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Protein

Hemoglobin subunit epsilon-Y2

Gene

Hbb-y

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Hemoglobin epsilon chain is a beta-type chain found in early embryos.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi64Iron (heme distal ligand)PROSITE-ProRule annotation1
Metal bindingi93Iron (heme proximal ligand)PROSITE-ProRule annotation1

GO - Molecular functioni

  • heme binding Source: GO_Central
  • hemoglobin alpha binding Source: MGI
  • metal ion binding Source: UniProtKB-KW
  • organic acid binding Source: GO_Central
  • oxygen binding Source: GO_Central
  • oxygen carrier activity Source: GO_Central

GO - Biological processi

Keywordsi

Biological processOxygen transport, Transport
LigandHeme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Hemoglobin subunit epsilon-Y2
Alternative name(s):
Epsilon-Y2-globin
Hemoglobin epsilon-Y2 chain
Gene namesi
Name:Hbb-y
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:96027 Hbb-y

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000532192 – 147Hemoglobin subunit epsilon-Y2Add BLAST146

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei51PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP02104
PaxDbiP02104
PeptideAtlasiP02104
PRIDEiP02104

PTM databases

iPTMnetiP02104
PhosphoSitePlusiP02104

Expressioni

Tissue specificityi

High expression in yolk sac blood islands, fetal liver, and embryonic erythrocytes. Very low levels in adult liver and spleen.

Gene expression databases

CleanExiMM_HBB-Y

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi200224, 1 interactor
ComplexPortaliCPX-2939 Embryonic hemoglobin complex
STRINGi10090.ENSMUSP00000033229

Structurei

3D structure databases

ProteinModelPortaliP02104
SMRiP02104
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the globin family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3378 Eukaryota
COG1018 LUCA
HOGENOMiHOG000036868
HOVERGENiHBG009709
InParanoidiP02104
KOiK13825
PhylomeDBiP02104

Family and domain databases

CDDicd08925 Hb-beta_like, 1 hit
Gene3Di1.10.490.10, 1 hit
InterProiView protein in InterPro
IPR000971 Globin
IPR009050 Globin-like_sf
IPR012292 Globin/Proto
IPR002337 Haemoglobin_b
PfamiView protein in Pfam
PF00042 Globin, 1 hit
PRINTSiPR00814 BETAHAEM
SUPFAMiSSF46458 SSF46458, 1 hit
PROSITEiView protein in PROSITE
PS01033 GLOBIN, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P02104-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVNFTAEEKT LINGLWSKVN VEEVGGEALG RLLVVYPWTQ RFFDSFGNLS
60 70 80 90 100
SASAIMGNPR VKAHGKKVLT AFGESIKNLD NLKSALAKLS ELHCDKLHVD
110 120 130 140
PENFKLLGNV LVIVLASHFG NEFTAEMQAA WQKLVAGVAT ALSHKYH
Length:147
Mass (Da):16,137
Last modified:January 23, 2007 - v2
Checksum:iBAA84E91B8864C88
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9CR49Q9CR49_MOUSE
Globin b1
Hbb-y Glnb1
147Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti22 – 23EE → GK. 2
Natural varianti40Q → H. 1
Natural varianti94Missing . 1
Natural varianti124Missing . 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14061 Genomic DNA Translation: CAA32219.1
V00726 Genomic DNA Translation: CAA24104.1
M95676 Genomic DNA Translation: AAA40575.1
M26897 mRNA Translation: AAA37701.1
V00857 mRNA Translation: CAA24225.1
V00742 Genomic DNA Translation: CAA24117.1
CCDSiCCDS21593.1
PIRiA92342 HEMSY2
RefSeqiNP_032247.1, NM_008221.4
UniGeneiMm.440164

Genome annotation databases

GeneIDi15135
KEGGimmu:15135

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14061 Genomic DNA Translation: CAA32219.1
V00726 Genomic DNA Translation: CAA24104.1
M95676 Genomic DNA Translation: AAA40575.1
M26897 mRNA Translation: AAA37701.1
V00857 mRNA Translation: CAA24225.1
V00742 Genomic DNA Translation: CAA24117.1
CCDSiCCDS21593.1
PIRiA92342 HEMSY2
RefSeqiNP_032247.1, NM_008221.4
UniGeneiMm.440164

3D structure databases

ProteinModelPortaliP02104
SMRiP02104
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200224, 1 interactor
ComplexPortaliCPX-2939 Embryonic hemoglobin complex
STRINGi10090.ENSMUSP00000033229

PTM databases

iPTMnetiP02104
PhosphoSitePlusiP02104

Proteomic databases

MaxQBiP02104
PaxDbiP02104
PeptideAtlasiP02104
PRIDEiP02104

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi15135
KEGGimmu:15135

Organism-specific databases

CTDi15135
MGIiMGI:96027 Hbb-y

Phylogenomic databases

eggNOGiKOG3378 Eukaryota
COG1018 LUCA
HOGENOMiHOG000036868
HOVERGENiHBG009709
InParanoidiP02104
KOiK13825
PhylomeDBiP02104

Miscellaneous databases

ChiTaRSiHbb-y mouse
PROiPR:P02104
SOURCEiSearch...

Gene expression databases

CleanExiMM_HBB-Y

Family and domain databases

CDDicd08925 Hb-beta_like, 1 hit
Gene3Di1.10.490.10, 1 hit
InterProiView protein in InterPro
IPR000971 Globin
IPR009050 Globin-like_sf
IPR012292 Globin/Proto
IPR002337 Haemoglobin_b
PfamiView protein in Pfam
PF00042 Globin, 1 hit
PRINTSiPR00814 BETAHAEM
SUPFAMiSSF46458 SSF46458, 1 hit
PROSITEiView protein in PROSITE
PS01033 GLOBIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHBE_MOUSE
AccessioniPrimary (citable) accession number: P02104
Secondary accession number(s): Q62480, Q64358
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 135 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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