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Entry version 189 (08 May 2019)
Sequence version 4 (23 Jan 2007)
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Protein

Histone H3

Gene

His3

more
Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-1266695 Interleukin-7 signaling
R-DME-212300 PRC2 methylates histones and DNA
R-DME-2559580 Oxidative Stress Induced Senescence
R-DME-2559582 Senescence-Associated Secretory Phenotype (SASP)
R-DME-3214847 HATs acetylate histones
R-DME-3247509 Chromatin modifying enzymes
R-DME-427359 SIRT1 negatively regulates rRNA expression
R-DME-5578749 Transcriptional regulation by small RNAs
R-DME-5625886 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
R-DME-73772 RNA Polymerase I Promoter Escape
R-DME-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
R-DME-9018519 Estrogen-dependent gene expression
R-DME-983231 Factors involved in megakaryocyte development and platelet production

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Histone H3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:His3
AND
ORF Names:CG31613
AND
ORF Names:CG33803
AND
ORF Names:CG33806
AND
ORF Names:CG33809
AND
ORF Names:CG33812
AND
ORF Names:CG33815
AND
ORF Names:CG33818
AND
ORF Names:CG33821
AND
ORF Names:CG33824
AND
ORF Names:CG33827
AND
ORF Names:CG33830
AND
ORF Names:CG33833
AND
ORF Names:CG33836
AND
ORF Names:CG33839
AND
ORF Names:CG33842
AND
ORF Names:CG33845
AND
ORF Names:CG33848
AND
ORF Names:CG33851
AND
ORF Names:CG33854
AND
ORF Names:CG33857
AND
ORF Names:CG33860
AND
ORF Names:CG33863
AND
ORF Names:CG33866
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2L

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0001199 His3
FBgn0051613 His3:CG31613
FBgn0053803 His3:CG33803
FBgn0053806 His3:CG33806
FBgn0053809 His3:CG33809
FBgn0053812 His3:CG33812
FBgn0053815 His3:CG33815
FBgn0053818 His3:CG33818
FBgn0053821 His3:CG33821
FBgn0053824 His3:CG33824
FBgn0053827 His3:CG33827
FBgn0053830 His3:CG33830
FBgn0053833 His3:CG33833
FBgn0053836 His3:CG33836
FBgn0053839 His3:CG33839
FBgn0053842 His3:CG33842
FBgn0053845 His3:CG33845
FBgn0053848 His3:CG33848
FBgn0053851 His3:CG33851
FBgn0053854 His3:CG33854
FBgn0053857 His3:CG33857
FBgn0053860 His3:CG33860
FBgn0053863 His3:CG33863
FBgn0053866 His3:CG33866

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleosome core, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCurated
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002213002 – 136Histone H3Add BLAST135

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei5N6,N6,N6-trimethyllysine; alternate2 Publications1
Modified residuei5N6,N6-dimethyllysine; alternate2 Publications1
Modified residuei5N6-methyllysine; alternate2 Publications1
Modified residuei10N6,N6-dimethyllysine; alternate1 Publication1
Modified residuei10N6-acetyllysine; alternate3 Publications1
Modified residuei10N6-methyllysine; alternate1 Publication1
Modified residuei11Phosphoserine5 Publications1
Modified residuei15N6,N6-dimethyllysine; alternate1 Publication1
Modified residuei15N6-acetyllysine; alternate4 Publications1
Modified residuei15N6-methyllysine; alternate1 Publication1
Modified residuei19N6-acetyllysine1 Publication1
Modified residuei24N6-acetyllysine1 Publication1
Modified residuei28N6,N6,N6-trimethyllysine; alternate1 Publication1
Modified residuei28N6,N6-dimethyllysine; alternate1 Publication1
Modified residuei28N6-methyllysine; alternate1 Publication1
Modified residuei37N6,N6-dimethyllysine; alternate1 Publication1
Modified residuei37N6-methyllysine; alternate1 Publication1
Modified residuei38N6,N6-dimethyllysine; alternate1 Publication1
Modified residuei38N6-methyllysine; alternate1 Publication1
Modified residuei57N6-succinyllysine1 Publication1
Modified residuei80N6,N6-dimethyllysine; alternate3 Publications1
Modified residuei80N6-methyllysine; alternate3 Publications1
Modified residuei80N6-succinyllysine; alternate1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation at Ser-11 by ial/aurora-B during mitosis and meiosis is crucial for chromosome condensation and cell-cycle progression. Phosphorylation at Ser-11 by JIL-1 during interphase is linked to gene activation and restricts the formation of heterochromatin at inappropriate sites. Phosphorylation at Ser-11 is enriched on male X chromosome compared to the autosome.5 Publications
Acetylation is generally linked to gene activation. Acetylated on Lys-15 during prophase I of meiosis. Phosphorylation of H2A 'Thr-119' is a prerequisite for H3 Lys-15 acetylation. Acetylation on Lys-15 is enriched on male X chromosome compared to the autosome.5 Publications
Methylation at Lys-5 or Lys-80 is generally associated with active chromatin. Methylation at Lys-80 by gpp occurs at low levels in specific developmental stages and tissues undergoing active cell division, and at highest levels in epidermal cells undergoing differentiation.3 Publications

