSNP:rs35795890EnsemblClinVar.	1
Natural variantⁱVAR_001776	635	P → L1 Publication	1
Natural variantⁱVAR_011124	636	G → R in EDSVASC. Corresponds to variant dbSNP:rs587779522EnsemblClinVar.	1
Natural variantⁱVAR_011125	657	G → E in EDSVASC. Corresponds to variant dbSNP:rs587779699EnsemblClinVar.	1
Natural variantⁱVAR_011126	660	G → D in EDSVASC. Corresponds to variant dbSNP:rs587779493EnsemblClinVar.	1
Natural variantⁱVAR_001777	666	G → D in EDSVASC. 1 PublicationCorresponds to variant dbSNP:rs121912921EnsemblClinVar.	1
Natural variantⁱVAR_011127	668	P → T1 PublicationCorresponds to variant dbSNP:rs1801183EnsemblClinVar.	1
Natural variantⁱVAR_055666	679	A → T1 PublicationCorresponds to variant dbSNP:rs41263773EnsemblClinVar.	1
Natural variantⁱVAR_055667	686	P → A. Corresponds to variant dbSNP:rs41263775EnsemblClinVar.	1
Natural variantⁱVAR_001778	698	A → T2 PublicationsCorresponds to variant dbSNP:rs1800255EnsemblClinVar.	1
Natural variantⁱVAR_011128	699	G → R in EDSVASC. Corresponds to variant dbSNP:rs587779668EnsemblClinVar.	1
Natural variantⁱVAR_001779	726	G → R in EDSVASC. 2 PublicationsCorresponds to variant dbSNP:rs587779638EnsemblClinVar.	1
Natural variantⁱVAR_011129	738	G → S in EDSVASC. Corresponds to variant dbSNP:rs121912925EnsemblClinVar.	1
Natural variantⁱVAR_011130	738	G → V in EDSVASC. Corresponds to variant dbSNP:rs587779615EnsemblClinVar.	1
Natural variantⁱVAR_011131	744	G → V in EDSVASC. Corresponds to variant dbSNP:rs587779697EnsemblClinVar.	1
Natural variantⁱVAR_001780	756	G → E in EDSVASC. 1 Publication	1
Natural variantⁱVAR_001781	762	G → C in EDSVASC. 1 Publication	1
Natural variantⁱVAR_001782	786	G → R in EDSVASC. 1 PublicationCorresponds to variant dbSNP:rs113485686EnsemblClinVar.	1
Natural variantⁱVAR_001783	804	G → S in EDSVASC. 1 PublicationCorresponds to variant dbSNP:rs121912920EnsemblClinVar.	1
Natural variantⁱVAR_001784	828	G → R in EDSVASC. 1 Publication	1
Natural variantⁱVAR_011132	828	G → W in EDSVASC. Corresponds to variant dbSNP:rs587779486EnsemblClinVar.	1
Natural variantⁱVAR_037008	830 – 838	Missing in EDSVASC. 1 Publication	9
Natural variantⁱVAR_011133	852	G → C in EDSVASC. Corresponds to variant dbSNP:rs587779690EnsemblClinVar.	1
Natural variantⁱVAR_011134	879	G → V in EDSVASC. Corresponds to variant dbSNP:rs587779645EnsemblClinVar.	1
Natural variantⁱVAR_011135	882	G → D in EDSVASC. Corresponds to variant dbSNP:rs587779622EnsemblClinVar.	1
Natural variantⁱVAR_011136	900	G → D in EDSVASC. Corresponds to variant dbSNP:rs587779599EnsemblClinVar.	1
Natural variantⁱVAR_011137	903	G → E in EDSVASC. Corresponds to variant dbSNP:rs587779505EnsemblClinVar.	1
Natural variantⁱVAR_001785	909	G → D in EDSVASC. 1 Publication	1
Natural variantⁱVAR_011138	909	G → V in EDSVASC. Corresponds to variant dbSNP:rs587779483EnsemblClinVar.	1
Natural variantⁱVAR_011139	918	G → E in EDSVASC. Corresponds to variant dbSNP:rs587779662EnsemblClinVar.	1
Natural variantⁱVAR_011140	924	G → C in EDSVASC. Corresponds to variant dbSNP:rs587779471EnsemblClinVar.	1
Natural variantⁱVAR_001786	936	G → R in EDSVASC. 2 PublicationsCorresponds to variant dbSNP:rs587779566EnsemblClinVar.	1
Natural variantⁱVAR_001787	936	G → S in EDSVASC.	1
Natural variantⁱVAR_001788	939	G → D in EDSVASC. 1 Publication

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UniProtKB - P02461 (CO3A1_HUMAN)

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Collagen alpha-1(III) chain

COL3A1

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3D structure databases

Miscellaneous databases

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