UniProtKB - P01910 (HA2K_MOUSE)
Protein
H-2 class II histocompatibility antigen, A-K alpha chain
Gene
H2-Aa
Organism
Mus musculus (Mouse)
Status
Functioni
GO - Molecular functioni
- peptide antigen binding Source: MGI
- protein heterodimerization activity Source: MGI
GO - Biological processi
- antigen processing and presentation Source: MGI
- antigen processing and presentation of exogenous peptide antigen via MHC class II Source: MGI
- antigen processing and presentation of peptide antigen Source: MGI
- immune response Source: InterPro
- negative regulation of T cell proliferation Source: MGI
- positive regulation of T cell differentiation Source: MGI
Keywordsi
Biological process | Immunity |
Names & Taxonomyi
Protein namesi | Recommended name: H-2 class II histocompatibility antigen, A-K alpha chain |
Gene namesi | Name:H2-Aa |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:95895 H2-Aa |
Subcellular locationi
Other locations
- Membrane Curated; Single-pass type I membrane protein Curated
Lysosome
- lysosome Source: MGI
Plasma Membrane
- external side of plasma membrane Source: MGI
- MHC class II protein complex Source: MGI
- plasma membrane Source: MGI
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 24 – 218 | ExtracellularSequence analysisAdd BLAST | 195 | |
Transmembranei | 219 – 241 | HelicalSequence analysisAdd BLAST | 23 | |
Topological domaini | 242 – 256 | CytoplasmicSequence analysisAdd BLAST | 15 |
Keywords - Cellular componenti
Membrane, MHC IIPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 23 | By similarityAdd BLAST | 23 | |
ChainiPRO_0000018977 | 24 – 256 | H-2 class II histocompatibility antigen, A-K alpha chainAdd BLAST | 233 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 105 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Disulfide bondi | 134 ↔ 190 | PROSITE-ProRule annotation | ||
Glycosylationi | 145 | N-linked (GlcNAc...) asparagine1 Publication | 1 |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
MaxQBi | P01910 |
PeptideAtlasi | P01910 |
PRIDEi | P01910 |
PTM databases
iPTMneti | P01910 |
Interactioni
GO - Molecular functioni
- protein heterodimerization activity Source: MGI
Protein-protein interaction databases
DIPi | DIP-6133N |
IntActi | P01910, 1 interactor |
MINTi | P01910 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1D9K | X-ray | 3.20 | C/G | 27-209 | [»] | |
1IAK | X-ray | 1.90 | A | 24-222 | [»] | |
1JL4 | X-ray | 4.30 | A | 31-208 | [»] | |
ProteinModelPortali | P01910 | |||||
SMRi | P01910 | |||||
ModBasei | Search... | |||||
MobiDBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P01910 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 114 – 206 | Ig-like C1-typeAdd BLAST | 93 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 24 – 111 | Alpha-1Add BLAST | 88 | |
Regioni | 112 – 205 | Alpha-2Add BLAST | 94 | |
Regioni | 206 – 218 | Connecting peptideAdd BLAST | 13 |
Sequence similaritiesi
Belongs to the MHC class II family.Curated
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG410IZMF Eukaryota ENOG410YHX9 LUCA |
HOVERGENi | HBG006862 |
InParanoidi | P01910 |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit 3.10.320.10, 1 hit |
InterProi | View protein in InterPro IPR007110 Ig-like_dom IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR003006 Ig/MHC_CS IPR003597 Ig_C1-set IPR011162 MHC_I/II-like_Ag-recog IPR014745 MHC_II_a/b_N IPR001003 MHC_II_a_N |
Pfami | View protein in Pfam PF07654 C1-set, 1 hit PF00993 MHC_II_alpha, 1 hit |
SMARTi | View protein in SMART SM00407 IGc1, 1 hit SM00920 MHC_II_alpha, 1 hit |
SUPFAMi | SSF48726 SSF48726, 1 hit SSF54452 SSF54452, 1 hit |