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P02299

PRoteomics IDEntifications database

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PRIDEi
P02299

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P02299

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0051613 Expressed in 2 organ(s), highest expression level in adult organism

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P02299 DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
534149, 3 interactors
77140, 72 interactors

Database of interacting proteins

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DIPi
DIP-38722N

Protein interaction database and analysis system

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IntActi
P02299, 19 interactors

Molecular INTeraction database

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MINTi
P02299

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0091112

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1136
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1KNAX-ray2.10P2-17[»]
1KNEX-ray2.40P2-17[»]
2NQBX-ray2.30A/E2-136[»]
2PYOX-ray2.43A/E2-136[»]
2YBAX-ray2.55C/D2-20[»]
4QLCX-ray3.50A/E2-136[»]
4UUZX-ray2.90A1-136[»]
4X23X-ray3.50A/E/K/O41-133[»]
5WCUX-ray5.53A/E/K/O39-136[»]
6ASZX-ray1.52P6-11[»]
6AT0X-ray1.28P6-11[»]

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P02299

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P02299

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni6 – 11Su(var)205 chromodomain-binding6

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the histone H3 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1745 Eukaryota
COG2036 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00950000182715

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P02299

KEGG Orthology (KO)

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KOi
K11253

Identification of Orthologs from Complete Genome Data

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OMAi
CQILANH

Database of Orthologous Groups

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OrthoDBi
1564596at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P02299

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.10.20.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009072 Histone-fold
IPR007125 Histone_H2A/H2B/H3
IPR000164 Histone_H3/CENP-A

The PANTHER Classification System

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PANTHERi
PTHR11426 PTHR11426, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00125 Histone, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00622 HISTONEH3

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00428 H3, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF47113 SSF47113, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00322 HISTONE_H3_1, 1 hit
PS00959 HISTONE_H3_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P02299-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MARTKQTARK STGGKAPRKQ LATKAARKSA PATGGVKKPH RYRPGTVALR
60 70 80 90 100
EIRRYQKSTE LLIRKLPFQR LVREIAQDFK TDLRFQSSAV MALQEASEAY
110 120 130
LVGLFEDTNL CAIHAKRVTI MPKDIQLARR IRGERA
Length:136
Mass (Da):15,388
Last modified:January 23, 2007 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6FD8508EA50A0EEC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti118V → I (PubMed:2536150).Curated1
Sequence conflicti118V → I (Ref. 2) Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X14215 Genomic DNA Translation: CAA32434.1
AB019400 Genomic DNA Translation: BAA93621.1
AE014134 Genomic DNA Translation: AAN11127.1
AE014134 Genomic DNA Translation: AAZ66481.1
AE014134 Genomic DNA Translation: AAZ66485.1
AE014134 Genomic DNA Translation: AAZ66490.1
AE014134 Genomic DNA Translation: AAZ66494.1
AE014134 Genomic DNA Translation: AAZ66499.1
AE014134 Genomic DNA Translation: AAZ66504.1
AE014134 Genomic DNA Translation: AAZ66509.1
AE014134 Genomic DNA Translation: AAZ66514.1
AE014134 Genomic DNA Translation: AAZ66519.1
AE014134 Genomic DNA Translation: AAZ66524.1
AE014134 Genomic DNA Translation: AAZ66529.1
AE014134 Genomic DNA Translation: AAZ66534.1
AE014134 Genomic DNA Translation: AAZ66539.1
AE014134 Genomic DNA Translation: AAZ66544.1
AE014134 Genomic DNA Translation: AAZ66549.1
AE014134 Genomic DNA Translation: AAZ66554.1
AE014134 Genomic DNA Translation: AAZ66559.1
AE014134 Genomic DNA Translation: AAZ66564.1
AE014134 Genomic DNA Translation: AAZ66569.1
AE014134 Genomic DNA Translation: AAZ66574.1
AE014134 Genomic DNA Translation: AAZ66579.1
AE014134 Genomic DNA Translation: AAZ66583.1

