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Protein

Extracellular globin-2

Gene
N/A
Organism
Lumbricus terrestris (Common earthworm)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi96Iron (heme proximal ligand)1

GO - Molecular functioni

Keywordsi

Biological processOxygen transport, Transport
LigandHeme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Extracellular globin-2
Alternative name(s):
Erythrocruorin
Globin AIII
Globin B
Globin II
OrganismiLumbricus terrestris (Common earthworm)
Taxonomic identifieri6398 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaAnnelidaClitellataOligochaetaHaplotaxidaLumbricinaLumbricidaeLumbricinaeLumbricus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000525121 – 145Extracellular globin-2Add BLAST145

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi4 ↔ 133By similarity
Disulfide bondi124Interchain (with chain IV)By similarity

Keywords - PTMi

Disulfide bond

Interactioni

Subunit structurei

The extracellular hemoglobin of the earthworm consists of 12 subunits that have a hexagonal bilayer structure with a molecular weight near 3.8 million. Each one-twelfth subunit is composed primarily of disulfide linked trimers (chains A, B, and C) and monomers (chain D).1 Publication

Protein-protein interaction databases

DIPiDIP-29123N
IntActiP02218, 1 interactor

Structurei

Secondary structure

1145
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP02218
SMRiP02218
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP02218

Family & Domainsi

Sequence similaritiesi

Belongs to the globin family.PROSITE-ProRule annotation

Family and domain databases

Gene3Di1.10.490.10, 1 hit
InterProiView protein in InterPro
IPR002336 Erythrocruorin
IPR000971 Globin
IPR009050 Globin-like_sf
IPR012292 Globin/Proto
IPR014610 Haemoglobin_extracell
PfamiView protein in Pfam
PF00042 Globin, 1 hit
PIRSFiPIRSF036517 Ext_hemo, 1 hit
PRINTSiPR00611 ERYTHCRUORIN
SUPFAMiSSF46458 SSF46458, 1 hit
PROSITEiView protein in PROSITE
PS01033 GLOBIN, 1 hit

Sequencei

Sequence statusi: Complete.

P02218-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
KKQCGVLEGL KVKSEWGRAY GSGHDREAFS QAIWRATFAQ VPESRSLFKR
60 70 80 90 100
VHGDDTSHPA FIAHAERVLG GLDIAISTLD QPATLKEELD HLQVQHEGRK
110 120 130 140
IPDNYFDAFK TAILHVVAAQ LGRCYDREAW DACIDHIEDG IKGHH
Length:145
Mass (Da):16,254
Last modified:January 1, 1990 - v2
Checksum:i5F62E08A11AA52A6
GO

Sequence databases

PIRiA02540 GGEWA3
B28151

Similar proteinsi

Cross-referencesi

Sequence databases

PIRiA02540 GGEWA3
B28151

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1X9FX-ray2.60B/F/J1-145[»]
2GTLX-ray3.50B/F/J1-145[»]
4V93electron microscopy8.10A4/AB/AG/AL/AQ/AV/Aa/Af/Ak/Ap/Au/Az/B2/B3/B7/BA/BE/BF/BJ/BK/BO/BP/BT/BU/BY/BZ/Bd/Be/Bi/Bj/Bn/Bo/Bs/Bt/Bx/By1-145[»]
5M3Lelectron microscopy3.80B/F/J1-145[»]
ProteinModelPortaliP02218
SMRiP02218
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-29123N
IntActiP02218, 1 interactor

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP02218

Family and domain databases

Gene3Di1.10.490.10, 1 hit
InterProiView protein in InterPro
IPR002336 Erythrocruorin
IPR000971 Globin
IPR009050 Globin-like_sf
IPR012292 Globin/Proto
IPR014610 Haemoglobin_extracell
PfamiView protein in Pfam
PF00042 Globin, 1 hit
PIRSFiPIRSF036517 Ext_hemo, 1 hit
PRINTSiPR00611 ERYTHCRUORIN
SUPFAMiSSF46458 SSF46458, 1 hit
PROSITEiView protein in PROSITE
PS01033 GLOBIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGLB2_LUMTE
AccessioniPrimary (citable) accession number: P02218
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 1, 1990
Last modified: April 25, 2018
This is version 95 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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