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Entry version 201 (17 Jun 2020)
Sequence version 2 (23 Jan 2007)
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Protein

Histone H2B

Gene

His2B

more
Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Caution

Was reported to be phosphorylated at Ser-34 (PubMed:15143281). However, the paper was retracted because some data, results and conclusions in the paper are not reliable.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-212300 PRC2 methylates histones and DNA
R-DME-2299718 Condensation of Prophase Chromosomes
R-DME-2559580 Oxidative Stress Induced Senescence
R-DME-2559582 Senescence-Associated Secretory Phenotype (SASP)
R-DME-3214847 HATs acetylate histones
R-DME-427359 SIRT1 negatively regulates rRNA expression
R-DME-5578749 Transcriptional regulation by small RNAs
R-DME-5625886 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
R-DME-5689880 Ub-specific processing proteases
R-DME-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
R-DME-73772 RNA Polymerase I Promoter Escape
R-DME-8866654 E3 ubiquitin ligases ubiquitinate target proteins
R-DME-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
R-DME-9018519 Estrogen-dependent gene expression

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Histone H2B
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:His2B
AND
ORF Names:CG17949
AND
ORF Names:CG33868
AND
ORF Names:CG33870
AND
ORF Names:CG33872
AND
ORF Names:CG33874
AND
ORF Names:CG33876
AND
ORF Names:CG33878
AND
ORF Names:CG33880
AND
ORF Names:CG33882
AND
ORF Names:CG33884
AND
ORF Names:CG33886
AND
ORF Names:CG33888
AND
ORF Names:CG33890
AND
ORF Names:CG33892
AND
ORF Names:CG33894
AND
ORF Names:CG33896
AND
ORF Names:CG33898
AND
ORF Names:CG33900
AND
ORF Names:CG33902
AND
ORF Names:CG33904
AND
ORF Names:CG33906
AND
ORF Names:CG33908
AND
ORF Names:CG33910
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2L

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0001198 His2B
FBgn0061209 His2B:CG17949
FBgn0053868 His2B:CG33868
FBgn0053870 His2B:CG33870
FBgn0053872 His2B:CG33872
FBgn0053874 His2B:CG33874
FBgn0053876 His2B:CG33876
FBgn0053878 His2B:CG33878
FBgn0053880 His2B:CG33880
FBgn0053882 His2B:CG33882
FBgn0053884 His2B:CG33884
FBgn0053886 His2B:CG33886
FBgn0053888 His2B:CG33888
FBgn0053890 His2B:CG33890
FBgn0053892 His2B:CG33892
FBgn0053894 His2B:CG33894
FBgn0053896 His2B:CG33896
FBgn0053898 His2B:CG33898
FBgn0053900 His2B:CG33900
FBgn0053902 His2B:CG33902
FBgn0053904 His2B:CG33904
FBgn0053906 His2B:CG33906
FBgn0053908 His2B:CG33908
FBgn0053910 His2B:CG33910

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleosome core, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000718612 – 123Histone H2BAdd BLAST122

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-methylproline; partial1 Publication1
Modified residuei44N6-succinyllysine1 Publication1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi110O-linked (GlcNAc) serineBy similarity1
Modified residuei114N6-succinyllysine1 Publication1
Modified residuei118N6-succinyllysine1 Publication1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki118Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)Curated

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Monoubiquitination of Lys-118 by Bre1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation.1 Publication
Methylation at Pro-2 increases upon heat shock.1 Publication
GlcNAcylation at Ser-110 promotes monoubiquitination of Lys-118. It fluctuates in response to extracellular glucose, and associates with transcribed genes (Probable).Curated

Keywords - PTMi

Glycoprotein, Isopeptide bond, Methylation, Ubl conjugation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P02283

PRoteomics IDEntifications database

More...
PRIDEi
P02283

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P02283

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0053868 Expressed in larva and 2 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P02283 DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
533862, 1 interactor
77520, 25 interactors

Database of interacting proteins

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DIPi
DIP-22804N

Protein interaction database and analysis system

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IntActi
P02283, 8 interactors

