HLA-DQA1

Functionⁱ

Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading.

GO - Molecular functionⁱ

MHC class II receptor activity
Source: UniProtKB
Traceable author statementⁱ
- 2300572
peptide antigen binding
Source: UniProtKB
Inferred from sequence or structural similarityⁱ
- 20356827

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

antigen processing and presentation of exogenous peptide antigen via MHC class II Source: Reactome
immune response
Source: UniProtKB
Non-traceable author statementⁱ
- 3584986
- 6415485
interferon-gamma-mediated signaling pathway Source: Reactome
T cell receptor signaling pathway Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Immunity

Biological process

Immunity

Enzyme and pathway databases

Reactomeⁱ	R-HSA-202424 Downstream TCR signaling R-HSA-202427 Phosphorylation of CD3 and TCR zeta chains R-HSA-202430 Translocation of ZAP-70 to Immunological synapse R-HSA-202433 Generation of second messenger molecules R-HSA-2132295 MHC class II antigen presentation R-HSA-389948 PD-1 signaling R-HSA-877300 Interferon gamma signaling
SIGNORⁱ	P01909

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: HLA class II histocompatibility antigen, DQ alpha 1 chain Alternative name(s): DC-1 alpha chain DC-alpha HLA-DCA MHC class II DQA1
Gene namesⁱ	Name:HLA-DQA1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 6

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000196735.11
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:4942 HLA-DQA1
MIMⁱ	146880 gene
neXtProtⁱ	NX_P01909

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	24 – 216	ExtracellularSequence analysisAdd BLAST	193
Transmembraneⁱ	217 – 239	HelicalSequence analysisAdd BLAST	23
Topological domainⁱ	240 – 254	CytoplasmicAdd BLAST	15

Keywords - Cellular componentⁱ

Cell membrane, Endoplasmic reticulum, Endosome, Golgi apparatus, Lysosome, Membrane, MHC II

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	3117
GeneReviewsⁱ	HLA-DQA1
MalaCards human disease database More...MalaCardsⁱ	HLA-DQA1
Orphanetⁱ	391490 Adult-onset myasthenia gravis 930 Idiopathic achalasia 555 NON RARE IN EUROPE: Celiac disease 243377 NON RARE IN EUROPE: Diabetes mellitus type 1
PharmGKBⁱ	PA35066

Polymorphism and mutation databases

BioMutaⁱ	HLA-DQA1
DMDMⁱ	122188

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 23	1 PublicationAdd BLAST		23
ChainⁱPRO_0000018970	24 – 254	HLA class II histocompatibility antigen, DQ alpha 1 chainAdd BLAST		231

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	103	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	132 ↔ 188	PROSITE-ProRule annotation3 Publications
Glycosylationⁱ	143	N-linked (GlcNAc...) asparagineSequence analysis	1

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

PeptideAtlas More...PeptideAtlasⁱ	P01909
PRIDEⁱ	P01909
ProteomicsDBⁱ	51510

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000196735 Expressed in 186 organ(s), highest expression level in leukocyte
CleanExⁱ	HS_HLA-DQA1
ExpressionAtlasⁱ	P01909 baseline and differential
Genevisibleⁱ	P01909 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA012315

HPAⁱ

HPA012315

Interactionⁱ

Subunit structureⁱ

Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. In the endoplasmic reticulum (ER) it forms a heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as invariant chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74 undergoes sequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II molecule. MHC class II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and facilitate the binding of antigenic peptides.4 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
HLA-DQB1	P01920	8	EBI-713389,EBI-1038012

With

Entry

#Exp.

IntAct

Notes

HLA-DQB1

P01920

8

EBI-713389,EBI-1038012

Protein-protein interaction databases

BioGridⁱ	109362, 34 interactors 1529240, 1 interactor
IntActⁱ	P01909, 12 interactors
Molecular INTeraction database More...MINTⁱ	P01909

