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UniProtKB - P02089 (HBB2_MOUSE)
Protein
Hemoglobin subunit beta-2
Gene
Hbb-b2
Organism
Mus musculus (Mouse)
Status
Functioni
Involved in oxygen transport from the lung to the various peripheral tissues.
Miscellaneous
The D-minor sequence is shown. See also the entry for the beta D-major chain and the S allele.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 64 | Iron (heme distal ligand) | 1 | |
Metal bindingi | 93 | Iron (heme proximal ligand) | 1 |
GO - Molecular functioni
- heme binding Source: GO_Central
- hemoglobin alpha binding Source: MGI
- hemoglobin beta binding Source: MGI
- hemoglobin binding Source: MGI
- metal ion binding Source: UniProtKB-KW
- organic acid binding Source: GO_Central
- oxygen binding Source: MGI
- oxygen carrier activity Source: GO_Central
- protein-containing complex binding Source: MGI
GO - Biological processi
- cellular oxidant detoxification Source: GOC
- erythrocyte development Source: MGI
- glutathione metabolic process Source: MGI
- hydrogen peroxide catabolic process Source: GO_Central
- oxygen transport Source: MGI
- positive regulation of myeloid cell differentiation Source: MGI
- regulation of erythrocyte differentiation Source: MGI
Keywordsi
Biological process | Oxygen transport, Transport |
Ligand | Heme, Iron, Metal-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Hemoglobin subunit beta-2Alternative name(s): Beta-2-globin Hemoglobin beta-2 chain Hemoglobin beta-minor chain |
Gene namesi | Name:Hbb-b2 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:96022, Hbb-b2 |
Subcellular locationi
Cytosol
- hemoglobin complex Source: MGI
Extracellular region or secreted
- extracellular space Source: MGI
Other locations
- haptoglobin-hemoglobin complex Source: MGI
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000053025 | 2 – 147 | Hemoglobin subunit beta-2Add BLAST | 146 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylvalineBy similarity | 1 | |
Modified residuei | 18 | N6-succinyllysineCombined sources | 1 | |
Modified residuei | 42 | PhosphotyrosineCombined sources | 1 | |
Modified residuei | 45 | PhosphoserineCombined sources | 1 | |
Modified residuei | 51 | PhosphoserineBy similarity | 1 | |
Modified residuei | 53 | PhosphoserineCombined sources | 1 | |
Modified residuei | 60 | N6-succinyllysineCombined sources | 1 | |
Modified residuei | 105 | Asymmetric dimethylarginineCombined sources | 1 | |
Modified residuei | 124 | PhosphothreonineBy similarity | 1 |
Keywords - PTMi
Acetylation, Methylation, PhosphoproteinProteomic databases
CPTACi | non-CPTAC-4038 |
jPOSTi | P02089 |
PeptideAtlasi | P02089 |
PRIDEi | P02089 |
ProteomicsDBi | 270896 |
PTM databases
CarbonylDBi | P02089 |
iPTMneti | P02089 |
PhosphoSitePlusi | P02089 |
SwissPalmi | P02089 |
Expressioni
Tissue specificityi
Red blood cells.
Interactioni
Subunit structurei
Heterotetramer of two alpha chains and two beta chains.
