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Protein

HLA class II histocompatibility antigen, DQ beta 1 chain

Gene

HLA-DQB1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • MHC class II receptor activity Source: UniProtKB
  • peptide antigen binding Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processImmunity

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-202424 Downstream TCR signaling
R-HSA-202427 Phosphorylation of CD3 and TCR zeta chains
R-HSA-202430 Translocation of ZAP-70 to Immunological synapse
R-HSA-202433 Generation of second messenger molecules
R-HSA-2132295 MHC class II antigen presentation
R-HSA-389948 PD-1 signaling
R-HSA-877300 Interferon gamma signaling

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P01920

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
HLA class II histocompatibility antigen, DQ beta 1 chain
Alternative name(s):
MHC class II antigen DQB1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HLA-DQB1
Synonyms:HLA-DQB
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:4944 HLA-DQB1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
604305 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P01920

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini33 – 230ExtracellularSequence analysisAdd BLAST198
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei231 – 251HelicalSequence analysisAdd BLAST21
Topological domaini252 – 261CytoplasmicSequence analysis10

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Endosome, Golgi apparatus, Lysosome, Membrane, MHC II

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
3119

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...
GeneReviewsi
HLA-DQB1

MalaCards human disease database

More...
MalaCardsi
HLA-DQB1

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
703 Bullous pemphigoid
930 Idiopathic achalasia
163908 Limbic encephalitis with LGI1 antibodies
2073 Narcolepsy type 1
83465 Narcolepsy type 2
555 NON RARE IN EUROPE: Celiac disease
243377 NON RARE IN EUROPE: Diabetes mellitus type 1
802 NON RARE IN EUROPE: Multiple sclerosis
477738 Pediatric multiple sclerosis

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA35068

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB00071 Insulin Pork

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
HLA-DQB1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
290457643

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 321 PublicationAdd BLAST32
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001898933 – 261HLA class II histocompatibility antigen, DQ beta 1 chainAdd BLAST229

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi47 ↔ 111
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi51N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi149 ↔ 205

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
P01920

PRoteomics IDEntifications database

More...
PRIDEi
P01920

ProteomicsDB human proteome resource

More...
ProteomicsDBi
51513

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P01920

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P01920

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

CleanEx database of gene expression profiles

More...
CleanExi
HS_HLA-DQB1

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA013667

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. In the endoplasmic reticulum (ER) it forms a heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as invariant chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74 undergoes sequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II molecule. MHC class II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and facilitate the binding of antigenic peptides.4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
HLA-DQA1P019098EBI-1038012,EBI-713389

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
109364, 11 interactors

Protein interaction database and analysis system

More...
IntActi
P01920, 3 interactors

Molecular INTeraction database

More...
MINTi
P01920

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1261
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P01920

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P01920

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P01920

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini129 – 217Ig-like C1-typeAdd BLAST89

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni33 – 126Beta-1Add BLAST94
Regioni127 – 220Beta-2Add BLAST94
Regioni221 – 230Connecting peptide10

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the MHC class II family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG012730

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P01920

KEGG Orthology (KO)

More...
KOi
K06752

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P01920

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 1 hit
3.10.320.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set
IPR011162 MHC_I/II-like_Ag-recog
IPR014745 MHC_II_a/b_N
IPR000353 MHC_II_b_N

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07654 C1-set, 1 hit
PF00969 MHC_II_beta, 1 hit

ProDom; a protein domain database

More...
ProDomi
View protein in ProDom or Entries sharing at least one domain
PD000328 MHC_II_b_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00407 IGc1, 1 hit
SM00921 MHC_II_beta, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726 SSF48726, 1 hit
SSF54452 SSF54452, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS00290 IG_MHC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 23 potential isoforms that are computationally mapped.Show allAlign All

P01920-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSWKKALRIP GGLRAATVTL MLAMLSTPVA EGRDSPEDFV YQFKAMCYFT
60 70 80 90 100
NGTERVRYVT RYIYNREEYA RFDSDVEVYR AVTPLGPPDA EYWNSQKEVL
110 120 130 140 150
ERTRAELDTV CRHNYQLELR TTLQRRVEPT VTISPSRTEA LNHHNLLVCS
160 170 180 190 200
VTDFYPAQIK VRWFRNDQEE TTGVVSTPLI RNGDWTFQIL VMLEMTPQHG
210 220 230 240 250
DVYTCHVEHP SLQNPITVEW RAQSESAQSK MLSGIGGFVL GLIFLGLGLI
260
IHHRSQKGLL H
Length:261
Mass (Da):29,991
Last modified:March 2, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i79B1E571A628CF96
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 23 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5Y7D3Q5Y7D3_HUMAN
HLA class II histocompatibility ant...
HLA-DQB1
261Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0U5Q247A0A0U5Q247_HUMAN
HLA class II histocompatibility ant...
HLA-DQB1
261Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0D5XQ77A0A0D5XQ77_HUMAN
HLA class II histocompatibility ant...
HLA-DQB1 DQB1
269Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5SU54Q5SU54_HUMAN
HLA class II histocompatibility ant...
HLA-DQB1
269Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5Y7D6Q5Y7D6_HUMAN
HLA class II histocompatibility ant...
HLA-DQB1
261Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A140T8Z5A0A140T8Z5_HUMAN
HLA class II histocompatibility ant...
HLA-DQB1
269Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A140T9S8A0A140T9S8_HUMAN
HLA class II histocompatibility ant...
HLA-DQB1
269Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2AAZ0A2AAZ0_HUMAN
HLA class II histocompatibility ant...
HLA-DQB1
224Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q29967Q29967_HUMAN
HLA class II histocompatibility ant...
HLA-DQB1
224Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A140T8Z1A0A140T8Z1_HUMAN
HLA class II histocompatibility ant...
HLA-DQB1
224Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC64403 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAJ57391 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti111C → S in AAD39697 (Ref. 71) Curated1
Sequence conflicti113H → Q in AAF28315 (PubMed:11098940).Curated1
Sequence conflicti173G → A in X76553 (PubMed:7928445).Curated1
Sequence conflicti173G → A in X76554 (PubMed:7928445).Curated1
Sequence conflicti214N → T in AAA59770 (PubMed:3584986).Curated1

<p>This subsection of the ‘Sequence’ section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement_in_disease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

