UniProtKB - P02407 (RS17A_YEAST)
Protein
40S ribosomal protein S17-A
Gene
RPS17A
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.1 Publication
Miscellaneous
Present with 30900 molecules/cell in log phase SD medium.1 Publication
There are 2 genes for eS17 in yeast.Curated
GO - Molecular functioni
- structural constituent of ribosome Source: SGD
GO - Biological processi
- cytoplasmic translation Source: SGD
- ribosomal small subunit assembly Source: SGD
Keywordsi
Molecular function | Ribonucleoprotein, Ribosomal protein |
Enzyme and pathway databases
Reactomei | R-SCE-156827, L13a-mediated translational silencing of Ceruloplasmin expression R-SCE-1799339, SRP-dependent cotranslational protein targeting to membrane R-SCE-72689, Formation of a pool of free 40S subunits R-SCE-72695, Formation of the ternary complex, and subsequently, the 43S complex R-SCE-72702, Ribosomal scanning and start codon recognition R-SCE-72706, GTP hydrolysis and joining of the 60S ribosomal subunit R-SCE-975956, Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-SCE-975957, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
Names & Taxonomyi
Protein namesi | Recommended name: 40S ribosomal protein S17-A1 PublicationAlternative name(s): RP51A Small ribosomal subunit protein eS17-A1 Publication |
Gene namesi | Ordered Locus Names:YML024W |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
EuPathDBi | FungiDB:YML024W |
SGDi | S000004486, RPS17A |
Subcellular locationi
Other locations
- Cytoplasm 2 Publications
Cytosol
- cytosolic small ribosomal subunit Source: SGD
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000141546 | 1 – 136 | 40S ribosomal protein S17-AAdd BLAST | 136 |
Proteomic databases
MaxQBi | P02407 |
PaxDbi | P02407 |
PRIDEi | P02407 |
PTM databases
iPTMneti | P02407 |
Interactioni
Subunit structurei
Component of the small ribosomal subunit (SSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:9559554, PubMed:22096102).
1 Publication1 PublicationProtein-protein interaction databases
BioGRIDi | 35145, 123 interactors |
IntActi | P02407, 63 interactors |
MINTi | P02407 |
STRINGi | 4932.YML024W |
Miscellaneous databases
RNActi | P02407, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P02407 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the eukaryotic ribosomal protein eS17 family.Curated
Phylogenomic databases
eggNOGi | KOG0187, Eukaryota |
GeneTreei | ENSGT00390000006548 |
HOGENOMi | CLU_112958_0_1_1 |
InParanoidi | P02407 |
OMAi | FITHMMK |
Family and domain databases
Gene3Di | 1.10.60.20, 1 hit |
HAMAPi | MF_00511, Ribosomal_S17e, 1 hit |
InterProi | View protein in InterPro IPR001210, Ribosomal_S17e IPR018273, Ribosomal_S17e_CS IPR036401, RPS17e-like_sf |
PANTHERi | PTHR10732, PTHR10732, 1 hit |
Pfami | View protein in Pfam PF00833, Ribosomal_S17e, 1 hit |
SUPFAMi | SSF116820, SSF116820, 1 hit |
PROSITEi | View protein in PROSITE PS00712, RIBOSOMAL_S17E, 1 hit |
i Sequence
Sequence statusi: Complete.