Molecular INTeraction database

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MINTi
P02283

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0091155

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1123
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P02283

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

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PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P02283

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the histone H2B family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1744 Eukaryota
ENOG4111NV5 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00990000203476

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_075666_2_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P02283

KEGG Orthology (KO)

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KOi
K11252

Identification of Orthologs from Complete Genome Data

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OMAi
CCHIYAS

Database of Orthologous Groups

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OrthoDBi
1536672at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P02283

Family and domain databases

Database of protein disorder

More...
DisProti
DP01250

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.10.20.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR009072 Histone-fold
IPR007125 Histone_H2A/H2B/H3
IPR000558 Histone_H2B

The PANTHER Classification System

More...
PANTHERi
PTHR23428 PTHR23428, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00125 Histone, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00621 HISTONEH2B

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00427 H2B, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47113 SSF47113, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00357 HISTONE_H2B, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P02283-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPPKTSGKAA KKAGKAQKNI TKTDKKKKRK RKESYAIYIY KVLKQVHPDT
60 70 80 90 100
GISSKAMSIM NSFVNDIFER IAAEASRLAH YNKRSTITSR EIQTAVRLLL
110 120
PGELAKHAVS EGTKAVTKYT SSK
Length:123
Mass (Da):13,696
Last modified:January 23, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0774D25F34003062
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti77R → C AA sequence (PubMed:117830).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X14215 Genomic DNA Translation: CAA32432.1
AE014134 Genomic DNA Translation: AAN11124.1
AE014134 Genomic DNA Translation: AAZ66483.1
AE014134 Genomic DNA Translation: AAZ66487.1
AE014134 Genomic DNA Translation: AAZ66492.1
AE014134 Genomic DNA Translation: AAZ66496.1
AE014134 Genomic DNA Translation: AAZ66501.1
AE014134 Genomic DNA Translation: AAZ66506.1
AE014134 Genomic DNA Translation: AAZ66511.1
AE014134 Genomic DNA Translation: AAZ66521.1
AE014134 Genomic DNA Translation: AAZ66531.1
AE014134 Genomic DNA Translation: AAZ66576.1
AE014134 Genomic DNA Translation: AAZ66571.1
AE014134 Genomic DNA Translation: AAZ66566.1
AE014134 Genomic DNA Translation: AAZ66561.1
AE014134 Genomic DNA Translation: AAZ66556.1
AE014134 Genomic DNA Translation: AAZ66551.1
AE014134 Genomic DNA Translation: AAZ66546.1
AE014134 Genomic DNA Translation: AAZ66541.1
AE014134 Genomic DNA Translation: AAZ66536.1
AE014134 Genomic DNA Translation: AAZ66479.1
AE014134 Genomic DNA Translation: AAZ66581.1
AE014134 Genomic DNA Translation: AAZ66526.1
AE014134 Genomic DNA Translation: AAZ66516.1

Protein sequence database of the Protein Information Resource

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PIRi
S10095 HSFF22

NCBI Reference Sequences

More...
RefSeqi
NP_001027283.1, NM_001032112.2
NP_001027287.1, NM_001032116.2
NP_001027291.1, NM_001032120.2
NP_001027296.1, NM_001032125.2
NP_001027300.1, NM_001032129.2
NP_001027305.1, NM_001032134.2
NP_001027310.1, NM_001032139.2
NP_001027315.1, NM_001032144.2
NP_001027320.1, NM_001032149.2
NP_001027325.1, NM_001032154.2
NP_001027330.1, NM_001032159.2
NP_001027335.1, NM_001032164.2
NP_001027340.1, NM_001032169.2
NP_001027345.1, NM_001032174.2
NP_001027350.1, NM_001032179.2
NP_001027355.1, NM_001032184.2
NP_001027360.1, NM_001032189.2
NP_001027365.1, NM_001032194.2
NP_001027370.1, NM_001032199.2
NP_001027375.1, NM_001032204.2
NP_001027380.1, NM_001032209.2
NP_001027385.1, NM_001032214.2
NP_724342.1, NM_165381.4