PROSITEi | View protein in PROSITE PS50835 IG_LIKE, 1 hit PS00290 IG_MHC, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 9 potential isoforms that are computationally mapped.Show allAlign All
P01910-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPRSRALILG VLALTTMLSL CGGEDDIEAD HVGSYGITVY QSPGDIGQYT
60 70 80 90 100
FEFDGDELFY VDLDKKETVW MLPEFAQLRR FEPQGGLQNI ATGKHNLEIL
110 120 130 140 150
TKRSNSTPAT NEAPQATVFP KSPVLLGQPN TLICFVDNIF PPVINITWLR
160 170 180 190 200
NSKSVTDGVY ETSFFVNRDY SFHKLSYLTF IPSDDDIYDC KVEHWGLEEP
210 220 230 240 250
VLKHWEPEIP APMSELTETV VCALGLSVGL VGIVVGTIFI IQGLRSGGTS
RHPGPL
Computationally mapped potential isoform sequencesi
There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP14434 | HA2B_MOUSE | H-2 class II histocompatibility ant... | H2-Aa | 256 | Annotation score: | ||
P23150 | HA2J_MOUSE | H-2 class II histocompatibility ant... | 254 | Annotation score: | |||
P04228 | HA2D_MOUSE | H-2 class II histocompatibility ant... | H2-Aa | 256 | Annotation score: | ||
P14438 | HA2U_MOUSE | H-2 class II histocompatibility ant... | H2-Aa | 227 | Annotation score: | ||
P14435 | HA2F_MOUSE | H-2 class II histocompatibility ant... | H2-Aa | 233 | Annotation score: | ||
P04227 | HA2Q_MOUSE | H-2 class II histocompatibility ant... | H2-Aa | 221 | Annotation score: | ||
P14437 | HA2S_MOUSE | H-2 class II histocompatibility ant... | H2-Aa | 233 | Annotation score: | ||
P14436 | HA2R_MOUSE | H-2 class II histocompatibility ant... | H2-Aa | 233 | Annotation score: | ||
G3UWR9 | G3UWR9_MOUSE | H-2 class II histocompatibility ant... | H2-Aa | 173 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M21931 mRNA Translation: AAA39636.1 V00832 mRNA Translation: CAA24215.1 M11357 mRNA Translation: AAA39613.1 |
PIRi | A02217 HLMSAA I54447 |
UniGenei | Mm.235338 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M21931 mRNA Translation: AAA39636.1 V00832 mRNA Translation: CAA24215.1 M11357 mRNA Translation: AAA39613.1 |
PIRi | A02217 HLMSAA I54447 |
UniGenei | Mm.235338 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1D9K | X-ray | 3.20 | C/G | 27-209 | [»] | |
1IAK | X-ray | 1.90 | A | 24-222 | [»] | |
1JL4 | X-ray | 4.30 | A | 31-208 | [»] | |
ProteinModelPortali | P01910 | |||||
SMRi | P01910 | |||||
ModBasei | Search... | |||||
MobiDBi | Search... |
Protein-protein interaction databases
DIPi | DIP-6133N |
IntActi | P01910, 1 interactor |
MINTi | P01910 |
PTM databases
iPTMneti | P01910 |
Proteomic databases
MaxQBi | P01910 |
PeptideAtlasi | P01910 |
PRIDEi | P01910 |
Protocols and materials databases
Structural Biology Knowledgebase | Search... |
Organism-specific databases
MGIi | MGI:95895 H2-Aa |
Phylogenomic databases
eggNOGi | ENOG410IZMF Eukaryota ENOG410YHX9 LUCA |
HOVERGENi | HBG006862 |
InParanoidi | P01910 |
Miscellaneous databases
EvolutionaryTracei | P01910 |
SOURCEi | Search... |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit 3.10.320.10, 1 hit |
InterProi | View protein in InterPro IPR007110 Ig-like_dom IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR003006 Ig/MHC_CS IPR003597 Ig_C1-set IPR011162 MHC_I/II-like_Ag-recog IPR014745 MHC_II_a/b_N IPR001003 MHC_II_a_N |
Pfami | View protein in Pfam PF07654 C1-set, 1 hit PF00993 MHC_II_alpha, 1 hit |
SMARTi | View protein in SMART SM00407 IGc1, 1 hit SM00920 MHC_II_alpha, 1 hit |
SUPFAMi | SSF48726 SSF48726, 1 hit SSF54452 SSF54452, 1 hit |
PROSITEi | View protein in PROSITE PS50835 IG_LIKE, 1 hit PS00290 IG_MHC, 1 hit |
ProtoNeti | Search... |
Entry informationi
Entry namei | HA2K_MOUSE | |
Accessioni | P01910Primary (citable) accession number: P01910 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 21, 1986 |
Last sequence update: | October 1, 1996 | |
Last modified: | February 13, 2019 | |
This is version 149 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot