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Protein

Hemoglobin subunit epsilon

Gene

HBE1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The epsilon chain is a beta-type chain of early mammalian embryonic hemoglobin.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi64Iron (heme distal ligand)By similarity1
Metal bindingi93Iron (heme proximal ligand)Combined sources1 Publication1

GO - Molecular functioni

  • heme binding Source: GO_Central
  • hemoglobin alpha binding Source: GO_Central
  • metal ion binding Source: UniProtKB-KW
  • organic acid binding Source: GO_Central
  • oxygen binding Source: GO_Central
  • oxygen carrier activity Source: GO_Central

GO - Biological processi

Keywordsi

Biological processOxygen transport, Transport
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiR-HSA-983231 Factors involved in megakaryocyte development and platelet production
SIGNORiP02100

Names & Taxonomyi

Protein namesi
Recommended name:
Hemoglobin subunit epsilon
Alternative name(s):
Epsilon-globin
Hemoglobin epsilon chain
Gene namesi
Name:HBE1
Synonyms:HBE
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000213931.5
HGNCiHGNC:4830 HBE1
MIMi142100 gene
neXtProtiNX_P02100

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi3046
OpenTargetsiENSG00000213931
PharmGKBiPA29205

Polymorphism and mutation databases

BioMutaiHBE1
DMDMi122726

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000532122 – 147Hemoglobin subunit epsilonAdd BLAST146

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei14PhosphoserineCombined sources1
Modified residuei51PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP02100
MaxQBiP02100
PaxDbiP02100
PeptideAtlasiP02100
PRIDEiP02100
ProteomicsDBi51516

PTM databases

iPTMnetiP02100
PhosphoSitePlusiP02100

Expressioni

Tissue specificityi

Red blood cells.

Gene expression databases

BgeeiENSG00000213931 Expressed in 97 organ(s), highest expression level in embryo
CleanExiHS_HBE1
ExpressionAtlasiP02100 baseline and differential
GenevisibleiP02100 HS

Organism-specific databases

HPAiHPA043234

Interactioni

Subunit structurei

Heterotetramer of two alpha chains and two epsilon chains in early embryonic hemoglobin Gower-2; two zeta chains and two epsilon chains in early embryonic hemoglobin Gower-1.1 Publication

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi109296, 5 interactors
ComplexPortaliCPX-2927 Hemoglobin E complex
CPX-2928 Embryonic hemoglobin Gower-1 complex
IntActiP02100, 6 interactors
STRINGi9606.ENSP00000292896

Structurei

Secondary structure

1147
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP02100
SMRiP02100
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP02100

Family & Domainsi

Sequence similaritiesi

Belongs to the globin family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3378 Eukaryota
COG1018 LUCA
GeneTreeiENSGT00760000119197
HOGENOMiHOG000036868
HOVERGENiHBG009709
InParanoidiP02100
KOiK13825
OMAiMVHFTPE
OrthoDBiEOG091G0R7W
PhylomeDBiP02100
TreeFamiTF333268

Family and domain databases

CDDicd08925 Hb-beta_like, 1 hit
Gene3Di1.10.490.10, 1 hit
InterProiView protein in InterPro
IPR000971 Globin
IPR009050 Globin-like_sf
IPR012292 Globin/Proto
IPR002337 Haemoglobin_b
PfamiView protein in Pfam
PF00042 Globin, 1 hit
PRINTSiPR00814 BETAHAEM
SUPFAMiSSF46458 SSF46458, 1 hit
PROSITEiView protein in PROSITE
PS01033 GLOBIN, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P02100-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVHFTAEEKA AVTSLWSKMN VEEAGGEALG RLLVVYPWTQ RFFDSFGNLS
60 70 80 90 100
SPSAILGNPK VKAHGKKVLT SFGDAIKNMD NLKPAFAKLS ELHCDKLHVD
110 120 130 140
PENFKLLGNV MVIILATHFG KEFTPEVQAA WQKLVSAVAI ALAHKYH
Length:147
Mass (Da):16,203
Last modified:January 23, 2007 - v2
Checksum:i223388816EDDE8D5
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A8MUF7A8MUF7_HUMAN
Hemoglobin subunit epsilon
HBE1
87Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti143A → G AA sequence (PubMed:6172865).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U01317 Genomic DNA Translation: AAA16330.1
V00508 Genomic DNA Translation: CAA23766.1
CR541912 mRNA Translation: CAG46710.1
CH471064 Genomic DNA Translation: EAW68802.1
BC015537 mRNA Translation: AAH15537.1
CCDSiCCDS7756.1
PIRiA90802 HEHU
RefSeqiNP_005321.1, NM_005330.3
UniGeneiHs.655195

Genome annotation databases

EnsembliENST00000292896; ENSP00000292896; ENSG00000213931
ENST00000380237; ENSP00000369586; ENSG00000213931
ENST00000396895; ENSP00000380104; ENSG00000213931
GeneIDi3046
KEGGihsa:3046
UCSCiuc001mal.2 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U01317 Genomic DNA Translation: AAA16330.1
V00508 Genomic DNA Translation: CAA23766.1
CR541912 mRNA Translation: CAG46710.1
CH471064 Genomic DNA Translation: EAW68802.1
BC015537 mRNA Translation: AAH15537.1
CCDSiCCDS7756.1
PIRiA90802 HEHU
RefSeqiNP_005321.1, NM_005330.3
UniGeneiHs.655195

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1A9WX-ray2.90E/F2-147[»]
ProteinModelPortaliP02100
SMRiP02100
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109296, 5 interactors
ComplexPortaliCPX-2927 Hemoglobin E complex
CPX-2928 Embryonic hemoglobin Gower-1 complex
IntActiP02100, 6 interactors
STRINGi9606.ENSP00000292896

PTM databases

iPTMnetiP02100
PhosphoSitePlusiP02100

Polymorphism and mutation databases

BioMutaiHBE1
DMDMi122726

Proteomic databases

EPDiP02100
MaxQBiP02100
PaxDbiP02100
PeptideAtlasiP02100
PRIDEiP02100
ProteomicsDBi51516

Protocols and materials databases

DNASUi3046
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000292896; ENSP00000292896; ENSG00000213931
ENST00000380237; ENSP00000369586; ENSG00000213931
ENST00000396895; ENSP00000380104; ENSG00000213931
GeneIDi3046
KEGGihsa:3046
UCSCiuc001mal.2 human

Organism-specific databases

CTDi3046
DisGeNETi3046
EuPathDBiHostDB:ENSG00000213931.5
GeneCardsiHBE1
HGNCiHGNC:4830 HBE1
HPAiHPA043234
MIMi142100 gene
neXtProtiNX_P02100
OpenTargetsiENSG00000213931
PharmGKBiPA29205
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3378 Eukaryota
COG1018 LUCA
GeneTreeiENSGT00760000119197
HOGENOMiHOG000036868
HOVERGENiHBG009709
InParanoidiP02100
KOiK13825
OMAiMVHFTPE
OrthoDBiEOG091G0R7W
PhylomeDBiP02100
TreeFamiTF333268

Enzyme and pathway databases

ReactomeiR-HSA-983231 Factors involved in megakaryocyte development and platelet production
SIGNORiP02100

Miscellaneous databases

ChiTaRSiHBE1 human
EvolutionaryTraceiP02100
GeneWikiiHBE1
GenomeRNAii3046
PROiPR:P02100
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000213931 Expressed in 97 organ(s), highest expression level in embryo
CleanExiHS_HBE1
ExpressionAtlasiP02100 baseline and differential
GenevisibleiP02100 HS

Family and domain databases

CDDicd08925 Hb-beta_like, 1 hit
Gene3Di1.10.490.10, 1 hit
InterProiView protein in InterPro
IPR000971 Globin
IPR009050 Globin-like_sf
IPR012292 Globin/Proto
IPR002337 Haemoglobin_b
PfamiView protein in Pfam
PF00042 Globin, 1 hit
PRINTSiPR00814 BETAHAEM
SUPFAMiSSF46458 SSF46458, 1 hit
PROSITEiView protein in PROSITE
PS01033 GLOBIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHBE_HUMAN
AccessioniPrimary (citable) accession number: P02100
Secondary accession number(s): Q6FH44
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 181 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
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