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Protein

Hemoglobin subunit beta-1

Gene

Hbb-b1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in oxygen transport from the lung to the various peripheral tissues.

Miscellaneous

The D-major sequence is shown. See also the entry for the beta D and P-minor chain.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi64Iron (heme distal ligand)By similarity1
Metal bindingi93Iron (heme proximal ligand)Combined sources1 Publication1

GO - Molecular functioni

  • heme binding Source: GO_Central
  • hemoglobin alpha binding Source: GO_Central
  • metal ion binding Source: UniProtKB-KW
  • organic acid binding Source: GO_Central
  • oxygen binding Source: GO_Central
  • oxygen carrier activity Source: MGI

GO - Biological processi

Keywordsi

Biological processOxygen transport, Transport
LigandHeme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Hemoglobin subunit beta-1
Alternative name(s):
Beta-1-globin
Hemoglobin beta-1 chain
Hemoglobin beta-major chain
Gene namesi
Name:Hbb-b1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:96021 Hbb-b1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000530242 – 147Hemoglobin subunit beta-1Add BLAST146

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylvalineBy similarity1
Modified residuei18N6-succinyllysineCombined sources1
Modified residuei21PhosphoserineCombined sources1
Modified residuei45PhosphoserineBy similarity1
Modified residuei51PhosphoserineBy similarity1
Modified residuei60N6-succinyllysineBy similarity1
Modified residuei105Asymmetric dimethylarginineBy similarity1
Modified residuei124PhosphothreonineBy similarity1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

MaxQBiP02088
PaxDbiP02088
PeptideAtlasiP02088
PRIDEiP02088

2D gel databases

REPRODUCTION-2DPAGEiIPI00553333
P02088
SWISS-2DPAGEiP02088

PTM databases

CarbonylDBiP02088
iPTMnetiP02088
PhosphoSitePlusiP02088
SwissPalmiP02088

Expressioni

Tissue specificityi

Red blood cells.

Gene expression databases

CleanExiMM_HBB-B1

Interactioni

Subunit structurei

Heterotetramer of two alpha chains and two beta chains.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi200219, 5 interactors
ComplexPortaliCPX-2922 Hemoglobin HbA Variant 1 complex
IntActiP02088, 11 interactors
MINTiP02088
STRINGi10090.ENSMUSP00000095794

Structurei

Secondary structure

1147
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP02088
SMRiP02088
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP02088

Family & Domainsi

Sequence similaritiesi

Belongs to the globin family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3378 Eukaryota
COG1018 LUCA
HOVERGENiHBG009709
InParanoidiP02088
KOiK13823
PhylomeDBiP02088

Family and domain databases

CDDicd08925 Hb-beta_like, 1 hit
Gene3Di1.10.490.10, 1 hit
InterProiView protein in InterPro
IPR000971 Globin
IPR009050 Globin-like_sf
IPR012292 Globin/Proto
IPR002337 Haemoglobin_b
PfamiView protein in Pfam
PF00042 Globin, 1 hit
PRINTSiPR00814 BETAHAEM
SUPFAMiSSF46458 SSF46458, 1 hit
PROSITEiView protein in PROSITE
PS01033 GLOBIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02088-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVHLTDAEKA AVSCLWGKVN SDEVGGEALG RLLVVYPWTQ RYFDSFGDLS
60 70 80 90 100
SASAIMGNAK VKAHGKKVIT AFNDGLNHLD SLKGTFASLS ELHCDKLHVD
110 120 130 140
PENFRLLGNM IVIVLGHHLG KDFTPAAQAA FQKVVAGVAT ALAHKYH
Length:147
Mass (Da):15,840
Last modified:January 23, 2007 - v2
Checksum:i8190EAEEFD9036A3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti15L → Q in BAB27362 (PubMed:16141072).Curated1
Sequence conflicti39T → A in BAB29299 (PubMed:16141072).Curated1
Sequence conflicti63A → T in BAB27237 (PubMed:16141072).Curated1
Sequence conflicti91E → Q (PubMed:482942).Curated1
Sequence conflicti109N → S in BAB29299 (PubMed:16141072).Curated1

Polymorphismi

Inbred mouse strains possess 1 of 4 alleles at the HBB locus: D (diffuse), S (single), P and W1. The D and P alleles are actually closely linked doublets that coordinately express a major and a minor chain, the minor chain being slightly different in the two alleles. The S allele produces only 1 chain, it is characteristic of North American wild mice. The W1 allele is observed mainly in Northwestern China.3 Publications