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0085927; FBpp0085281; FBgn0061209
FBtr0091872; FBpp0091113; FBgn0053868
FBtr0091874; FBpp0091115; FBgn0053870
FBtr0091876; FBpp0091117; FBgn0053872
FBtr0091878; FBpp0091119; FBgn0053874
FBtr0091880; FBpp0091121; FBgn0053876
FBtr0091882; FBpp0091123; FBgn0053878
FBtr0091884; FBpp0091125; FBgn0053880
FBtr0091886; FBpp0091127; FBgn0053882
FBtr0091888; FBpp0091129; FBgn0053884
FBtr0091890; FBpp0091131; FBgn0053886
FBtr0091892; FBpp0091133; FBgn0053888
FBtr0091894; FBpp0091135; FBgn0053890
FBtr0091896; FBpp0091137; FBgn0053892
FBtr0091898; FBpp0091139; FBgn0053894
FBtr0091900; FBpp0091141; FBgn0053896
FBtr0091902; FBpp0091143; FBgn0053898
FBtr0091904; FBpp0091145; FBgn0053900
FBtr0091906; FBpp0091147; FBgn0053902
FBtr0091908; FBpp0091149; FBgn0053904
FBtr0091910; FBpp0091151; FBgn0053906
FBtr0091912; FBpp0091153; FBgn0053908
FBtr0091914; FBpp0091155; FBgn0053910

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
326273
3771809
3771891
3771957
3772013
3772058
3772081
3772083
3772094
3772099
3772104
3772166
3772203
3772248
3772264
3772265
3772271
3772276
3772299
3772336
3772496
3772502
3772575

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG17949
dme:Dmel_CG33868
dme:Dmel_CG33870
dme:Dmel_CG33872
dme:Dmel_CG33874
dme:Dmel_CG33876
dme:Dmel_CG33878
dme:Dmel_CG33880
dme:Dmel_CG33882
dme:Dmel_CG33884
dme:Dmel_CG33886
dme:Dmel_CG33888
dme:Dmel_CG33890
dme:Dmel_CG33892
dme:Dmel_CG33894
dme:Dmel_CG33896
dme:Dmel_CG33898
dme:Dmel_CG33900
dme:Dmel_CG33902
dme:Dmel_CG33904
dme:Dmel_CG33906
dme:Dmel_CG33908
dme:Dmel_CG33910

UCSC genome browser

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UCSCi
CG17949-RA d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14215 Genomic DNA Translation: CAA32432.1
AE014134 Genomic DNA Translation: AAN11124.1
AE014134 Genomic DNA Translation: AAZ66483.1
AE014134 Genomic DNA Translation: AAZ66487.1
AE014134 Genomic DNA Translation: AAZ66492.1
AE014134 Genomic DNA Translation: AAZ66496.1
AE014134 Genomic DNA Translation: AAZ66501.1
AE014134 Genomic DNA Translation: AAZ66506.1
AE014134 Genomic DNA Translation: AAZ66511.1
AE014134 Genomic DNA Translation: AAZ66521.1
AE014134 Genomic DNA Translation: AAZ66531.1
AE014134 Genomic DNA Translation: AAZ66576.1
AE014134 Genomic DNA Translation: AAZ66571.1
AE014134 Genomic DNA Translation: AAZ66566.1
AE014134 Genomic DNA Translation: AAZ66561.1
AE014134 Genomic DNA Translation: AAZ66556.1
AE014134 Genomic DNA Translation: AAZ66551.1
AE014134 Genomic DNA Translation: AAZ66546.1
AE014134 Genomic DNA Translation: AAZ66541.1
AE014134 Genomic DNA Translation: AAZ66536.1
AE014134 Genomic DNA Translation: AAZ66479.1
AE014134 Genomic DNA Translation: AAZ66581.1
AE014134 Genomic DNA Translation: AAZ66526.1
AE014134 Genomic DNA Translation: AAZ66516.1
PIRiS10095 HSFF22
RefSeqiNP_001027283.1, NM_001032112.2
NP_001027287.1, NM_001032116.2
NP_001027291.1, NM_001032120.2
NP_001027296.1, NM_001032125.2
NP_001027300.1, NM_001032129.2
NP_001027305.1, NM_001032134.2
NP_001027310.1, NM_001032139.2
NP_001027315.1, NM_001032144.2
NP_001027320.1, NM_001032149.2
NP_001027325.1, NM_001032154.2
NP_001027330.1, NM_001032159.2
NP_001027335.1, NM_001032164.2
NP_001027340.1, NM_001032169.2
NP_001027345.1, NM_001032174.2
NP_001027350.1, NM_001032179.2
NP_001027355.1, NM_001032184.2
NP_001027360.1, NM_001032189.2
NP_001027365.1, NM_001032194.2
NP_001027370.1, NM_001032199.2
NP_001027375.1, NM_001032204.2
NP_001027380.1, NM_001032209.2
NP_001027385.1, NM_001032214.2
NP_724342.1, NM_165381.4