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	29 – 40	Combined sources	12
Turnⁱ	41 – 44	Combined sources	4
Beta strandⁱ	45 – 52	Combined sources	8
Beta strandⁱ	55 – 61	Combined sources	7
Turnⁱ	62 – 65	Combined sources	4
Beta strandⁱ	66 – 71	Combined sources	6
Helixⁱ	72 – 76	Combined sources	5
Helixⁱ	81 – 101	Combined sources	21
Turnⁱ	102 – 104	Combined sources	3
Beta strandⁱ	113 – 120	Combined sources	8
Beta strandⁱ	124 – 126	Combined sources	3
Beta strandⁱ	128 – 137	Combined sources	10
Beta strandⁱ	143 – 148	Combined sources	6
Beta strandⁱ	151 – 153	Combined sources	3
Beta strandⁱ	157 – 159	Combined sources	3
Beta strandⁱ	170 – 178	Combined sources	9
Beta strandⁱ	186 – 191	Combined sources	6
Beta strandⁱ	195 – 197	Combined sources	3
Beta strandⁱ	199 – 203	Combined sources	5

Show more details

3D structure databases

ProteinModelPortalⁱ	P01909
SMRⁱ	P01909
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P01909

EvolutionaryTraceⁱ

P01909

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	112 – 204	Ig-like C1-typeAdd BLAST		93

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	24 – 119	Alpha-1Add BLAST	96
Regionⁱ	120 – 203	Alpha-2Add BLAST	84
Regionⁱ	204 – 216	Connecting peptideAdd BLAST	13

Sequence similaritiesⁱ

Belongs to the MHC class II family.Curated

Keywords - Domainⁱ

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENⁱ	HBG006862
InParanoidⁱ	P01909
KEGG Orthology (KO) More...KOⁱ	K06752
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0IC9
PhylomeDBⁱ	P01909
TreeFamⁱ	TF333797

Family and domain databases

Gene3Dⁱ	2.60.40.10, 1 hit 3.10.320.10, 1 hit
InterProⁱ	View protein in InterPro IPR007110 Ig-like_dom IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR003006 Ig/MHC_CS IPR003597 Ig_C1-set IPR011162 MHC_I/II-like_Ag-recog IPR014745 MHC_II_a/b_N IPR001003 MHC_II_a_N
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07654 C1-set, 1 hit PF00993 MHC_II_alpha, 1 hit
SMARTⁱ	View protein in SMART SM00407 IGc1, 1 hit SM00920 MHC_II_alpha, 1 hit
SUPFAMⁱ	SSF48726 SSF48726, 1 hit SSF54452 SSF54452, 1 hit
PROSITEⁱ	View protein in PROSITE PS50835 IG_LIKE, 1 hit PS00290 IG_MHC, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 11 potential isoforms that are computationally mapped.Show all Align All

P01909-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MILNKALMLG ALALTTVMSP CGGEDIVADH VASYGVNLYQ SYGPSGQYTH 
        60         70         80         90        100
EFDGDEQFYV DLGRKETVWC LPVLRQFRFD PQFALTNIAV LKHNLNSLIK 
       110        120        130        140        150
RSNSTAATNE VPEVTVFSKS PVTLGQPNIL ICLVDNIFPP VVNITWLSNG 
       160        170        180        190        200
HSVTEGVSET SFLSKSDHSF FKISYLTLLP SAEESYDCKV EHWGLDKPLL 
       210        220        230        240        250
KHWEPEIPAP MSELTETVVC ALGLSVGLVG IVVGTVFIIR GLRSVGASRH 

QGPL

Length:254

Mass (Da):27,805

Last modified:July 21, 1986 - v1

Checksum:ⁱ84E12B5A80E2A028

GO

Computationally mapped potential isoform sequencesⁱ

There are 11 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name	Protein names	Gene names	Length	Annotation