The following alleles of HLA-DQB1 are known: DQB1*02:01, DQB1*02:02, DQB1*02:03, DQB1*02:04, DQB1*02:05, DQB1*03:01, DQB1*03:02, DQB1*03:03, DQB1*03:04, DQB1*03:05, DQB1*03:06, DQB1*03:07, DQB1*03:08, DQB1*03:09, DQB1*03:10, DQB1*03:11, DQB1*03:12, DQB1*03:13, DQB1*03:14, DQB1*03:15, DQB1*03:16, DQB1*03:17, DQB1*03:18, DQB1*03:19, DQB1*03:20, DQB1*03:21, DQB1*03:22, DQB1*03:23, DQB1*03:24, DQB1*03:25, DQB1*03:26, DQB1*04:01, DQB1*04:02, DQB1*04:03, DQB1*05:01, DQB1*05:02, DQB1*05:03, DQB1*05:04, DQB1*05:05, DQB1*06:01, DQB1*06:02, DQB1*06:03, DQB1*06:04, DQB1*06:05, DQB1*06:06, DQB1*06:07, DQB1*06:08, DQB1*06:09, DQB1*06:10, DQB1*06:11, DQB1*06:12, DQB1*06:13, DQB1*06:14, DQB1*06:15, DQB1*06:16, DQB1*06:17, DQB1*06:18, DQB1*06:19, DQB1*06:20, DQB1*06:21, DQB1*06:22, DQB1*06:23, DQB1*06:24, DQB1*06:25, DQB1*06:27, DQB1*06:28, DQB1*06:29, DQB1*06:30, DQB1*06:31, DQB1*06:32, DQB1*06:33, DQB1*06:34, DQB1*06:35, DQB1*06:36, DQB1*06:37, DQB1*06:38, and DQB1*06:39. The sequence shown is that of DQB1*03:01.
DQ2 (heterodimer of DQA1*05:01/DQB1*02:01) is associated with more than 90% of celiac disease patients. A minority displays DQ8 (heterodimer of DQA1*03/DQB1*03:02).
DQ0602 (heterodimer of DQA1*01:02/DQB1*06:02) confers dominant protection against type 1 diabetes (T1D) and strong susceptibility to narcolepsy. DQB1*06:02 has been found to be present in most of the narcolepsy patients. As well 98% of the patients with an HCRT deficiency are positive for DQB1*06:02.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0565706A → S in allele DQB1*05:01 and allele DQB1*05:02. Corresponds to variant dbSNP:rs1049056Ensembl.1
Natural variantiVAR_06267912G → D in allele DQB1*05:01, allele DQB1*05:02, allele DQB1*06:02 and allele DQB1*06:12. Corresponds to variant dbSNP:rs1049057Ensembl.1
Natural variantiVAR_06268015A → V in allele DQB1*03:02, allele DQB1*03:03, allele DQB1*04:01, allele DQB1*05:01, allele DQB1*05:02, allele DQB1*06:02 and allele DQB1*06:12. 1 PublicationCorresponds to variant dbSNP:rs3189152Ensembl.1
Natural variantiVAR_06268123A → S in allele DQB1*02:01 and allele DQB1*02:02. Corresponds to variant dbSNP:rs3891176Ensembl.1
Natural variantiVAR_06268224M → I in allele DQB1*05:01 and allele DQB1*05:02. Corresponds to variant dbSNP:rs1049059Ensembl.1
Natural variantiVAR_06268327T → A in allele DQB1*04:01. Corresponds to variant dbSNP:rs1049060Ensembl.1
Natural variantiVAR_06268427T → S in allele DQB1*05:01, allele DQB1*05:02, allele DQB1*06:02 and allele DQB1*06:12. Corresponds to variant dbSNP:rs1049060Ensembl.1
Natural variantiVAR_06268528P → L in allele DQB1*06:02 and allele DQB1*06:12. Corresponds to variant dbSNP:rs1049062Ensembl.1
Natural variantiVAR_06268628P → S in allele DQB1*05:01 and allele DQB1*05:02. 1 PublicationCorresponds to variant dbSNP:rs1049061Ensembl.1
Natural variantiVAR_06268729V → L in allele DQB1*05:01, allele DQB1*05:02, allele DQB1*06:02 and allele DQB1*06:12. Corresponds to variant dbSNP:rs1130366Ensembl.1
Natural variantiVAR_06268835S → P in allele DQB1*06:01. Corresponds to variant dbSNP:rs12722106Ensembl.1
Natural variantiVAR_06268941Y → F in allele DQB1*04:01, allele DQB1*04:02, allele DQB1*04:03, allele DQB1*06:02, allele DQB1*06:10, allele DQB1*06:13, allele DQB1*06:14, allele DQB1*06:15, allele DQB1*06:16, allele DQB1*06:19, allele DQB1*06:20, allele DQB1*06:22, allele DQB1*06:23, allele DQB1*06:24, allele DQB1*06:29, allele DQB1*06:33 and allele DQB1*06:37. Corresponds to variant dbSNP:rs9274407Ensembl.1
Natural variantiVAR_06269041Y → L in allele DQB1*06:01 and allele DQB1*06:35; requires 2 nucleotide substitutions. 1
Natural variantiVAR_06269143F → L in allele DQB1*06:33. Corresponds to variant dbSNP:rs56173496Ensembl.1
Natural variantiVAR_06147245A → G in allele DQB1*02:01, allele DQB1*02:02, allele DQB1*02:03, allele DQB1*02:04, allele DQB1*02:05, allele DQB1*03:02, allele DQB1*03:03, allele DQB1*03:05, allele DQB1*03:06, allele DQB1*03:07, allele DQB1*03:08, allele DQB1*03:11, allele DQB1*03:15, allele DQB1*03:17, allele DQB1*03:18, allele DQB1*03:20, allele DQB1*03:23, allele DQB1*03:25, allele DQB1*03:26, allele DQB1*04:01, allele DQB1*04:02, allele DQB1*04:03, allele DQB1*05:01, allele DQB1*05:02, allele DQB1*05:03, allele DQB1*05:04, allele DQB1*05:05, allele DQB1*06:02, allele DQB1*06:03, allele DQB1*06:04, allele DQB1*06:05, allele DQB1*06:07, allele DQB1*06:08, allele DQB1*06:09, allele DQB1*06:10, allele DQB1*06:11, allele DQB1*06:12, allele DQB1*06:13, allele DQB1*06:14, allele DQB1*06:15, allele DQB1*06:16, allele DQB1*06:17, allele DQB1*06:18, allele DQB1*06:19, allele DQB1*06:20, allele DQB1*06:21, allele DQB1*06:22, allele DQB1*06:23, allele DQB1*06:24, allele DQB1*06:25, allele DQB1*06:27, allele DQB1*06:28, allele DQB1*06:29, allele DQB1*06:30, allele DQB1*06:31, allele DQB1*06:32, allele DQB1*06:33, allele DQB1*06:34, allele DQB1*06:36, allele DQB1*06:37, allele DQB1*06:38 and allele DQB1*06:39. 1 PublicationCorresponds to variant dbSNP:rs1130375Ensembl.1
Natural variantiVAR_06147346M → L in allele DQB1*03:11, allele DQB1*03:26, allele DQB1*05:01, allele DQB1*05:02, allele DQB1*05:03, allele DQB1*05:04, allele DQB1*05:05, allele DQB1*06:05, allele DQB1*06:20 and allele DQB1*06:31. Corresponds to variant dbSNP:rs1130368Ensembl.1
Natural variantiVAR_06269255R → L in allele DQB1*04:01. Corresponds to variant dbSNP:rs41540813Ensembl.1
Natural variantiVAR_06269358Y → G in allele DQB1*03:05, allele DQB1*03:17, allele DQB1*04:01, allele DQB1*04:02, allele DQB1*05:01, allele DQB1*05:02, allele DQB1*05:03, allele DQB1*05:04, allele DQB1*05:05 and allele DQB1*06:23; requires 2 nucleotide substitutions. 1
Natural variantiVAR_06269458Y → L in allele DQB1*02:01, allele DQB1*02:02, allele DQB1*02:03, allele DQB1*02:04, allele DQB1*02:05, allele DQB1*03:02, allele DQB1*03:03, allele DQB1*03:06, allele DQB1*03:07, allele DQB1*03:08, allele DQB1*03:11, allele DQB1*03:12, allele DQB1*03:15, allele DQB1*03:18, allele DQB1*03:20, allele DQB1*03:23, allele DQB1*03:25, allele DQB1*03:26, allele DQB1*04:03, allele DQB1*06:02, allele DQB1*06:03, allele DQB1*06:04, allele DQB1*06:05, allele DQB1*06:06, allele DQB1*06:07, allele DQB1*06:08, allele DQB1*06:09, allele DQB1*06:10, allele DQB1*06:11, allele DQB1*06:12, allele DQB1*06:13, allele DQB1*06:14, allele DQB1*06:15, allele DQB1*06:16, allele DQB1*06:17, allele DQB1*06:18, allele DQB1*06:19, allele DQB1*06:20, allele DQB1*06:21, allele DQB1*06:22, allele DQB1*06:24, allele DQB1*06:25, allele DQB1*06:27, allele DQB1*06:28, allele DQB1*06:29, allele DQB1*06:30, allele DQB1*06:31, allele DQB1*06:32, allele DQB1*06:33, allele DQB1*06:34, allele DQB1*06:36, allele DQB1*06:37, allele DQB1*06:38 and allele DQB1*06:39; requires 2 nucleotide substitutions. 1 PublicationCorresponds to variant dbSNP:rs766817072Ensembl.1
Natural variantiVAR_06269559V → L in allele DQB1*03:18. Corresponds to variant dbSNP:rs41563539Ensembl.1
Natural variantiVAR_06269660T → S in allele DQB1*02:01, allele DQB1*02:02, allele DQB1*02:03, allele DQB1*02:04 and allele DQB1*02:05. Corresponds to variant dbSNP:rs9274405Ensembl.1
Natural variantiVAR_06269762Y → H in allele DQB1*05:01, allele DQB1*05:02, allele DQB1*05:03, allele DQB1*05:05, allele DQB1*06:03, allele DQB1*06:04, allele DQB1*06:07, allele DQB1*06:08, allele DQB1*06:14, allele DQB1*06:17, allele DQB1*06:21, allele DQB1*06:25, allele DQB1*06:27, allele DQB1*06:28, allele DQB1*06:30, allele DQB1*06:31, allele DQB1*06:32, allele DQB1*06:34, allele DQB1*06:36, allele DQB1*06:38 and allele DQB1*06:39. Corresponds to variant dbSNP:rs281862065Ensembl.1
Natural variantiVAR_06269862Y → S in allele DQB1*02:01, allele DQB1*02:02, allele DQB1*02:03, allele DQB1*02:04 and allele DQB1*02:05. 1
Natural variantiVAR_06269969Y → D in allele DQB1*06:01 and allele DQB1*06:35. Corresponds to variant dbSNP:rs281874782Ensembl.1
Natural variantiVAR_06270069Y → I in allele DQB1*02:01, allele DQB1*02:02, allele DQB1*02:03, allele DQB1*02:04 and allele DQB1*02:05; requires 2 nucleotide substitutions. 1
Natural variantiVAR_06270170A → T in allele DQB1*03:20. Corresponds to variant dbSNP:rs45519640Ensembl.1
Natural variantiVAR_06270270A → V in allele DQB1*02:01, allele DQB1*02:02, allele DQB1*02:03, allele DQB1*02:04, allele DQB1*02:05, allele DQB1*05:01, allele DQB1*05:02, allele DQB1*05:03, allele DQB1*05:04, allele DQB1*06:01, allele DQB1*06:28 and allele DQB1*06:35. Corresponds to variant dbSNP:rs1063318Ensembl.1
Natural variantiVAR_06270377E → G in allele DQB1*02:01, allele DQB1*02:02, allele DQB1*02:03, allele DQB1*02:04, allele DQB1*02:05, allele DQB1*03:02, allele DQB1*03:03, allele DQB1*03:05, allele DQB1*03:06, allele DQB1*03:07, allele DQB1*03:08, allele DQB1*03:10, allele DQB1*03:11, allele DQB1*03:12, allele DQB1*03:14, allele DQB1*03:15, allele DQB1*03:17, allele DQB1*03:18, allele DQB1*03:20, allele DQB1*03:23, allele DQB1*03:25, allele DQB1*03:26, allele DQB1*04:01, allele DQB1*04:02, allele DQB1*04:03, allele DQB1*05:01, allele DQB1*05:02, allele DQB1*05:03, allele DQB1*05:04, allele DQB1*05:05, allele DQB1*06:01, allele DQB1*06:02, allele DQB1*06:03, allele DQB1*06:04, allele DQB1*06:05, allele DQB1*06:06, allele DQB1*06:07, allele DQB1*06:08, allele DQB1*06:09, allele DQB1*06:10, allele DQB1*06:11, allele DQB1*06:12, allele DQB1*06:13, allele DQB1*06:14, allele DQB1*06:15, allele DQB1*06:16, allele DQB1*06:17, allele DQB1*06:18, allele DQB1*06:19, allele DQB1*06:20, allele DQB1*06:21, allele DQB1*06:22, allele DQB1*06:23, allele DQB1*06:24, allele DQB1*06:25, allele DQB1*06:27, allele DQB1*06:28, allele DQB1*06:29, allele DQB1*06:30, allele DQB1*06:31, allele DQB1*06:32, allele DQB1*06:33, allele DQB1*06:34, allele DQB1*06:36, allele DQB1*06:37, allele DQB1*06:38 and allele DQB1*06:39. 1 PublicationCorresponds to variant dbSNP:rs1049083Ensembl.1
Natural variantiVAR_06270478V → E in allele DQB1*02:01, allele DQB1*02:02, allele DQB1*02:03, allele DQB1*02:04 and allele DQB1*02:05. Corresponds to variant dbSNP:rs9274398Ensembl.1
Natural variantiVAR_06270579Y → F in allele DQB1*02:01, allele DQB1*02:02, allele DQB1*02:03, allele DQB1*02:04 and allele DQB1*02:05. Corresponds to variant dbSNP:rs9274397Ensembl.1
Natural variantiVAR_06270681A → V in allele DQB1*03:07. Corresponds to variant dbSNP:rs41558214Ensembl.1
Natural variantiVAR_06270784P → L in allele DQB1*02:01, allele DQB1*02:02, allele DQB1*02:03, allele DQB1*02:04 and allele DQB1*02:05. Corresponds to variant dbSNP:rs9274395Ensembl.1
Natural variantiVAR_06270885L → Q in allele DQB1*03:23, allele DQB1*05:01, allele DQB1*05:02, allele DQB1*05:03, allele DQB1*05:04, allele DQB1*05:05, allele DQB1*06:01, allele DQB1*06:02, allele DQB1*06:03, allele DQB1*06:04, allele DQB1*06:05, allele DQB1*06:06, allele DQB1*06:07, allele DQB1*06:08, allele DQB1*06:09, allele DQB1*06:10, allele DQB1*06:11, allele DQB1*06:12, allele DQB1*06:13, allele DQB1*06:14, allele DQB1*06:15, allele DQB1*06:16, allele DQB1*06:17, allele DQB1*06:18, allele DQB1*06:20, allele DQB1*06:22, allele DQB1*06:21, allele DQB1*06:23, allele DQB1*06:24, allele DQB1*06:25, allele DQB1*06:27, allele DQB1*06:28, allele DQB1*06:29, allele DQB1*06:30, allele DQB1*06:31, allele DQB1*06:32, allele DQB1*06:33, allele DQB1*06:34, allele DQB1*06:36, allele DQB1*06:37, allele DQB1*06:38 and allele DQB1*06:39. Corresponds to variant dbSNP:rs1140313Ensembl.1
Natural variantiVAR_06270987P → L in allele DQB1*02:01, allele DQB1*02:02, allele DQB1*02:03, allele DQB1*02:04 and allele DQB1*02:05. Corresponds to variant dbSNP:rs1130380Ensembl.1
Natural variantiVAR_06271087P → Q in allele DQB1*03:16. Corresponds to variant dbSNP:rs1130380Ensembl.1
Natural variantiVAR_06271187P → R in allele DQB1*03:23, allele DQB1*03:25, allele DQB1*04:01, allele DQB1*04:02, allele DQB1*04:03, allele DQB1*05:01, allele DQB1*05:02, allele DQB1*05:03, allele DQB1*05:04, allele DQB1*05:05, allele DQB1*06:01, allele DQB1*06:02, allele DQB1*06:03, allele DQB1*06:04, allele DQB1*06:05, allele DQB1*06:06, allele DQB1*06:07, allele DQB1*06:08, allele DQB1*06:09, allele DQB1*06:10, allele DQB1*06:11, allele DQB1*06:12, allele DQB1*06:13, allele DQB1*06:14, allele DQB1*06:15, allele DQB1*06:16, allele DQB1*06:17, allele DQB1*06:18, allele DQB1*06:19, allele DQB1*06:20, allele DQB1*06:21, allele DQB1*06:22, allele DQB1*06:23, allele DQB1*06:24, allele DQB1*06:25, allele DQB1*06:27, allele DQB1*06:28, allele DQB1*06:30, allele DQB1*06:31, allele DQB1*06:32, allele DQB1*06:33, allele DQB1*06:34, allele DQB1*06:35, allele DQB1*06:36, allele DQB1*06:37, allele DQB1*06:38 and allele DQB1*06:39. Corresponds to variant dbSNP:rs1130380Ensembl.1
Natural variantiVAR_06271288P → L in allele DQB1*03:25, allele DQB1*04:01, allele DQB1*04:02 and allele DQB1*04:03. Corresponds to variant dbSNP:rs1130381Ensembl.1
Natural variantiVAR_06271389D → A in allele DQB1*02:01, allele DQB1*02:02, allele DQB1*02:04, allele DQB1*02:05, allele DQB1*03:02, allele DQB1*03:04, allele DQB1*03:05, allele DQB1*03:07, allele DQB1*03:08, allele DQB1*03:11, allele DQB1*03:14, allele DQB1*03:18 and allele DQB1*06:29. Corresponds to variant dbSNP:rs1071637Ensembl.1
Natural variantiVAR_06271489D → S in allele DQB1*05:02, allele DQB1*05:04, allele DQB1*05:05, allele DQB1*06:10 and allele DQB1*06:25; requires 2 nucleotide substitutions. 1
Natural variantiVAR_06271589D → V in allele DQB1*05:01, allele DQB1*06:04, allele DQB1*06:05, allele DQB1*06:06, allele DQB1*06:08, allele DQB1*06:09, allele DQB1*06:12, allele DQB1*06:13, allele DQB1*06:17, allele DQB1*06:18, allele DQB1*06:21, allele DQB1*06:22, allele DQB1*06:27, allele DQB1*06:34, allele DQB1*06:36, allele DQB1*06:38 and allele DQB1*06:39. Corresponds to variant dbSNP:rs1071637Ensembl.1
Natural variantiVAR_06271692Y → N in allele DQB1*06:16. Corresponds to variant dbSNP:rs41562414Ensembl.1
Natural variantiVAR_06271794N → K in allele DQB1*06:37. Corresponds to variant dbSNP:rs1130382Ensembl.1
Natural variantiVAR_06271895S → R in allele DQB1*03:15. Corresponds to variant dbSNP:rs41556215Ensembl.1
Natural variantiVAR_06271998E → D in allele DQB1*02:01, allele DQB1*02:02, allele DQB1*02:03, allele DQB1*02:04, allele DQB1*02:05, allele DQB1*03:06, allele DQB1*03:25, allele DQB1*04:01, allele DQB1*04:02, allele DQB1*04:03, allele DQB1*05:04, allele DQB1*06:01 and allele DQB1*06:35. Corresponds to variant dbSNP:rs9274390Ensembl.1
Natural variantiVAR_06272099V → D in allele DQB1*03:13. Corresponds to variant dbSNP:rs41563814Ensembl.1
Natural variantiVAR_06272199V → I in allele DQB1*02:01, allele DQB1*02:02, allele DQB1*02:03, allele DQB1*02:04, allele DQB1*02:05, allele DQB1*03:06, allele DQB1*03:25, allele DQB1*04:01, allele DQB1*04:02, allele DQB1*04:03, allele DQB1*05:04, allele DQB1*06:01 and allele DQB1*06:35. Corresponds to variant dbSNP:rs9274390Ensembl.1
Natural variantiVAR_062722102R → E in allele DQB1*03:06, allele DQB1*03:25, allele DQB1*04:01, allele DQB1*04:02, allele DQB1*04:03 and allele DQB1*05:04; requires 2 nucleotide substitutions. 1
Natural variantiVAR_062723102R → G in allele DQB1*03:08, allele DQB1*05:01, allele DQB1*05:02, allele DQB1*05:03, allele DQB1*05:05, allele DQB1*06:02, allele DQB1*06:03, allele DQB1*06:08, allele DQB1*06:10, allele DQB1*06:11, allele DQB1*06:12, allele DQB1*06:13, allele DQB1*06:14, allele DQB1*06:16, allele DQB1*06:17, allele DQB1*06:19, allele DQB1*06:20, allele DQB1*06:21, allele DQB1*06:23, allele DQB1*06:24, allele DQB1*06:28, allele DQB1*06:29, allele DQB1*06:30, allele DQB1*06:31 and allele DQB1*06:33. 1 PublicationCorresponds to variant dbSNP:rs1130386Ensembl.1
Natural variantiVAR_062724103T → A in allele DQB1*05:01, allele DQB1*05:02, allele DQB1*05:03, allele DQB1*05:05, allele DQB1*06:17, allele DQB1*06:24 and allele DQB1*06:30. Corresponds to variant dbSNP:rs1130390Ensembl.1
Natural variantiVAR_062725103T → D in allele DQB1*03:06, allele DQB1*03:25, allele DQB1*04:01, allele DQB1*04:02, allele DQB1*04:03 and allele DQB1*05:04; requires 2 nucleotide substitutions. 1
Natural variantiVAR_062726103T → K in allele DQB1*02:01, allele DQB1*02:02, allele DQB1*02:03, allele DQB1*02:04 and allele DQB1*02:05. 1
Natural variantiVAR_062727106E → A in allele DQB1*02:01, allele DQB1*02:02, allele DQB1*02:03, allele DQB1*02:04, allele DQB1*02:05 and allele DQB1*06:06. Corresponds to variant dbSNP:rs1130387Ensembl.1
Natural variantiVAR_062728106E → S in allele DQB1*03:06, allele DQB1*03:25, allele DQB1*04:01, allele DQB1*04:02, allele DQB1*04:03, allele DQB1*05:01, allele DQB1*05:02, allele DQB1*05:03, allele DQB1*05:04 and allele DQB1*05:05; requires 2 nucleotide substitutions. 1
Natural variantiVAR_062729107L → V in allele DQB1*02:01, allele DQB1*02:02, allele DQB1*02:03, allele DQB1*02:04, allele DQB1*02:05, allele DQB1*03:06, allele DQB1*03:25, allele DQB1*04:01, allele DQB1*04:02, allele DQB1*04:03, allele DQB1*05:01, allele DQB1*05:02, allele DQB1*05:03, allele DQB1*05:04, allele DQB1*05:05 and allele DQB1*06:06. Corresponds to variant dbSNP:rs9274384Ensembl.1
Natural variantiVAR_062730109T → R in allele DQB1*02:01, allele DQB1*02:02, allele DQB1*02:03, allele DQB1*02:04, allele DQB1*05:01, allele DQB1*05:02, allele DQB1*05:03, allele DQB1*05:04, allele DQB1*05:05 and allele DQB1*06:06. Corresponds to variant dbSNP:rs1130392Ensembl.1
Natural variantiVAR_062731116Q → E in allele DQB1*05:01, allele DQB1*05:02, allele DQB1*05:03, allele DQB1*05:05, allele DQB1*06:01, allele DQB1*06:02, allele DQB1*06:03, allele DQB1*06:04, allele DQB1*06:05, allele DQB1*06:07, allele DQB1*06:08, allele DQB1*06:09, allele DQB1*06:10, allele DQB1*06:11, allele DQB1*06:12, allele DQB1*06:13, allele DQB1*06:14, allele DQB1*06:15, allele DQB1*06:16, allele DQB1*06:17, allele DQB1*06:18, allele DQB1*06:19, allele DQB1*06:20, allele DQB1*06:21, allele DQB1*06:22, allele DQB1*06:23, allele DQB1*06:24, allele DQB1*06:25, allele DQB1*06:27, allele DQB1*06:28, allele DQB1*06:29, allele DQB1*06:30, allele DQB1*06:31, allele DQB1*06:32, allele DQB1*06:33, allele DQB1*06:34, allele DQB1*06:35, allele DQB1*06:36, allele DQB1*06:37, allele DQB1*06:38, allele DQB1*06:39. Corresponds to variant dbSNP:rs1140316Ensembl.1
Natural variantiVAR_062732117L → V in allele DQB1*05:01, allele DQB1*05:02, allele DQB1*05:03, allele DQB1*05:05, allele DQB1*06:01, allele DQB1*06:02, allele DQB1*06:03, allele DQB1*06:04, allele DQB1*06:05, allele DQB1*06:07, allele DQB1*06:08, allele DQB1*06:09, allele DQB1*06:10, allele DQB1*06:11, allele DQB1*06:12, allele DQB1*06:13, allele DQB1*06:14, allele DQB1*06:15, allele DQB1*06:16, allele DQB1*06:17, allele DQB1*06:18, allele DQB1*06:19, allele DQB1*06:20, allele DQB1*06:21, allele DQB1*06:22, allele DQB1*06:23, allele DQB1*06:24, allele DQB1*06:25, allele DQB1*06:27, allele DQB1*06:28, allele DQB1*06:29, allele DQB1*06:30, allele DQB1*06:31, allele DQB1*06:32, allele DQB1*06:33, allele DQB1*06:34, allele DQB1*06:35, allele DQB1*06:36, allele DQB1*06:37, allele DQB1*06:38 and allele DQB1*06:39. Corresponds to variant dbSNP:rs1140317Ensembl.1