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti14C → G in allele S and allele W1. 3 Publications1
Natural varianti21S → A in allele S. 2 Publications1
Natural varianti74D → E in allele W1. 2 Publications1
Natural varianti135V → M in allele W1. 2 Publications1
Natural varianti140T → A in allele S. 2 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14061 Genomic DNA Translation: CAA32224.1
J00413 Genomic DNA Translation: AAA37791.1
AB020013 mRNA Translation: BAA77353.1
AB020015 mRNA Translation: BAA77355.1
AK002258 mRNA Translation: BAB21971.1
AK002394 mRNA Translation: BAB22067.1
AK003096 mRNA Translation: BAB22562.1
AK003472 mRNA Translation: BAB22806.1
AK005442 mRNA Translation: BAB24036.1
AK005490 mRNA Translation: BAB24075.1
AK005496 mRNA Translation: BAB24080.1
AK010873 mRNA Translation: BAB27237.1
AK010902 mRNA Translation: BAB27255.1
AK010980 mRNA Translation: BAB27302.1
AK010981 mRNA Translation: BAB27303.1
AK010991 mRNA Translation: BAB27310.1
AK010993 mRNA Translation: BAB27312.1
AK011006 mRNA Translation: BAB27325.1
AK011013 mRNA Translation: BAB27331.1
AK011016 mRNA Translation: BAB27334.1
AK011027 mRNA Translation: BAB27343.1
AK011033 mRNA Translation: BAB27347.1
AK011050 mRNA Translation: BAB27360.1
AK011052 mRNA Translation: BAB27361.1
AK011053 mRNA Translation: BAB27362.1
AK011057 mRNA Translation: BAB27365.1
AK011067 mRNA Translation: BAB27374.1
AK011069 mRNA Translation: BAB27376.1
AK011075 mRNA Translation: BAB27380.1
AK011077 mRNA Translation: BAB27382.1
AK011083 mRNA Translation: BAB27387.1
AK011102 mRNA Translation: BAB27399.1
AK012551 mRNA Translation: BAB28311.1
AK014364 mRNA Translation: BAB29299.1
AK027903 mRNA Translation: BAC25655.1
AK027904 mRNA Translation: BAC25656.1
AK028067 mRNA Translation: BAC25734.1
AK088149 mRNA Translation: BAC40173.1
AK133714 mRNA Translation: BAE21794.1
AK147001 mRNA Translation: BAE27598.1
AK160629 mRNA Translation: BAE35926.1
AK161021 mRNA Translation: BAE36152.1
AK165490 mRNA Translation: BAE38217.1
AK167615 mRNA Translation: BAE39668.1
AK168412 mRNA Translation: BAE40327.1
AK168477 mRNA Translation: BAE40366.1
AK168562 mRNA Translation: BAE40435.1
AK168584 mRNA Translation: BAE40453.1
AK168819 mRNA Translation: BAE40646.1
AK168826 mRNA Translation: BAE40653.1
AK168846 mRNA Translation: BAE40669.1
M19236 mRNA Translation: AAA37788.1
M10828 Genomic DNA Translation: AAA37786.1
M10830, M10829 Genomic DNA Translation: AAA37787.1
M10688 Genomic DNA Translation: AAA37790.1
PIRiA90790 HBMS
RefSeqiNP_001188320.1, NM_001201391.1
NP_001265090.1, NM_001278161.1
NP_032246.2, NM_008220.5
UniGeneiMm.288567
Mm.467412

Genome annotation databases

GeneIDi100503605
101488143
15129
KEGGimmu:100503605
mmu:101488143
mmu:15129
UCSCiuc009iuq.3 mouse