	E9PMV2	E9PMV2_HUMAN	HLA class II histocompatibility ant... HLA class II histocompatibility antigen, DQ alpha 1 chain	HLA-DQA1	214	Annotation score:
	Q5Y7H0	Q5Y7H0_HUMAN	HLA class II histocompatibility ant... HLA class II histocompatibility antigen, DQ alpha 1 chain (MHC class II antigen)	HLA-DQA1	255	Annotation score:
	Q08AS3	Q08AS3_HUMAN	HLA class II histocompatibility ant... HLA class II histocompatibility antigen, DQ alpha 1 chain (HLA-DQA1 protein) (MHC class II antigen)	HLA-DQA1	254	Annotation score:
	A0A1W2PP70	A0A1W2PP70_HUMAN	HLA class II histocompatibility ant... HLA class II histocompatibility antigen, DQ alpha 1 chain	HLA-DQA1	190	Annotation score:
	E9PI37	E9PI37_HUMAN	HLA class II histocompatibility ant... HLA class II histocompatibility antigen, DQ alpha 1 chain	HLA-DQA1	53	Annotation score:
	A0A0G2JKJ3	A0A0G2JKJ3_HUMAN	HLA class II histocompatibility ant... HLA class II histocompatibility antigen, DQ alpha 1 chain	HLA-DQA1	115	Annotation score:
	A0A140TA20	A0A140TA20_HUMAN	HLA class II histocompatibility ant... HLA class II histocompatibility antigen, DQ alpha 1 chain	HLA-DQA1	41	Annotation score:
	F6UB03	F6UB03_HUMAN	HLA class II histocompatibility ant... HLA class II histocompatibility antigen, DQ alpha 1 chain	HLA-DQA1	24	Annotation score:
	A0A182DWH0	A0A182DWH0_HUMAN	HLA class II histocompatibility ant... HLA class II histocompatibility antigen, DQ alpha 1 chain	HLA-DQA1	24	Annotation score:
	A0A182DWF8	A0A182DWF8_HUMAN	HLA class II histocompatibility ant... HLA class II histocompatibility antigen, DQ alpha 1 chain	HLA-DQA1	24	Annotation score:
There is more potential isoformShow all

Sequence cautionⁱ

The sequence AAD56720 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	11	A → S in AAA59760 (PubMed:3584986).Curated	1
Sequence conflictⁱ	23 – 27	Missing in AAA59754 (PubMed:3879967).Curated	5
Sequence conflictⁱ	91	L → H in AAA59760 (PubMed:3584986).Curated	1
Sequence conflictⁱ	107	A → P in AAA59754 (PubMed:3879967).Curated	1
Sequence conflictⁱ	156	G → D in CAA25141 (PubMed:6584734).Curated	1
Sequence conflictⁱ	213	E → D in AAA59754 (PubMed:3879967).Curated	1

Polymorphismⁱ

The following alleles of DQA1 are known: DQA1*01:01, DQA1*01:02, DQA1*01:03, DQA1*01:04, DQA1*01:05, DQA1*01:06, DQA1*01:07, DQA1*02:01, DQA1*03:01, DQA1*03:02, DQA1*03:03, DQA1*04:01, DQA1*04:02, DQA1*04:03, DQA1*04:04, DQA1*05:01, DQA1*05:02, DQA1*05:03, DQA1*05:04, DQA1*05:05, DQA1*05:06, DQA1*05:07, DQA1*05:08, DQA1*05:09, DQA1*06:01, DQA1*06:02. The sequence shown is that of DQA1*05:01.

DQ2 (heterodimer of DQA1*05:01/DQB1*02:01) is associated with more than 90% of celiac disease patients. A minority displays DQ8 (heterodimer of DQA1*03/DQB1*03:02). DQ0602 (heterodimer of DQA1*01:02/DQB1*06:02) confers dominant protection against type 1 diabetes (T1D) and strong susceptibility to narcolepsy.