Protein sequence database of the Protein Information Resource

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PIRi
A02630
S10097

NCBI Reference Sequences

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RefSeqi
NP_001027285.1, NM_001032114.2
NP_001027289.1, NM_001032118.2
NP_001027294.1, NM_001032123.2
NP_001027298.1, NM_001032127.2
NP_001027303.1, NM_001032132.2
NP_001027308.1, NM_001032137.2
NP_001027313.1, NM_001032142.2
NP_001027318.1, NM_001032147.2
NP_001027323.1, NM_001032152.2
NP_001027328.1, NM_001032157.2
NP_001027333.1, NM_001032162.2
NP_001027338.1, NM_001032167.2
NP_001027343.1, NM_001032172.2
NP_001027348.1, NM_001032177.2
NP_001027353.1, NM_001032182.2
NP_001027358.1, NM_001032187.2
NP_001027363.1, NM_001032192.2
NP_001027368.1, NM_001032197.2
NP_001027373.1, NM_001032202.2
NP_001027378.1, NM_001032207.2
NP_001027383.1, NM_001032212.2
NP_001027387.1, NM_001032216.2
NP_724345.1, NM_165384.3

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0085894; FBpp0085250; FBgn0051613
FBtr0091807; FBpp0091051; FBgn0053803
FBtr0091810; FBpp0091053; FBgn0053806
FBtr0091813; FBpp0091056; FBgn0053809
FBtr0091816; FBpp0091058; FBgn0053812
FBtr0091819; FBpp0091061; FBgn0053815
FBtr0091822; FBpp0091064; FBgn0053818
FBtr0091825; FBpp0091067; FBgn0053821
FBtr0091828; FBpp0091070; FBgn0053824
FBtr0091831; FBpp0091073; FBgn0053827
FBtr0091834; FBpp0091076; FBgn0053830
FBtr0091837; FBpp0091079; FBgn0053833
FBtr0091840; FBpp0091082; FBgn0053836
FBtr0091843; FBpp0091085; FBgn0053839
FBtr0091846; FBpp0091088; FBgn0053842
FBtr0091849; FBpp0091091; FBgn0053845
FBtr0091852; FBpp0091094; FBgn0053848
FBtr0091855; FBpp0091097; FBgn0053851
FBtr0091858; FBpp0091100; FBgn0053854
FBtr0091861; FBpp0091103; FBgn0053857
FBtr0091864; FBpp0091106; FBgn0053860
FBtr0091867; FBpp0091109; FBgn0053863
FBtr0091870; FBpp0091112; FBgn0053866

Database of genes from NCBI RefSeq genomes

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GeneIDi
318847
3771723
3771729
3771771
3771792
3771959
3772032
3772149
3772163
3772173
3772189
3772191
3772198
3772231
3772370
3772374
3772421
3772489
3772517
3772518
3772552
3772607
3772619

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
dme:Dmel_CG31613
dme:Dmel_CG33803
dme:Dmel_CG33806
dme:Dmel_CG33809
dme:Dmel_CG33812
dme:Dmel_CG33815
dme:Dmel_CG33818
dme:Dmel_CG33821
dme:Dmel_CG33824
dme:Dmel_CG33827
dme:Dmel_CG33830
dme:Dmel_CG33833
dme:Dmel_CG33836
dme:Dmel_CG33839
dme:Dmel_CG33842
dme:Dmel_CG33845
dme:Dmel_CG33848
dme:Dmel_CG33851
dme:Dmel_CG33854
dme:Dmel_CG33857
dme:Dmel_CG33860
dme:Dmel_CG33863
dme:Dmel_CG33866