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14061 Genomic DNA Translation: CAA32224.1
J00413 Genomic DNA Translation: AAA37791.1
AB020013 mRNA Translation: BAA77353.1
AB020015 mRNA Translation: BAA77355.1
AK002258 mRNA Translation: BAB21971.1
AK002394 mRNA Translation: BAB22067.1
AK003096 mRNA Translation: BAB22562.1
AK003472 mRNA Translation: BAB22806.1
AK005442 mRNA Translation: BAB24036.1
AK005490 mRNA Translation: BAB24075.1
AK005496 mRNA Translation: BAB24080.1
AK010873 mRNA Translation: BAB27237.1
AK010902 mRNA Translation: BAB27255.1
AK010980 mRNA Translation: BAB27302.1
AK010981 mRNA Translation: BAB27303.1
AK010991 mRNA Translation: BAB27310.1
AK010993 mRNA Translation: BAB27312.1
AK011006 mRNA Translation: BAB27325.1
AK011013 mRNA Translation: BAB27331.1
AK011016 mRNA Translation: BAB27334.1
AK011027 mRNA Translation: BAB27343.1
AK011033 mRNA Translation: BAB27347.1
AK011050 mRNA Translation: BAB27360.1
AK011052 mRNA Translation: BAB27361.1
AK011053 mRNA Translation: BAB27362.1
AK011057 mRNA Translation: BAB27365.1
AK011067 mRNA Translation: BAB27374.1
AK011069 mRNA Translation: BAB27376.1
AK011075 mRNA Translation: BAB27380.1
AK011077 mRNA Translation: BAB27382.1
AK011083 mRNA Translation: BAB27387.1
AK011102 mRNA Translation: BAB27399.1
AK012551 mRNA Translation: BAB28311.1
AK014364 mRNA Translation: BAB29299.1
AK027903 mRNA Translation: BAC25655.1
AK027904 mRNA Translation: BAC25656.1
AK028067 mRNA Translation: BAC25734.1
AK088149 mRNA Translation: BAC40173.1
AK133714 mRNA Translation: BAE21794.1
AK147001 mRNA Translation: BAE27598.1
AK160629 mRNA Translation: BAE35926.1
AK161021 mRNA Translation: BAE36152.1
AK165490 mRNA Translation: BAE38217.1
AK167615 mRNA Translation: BAE39668.1
AK168412 mRNA Translation: BAE40327.1
AK168477 mRNA Translation: BAE40366.1
AK168562 mRNA Translation: BAE40435.1
AK168584 mRNA Translation: BAE40453.1
AK168819 mRNA Translation: BAE40646.1
AK168826 mRNA Translation: BAE40653.1
AK168846 mRNA Translation: BAE40669.1
M19236 mRNA Translation: AAA37788.1
M10828 Genomic DNA Translation: AAA37786.1
M10830, M10829 Genomic DNA Translation: AAA37787.1
M10688 Genomic DNA Translation: AAA37790.1
PIRiA90790 HBMS
RefSeqiNP_001188320.1, NM_001201391.1
NP_001265090.1, NM_001278161.1
NP_032246.2, NM_008220.5
UniGeneiMm.288567
Mm.467412

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1JEBX-ray2.10B/D2-147[»]
3HRWX-ray2.80B/D2-147[»]
ProteinModelPortaliP02088
SMRiP02088
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200219, 5 interactors
ComplexPortaliCPX-2922 Hemoglobin HbA Variant 1 complex
IntActiP02088, 11 interactors
MINTiP02088
STRINGi10090.ENSMUSP00000095794

PTM databases

CarbonylDBiP02088
iPTMnetiP02088
PhosphoSitePlusiP02088
SwissPalmiP02088

2D gel databases

REPRODUCTION-2DPAGEiIPI00553333
P02088
SWISS-2DPAGEiP02088

Proteomic databases

MaxQBiP02088
PaxDbiP02088
PeptideAtlasiP02088
PRIDEiP02088

Protocols and materials databases

DNASUi15129
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100503605
101488143
15129
KEGGimmu:100503605
mmu:101488143
mmu:15129
UCSCiuc009iuq.3 mouse

Organism-specific databases

CTDi100503605
101488143
15129
MGIiMGI:96021 Hbb-b1

Phylogenomic databases

eggNOGiKOG3378 Eukaryota
COG1018 LUCA
HOVERGENiHBG009709
InParanoidiP02088
KOiK13823
PhylomeDBiP02088

Miscellaneous databases

ChiTaRSiHbb-b1 mouse
EvolutionaryTraceiP02088
PROiPR:P02088
SOURCEiSearch...

Gene expression databases

CleanExiMM_HBB-B1

Family and domain databases

CDDicd08925 Hb-beta_like, 1 hit
Gene3Di1.10.490.10, 1 hit
InterProiView protein in InterPro
IPR000971 Globin
IPR009050 Globin-like_sf
IPR012292 Globin/Proto
IPR002337 Haemoglobin_b
PfamiView protein in Pfam
PF00042 Globin, 1 hit
PRINTSiPR00814 BETAHAEM
SUPFAMiSSF46458 SSF46458, 1 hit
PROSITEiView protein in PROSITE
PS01033 GLOBIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHBB1_MOUSE
AccessioniPrimary (citable) accession number: P02088
Secondary accession number(s): Q54AI0
, Q91V86, Q9CRZ2, Q9CXH5, Q9CY12, Q9CY54, Q9R0S6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 173 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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