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Protein

Histone H1.3

Gene
N/A
Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Histone H1.3
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001959211 – 213Histone H1.3Add BLAST213

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylserine1 Publication1
Modified residuei15N6-acetyllysineBy similarity1
Modified residuei35N6-(beta-hydroxybutyryl)lysineBy similarity1
Modified residuei53N6-(beta-hydroxybutyryl)lysineBy similarity1
Modified residuei55CitrullineBy similarity1
Modified residuei65N6-(beta-hydroxybutyryl)lysineBy similarity1
Modified residuei86N6-(beta-hydroxybutyryl)lysineBy similarity1
Modified residuei91N6-(beta-hydroxybutyryl)lysineBy similarity1
Modified residuei105PhosphoserineBy similarity1
Modified residuei107N6-(beta-hydroxybutyryl)lysineBy similarity1

Post-translational modificationi

H1 histones are progressively phosphorylated during the cell cycle, becoming maximally phosphorylated during late G2 phase and M phase, and being dephosphorylated sharply thereafter.By similarity
Citrullination at Arg-55 (H1R54ci) by PADI4 takes place within the DNA-binding site of H1 and results in its displacement from chromatin and global chromatin decondensation, thereby promoting pluripotency and stem cell maintenance.By similarity

Keywords - PTMi

Acetylation, Citrullination, Hydroxylation, Phosphoprotein

Proteomic databases

PRIDEiP02251

PTM databases

iPTMnetiP02251

Structurei

3D structure databases

ProteinModelPortaliP02251
SMRiP02251
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini37 – 110H15PROSITE-ProRule annotationAdd BLAST74

Sequence similaritiesi

Belongs to the histone H1/H5 family.PROSITE-ProRule annotation

Phylogenomic databases

HOVERGENiHBG009035

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR005818 Histone_H1/H5_H15
IPR005819 Histone_H5
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00538 Linker_histone, 1 hit
PRINTSiPR00624 HISTONEH5
SMARTiView protein in SMART
SM00526 H15, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS51504 H15, 1 hit

Sequencei

Sequence statusi: Complete.

P02251-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
SEAPAETAAP APAEKSPAKK KKAAKKPGAG AAKRKAAGPP VSELITKAVA
60 70 80 90 100
ASKERNGLSL AALKKALAAG GYDVEKNNSR IKLGLKSLVS KGTLVETKGT
110 120 130 140 150
GASGSFKLDK KAASGEAKPK PKKAGAAKPK KPAGATPKKP KKAAGAKKAV
160 170 180 190 200
KKTPKKAPKP KAAAKPKVAK PKSPAKVAKS PKKAKAVKPK AAKPKAPKPK
210
AAKAKKTAAK KKK
Length:213
Mass (Da):21,423
Last modified:July 21, 1986 - v1
Checksum:i21DE34BBD10D894E
GO

Sequence databases

PIRiA94467 HSRB13

Similar proteinsi

Entry informationi

Entry nameiH13_RABIT
AccessioniPrimary (citable) accession number: P02251
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: October 25, 2017
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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