P02407-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGRVRTKTVK RASKALIERY YPKLTLDFQT NKRLCDEIAT IQSKRLRNKI
60 70 80 90 100
AGYTTHLMKR IQKGPVRGIS FKLQEEERER KDQYVPEVSA LDLSRSNGVL
110 120 130
NVDNQTSDLV KSLGLKLPLS VINVSAQRDR RYRKRV
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J01349 Genomic DNA Translation: AAA88733.1 Z46659 Genomic DNA Translation: CAA86631.1 BK006946 Genomic DNA Translation: DAA09874.1 |
PIRi | A02784, R5BY51 |
RefSeqi | NP_013688.1, NM_001182382.1 |
Genome annotation databases
EnsemblFungii | YML024W_mRNA; YML024W; YML024W |
GeneIDi | 854984 |
KEGGi | sce:YML024W |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J01349 Genomic DNA Translation: AAA88733.1 Z46659 Genomic DNA Translation: CAA86631.1 BK006946 Genomic DNA Translation: DAA09874.1 |
PIRi | A02784, R5BY51 |
RefSeqi | NP_013688.1, NM_001182382.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3J6X | electron microscopy | 6.10 | 17 | 1-136 | [»] | |
3J6Y | electron microscopy | 6.10 | 17 | 1-136 | [»] | |
3J77 | electron microscopy | 6.20 | 17 | 1-136 | [»] | |
3J78 | electron microscopy | 6.30 | 17 | 1-136 | [»] | |
4U3M | X-ray | 3.00 | C7/c7 | 1-136 | [»] | |
4U3N | X-ray | 3.20 | C7/c7 | 1-136 | [»] | |
4U3U | X-ray | 2.90 | C7/c7 | 1-136 | [»] | |
4U4N | X-ray | 3.10 | C7/c7 | 1-136 | [»] | |
4U4O | X-ray | 3.60 | C7/c7 | 1-136 | [»] | |
4U4Q | X-ray | 3.00 | C7/c7 | 1-136 | [»] | |
4U4R | X-ray | 2.80 | C7/c7 | 1-136 | [»] | |
4U4U | X-ray | 3.00 | C7/c7 | 1-136 | [»] | |
4U4Y | X-ray | 3.20 | C7/c7 | 1-136 | [»] | |
4U4Z | X-ray | 3.10 | C7/c7 | 1-136 | [»] | |
4U50 | X-ray | 3.20 | C7/c7 | 1-136 | [»] | |
4U51 | X-ray | 3.20 | C7/c7 | 1-136 | [»] | |
4U52 | X-ray | 3.00 | C7/c7 | 1-136 | [»] | |
4U53 | X-ray | 3.30 | C7/c7 | 1-136 | [»] | |
4U55 | X-ray | 3.20 | C7/c7 | 1-136 | [»] | |
4U56 | X-ray | 3.45 | C7/c7 | 1-136 | [»] | |
4U6F | X-ray | 3.10 | C7/c7 | 1-136 | [»] | |
4V6I | electron microscopy | 8.80 | AQ | 1-136 | [»] | |
4V7R | X-ray | 4.00 | AK/CK | 1-136 | [»] | |
4V88 | X-ray | 3.00 | AR/CR | 1-136 | [»] | |
4V8Y | electron microscopy | 4.30 | AR | 1-136 | [»] | |
4V8Z | electron microscopy | 6.60 | AR | 1-136 | [»] | |
4V92 | electron microscopy | 3.70 | R | 2-125 | [»] | |
5DAT | X-ray | 3.15 | C7/c7 | 1-136 | [»] | |
5DC3 | X-ray | 3.25 | C7/c7 | 1-136 | [»] | |
5DGE | X-ray | 3.45 | C7/c7 | 1-136 | [»] | |
5DGF | X-ray | 3.30 | C7/c7 | 1-136 | [»] | |
5DGV | X-ray | 3.10 | C7/c7 | 1-136 | [»] | |
5FCI | X-ray | 3.40 | C7/c7 | 1-136 | [»] | |
5FCJ | X-ray | 3.10 | C7/c7 | 1-136 | [»] | |
5I4L | X-ray | 3.10 | C7/c7 | 1-136 | [»] | |
5JUO | electron microscopy | 4.00 | OB | 1-136 | [»] | |
5JUP | electron microscopy | 3.50 | OB | 1-136 | [»] | |
5JUS | electron microscopy | 4.20 | OB | 1-136 | [»] | |
5JUT | electron microscopy | 4.00 | OB | 1-136 | [»] | |
5JUU | electron microscopy | 4.00 | OB | 1-136 | [»] | |
5LYB | X-ray | 3.25 | C7/c7 | 2-126 | [»] | |
5MEI | X-ray | 3.50 | c7 | 2-122 | [»] | |
5NDG | X-ray | 3.70 | C7/c7 | 1-136 | [»] | |
5NDV | X-ray | 3.30 | C7/c7 | 1-136 | [»] | |
5NDW | X-ray | 3.70 | C7/c7 | 1-136 | [»] | |