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14215 Genomic DNA Translation: CAA32434.1
AB019400 Genomic DNA Translation: BAA93621.1
AE014134 Genomic DNA Translation: AAN11127.1
AE014134 Genomic DNA Translation: AAZ66481.1
AE014134 Genomic DNA Translation: AAZ66485.1
AE014134 Genomic DNA Translation: AAZ66490.1
AE014134 Genomic DNA Translation: AAZ66494.1
AE014134 Genomic DNA Translation: AAZ66499.1
AE014134 Genomic DNA Translation: AAZ66504.1
AE014134 Genomic DNA Translation: AAZ66509.1
AE014134 Genomic DNA Translation: AAZ66514.1
AE014134 Genomic DNA Translation: AAZ66519.1
AE014134 Genomic DNA Translation: AAZ66524.1
AE014134 Genomic DNA Translation: AAZ66529.1
AE014134 Genomic DNA Translation: AAZ66534.1
AE014134 Genomic DNA Translation: AAZ66539.1
AE014134 Genomic DNA Translation: AAZ66544.1
AE014134 Genomic DNA Translation: AAZ66549.1
AE014134 Genomic DNA Translation: AAZ66554.1
AE014134 Genomic DNA Translation: AAZ66559.1
AE014134 Genomic DNA Translation: AAZ66564.1
AE014134 Genomic DNA Translation: AAZ66569.1
AE014134 Genomic DNA Translation: AAZ66574.1
AE014134 Genomic DNA Translation: AAZ66579.1
AE014134 Genomic DNA Translation: AAZ66583.1
PIRiA02630
S10097
RefSeqiNP_001027285.1, NM_001032114.2
NP_001027289.1, NM_001032118.2
NP_001027294.1, NM_001032123.2
NP_001027298.1, NM_001032127.2
NP_001027303.1, NM_001032132.2
NP_001027308.1, NM_001032137.2
NP_001027313.1, NM_001032142.2
NP_001027318.1, NM_001032147.2
NP_001027323.1, NM_001032152.2
NP_001027328.1, NM_001032157.2
NP_001027333.1, NM_001032162.2
NP_001027338.1, NM_001032167.2
NP_001027343.1, NM_001032172.2
NP_001027348.1, NM_001032177.2
NP_001027353.1, NM_001032182.2
NP_001027358.1, NM_001032187.2
NP_001027363.1, NM_001032192.2
NP_001027368.1, NM_001032197.2
NP_001027373.1, NM_001032202.2
NP_001027378.1, NM_001032207.2
NP_001027383.1, NM_001032212.2
NP_001027387.1, NM_001032216.2
NP_724345.1, NM_165384.3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1KNAX-ray2.10P2-17[»]
1KNEX-ray2.40P2-17[»]
2NQBX-ray2.30A/E2-136[»]
2PYOX-ray2.43A/E2-136[»]
2YBAX-ray2.55C/D2-20[»]
4QLCX-ray3.50A/E2-136[»]
4UUZX-ray2.90A1-136[»]
4X23X-ray3.50A/E/K/O41-133[»]
5WCUX-ray5.53A/E/K/O39-136[»]
6ASZX-ray1.52P6-11[»]
6AT0X-ray1.28P6-11[»]
SMRiP02299
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi534149, 3 interactors
77140, 72 interactors
DIPiDIP-38722N
IntActiP02299, 19 interactors
MINTiP02299
STRINGi7227.FBpp0091112

PTM databases

iPTMnetiP02299

Proteomic databases

PaxDbiP02299
PRIDEiP02299

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0085894; FBpp0085250; FBgn0051613
FBtr0091807; FBpp0091051; FBgn0053803
FBtr0091810; FBpp0091053; FBgn0053806
FBtr0091813; FBpp0091056; FBgn0053809
FBtr0091816; FBpp0091058; FBgn0053812
FBtr0091819; FBpp0091061; FBgn0053815
FBtr0091822; FBpp0091064; FBgn0053818
FBtr0091825; FBpp0091067; FBgn0053821
FBtr0091828; FBpp0091070; FBgn0053824
FBtr0091831; FBpp0091073; FBgn0053827
FBtr0091834; FBpp0091076; FBgn0053830
FBtr0091837; FBpp0091079; FBgn0053833
FBtr0091840; FBpp0091082; FBgn0053836
FBtr0091843; FBpp0091085; FBgn0053839
FBtr0091846; FBpp0091088; FBgn0053842
FBtr0091849; FBpp0091091; FBgn0053845
FBtr0091852; FBpp0091094; FBgn0053848
FBtr0091855; FBpp0091097; FBgn0053851
FBtr0091858; FBpp0091100; FBgn0053854
FBtr0091861; FBpp0091103; FBgn0053857
FBtr0091864; FBpp0091106; FBgn0053860
FBtr0091867; FBpp0091109; FBgn0053863
FBtr0091870; FBpp0091112; FBgn0053866
GeneIDi318847
3771723
3771729
3771771
3771792
3771959
3772032
3772149
3772163
3772173
3772189
3772191
3772198
3772231
3772370
3772374
3772421
3772489
3772517
3772518
3772552
3772607
3772619
KEGGidme:Dmel_CG31613
dme:Dmel_CG33803
dme:Dmel_CG33806
dme:Dmel_CG33809
dme:Dmel_CG33812
dme:Dmel_CG33815
dme:Dmel_CG33818
dme:Dmel_CG33821
dme:Dmel_CG33824
dme:Dmel_CG33827
dme:Dmel_CG33830
dme:Dmel_CG33833
dme:Dmel_CG33836
dme:Dmel_CG33839
dme:Dmel_CG33842
dme:Dmel_CG33845
dme:Dmel_CG33848
dme:Dmel_CG33851
dme:Dmel_CG33854
dme:Dmel_CG33857
dme:Dmel_CG33860
dme:Dmel_CG33863
dme:Dmel_CG33866