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_033399	8	M → L in allele DQA101:01, allele DQA101:02, allele DQA101:03, allele DQA101:04, allele DQA101:05, allele DQA104:01 and allele DQA1*06:01. Corresponds to variant dbSNP:rs1047989Ensembl.	1
Natural variantⁱVAR_033400	11	A → T in allele DQA105:05, allele DQA105:08 and allele DQA1*05:09. Corresponds to variant dbSNP:rs1047992Ensembl.	1
Natural variantⁱVAR_050380	17	V → M in allele DQA101:04 and allele DQA101:05. Corresponds to variant dbSNP:rs12722039Ensembl.	1
Natural variantⁱVAR_050381	18	M → T in allele DQA1*03:03. Corresponds to variant dbSNP:rs11545686Ensembl.	1
Natural variantⁱVAR_060493	24	E → K in allele DQA1*05:09. Corresponds to variant dbSNP:rs41545012Ensembl.	1
Natural variantⁱVAR_050382	25	D → G in allele DQA101:04 and allele DQA101:05. Corresponds to variant dbSNP:rs12722042Ensembl.	1
Natural variantⁱVAR_060494	34	Y → C in allele DQA101:01, allele DQA101:02, allele DQA101:03, allele DQA101:04, allele DQA101:05, allele DQA101:06 and allele DQA1*01:07. Corresponds to variant dbSNP:rs1129740Ensembl.	1
Natural variantⁱVAR_033401	41	S → F in allele DQA101:01, allele DQA101:02, allele DQA101:03, allele DQA101:04, allele DQA101:05, allele DQA101:06 and allele DQA1*01:07. Corresponds to variant dbSNP:rs1071630Ensembl.	1
Natural variantⁱVAR_060495	44	P → L in allele DQA1*05:04. Corresponds to variant dbSNP:rs41549715Ensembl.	1
Natural variantⁱVAR_033402	48	Y → F in allele DQA102:01, allele DQA101:03, allele DQA106:01 and allele DQA106:02. Corresponds to variant dbSNP:rs12722051Ensembl.	1
Natural variantⁱVAR_033403	49	T → S in allele DQA103:01, allele DQA103:02 and allele DQA1*03:03. Corresponds to variant dbSNP:rs1048023Ensembl.	1
Natural variantⁱVAR_014604	57	Q → E in allele DQA101:01, allele DQA101:04, allele DQA101:05, allele DQA101:07, allele DQA102:01, allele DQA103:01, allele DQA103:02 and allele DQA103:03. Corresponds to variant dbSNP:rs10093Ensembl.	1
Natural variantⁱVAR_060496	63	G → E in allele DQA101:01, allele DQA101:02, allele DQA101:03, allele DQA101:04, allele DQA101:05, allele DQA101:06, allele DQA101:07, allele DQA102:01, allele DQA103:01, allele DQA103:02 and allele DQA1*03:03. Corresponds to variant dbSNP:rs1142323Ensembl.	1
Natural variantⁱVAR_050383	64	R → K in allele DQA1*01:03. Corresponds to variant dbSNP:rs36219699Ensembl.	1
Natural variantⁱVAR_060497	67	T → A in allele DQA1*01:06. Corresponds to variant dbSNP:rs41543221Ensembl.	1
Natural variantⁱVAR_060498	68	V → A in allele DQA101:01, allele DQA101:02, allele DQA101:03, allele DQA101:04, allele DQA101:05, allele DQA101:06 and allele DQA1*01:07. Corresponds to variant dbSNP:rs1142324Ensembl.	1
Natural variantⁱVAR_060499	70	C → K in allele DQA1*02:01; requires 2 nucleotide substitutions.	1
Natural variantⁱVAR_060500	70	C → Q in allele DQA103:01, allele DQA103:02 and allele DQA1*03:03; requires 2 nucleotide substitutions.	1
Natural variantⁱVAR_060501	70	C → R in allele DQA101:01, allele DQA101:02, allele DQA101:03, allele DQA101:04, allele DQA101:05, allele DQA101:06 and allele DQA1*01:07. Corresponds to variant dbSNP:rs1142326Ensembl.	1
Natural variantⁱVAR_033404	70	C → Y. Corresponds to variant dbSNP:rs3207983Ensembl.	1
Natural variantⁱVAR_060502	71	L → W in allele DQA101:01, allele DQA101:02,allele DQA101:03, allele DQA101:04, allele DQA101:05, allele DQA101:06 and allele DQA1*01:07. Corresponds to variant dbSNP:rs1142328Ensembl.	1