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2NQBX-ray2.30D/H2-123[»]
2PYOX-ray2.43D/H2-123[»]
4QLCX-ray3.50D/H2-123[»]
4X23X-ray3.50D/H/N/R33-122[»]
5CVEX-ray1.50D/E3-10[»]
5WCUX-ray5.53D/H/N/R29-122[»]
6DZTelectron microscopy2.99D/H2-123[»]
6PWEelectron microscopy3.95D/H1-123[»]
6PWFelectron microscopy4.07D/H1-123[»]
SMRiP02283
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi533862, 1 interactor
77520, 25 interactors
DIPiDIP-22804N
IntActiP02283, 8 interactors
MINTiP02283
STRINGi7227.FBpp0091155

PTM databases

iPTMnetiP02283

Proteomic databases

PaxDbiP02283
PRIDEiP02283

Protocols and materials databases

ABCD curated depository of sequenced antibodies

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ABCDi
P02283 1 sequenced antibody

Genome annotation databases

EnsemblMetazoaiFBtr0085927; FBpp0085281; FBgn0061209
FBtr0091872; FBpp0091113; FBgn0053868
FBtr0091874; FBpp0091115; FBgn0053870
FBtr0091876; FBpp0091117; FBgn0053872
FBtr0091878; FBpp0091119; FBgn0053874
FBtr0091880; FBpp0091121; FBgn0053876
FBtr0091882; FBpp0091123; FBgn0053878
FBtr0091884; FBpp0091125; FBgn0053880
FBtr0091886; FBpp0091127; FBgn0053882
FBtr0091888; FBpp0091129; FBgn0053884
FBtr0091890; FBpp0091131; FBgn0053886
FBtr0091892; FBpp0091133; FBgn0053888
FBtr0091894; FBpp0091135; FBgn0053890
FBtr0091896; FBpp0091137; FBgn0053892
FBtr0091898; FBpp0091139; FBgn0053894
FBtr0091900; FBpp0091141; FBgn0053896
FBtr0091902; FBpp0091143; FBgn0053898
FBtr0091904; FBpp0091145; FBgn0053900
FBtr0091906; FBpp0091147; FBgn0053902
FBtr0091908; FBpp0091149; FBgn0053904
FBtr0091910; FBpp0091151; FBgn0053906
FBtr0091912; FBpp0091153; FBgn0053908
FBtr0091914; FBpp0091155; FBgn0053910
GeneIDi326273
3771809
3771891
3771957
3772013
3772058
3772081
3772083
3772094
3772099
3772104
3772166
3772203
3772248
3772264
3772265
3772271
3772276
3772299
3772336
3772496
3772502
3772575
KEGGidme:Dmel_CG17949
dme:Dmel_CG33868
dme:Dmel_CG33870
dme:Dmel_CG33872
dme:Dmel_CG33874
dme:Dmel_CG33876
dme:Dmel_CG33878
dme:Dmel_CG33880
dme:Dmel_CG33882
dme:Dmel_CG33884
dme:Dmel_CG33886
dme:Dmel_CG33888
dme:Dmel_CG33890
dme:Dmel_CG33892
dme:Dmel_CG33894
dme:Dmel_CG33896
dme:Dmel_CG33898
dme:Dmel_CG33900
dme:Dmel_CG33902
dme:Dmel_CG33904
dme:Dmel_CG33906
dme:Dmel_CG33908
dme:Dmel_CG33910
UCSCiCG17949-RA d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
326273
3771809
3771891
3771957
3772013
3772058
3772081
3772083
3772094
3772099
3772104
3772166
3772203
3772248
3772264
3772265
3772271
3772276
3772299
3772336
3772496
3772502
3772575
FlyBaseiFBgn0001198 His2B
FBgn0061209 His2B:CG17949
FBgn0053868 His2B:CG33868
FBgn0053870 His2B:CG33870
FBgn0053872 His2B:CG33872
FBgn0053874 His2B:CG33874
FBgn0053876 His2B:CG33876
FBgn0053878 His2B:CG33878
FBgn0053880 His2B:CG33880
FBgn0053882 His2B:CG33882
FBgn0053884 His2B:CG33884
FBgn0053886 His2B:CG33886
FBgn0053888 His2B:CG33888
FBgn0053890 His2B:CG33890
FBgn0053892 His2B:CG33892
FBgn0053894 His2B:CG33894
FBgn0053896 His2B:CG33896
FBgn0053898 His2B:CG33898
FBgn0053900 His2B:CG33900
FBgn0053902 His2B:CG33902
FBgn0053904 His2B:CG33904
FBgn0053906 His2B:CG33906
FBgn0053908 His2B:CG33908
FBgn0053910 His2B:CG33910

