UniProtKB - P02192 (MYG_BOVIN)
Protein
Myoglobin
Gene
MB
Organism
Bos taurus (Bovine)
Status
Functioni
Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 65 | Iron (heme distal ligand) | 1 | |
Metal bindingi | 94 | Iron (heme proximal ligand) | 1 |
GO - Molecular functioni
- heme binding Source: InterPro
- metal ion binding Source: UniProtKB-KW
- oxygen binding Source: GO_Central
- oxygen carrier activity Source: UniProtKB-KW
GO - Biological processi
- brown fat cell differentiation Source: Ensembl
- enucleate erythrocyte differentiation Source: Ensembl
- heart development Source: Ensembl
- oxygen transport Source: GO_Central
- response to hypoxia Source: Ensembl
Keywordsi
Molecular function | Muscle protein |
Biological process | Oxygen transport, Transport |
Ligand | Heme, Iron, Metal-binding |
Enzyme and pathway databases
Reactomei | R-BTA-8981607, Intracellular oxygen transport |
Names & Taxonomyi
Protein namesi | Recommended name: Myoglobin |
Gene namesi | Name:MB |
Organismi | Bos taurus (Bovine) |
Taxonomic identifieri | 9913 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Proteomesi |
|
Organism-specific databases
VGNCi | VGNC:31270, MB |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | Removed1 Publication | |||
ChainiPRO_0000053280 | 2 – 154 | MyoglobinAdd BLAST | 153 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 4 | PhosphoserineBy similarity | 1 | |
Modified residuei | 68 | PhosphothreonineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | P02192 |
PRIDEi | P02192 |
PTM databases
CarbonylDBi | P02192 |
Expressioni
Gene expression databases
Bgeei | ENSBTAG00000005333, Expressed in skeletal muscle tissue and 13 other tissues |
ExpressionAtlasi | P02192, baseline |
Family & Domainsi
Sequence similaritiesi
Belongs to the globin family.PROSITE-ProRule annotation
Phylogenomic databases
eggNOGi | KOG3378, Eukaryota |
GeneTreei | ENSGT00940000160809 |
HOGENOMi | CLU_003827_18_0_1 |
InParanoidi | P02192 |
OMAi | AQGAMRK |
OrthoDBi | 1405713at2759 |
TreeFami | TF332967 |
Family and domain databases
Gene3Di | 1.10.490.10, 1 hit |
InterProi | View protein in InterPro IPR000971, Globin IPR009050, Globin-like_sf IPR012292, Globin/Proto IPR002335, Myoglobin |
PANTHERi | PTHR47132, PTHR47132, 1 hit |
Pfami | View protein in Pfam PF00042, Globin, 1 hit |
PRINTSi | PR00613, MYOGLOBIN |
SUPFAMi | SSF46458, SSF46458, 1 hit |
PROSITEi | View protein in PROSITE PS01033, GLOBIN, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P02192-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGLSDGEWQL VLNAWGKVEA DVAGHGQEVL IRLFTGHPET LEKFDKFKHL
60 70 80 90 100
KTEAEMKASE DLKKHGNTVL TALGGILKKK GHHEAEVKHL AESHANKHKI
110 120 130 140 150
PVKYLEFISD AIIHVLHAKH PSDFGADAQA AMSKALELFR NDMAAQYKVL
GFHG
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 6 | G → W in AAI02987 (Ref. 2) Curated | 1 | |
Sequence conflicti | 10 | L → A AA sequence (PubMed:5477290).Curated | 1 | |
Sequence conflicti | 100 – 102 | IPV → VIP AA sequence (PubMed:5477290).Curated | 3 | |
Sequence conflicti | 123 – 125 | DFG → NFA AA sequence (PubMed:5477290).Curated | 3 | |
Sequence conflicti | 143 – 146 | MAAQ → AAEK AA sequence (PubMed:5477290).Curated | 4 |
Mass spectrometryi
Molecular mass is 16949 Da. Determined by MALDI. 1 Publication
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D00409 mRNA Translation: BAA00311.1 BC102986 mRNA Translation: AAI02987.1 |
PIRi | JX0068, MYBO |
RefSeqi | NP_776306.1, NM_173881.2 |
Genome annotation databases
Ensembli | ENSBTAT00000007014; ENSBTAP00000007014; ENSBTAG00000005333 ENSBTAT00000084629; ENSBTAP00000065000; ENSBTAG00000005333 |
GeneIDi | 280695 |
KEGGi | bta:280695 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D00409 mRNA Translation: BAA00311.1 BC102986 mRNA Translation: AAI02987.1 |
PIRi | JX0068, MYBO |
RefSeqi | NP_776306.1, NM_173881.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1Z2H | model | - | A | 1-154 | [»] | |
1Z2S | model | - | A | 1-154 | [»] | |
SMRi | P02192 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000007014 |
Protein family/group databases
Allergomei | 1305, Bos d Myoglobin |
PTM databases
CarbonylDBi | P02192 |
Proteomic databases
PaxDbi | P02192 |
PRIDEi | P02192 |
Genome annotation databases
Ensembli | ENSBTAT00000007014; ENSBTAP00000007014; ENSBTAG00000005333 ENSBTAT00000084629; ENSBTAP00000065000; ENSBTAG00000005333 |
GeneIDi | 280695 |
KEGGi | bta:280695 |
Organism-specific databases
CTDi | 4151 |
VGNCi | VGNC:31270, MB |
Phylogenomic databases
eggNOGi | KOG3378, Eukaryota |
GeneTreei | ENSGT00940000160809 |
HOGENOMi | CLU_003827_18_0_1 |
InParanoidi | P02192 |
OMAi | AQGAMRK |
OrthoDBi | 1405713at2759 |
TreeFami | TF332967 |
Enzyme and pathway databases
Reactomei | R-BTA-8981607, Intracellular oxygen transport |
Gene expression databases
Bgeei | ENSBTAG00000005333, Expressed in skeletal muscle tissue and 13 other tissues |
ExpressionAtlasi | P02192, baseline |
Family and domain databases
Gene3Di | 1.10.490.10, 1 hit |
InterProi | View protein in InterPro IPR000971, Globin IPR009050, Globin-like_sf IPR012292, Globin/Proto IPR002335, Myoglobin |
PANTHERi | PTHR47132, PTHR47132, 1 hit |
Pfami | View protein in Pfam PF00042, Globin, 1 hit |
PRINTSi | PR00613, MYOGLOBIN |
SUPFAMi | SSF46458, SSF46458, 1 hit |
PROSITEi | View protein in PROSITE PS01033, GLOBIN, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MYG_BOVIN | |
Accessioni | P02192Primary (citable) accession number: P02192 Secondary accession number(s): Q3ZC11 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 21, 1986 |
Last sequence update: | January 23, 2007 | |
Last modified: | December 2, 2020 | |
This is version 144 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families