5OBM | X-ray | 3.40 | C7/c7 | 1-136 | [»] | |
5ON6 | X-ray | 3.10 | S/c7 | 2-126 | [»] | |
5TBW | X-ray | 3.00 | S | 2-126 | [»] | |
c7 | 2-122 | [»] | ||||
6EML | electron microscopy | 3.60 | C | 1-136 | [»] | |
6FAI | electron microscopy | 3.40 | R | 1-136 | [»] | |
6HHQ | X-ray | 3.10 | S/c7 | 1-136 | [»] | |
6I7O | electron microscopy | 5.30 | G/Gb | 2-126 | [»] | |
6Q8Y | electron microscopy | 3.10 | G | 2-126 | [»] | |
6RBD | electron microscopy | 3.47 | R | 1-136 | [»] | |
6RBE | electron microscopy | 3.80 | R | 1-136 | [»] | |
6S47 | electron microscopy | 3.28 | BS | 2-136 | [»] | |
6T4Q | electron microscopy | 2.60 | SR | 2-126 | [»] | |
6Y7C | electron microscopy | 3.80 | R | 1-136 | [»] | |
6Z6J | electron microscopy | 3.40 | SR | 1-136 | [»] | |
6Z6K | electron microscopy | 3.40 | SR | 1-136 | [»] | |
6ZVI | electron microscopy | 3.00 | z | 2-126 | [»] | |
SMRi | P02407 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 35145, 123 interactors |
IntActi | P02407, 63 interactors |
MINTi | P02407 |
STRINGi | 4932.YML024W |
PTM databases
iPTMneti | P02407 |
Proteomic databases
MaxQBi | P02407 |
PaxDbi | P02407 |
PRIDEi | P02407 |
Genome annotation databases
EnsemblFungii | YML024W_mRNA; YML024W; YML024W |
GeneIDi | 854984 |
KEGGi | sce:YML024W |
Organism-specific databases
EuPathDBi | FungiDB:YML024W |
SGDi | S000004486, RPS17A |
Phylogenomic databases
eggNOGi | KOG0187, Eukaryota |
GeneTreei | ENSGT00390000006548 |
HOGENOMi | CLU_112958_0_1_1 |
InParanoidi | P02407 |
OMAi | FITHMMK |
Enzyme and pathway databases
Reactomei | R-SCE-156827, L13a-mediated translational silencing of Ceruloplasmin expression R-SCE-1799339, SRP-dependent cotranslational protein targeting to membrane R-SCE-72689, Formation of a pool of free 40S subunits R-SCE-72695, Formation of the ternary complex, and subsequently, the 43S complex R-SCE-72702, Ribosomal scanning and start codon recognition R-SCE-72706, GTP hydrolysis and joining of the 60S ribosomal subunit R-SCE-975956, Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-SCE-975957, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
Miscellaneous databases
PROi | PR:P02407 |
RNActi | P02407, protein |
Family and domain databases
Gene3Di | 1.10.60.20, 1 hit |
HAMAPi | MF_00511, Ribosomal_S17e, 1 hit |
InterProi | View protein in InterPro IPR001210, Ribosomal_S17e IPR018273, Ribosomal_S17e_CS IPR036401, RPS17e-like_sf |
PANTHERi | PTHR10732, PTHR10732, 1 hit |
Pfami | View protein in Pfam PF00833, Ribosomal_S17e, 1 hit |
SUPFAMi | SSF116820, SSF116820, 1 hit |
PROSITEi | View protein in PROSITE PS00712, RIBOSOMAL_S17E, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RS17A_YEAST | |
Accessioni | P02407Primary (citable) accession number: P02407 Secondary accession number(s): D6VZF0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 21, 1986 |
Last sequence update: | July 21, 1986 | |
Last modified: | December 2, 2020 | |
This is version 177 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Yeast chromosome XIII
Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Ribosomal proteins
Ribosomal proteins families and list of entries