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Protein

Myoglobin

Gene

MB

Organism
Physeter catodon (Sperm whale) (Physeter macrocephalus)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi65Iron (heme distal ligand)PROSITE-ProRule annotation1 Publication1
Metal bindingi94Iron (heme proximal ligand)PROSITE-ProRule annotation1 Publication1

GO - Molecular functioni

Keywordsi

Molecular functionMuscle protein
Biological processOxygen transport, Transport
LigandHeme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Myoglobin
Gene namesi
Name:MB
OrganismiPhyseter catodon (Sperm whale) (Physeter macrocephalus)
Taxonomic identifieri9755 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaCetaceaOdontocetiPhyseteridaePhyseter

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000533352 – 154MyoglobinAdd BLAST153

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei4PhosphoserineBy similarity1
Modified residuei68PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PeptideAtlasiP02185

Structurei

Secondary structure

1154
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi5 – 18Combined sources14
Helixi19 – 21Combined sources3
Helixi22 – 36Combined sources15
Helixi38 – 41Combined sources4
Turni45 – 49Combined sources5
Helixi53 – 57Combined sources5
Helixi60 – 77Combined sources18
Turni78 – 81Combined sources4
Helixi84 – 96Combined sources13
Turni97 – 99Combined sources3
Helixi102 – 119Combined sources18
Helixi121 – 123Combined sources3
Helixi126 – 150Combined sources25

3D structure databases

DisProtiDP00303
ProteinModelPortaliP02185
SMRiP02185
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP02185

Family & Domainsi

Sequence similaritiesi

Belongs to the globin family.PROSITE-ProRule annotation

Phylogenomic databases

HOVERGENiHBG107340
OrthoDBiEOG091G0OAO

Family and domain databases

Gene3Di1.10.490.10, 1 hit
InterProiView protein in InterPro
IPR000971 Globin
IPR009050 Globin-like_sf
IPR012292 Globin/Proto
IPR002335 Myoglobin
PANTHERiPTHR11442:SF5 PTHR11442:SF5, 1 hit
PfamiView protein in Pfam
PF00042 Globin, 1 hit
PRINTSiPR00613 MYOGLOBIN
SUPFAMiSSF46458 SSF46458, 1 hit
PROSITEiView protein in PROSITE
PS01033 GLOBIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02185-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLSEGEWQL VLHVWAKVEA DVAGHGQDIL IRLFKSHPET LEKFDRFKHL
60 70 80 90 100
KTEAEMKASE DLKKHGVTVL TALGAILKKK GHHEAELKPL AQSHATKHKI
110 120 130 140 150
PIKYLEFISE AIIHVLHSRH PGDFGADAQG AMNKALELFR KDIAAKYKEL

GYQG
Length:154
Mass (Da):17,331
Last modified:January 23, 2007 - v2
Checksum:iFD1D85814263E1A8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti123D → N AA sequence (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti122G → A in metmyoglobin. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB271144 mRNA Translation: BAF03579.1
PIRiA90591 MYWHP
RefSeqiNP_001277651.1, NM_001290722.1

Genome annotation databases

GeneIDi102975021

Similar proteinsi

Entry informationi

Entry nameiMYG_PHYCD
AccessioniPrimary (citable) accession number: P02185
Secondary accession number(s): Q0KIY8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: July 18, 2018
This is version 151 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

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