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
318847
3771723
3771729
3771771
3771792
3771959
3772032
3772149
3772163
3772173
3772189
3772191
3772198
3772231
3772370
3772374
3772421
3772489
3772517
3772518
3772552
3772607
3772619
FlyBaseiFBgn0001199 His3
FBgn0051613 His3:CG31613
FBgn0053803 His3:CG33803
FBgn0053806 His3:CG33806
FBgn0053809 His3:CG33809
FBgn0053812 His3:CG33812
FBgn0053815 His3:CG33815
FBgn0053818 His3:CG33818
FBgn0053821 His3:CG33821
FBgn0053824 His3:CG33824
FBgn0053827 His3:CG33827
FBgn0053830 His3:CG33830
FBgn0053833 His3:CG33833
FBgn0053836 His3:CG33836
FBgn0053839 His3:CG33839
FBgn0053842 His3:CG33842
FBgn0053845 His3:CG33845
FBgn0053848 His3:CG33848
FBgn0053851 His3:CG33851
FBgn0053854 His3:CG33854
FBgn0053857 His3:CG33857
FBgn0053860 His3:CG33860
FBgn0053863 His3:CG33863
FBgn0053866 His3:CG33866

Phylogenomic databases

eggNOGiKOG1745 Eukaryota
COG2036 LUCA
GeneTreeiENSGT00950000182715
InParanoidiP02299
KOiK11253
OMAiCQILANH
OrthoDBi1564596at2759
PhylomeDBiP02299

Enzyme and pathway databases

ReactomeiR-DME-1266695 Interleukin-7 signaling
R-DME-212300 PRC2 methylates histones and DNA
R-DME-2559580 Oxidative Stress Induced Senescence
R-DME-2559582 Senescence-Associated Secretory Phenotype (SASP)
R-DME-3214847 HATs acetylate histones
R-DME-3247509 Chromatin modifying enzymes
R-DME-427359 SIRT1 negatively regulates rRNA expression
R-DME-5578749 Transcriptional regulation by small RNAs
R-DME-5625886 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
R-DME-73772 RNA Polymerase I Promoter Escape
R-DME-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
R-DME-9018519 Estrogen-dependent gene expression
R-DME-983231 Factors involved in megakaryocyte development and platelet production

Miscellaneous databases

EvolutionaryTraceiP02299

Protein Ontology

More...
PROi
PR:P02299

Gene expression databases

BgeeiFBgn0051613 Expressed in 2 organ(s), highest expression level in adult organism
GenevisibleiP02299 DM

Family and domain databases

Gene3Di1.10.20.10, 1 hit
InterProiView protein in InterPro
IPR009072 Histone-fold
IPR007125 Histone_H2A/H2B/H3
IPR000164 Histone_H3/CENP-A
PANTHERiPTHR11426 PTHR11426, 1 hit
PfamiView protein in Pfam
PF00125 Histone, 1 hit
PRINTSiPR00622 HISTONEH3
SMARTiView protein in SMART
SM00428 H3, 1 hit
SUPFAMiSSF47113 SSF47113, 1 hit
PROSITEiView protein in PROSITE
PS00322 HISTONE_H3_1, 1 hit
PS00959 HISTONE_H3_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiH3_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P02299
Secondary accession number(s): Q4ABE4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: May 8, 2019
This is version 189 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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