Natural variantiVAR_062733118E → A in allele DQB1*05:01, allele DQB1*05:02, allele DQB1*05:03, allele DQB1*05:05, allele DQB1*06:01, allele DQB1*06:02, allele DQB1*06:03, allele DQB1*06:08, allele DQB1*06:10, allele DQB1*06:11, allele DQB1*06:13, allele DQB1*06:14, allele DQB1*06:16, allele DQB1*06:18, allele DQB1*06:19, allele DQB1*06:20, allele DQB1*06:23, allele DQB1*06:24, allele DQB1*06:27, allele DQB1*06:28, allele DQB1*06:29, allele DQB1*06:30, allele DQB1*06:31, allele DQB1*06:32, allele DQB1*06:33, allele DQB1*06:35 and allele DQB1*06:37. Corresponds to variant dbSNP:rs9274380Ensembl.1
Natural variantiVAR_062734118E → G in allele DQB1*06:04, allele DQB1*06:05, allele DQB1*06:07, allele DQB1*06:09, allele DQB1*06:12, allele DQB1*06:15, allele DQB1*06:17, allele DQB1*06:21, allele DQB1*06:22, allele DQB1*06:25, allele DQB1*06:34, allele DQB1*06:36, allele DQB1*06:38 and allele DQB1*06:39. Corresponds to variant dbSNP:rs9274380Ensembl.1
Natural variantiVAR_062735119L → F in allele DQB1*06:01, allele DQB1*06:02, allele DQB1*06:03, allele DQB1*06:08, allele DQB1*06:10, allele DQB1*06:11, allele DQB1*06:13, allele DQB1*06:14, allele DQB1*06:16, allele DQB1*06:18, allele DQB1*06:19, allele DQB1*06:20, allele DQB1*06:23, allele DQB1*06:24, allele DQB1*06:27, allele DQB1*06:28, allele DQB1*06:29, allele DQB1*06:30, allele DQB1*06:31, allele DQB1*06:32, allele DQB1*06:33, allele DQB1*06:35 and allele DQB1*06:37. Corresponds to variant dbSNP:rs9274379Ensembl.1
Natural variantiVAR_062736119L → Y in allele DQB1*05:01, allele DQB1*05:02, allele DQB1*05:03, allele DQB1*05:05, allele DQB1*06:04, allele DQB1*06:05, allele DQB1*06:07, allele DQB1*06:09, allele DQB1*06:12, allele DQB1*06:15, allele DQB1*06:17, allele DQB1*06:21, allele DQB1*06:22, allele DQB1*06:25, allele DQB1*06:34, allele DQB1*06:36, allele DQB1*06:38 and allele DQB1*06:39; requires 2 nucleotide substitutions. 1
Natural variantiVAR_062737121T → G in allele DQB1*05:01, allele DQB1*05:02, allele DQB1*05:03, allele DQB1*05:05, allele DQB1*06:01, allele DQB1*06:02, allele DQB1*06:03, allele DQB1*06:04, allele DQB1*06:05, allele DQB1*06:07, allele DQB1*06:08, allele DQB1*06:09, allele DQB1*06:10, allele DQB1*06:11, allele DQB1*06:12, allele DQB1*06:13, allele DQB1*06:14, allele DQB1*06:15, allele DQB1*06:16, allele DQB1*06:17, allele DQB1*06:18, allele DQB1*06:19, allele DQB1*06:21, allele DQB1*06:22, allele DQB1*06:23, allele DQB1*06:24, allele DQB1*06:25, allele DQB1*06:27, allele DQB1*06:28, allele DQB1*06:29, allele DQB1*06:30, allele DQB1*06:31, allele DQB1*06:32, allele DQB1*06:33, allele DQB1*06:34, allele DQB1*06:35, allele DQB1*06:36, allele DQB1*06:37, allele DQB1*06:38 and allele DQB1*06:39; requires 2 nucleotide substitutions. 1
Natural variantiVAR_062738122T → I in allele DQB1*05:01, allele DQB1*05:02, allele DQB1*05:03, allele DQB1*05:05, allele DQB1*06:01, allele DQB1*06:02, allele DQB1*06:03, allele DQB1*06:04, allele DQB1*06:05, allele DQB1*06:07, allele DQB1*06:08, allele DQB1*06:09, allele DQB1*06:10, allele DQB1*06:11, allele DQB1*06:12, allele DQB1*06:14, allele DQB1*06:15, allele DQB1*06:16, allele DQB1*06:17, allele DQB1*06:18, allele DQB1*06:19, allele DQB1*06:21, allele DQB1*06:22, allele DQB1*06:23, allele DQB1*06:24, allele DQB1*06:25, allele DQB1*06:27, allele DQB1*06:28, allele DQB1*06:29, allele DQB1*06:30, allele DQB1*06:31, allele DQB1*06:32, allele DQB1*06:33, allele DQB1*06:34, allele DQB1*06:35, allele DQB1*06:36, allele DQB1*06:37, allele DQB1*06:38 and allele DQB1*06:39. Corresponds to variant dbSNP:rs1140320Ensembl.1
Natural variantiVAR_056571148V → I in allele DQB1*05:01, allele DQB1*05:02 and allele DQB1*05:03. Corresponds to variant dbSNP:rs1049100Ensembl.1
Natural variantiVAR_062739157A → G in allele DQB1*06:01, allele DQB1*06:02, allele DQB1*06:03, allele DQB1*06:04, allele DQB1*06:09, allele DQB1*06:12, allele DQB1*06:34, allele DQB1*06:36, allele DQB1*06:38 and allele DQB1*06:39. Corresponds to variant dbSNP:rs1063322Ensembl.1
Natural variantiVAR_062740157A → S in allele DQB1*05:01, allele DQB1*05:02 and allele DQB1*05:03. 1
Natural variantiVAR_062741158Q → H in allele DQB1*05:02. Corresponds to variant dbSNP:rs41542812Ensembl.1
Natural variantiVAR_062742162R → Q in allele DQB1*03:22, allele DQB1*06:04, allele DQB1*06:09, allele DQB1*06:12, allele DQB1*06:34, allele DQB1*06:36 and allele DQB1*06:38. Corresponds to variant dbSNP:rs41544112Ensembl.1
Natural variantiVAR_062744165R → Q in allele DQB1*06:38. Corresponds to variant dbSNP:rs9273989Ensembl.1
Natural variantiVAR_062743165R → W in allele DQB1*03:21. Corresponds to variant dbSNP:rs63626961Ensembl.1
Natural variantiVAR_062745167D → G in allele DQB1*02:02. Corresponds to variant dbSNP:rs2647032Ensembl.1
Natural variantiVAR_062746168Q → E in allele DQB1*02:04. Corresponds to variant dbSNP:rs9273981Ensembl.1
Natural variantiVAR_062747172T → A in allele DQB1*02:01, allele DQB1*02:02, allele DQB1*02:04, allele DQB1*05:01, allele DQB1*05:02, allele DQB1*05:03, allele DQB1*06:01, allele DQB1*06:02, allele DQB1*06:03, allele DQB1*06:04, allele DQB1*06:09, allele DQB1*06:12, allele DQB1*06:34, allele DQB1*06:36, allele DQB1*06:38 and allele DQB1*06:39. Combined sourcesCorresponds to variant dbSNP:rs1063323Ensembl.1
Natural variantiVAR_056572194E → D. Corresponds to variant dbSNP:rs9273952Ensembl.1
Natural variantiVAR_059522197P → L. Corresponds to variant dbSNP:rs9273948Ensembl.1
Natural variantiVAR_062748199H → R in allele DQB1*02:01, allele DQB1*02:02, allele DQB1*02:04, allele DQB1*03:02, allele DQB1*03:03, allele DQB1*03:05, allele DQB1*03:23, allele DQB1*03:25, allele DQB1*04:01, allele DQB1*04:02, allele DQB1*05:01, allele DQB1*05:02, allele DQB1*05:03, allele DQB1*06:02, allele DQB1*06:03, allele DQB1*06:04, allele DQB1*06:09, allele DQB1*06:12, allele DQB1*06:34, allele DQB1*06:36, allele DQB1*06:38 and allele DQB1*06:39. 1 PublicationCorresponds to variant dbSNP:rs701564Ensembl.1
Natural variantiVAR_062749200 – 201GD → A in allele DQB1*03:09. 2
Natural variantiVAR_062750202V → I in allele DQB1*03:24. Corresponds to variant dbSNP:rs80255621Ensembl.1
