UniProtKB - P02111 (HBB_ORNAN)
Protein
Hemoglobin subunit beta
Gene
HBB
Organism
Ornithorhynchus anatinus (Duckbill platypus)
Status
Functioni
Involved in oxygen transport from the lung to the various peripheral tissues.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 63 | Iron (heme distal ligand) | 1 | |
Metal bindingi | 92 | Iron (heme proximal ligand) | 1 |
GO - Molecular functioni
- heme binding Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- organic acid binding Source: GO_Central
- oxygen binding Source: GO_Central
- oxygen carrier activity Source: GO_Central
GO - Biological processi
- cellular oxidant detoxification Source: GOC
- hydrogen peroxide catabolic process Source: GO_Central
- protein heterooligomerization Source: GO_Central
Keywordsi
Biological process | Oxygen transport, Transport |
Ligand | Heme, Iron, Metal-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Hemoglobin subunit betaAlternative name(s): Beta-globin Hemoglobin beta chain |
Gene namesi | Name:HBB |
Organismi | Ornithorhynchus anatinus (Duckbill platypus) |
Taxonomic identifieri | 9258 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Monotremata › Ornithorhynchidae › Ornithorhynchus |
Proteomesi |
|
Subcellular locationi
Cytosol
- hemoglobin complex Source: GO_Central
Other locations
- haptoglobin-hemoglobin complex Source: GO_Central
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000053043 | 1 – 146 | Hemoglobin subunit betaAdd BLAST | 146 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylvalineBy similarity | 1 | |
Modified residuei | 12 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 59 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 82 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 93 | S-nitrosocysteineBy similarity | 1 | |
Modified residuei | 144 | N6-acetyllysineBy similarity | 1 |
Keywords - PTMi
Acetylation, Phosphoprotein, S-nitrosylationProteomic databases
PRIDEi | P02111 |
Expressioni
Tissue specificityi
Red blood cells.
Interactioni
Subunit structurei
Heterotetramer of two alpha chains and two beta chains.
Structurei
3D structure databases
ProteinModelPortali | P02111 |
SMRi | P02111 |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the globin family.PROSITE-ProRule annotation
Phylogenomic databases
HOVERGENi | HBG009709 |
InParanoidi | P02111 |
Family and domain databases
CDDi | cd08925 Hb-beta_like, 1 hit |
Gene3Di | 1.10.490.10, 1 hit |
InterProi | View protein in InterPro IPR000971 Globin IPR009050 Globin-like_sf IPR012292 Globin/Proto IPR002337 Haemoglobin_b |
Pfami | View protein in Pfam PF00042 Globin, 1 hit |
PRINTSi | PR00814 BETAHAEM |
SUPFAMi | SSF46458 SSF46458, 1 hit |
PROSITEi | View protein in PROSITE PS01033 GLOBIN, 1 hit |
i Sequence
Sequence statusi: Complete.
P02111-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
VHLSGGEKSA VTNLWGKVNI NELGGEALGR LLVVYPWTQR FFEAFGDLSS
60 70 80 90 100
AGAVMGNPKV KAHGAKVLTS FGDALKNLDD LKGTFAKLSE LHCDKLHVDP
110 120 130 140
ENFNRLGNVL IVVLARHFSK DFSPEVQAAW QKLVSGVAHA LGHKYH
Sequence databases
PIRi | A02431 HBOR |
Similar proteinsi
Cross-referencesi
Sequence databases
PIRi | A02431 HBOR |
3D structure databases
ProteinModelPortali | P02111 |
SMRi | P02111 |
ModBasei | Search... |
MobiDBi | Search... |
Proteomic databases
PRIDEi | P02111 |
Protocols and materials databases
Structural Biology Knowledgebase | Search... |
Phylogenomic databases
HOVERGENi | HBG009709 |
InParanoidi | P02111 |
Family and domain databases
CDDi | cd08925 Hb-beta_like, 1 hit |
Gene3Di | 1.10.490.10, 1 hit |
InterProi | View protein in InterPro IPR000971 Globin IPR009050 Globin-like_sf IPR012292 Globin/Proto IPR002337 Haemoglobin_b |
Pfami | View protein in Pfam PF00042 Globin, 1 hit |
PRINTSi | PR00814 BETAHAEM |
SUPFAMi | SSF46458 SSF46458, 1 hit |
PROSITEi | View protein in PROSITE PS01033 GLOBIN, 1 hit |
ProtoNeti | Search... |
Entry informationi
Entry namei | HBB_ORNAN | |
Accessioni | P02111Primary (citable) accession number: P02111 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 21, 1986 |
Last sequence update: | July 21, 1986 | |
Last modified: | November 7, 2018 | |
This is version 90 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Direct protein sequencing, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families