Natural variantⁱVAR_033406	73	V → D. Corresponds to variant dbSNP:rs760671632Ensembl.	1
Natural variantⁱVAR_060503	73	V → E in allele DQA101:01, allele DQA101:02, allele DQA101:03, allele DQA101:04, allele DQA101:05, allele DQA101:06 and allele DQA1*01:07. Corresponds to variant dbSNP:rs3208105Ensembl.	1
Natural variantⁱVAR_033405	73	V → L in allele DQA102:01, allele DQA103:01, allele DQA103:02 and allele DQA103:03. Corresponds to variant dbSNP:rs12722061Ensembl.	1
Natural variantⁱVAR_060504	74	L → F in allele DQA101:01, allele DQA101:02, allele DQA101:03, allele DQA101:04, allele DQA101:05, allele DQA101:06, allele DQA101:07, allele DQA102:01, allele DQA103:01, allele DQA103:02 and allele DQA1*03:03. Corresponds to variant dbSNP:rs9272698Ensembl.	1
Natural variantⁱVAR_060505	75	R → H in allele DQA1*02:01.	1
Natural variantⁱVAR_060506	75	R → S in allele DQA101:01, allele DQA101:02, allele DQA101:03, allele DQA101:04, allele DQA101:05, allele DQA101:06 and allele DQA1*01:07. Corresponds to variant dbSNP:rs9272699Ensembl.	1
Natural variantⁱVAR_060507	76	Q → K in allele DQA101:01, allele DQA101:02, allele DQA101:03, allele DQA101:04, allele DQA101:05, allele DQA101:06 and allele DQA1*01:07. Corresponds to variant dbSNP:rs1048052Ensembl.	1
Natural variantⁱVAR_060508	76	Q → R in allele DQA102:01, allele DQA103:01, allele DQA103:02 and allele DQA103:03. Corresponds to variant dbSNP:rs12722069Ensembl.	1
Natural variantⁱVAR_060509	77	F → L in allele DQA1*02:01. Corresponds to variant dbSNP:rs3188043Ensembl.	1
Natural variantⁱVAR_060510	78	R → GG in allele DQA101:01, allele DQA101:02, allele DQA101:03, allele DQA101:04, allele DQA101:05,allele DQA101:06 and allele DQA1*01:07. Corresponds to variant dbSNP:rs4193Ensembl.	1
Natural variantⁱVAR_060511	78	R → RR in allele DQA103:01, allele DQA103:02 and allele DQA1*03:03.	1
Natural variantⁱVAR_060512	81	P → R in allele DQA1*05:02. Corresponds to variant dbSNP:rs41541412Ensembl.	1
Natural variantⁱVAR_060513	83	F → G in allele DQA101:01, allele DQA101:02, allele DQA101:03, allele DQA101:04, allele DQA101:05, allele DQA101:06 and allele DQA1*01:07; requires 2 nucleotide substitutions.	1
Natural variantⁱVAR_033408	86	T → R in allele DQA101:01, allele DQA101:02, allele DQA101:03, allele DQA101:04, allele DQA101:05, allele DQA101:06 and allele DQA1*01:07. Corresponds to variant dbSNP:rs1142333Ensembl.	1
Natural variantⁱVAR_033409	88	I → M in allele DQA101:01, allele DQA101:02, allele DQA101:03, allele DQA101:04, allele DQA101:05, allele DQA101:06 and allele DQA1*01:07. Corresponds to variant dbSNP:rs1142334Ensembl.	1
Natural variantⁱVAR_060514	91	L → A in allele DQA101:01, allele DQA101:02, allele DQA101:03, allele DQA101:04, allele DQA101:05, allele DQA101:06 and allele DQA1*01:07; requires 2 nucleotide substitutions.	1
Natural variantⁱVAR_060515	91	L → T in allele DQA104:01, allele DQA104:02, allele DQA104:04, allele DQA106:01 and allele DQA1*06:02; requires 2 nucleotide substitutions.	1
Natural variantⁱVAR_060516	97	S → I in allele DQA101:01, allele DQA101:02, allele DQA101:03, allele DQA101:04, allele DQA101:05, allele DQA101:06, allele DQA101:07, allele DQA102:01, allele DQA103:01, allele DQA103:02, allele DQA103:03, allele DQA104:01, allele DQA104:02, allele DQA104:04, allele DQA106:01 and allele DQA106:02. Corresponds to variant dbSNP:rs9279910Ensembl.	1
Natural variantⁱVAR_060517	98	L → M in allele DQA101:01, allele DQA101:02, allele DQA101:03, allele DQA101:04, allele DQA101:05, allele DQA101:06 and allele DQA1*01:07. Corresponds to variant dbSNP:rs1064944Ensembl.	1