Natural variantiVAR_062751214N → S in allele DQB1*02:01, allele DQB1*02:02, allele DQB1*02:04, allele DQB1*05:01, allele DQB1*05:02, allele DQB1*05:03, allele DQB1*06:01, allele DQB1*06:02, allele DQB1*06:03, allele DQB1*06:04, allele DQB1*06:09, allele DQB1*06:12, allele DQB1*06:34, allele DQB1*06:36, allele DQB1*06:38 and allele DQB1*06:39. Corresponds to variant dbSNP:rs1130398Ensembl.1
Natural variantiVAR_062752217T → I in allele DQB1*03:02, allele DQB1*03:03, allele DQB1*03:05, allele DQB1*03:19, allele DQB1*03:25, allele DQB1*04:01 and allele DQB1*04:02. Corresponds to variant dbSNP:rs1130399Ensembl.1
Natural variantiVAR_062753218V → A in allele DQB1*06:36. Corresponds to variant dbSNP:rs281864132Ensembl.1
Natural variantiVAR_062754229S → N in allele DQB1*06:01. Corresponds to variant dbSNP:rs1130429Ensembl.1
Natural variantiVAR_062755235I → V in allele DQB1*05:01, allele DQB1*05:02, allele DQB1*05:03, allele DQB1*06:02, allele DQB1*06:03, allele DQB1*06:04, allele DQB1*06:09, allele DQB1*06:12 and allele DQB1*06:36. Corresponds to variant dbSNP:rs1049163Ensembl.1
Natural variantiVAR_062756252H → R in allele DQB1*05:01, allele DQB1*05:02, allele DQB1*05:03, allele DQB1*06:01, allele DQB1*06:02, allele DQB1*06:03, allele DQB1*06:04, allele DQB1*06:09, allele DQB1*06:12 and allele DQB1*06:36. Corresponds to variant dbSNP:rs1140342Ensembl.1
Natural variantiVAR_062757253H → Q in allele DQB1*05:01, allele DQB1*05:02, allele DQB1*05:03, allele DQB1*06:01, allele DQB1*06:02, allele DQB1*06:03, allele DQB1*06:04, allele DQB1*06:09, allele DQB1*06:12 and allele DQB1*06:36. Corresponds to variant dbSNP:rs1140343Ensembl.1
Natural variantiVAR_061474256Q → R in allele DQB1*05:01, allele DQB1*05:02 and allele DQB1*05:03. Corresponds to variant dbSNP:rs1130432Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
K01499 Genomic DNA Translation: AAA98746.1
K02405 Genomic DNA Translation: AAA75521.1
X03068 mRNA Translation: CAA26872.1
M17564 mRNA Translation: AAA59765.1
M29613 Genomic DNA No translation available.
M29616 Genomic DNA No translation available.
M16996 mRNA Translation: AAA59770.1
M20432 mRNA Translation: AAA59769.1
M60028 mRNA Translation: AAA59755.1
X96420 mRNA Translation: CAA65280.1
U92032 Genomic DNA Translation: AAB91991.1
AY663393 Genomic DNA Translation: AAU87973.1
AY663394 Genomic DNA Translation: AAU87977.1
AY663397 Genomic DNA Translation: AAU87986.1
AY663409 Genomic DNA Translation: AAU88017.1
AY663404 Genomic DNA Translation: AAU88002.1
AY663410 Genomic DNA Translation: AAU88020.1
AY663412 Genomic DNA Translation: AAU88027.1
AY656681 mRNA Translation: AAV71028.1
AY656682 mRNA Translation: AAV71029.1
AY656683 mRNA Translation: AAV71030.1
BX927168 Genomic DNA No translation available.
CR753846 Genomic DNA No translation available.
CR933859 Genomic DNA No translation available.
BC012106 mRNA Translation: AAH12106.1
M25327 mRNA Translation: AAA59677.1
U66400 mRNA Translation: AAB51698.1
U83582 mRNA Translation: AAB41231.1
AH002887 Genomic DNA Translation: AAA59762.1
M26042 mRNA Translation: AAA36270.1
M33907 mRNA Translation: AAA52672.1
L34096 mRNA Translation: AAC41964.1
L34098 mRNA Translation: AAC41966.1
L34101 mRNA Translation: AAC41969.1
L34103 mRNA Translation: AAC41971.1
L34104 mRNA Translation: AAC41972.1
L34105 mRNA Translation: AAC41973.1
L34106 mRNA Translation: AAC41974.1
L34107 mRNA Translation: AAC41975.1
AF195245 mRNA Translation: AAF28315.1
L42626 mRNA Translation: AAA85335.1
X76553 mRNA No translation available.
X76554 mRNA No translation available.
M59800 mRNA Translation: AAA64235.1
M14189 mRNA Translation: AAA36268.1
AY672649 Genomic DNA Translation: AAT77952.1
M17207 mRNA Translation: AAA59697.1
Z49215 Genomic DNA No translation available.
AY026349 Genomic DNA Translation: AAK01944.1
AF091305 Genomic DNA Translation: AAC64403.2 Sequence problems.
U77344 Genomic DNA Translation: AAB19215.1
FN256435 Genomic DNA Translation: CAX62164.1
FN256435 Genomic DNA Translation: CAX62165.1
AM400970 Genomic DNA Translation: CAL47037.1
AM421131 Genomic DNA Translation: CAM07104.1
EF484936 Genomic DNA Translation: ABO87661.1
EF484939 Genomic DNA Translation: ABO87664.1
EU275158 Genomic DNA Translation: ABY26531.1
AM944346 Genomic DNA Translation: CAQ16179.1
FM200854 Genomic DNA Translation: CAR31119.1
AH013029 Genomic DNA Translation: AAP93137.1
EU770203 Genomic DNA Translation: ACF16333.1
FM955320 Genomic DNA Translation: CAW24712.1
FN552709 Genomic DNA Translation: CBF35736.1
FN552710 Genomic DNA Translation: CBF35739.1
X86327 Genomic DNA No translation available.
D78569 Genomic DNA Translation: BAA11413.1
AF439338 Genomic DNA Translation: AAL35222.1
AF384556 Genomic DNA Translation: AAM53072.1
DQ026226 Genomic DNA Translation: AAY89656.1
AY762968 Genomic DNA Translation: AAV97949.1
AM181332 Genomic DNA Translation: CAJ57391.1 Sequence problems.
AM691798 Genomic DNA Translation: CAM88661.1
AM259942 Genomic DNA Translation: CAJ90956.1
U39090 Genomic DNA Translation: AAB02681.1
AJ003005 Genomic DNA No translation available.
AJ012156 Genomic DNA Translation: CAA09929.1
AJ290396 Genomic DNA Translation: CAC27418.1
AF469118 Genomic DNA Translation: AAL77085.1
AF479569 Genomic DNA Translation: AAM09472.1
AJ535315 Genomic DNA Translation: CAD59445.2
AF181983 Genomic DNA Translation: AAD54423.2
AY733062 Genomic DNA Translation: AAU33811.1
AJ854065 Genomic DNA Translation: CAH69441.1
AJ964903 Genomic DNA Translation: CAI79639.1
AB211231 Genomic DNA Translation: BAD95610.1
DQ114427 Genomic DNA Translation: AAZ20753.1
DQ227421 Genomic DNA Translation: ABB05231.1
AM403489 Genomic DNA Translation: CAL48285.1
AM490069 Genomic DNA Translation: CAM32717.1
EF622510 Genomic DNA Translation: ABR24117.1
EU410617 Genomic DNA Translation: ABZ89500.1
GQ422610 Genomic DNA Translation: ACV66342.1
FN550110 Genomic DNA Translation: CBE66554.1
AF087939 Genomic DNA Translation: AAD39697.1
AY094140 Genomic DNA Translation: AAM14401.1
AJ001257 Genomic DNA Translation: CAA04631.1
U39086 Genomic DNA Translation: AAA93181.1
AJ965439 Genomic DNA Translation: CAI84643.1
AF112463 Genomic DNA Translation: AAD23990.1
AF112464 Genomic DNA Translation: AAD23991.1
M94773 Genomic DNA No translation available.
M65042 Genomic DNA Translation: AAA36241.1
M25025 mRNA Translation: AAA59793.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A02234 HLHU1C
A35055
A94003 HLHUDB
B32527
B37044
C24669 HLHU2C
F30575
I54480
I68732
I72482
S46648

NCBI Reference Sequences

More...
RefSeqi
NP_001230891.1, NM_001243962.1
NP_002114.3, NM_002123.4

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.409934
Hs.534322

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000399088; ENSP00000382038; ENSG00000231286
ENST00000413089; ENSP00000396539; ENSG00000231286
ENST00000416192; ENSP00000410107; ENSG00000233209
ENST00000419914; ENSP00000402865; ENSG00000225824
ENST00000422950; ENSP00000414079; ENSG00000233209
ENST00000424806; ENSP00000410330; ENSG00000225824

Database of genes from NCBI RefSeq genomes

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GeneIDi
3119

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:3119

UCSC genome browser

More...
UCSCi
uc011hep.3 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

SHMPD

The Singapore human mutation and polymorphism database

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K01499 Genomic DNA Translation: AAA98746.1
K02405 Genomic DNA Translation: AAA75521.1
X03068 mRNA Translation: CAA26872.1
M17564 mRNA Translation: AAA59765.1
M29613 Genomic DNA No translation available.
M29616 Genomic DNA No translation available.
M16996 mRNA Translation: AAA59770.1
M20432 mRNA Translation: AAA59769.1
M60028 mRNA Translation: AAA59755.1
X96420 mRNA Translation: CAA65280.1
U92032 Genomic DNA Translation: AAB91991.1
AY663393 Genomic DNA Translation: AAU87973.1
AY663394 Genomic DNA Translation: AAU87977.1
AY663397 Genomic DNA Translation: AAU87986.1
AY663409 Genomic DNA Translation: AAU88017.1
AY663404 Genomic DNA Translation: AAU88002.1
AY663410 Genomic DNA Translation: AAU88020.1
AY663412 Genomic DNA Translation: AAU88027.1
AY656681 mRNA Translation: AAV71028.1
AY656682 mRNA Translation: AAV71029.1
AY656683 mRNA Translation: AAV71030.1
BX927168 Genomic DNA No translation available.
CR753846 Genomic DNA No translation available.
CR933859 Genomic DNA No translation available.
BC012106 mRNA Translation: AAH12106.1
M25327 mRNA Translation: AAA59677.1
U66400 mRNA Translation: AAB51698.1
U83582 mRNA Translation: AAB41231.1
AH002887 Genomic DNA Translation: AAA59762.1
M26042 mRNA Translation: AAA36270.1
M33907 mRNA Translation: AAA52672.1
L34096 mRNA Translation: AAC41964.1
L34098 mRNA Translation: AAC41966.1
L34101 mRNA Translation: AAC41969.1
L34103 mRNA Translation: AAC41971.1
L34104 mRNA Translation: AAC41972.1
L34105 mRNA Translation: AAC41973.1
L34106 mRNA Translation: AAC41974.1
L34107 mRNA Translation: AAC41975.1
AF195245 mRNA Translation: AAF28315.1
L42626 mRNA Translation: AAA85335.1
X76553 mRNA No translation available.
X76554 mRNA No translation available.
M59800 mRNA Translation: AAA64235.1
M14189 mRNA Translation: AAA36268.1
AY672649 Genomic DNA Translation: AAT77952.1
M17207 mRNA Translation: AAA59697.1
Z49215 Genomic DNA No translation available.
AY026349 Genomic DNA Translation: AAK01944.1
AF091305 Genomic DNA Translation: AAC64403.2 Sequence problems.
U77344 Genomic DNA Translation: AAB19215.1
FN256435 Genomic DNA Translation: CAX62164.1
FN256435 Genomic DNA Translation: CAX62165.1
AM400970 Genomic DNA Translation: CAL47037.1
AM421131 Genomic DNA Translation: CAM07104.1
EF484936 Genomic DNA Translation: ABO87661.1
EF484939 Genomic DNA Translation: ABO87664.1
EU275158 Genomic DNA Translation: ABY26531.1
AM944346 Genomic DNA Translation: CAQ16179.1
FM200854 Genomic DNA Translation: CAR31119.1
AH013029 Genomic DNA Translation: AAP93137.1
EU770203 Genomic DNA Translation: ACF16333.1
FM955320 Genomic DNA Translation: CAW24712.1
FN552709 Genomic DNA Translation: CBF35736.1
FN552710 Genomic DNA Translation: CBF35739.1
X86327 Genomic DNA No translation available.
D78569 Genomic DNA Translation: BAA11413.1
AF439338 Genomic DNA Translation: AAL35222.1
AF384556 Genomic DNA Translation: AAM53072.1
DQ026226 Genomic DNA Translation: AAY89656.1
AY762968 Genomic DNA Translation: AAV97949.1
AM181332 Genomic DNA Translation: CAJ57391.1 Sequence problems.
AM691798 Genomic DNA Translation: CAM88661.1
AM259942 Genomic DNA Translation: CAJ90956.1
U39090 Genomic DNA Translation: AAB02681.1
AJ003005 Genomic DNA No translation available.
AJ012156 Genomic DNA Translation: CAA09929.1
AJ290396 Genomic DNA Translation: CAC27418.1
AF469118 Genomic DNA Translation: AAL77085.1
AF479569 Genomic DNA Translation: AAM09472.1
AJ535315 Genomic DNA Translation: CAD59445.2
AF181983 Genomic DNA Translation: AAD54423.2
AY733062 Genomic DNA Translation: AAU33811.1
AJ854065 Genomic DNA Translation: CAH69441.1
AJ964903 Genomic DNA Translation: CAI79639.1
AB211231 Genomic DNA Translation: BAD95610.1
DQ114427 Genomic DNA Translation: AAZ20753.1
DQ227421 Genomic DNA Translation: ABB05231.1
AM403489 Genomic DNA Translation: CAL48285.1
AM490069 Genomic DNA Translation: CAM32717.1
EF622510 Genomic DNA Translation: ABR24117.1
EU410617 Genomic DNA Translation: ABZ89500.1
GQ422610 Genomic DNA Translation: ACV66342.1
FN550110 Genomic DNA Translation: CBE66554.1
AF087939 Genomic DNA Translation: AAD39697.1
AY094140 Genomic DNA Translation: AAM14401.1
AJ001257 Genomic DNA Translation: CAA04631.1
U39086 Genomic DNA Translation: AAA93181.1
AJ965439 Genomic DNA Translation: CAI84643.1
AF112463 Genomic DNA Translation: AAD23990.1
AF112464 Genomic DNA Translation: AAD23991.1
M94773 Genomic DNA No translation available.
M65042 Genomic DNA Translation: AAA36241.1
M25025 mRNA Translation: AAA59793.1
PIRiA02234 HLHU1C
A35055
A94003 HLHUDB
B32527
B37044
C24669 HLHU2C
F30575
I54480
I68732
I72482
S46648
RefSeqiNP_001230891.1, NM_001243962.1
NP_002114.3, NM_002123.4
UniGeneiHs.409934
Hs.534322

