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Protein

Histone H5

Gene
N/A
Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Histone H5 performs the same function as H1, being necessary for the condensation of nucleosome chains into higher order structures, and replaces histone H1 in certain cells.

GO - Molecular functioni

  • AT DNA binding Source: Ensembl
  • nucleosomal DNA binding Source: CAFA

GO - Biological processi

  • chromatin organization Source: CAFA
  • chromosome condensation Source: UniProtKB-KW
  • nucleosome assembly Source: CAFA

Keywordsi

Molecular functionDNA-binding
Biological processDNA condensation

Enzyme and pathway databases

ReactomeiR-GGA-211227 Activation of DNA fragmentation factor
R-GGA-2559584 Formation of Senescence-Associated Heterochromatin Foci (SAHF)

Names & Taxonomyi

Protein namesi
Recommended name:
Histone H5
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001960052 – 190Histone H5Add BLAST189

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei23Phosphoserine1 Publication1
Modified residuei30Phosphoserine1 Publication1
Modified residuei146Phosphoserine1 Publication1
Modified residuei167Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP02259

PTM databases

iPTMnetiP02259

Miscellaneous databases

PMAP-CutDBiP02259

Expressioni

Tissue specificityi

Erythroid cells.

Gene expression databases

BgeeiENSGALG00000012313

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000020094

Structurei

Secondary structure

1190
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi29 – 38Combined sources10
Helixi48 – 58Combined sources11
Helixi65 – 78Combined sources14
Beta strandi81 – 85Combined sources5
Beta strandi93 – 96Combined sources4

3D structure databases

DisProtiDP00044
ProteinModelPortaliP02259
SMRiP02259
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP02259

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 98H15PROSITE-ProRule annotationAdd BLAST74

Sequence similaritiesi

Belongs to the histone H1/H5 family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4012 Eukaryota
ENOG4112541 LUCA
GeneTreeiENSGT00810000125570
HOGENOMiHOG000251627
HOVERGENiHBG005939
InParanoidiP02259
KOiK11275
OMAiFEQPKGP
OrthoDBiEOG091G0LIU
PhylomeDBiP02259
TreeFamiTF313664

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR005818 Histone_H1/H5_H15
IPR005819 Histone_H5
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00538 Linker_histone, 1 hit
PRINTSiPR00624 HISTONEH5
SMARTiView protein in SMART
SM00526 H15, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS51504 H15, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02259-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTESLVLSPA PAKPKRVKAS RRSASHPTYS EMIAAAIRAE KSRGGSSRQS
60 70 80 90 100
IQKYIKSHYK VGHNADLQIK LSIRRLLAAG VLKQTKGVGA SGSFRLAKSD
110 120 130 140 150
KAKRSPGKKK KAVRRSTSPK KAARPRKARS PAKKPKATAR KARKKSRASP
160 170 180 190
KKAKKPKTVK AKSRKASKAK KVKRSKPRAK SGARKSPKKK
Length:190
Mass (Da):20,734
Last modified:January 23, 2007 - v2
Checksum:iE2BA83C7A39F87DF
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti16R → Q. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00870 Genomic DNA Translation: AAA48798.1
X00169 mRNA Translation: CAA24994.1
PIRiA93487 HSCH5
RefSeqiNP_001038138.1, NM_001044673.1
UniGeneiGga.48182

Genome annotation databases

EnsembliENSGALT00000085633; ENSGALP00000063019; ENSGALG00000044240
GeneIDi693250
KEGGigga:693250

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiH5_CHICK
AccessioniPrimary (citable) accession number: P02259
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: July 18, 2018
This is version 141 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

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