GO - Molecular functioni
- hemoglobin alpha binding Source: MGI
- hemoglobin beta binding Source: MGI
- hemoglobin binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 200220, 3 interactors |
ComplexPortali | CPX-2924, Hemoglobin HbA complex, variant HBB2 |
IntActi | P02089, 8 interactors |
MINTi | P02089 |
Miscellaneous databases
RNActi | P02089, protein |
Structurei
3D structure databases
SMRi | P02089 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P02089 |
Family & Domainsi
Sequence similaritiesi
Belongs to the globin family.PROSITE-ProRule annotation
Phylogenomic databases
InParanoidi | P02089 |
OrthoDBi | 1370439at2759 |
Family and domain databases
CDDi | cd08925, Hb-beta-like, 1 hit |
Gene3Di | 1.10.490.10, 1 hit |
InterProi | View protein in InterPro IPR000971, Globin IPR009050, Globin-like_sf IPR012292, Globin/Proto IPR002337, Haemoglobin_b |
Pfami | View protein in Pfam PF00042, Globin, 1 hit |
PRINTSi | PR00814, BETAHAEM |
SUPFAMi | SSF46458, SSF46458, 1 hit |
PROSITEi | View protein in PROSITE PS01033, GLOBIN, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P02089-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVHLTDAEKS AVSCLWAKVN PDEVGGEALG RLLVVYPWTQ RYFDSFGDLS
60 70 80 90 100
SASAIMGNPK VKAHGKKVIT AFNEGLKNLD NLKGTFASLS ELHCDKLHVD
110 120 130 140
PENFRLLGNA IVIVLGHHLG KDFTPAAQAA FQKVVAGVAT ALAHKYH
Polymorphismi
Inbred mouse strains possess 1 of 3 alleles at the HBB locus: D (diffuse), S (single), and P. The D and P alleles are actually closely linked doublets that coordinately express a major and a minor chain, the minor chain being slightly different in the two alleles. The S allele produces only 1 chain, it is characteristic of North American wild mice.1 Publication
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural varianti | 23 – 24 | EV → AI in allele P. 1 Publication | 2 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | V00722 Genomic DNA Translation: CAA24101.1 X14061 Genomic DNA Translation: CAA32225.1 Sequence problems. BC027434 mRNA Translation: AAH27434.1 BC032264 mRNA Translation: AAH32264.1 |
PIRi | B90790, HBMSN1 |
RefSeqi | NP_058652.1, NM_016956.3 |
Genome annotation databases
GeneIDi | 15130 |
KEGGi | mmu:15130 |
UCSCi | uc009iup.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | V00722 Genomic DNA Translation: CAA24101.1 X14061 Genomic DNA Translation: CAA32225.1 Sequence problems. BC027434 mRNA Translation: AAH27434.1 BC032264 mRNA Translation: AAH32264.1 |
PIRi | B90790, HBMSN1 |
RefSeqi | NP_058652.1, NM_016956.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1FNE | X-ray | 1.90 | B/D | 65-77 | [»] | |
1FNG | X-ray | 1.90 | B/D | 65-77 | [»] | |
1I3R | X-ray | 2.40 | B/D/F/H | 65-77 | [»] | |
SMRi | P02089 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 200220, 3 interactors |
ComplexPortali | CPX-2924, Hemoglobin HbA complex, variant HBB2 |
IntActi | P02089, 8 interactors |
MINTi | P02089 |
Chemistry databases
ChEMBLi | CHEMBL4007 |
PTM databases
CarbonylDBi | P02089 |
iPTMneti | P02089 |
PhosphoSitePlusi | P02089 |
SwissPalmi | P02089 |
Proteomic databases
CPTACi | non-CPTAC-4038 |
jPOSTi | P02089 |
PeptideAtlasi | P02089 |
PRIDEi | P02089 |
ProteomicsDBi | 270896 |
Protocols and materials databases
DNASUi | 15130 |
Genome annotation databases
GeneIDi | 15130 |
KEGGi | mmu:15130 |
UCSCi | uc009iup.1, mouse |
Organism-specific databases
CTDi | 15130 |
MGIi | MGI:96022, Hbb-b2 |
Phylogenomic databases
InParanoidi | P02089 |
OrthoDBi | 1370439at2759 |
Miscellaneous databases
BioGRID-ORCSi | 15130, 0 hits in 10 CRISPR screens |
EvolutionaryTracei | P02089 |
PROi | PR:P02089 |
RNActi | P02089, protein |
SOURCEi | Search... |
Family and domain databases
CDDi | cd08925, Hb-beta-like, 1 hit |
Gene3Di | 1.10.490.10, 1 hit |
InterProi | View protein in InterPro IPR000971, Globin IPR009050, Globin-like_sf IPR012292, Globin/Proto IPR002337, Haemoglobin_b |
Pfami | View protein in Pfam PF00042, Globin, 1 hit |
PRINTSi | PR00814, BETAHAEM |
SUPFAMi | SSF46458, SSF46458, 1 hit |
PROSITEi | View protein in PROSITE PS01033, GLOBIN, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | HBB2_MOUSE | |
Accessioni | P02089Primary (citable) accession number: P02089 Secondary accession number(s): Q5D0E8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 21, 1986 |
Last sequence update: | January 23, 2007 | |
Last modified: | February 23, 2022 | |
This is version 168 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families