Phylogenomic databases

eggNOGiKOG1744 Eukaryota
ENOG4111NV5 LUCA
GeneTreeiENSGT00990000203476
HOGENOMiCLU_075666_2_0_1
InParanoidiP02283
KOiK11252
OMAiCCHIYAS
OrthoDBi1536672at2759
PhylomeDBiP02283

Enzyme and pathway databases

ReactomeiR-DME-212300 PRC2 methylates histones and DNA
R-DME-2299718 Condensation of Prophase Chromosomes
R-DME-2559580 Oxidative Stress Induced Senescence
R-DME-2559582 Senescence-Associated Secretory Phenotype (SASP)
R-DME-3214847 HATs acetylate histones
R-DME-427359 SIRT1 negatively regulates rRNA expression
R-DME-5578749 Transcriptional regulation by small RNAs
R-DME-5625886 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
R-DME-5689880 Ub-specific processing proteases
R-DME-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
R-DME-73772 RNA Polymerase I Promoter Escape
R-DME-8866654 E3 ubiquitin ligases ubiquitinate target proteins
R-DME-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
R-DME-9018519 Estrogen-dependent gene expression

Miscellaneous databases

EvolutionaryTraceiP02283

Protein Ontology

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PROi
PR:P02283

Gene expression databases

BgeeiFBgn0053868 Expressed in larva and 2 other tissues
GenevisibleiP02283 DM

Family and domain databases

DisProtiDP01250
Gene3Di1.10.20.10, 1 hit
InterProiView protein in InterPro
IPR009072 Histone-fold
IPR007125 Histone_H2A/H2B/H3
IPR000558 Histone_H2B
PANTHERiPTHR23428 PTHR23428, 1 hit
PfamiView protein in Pfam
PF00125 Histone, 1 hit
PRINTSiPR00621 HISTONEH2B
SMARTiView protein in SMART
SM00427 H2B, 1 hit
SUPFAMiSSF47113 SSF47113, 1 hit
PROSITEiView protein in PROSITE
PS00357 HISTONE_H2B, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiH2B_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P02283
Secondary accession number(s): Q4ABE1, Q9W5U7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: June 17, 2020
This is version 201 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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