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1JK8X-ray2.40B35-224[»]
1NBNmodel-B35-224[»]
1S9VX-ray2.22B/E33-230[»]
1UVQX-ray1.80B35-230[»]
2NNAX-ray2.10B33-224[»]
4GG6X-ray3.20B/D33-224[»]
4OZFX-ray2.70B33-224[»]
4OZGX-ray3.00B/D33-224[»]
4OZHX-ray2.80B/D33-224[»]
4OZIX-ray3.20B/D33-224[»]
ProteinModelPortaliP01920
SMRiP01920
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109364, 11 interactors
IntActiP01920, 3 interactors
MINTiP01920

Chemistry databases

DrugBankiDB00071 Insulin Pork

PTM databases

iPTMnetiP01920
PhosphoSitePlusiP01920

Polymorphism and mutation databases

BioMutaiHLA-DQB1
DMDMi290457643

Proteomic databases

PeptideAtlasiP01920
PRIDEiP01920
ProteomicsDBi51513

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
3119
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000399088; ENSP00000382038; ENSG00000231286
ENST00000413089; ENSP00000396539; ENSG00000231286
ENST00000416192; ENSP00000410107; ENSG00000233209
ENST00000419914; ENSP00000402865; ENSG00000225824
ENST00000422950; ENSP00000414079; ENSG00000233209
ENST00000424806; ENSP00000410330; ENSG00000225824
GeneIDi3119
KEGGihsa:3119
UCSCiuc011hep.3 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
3119
DisGeNETi3119

GeneCards: human genes, protein and diseases

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GeneCardsi
HLA-DQB1
GeneReviewsiHLA-DQB1
HGNCiHGNC:4944 HLA-DQB1
HPAiHPA013667
MalaCardsiHLA-DQB1
MIMi604305 gene
neXtProtiNX_P01920
Orphaneti703 Bullous pemphigoid
930 Idiopathic achalasia
163908 Limbic encephalitis with LGI1 antibodies
2073 Narcolepsy type 1
83465 Narcolepsy type 2
555 NON RARE IN EUROPE: Celiac disease
243377 NON RARE IN EUROPE: Diabetes mellitus type 1
802 NON RARE IN EUROPE: Multiple sclerosis
477738 Pediatric multiple sclerosis
PharmGKBiPA35068

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

HOVERGENiHBG012730
InParanoidiP01920
KOiK06752
PhylomeDBiP01920

Enzyme and pathway databases

ReactomeiR-HSA-202424 Downstream TCR signaling
R-HSA-202427 Phosphorylation of CD3 and TCR zeta chains
R-HSA-202430 Translocation of ZAP-70 to Immunological synapse
R-HSA-202433 Generation of second messenger molecules
R-HSA-2132295 MHC class II antigen presentation
R-HSA-389948 PD-1 signaling
R-HSA-877300 Interferon gamma signaling
SIGNORiP01920

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
HLA-DQB1 human
EvolutionaryTraceiP01920

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
HLA-DQB1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
3119

Protein Ontology

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PROi
PR:P01920

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

CleanExiHS_HLA-DQB1

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.10.320.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set
IPR011162 MHC_I/II-like_Ag-recog
IPR014745 MHC_II_a/b_N
IPR000353 MHC_II_b_N
PfamiView protein in Pfam
PF07654 C1-set, 1 hit
PF00969 MHC_II_beta, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD000328 MHC_II_b_N, 1 hit
SMARTiView protein in SMART
SM00407 IGc1, 1 hit
SM00921 MHC_II_beta, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF54452 SSF54452, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS00290 IG_MHC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDQB1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P01920
Secondary accession number(s): A1KR27
, A2RPH3, A4Q9R4, A4USG2, A4USG5, A6N8I7, A9YQA0, B0S7Y7, B1A0K6, B1GXI3, B3VLT3, B5BLN7, B7VU69, C0MQ34, C0MQ35, C8ZL52, C8ZLJ8, C8ZLJ9, C9DRQ3, O19708, O19713, O19724, O62861, O78046, O78221, O78223, O98034, O98201, P01917, P01918, P01919, P03992, P05537, P79482, P79526, P79544, P79551, Q08GC8, Q09035, Q0E4V9, Q1M312, Q29731, Q29877, Q29884, Q29915, Q29966, Q2P9N3, Q2QK85, Q30061, Q30075, Q30076, Q30080, Q30081, Q30082, Q30083, Q30084, Q30089, Q30095, Q31633, Q38I47, Q45UE3, Q4QZB5, Q53I44, Q564J6, Q5G841, Q5ISH1, Q5ISH3, Q5W1E1, Q5Y7G8, Q643R4, Q6B9X1, Q70VH8, Q7YP69, Q8HWH0, Q8MH58, Q8SNB4, Q8SND1, Q8SP70, Q8WMA3, Q9BD17, Q9MYH2, Q9TPA9, Q9XRY6, Q9XRY7, Q9XRZ2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: March 2, 2010
Last modified: December 5, 2018
This is version 179 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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