Natural variantⁱVAR_060518	98	L → V in allele DQA103:01, allele DQA103:02 and allele DQA1*03:03. Corresponds to variant dbSNP:rs1064944Ensembl.	1
Natural variantⁱVAR_060519	101	R → C in allele DQA1*01:07. Corresponds to variant dbSNP:rs41542116Ensembl.	1
Natural variantⁱVAR_050384	102	S → Y in allele DQA101:01, allele DQA101:02, allele DQA101:03, allele DQA101:04, allele DQA101:05, allele DQA101:06 and allele DQA1*01:07. Corresponds to variant dbSNP:rs1129808Ensembl.	1
Natural variantⁱVAR_060520	124	L → V in allele DQA1*05:06. Corresponds to variant dbSNP:rs41555012Ensembl.	1
Natural variantⁱVAR_050385	129	I → T in allele DQA101:01, allele DQA101:02, allele DQA101:03, allele DQA101:04, allele DQA101:05, allele DQA101:07, allele DQA102:01, allele DQA103:01, allele DQA103:02, allele DQA103:03, allele DQA104:01, allele DQA104:02, allele DQA104:04, allele DQA106:01 and allele DQA1*06:02. Corresponds to variant dbSNP:rs707952Ensembl.	1
Natural variantⁱVAR_050386	151	H → Q in allele DQA101:01, allele DQA101:02, allele DQA101:04, allele DQA101:05 and allele DQA1*01:07. Corresponds to variant dbSNP:rs707950Ensembl.	1
Natural variantⁱVAR_060521	152	S → A in allele DQA1*01:03. Corresponds to variant dbSNP:rs41547417Ensembl.	1
Natural variantⁱVAR_060522	160	T → I in allele DQA1*04:02. Corresponds to variant dbSNP:rs41545514Ensembl.	1
Natural variantⁱVAR_060524	161	S → I in allele DQA1*05:08. Corresponds to variant dbSNP:rs41544114Ensembl.	1
Natural variantⁱVAR_060523	161	S → R in allele DQA1*06:02. Corresponds to variant dbSNP:rs41552014Ensembl.	1
Natural variantⁱVAR_060525	175	Y → H in allele DQA1*04:04. Corresponds to variant dbSNP:rs41550317Ensembl.	1
Natural variantⁱVAR_060526	178	L → F in allele DQA101:01, allele DQA101:02, allele DQA101:03, allele DQA101:04, allele DQA101:05, allele DQA101:07, allele DQA102:01, allele DQA103:01, allele DQA103:02, allele DQA103:03, allele DQA104:01, allele DQA104:02, allele DQA104:04, allele DQA106:01 and allele DQA1*06:02. Corresponds to variant dbSNP:rs707949Ensembl.	1
Natural variantⁱVAR_060527	182	A → D in allele DQA103:02 and allele DQA103:03. Corresponds to variant dbSNP:rs7990Ensembl.	1
Natural variantⁱVAR_060528	182	A → S in allele DQA105:03, allele DQA105:06 and allele DQA1*05:07. Corresponds to variant dbSNP:rs41561312Ensembl.	1
Natural variantⁱVAR_060529	183	E → D in allele DQA101:01, allele DQA101:02, allele DQA101:03, allele DQA101:04, allele DQA101:05, allele DQA101:07, allele DQA102:01, allele DQA103:01, allele DQA103:02, allele DQA103:03, allele DQA104:01, allele DQA104:02, allele DQA104:04, allele DQA106:01 and allele DQA1*06:02. Corresponds to variant dbSNP:rs707963Ensembl.	1
Natural variantⁱVAR_060530	185	S → I in allele DQA101:01, allele DQA101:02, allele DQA101:03, allele DQA101:04, allele DQA101:05, allele DQA101:07, allele DQA102:01, allele DQA103:01, allele DQA103:02, allele DQA103:03, allele DQA104:01, allele DQA104:02, allele DQA104:04, allele DQA106:01 and allele DQA1*06:02. Corresponds to variant dbSNP:rs707962Ensembl.	1
Natural variantⁱVAR_060531	197	K → E in allele DQA102:01, allele DQA103:01, allele DQA103:02, allele DQA103:03, allele DQA104:01, allele DQA104:02, allele DQA104:04, allele DQA106:01 and allele DQA1*06:02. Corresponds to variant dbSNP:rs2308891Ensembl.	1
Natural variantⁱVAR_060532	197	K → Q in allele DQA101:01, allele DQA101:02, allele DQA101:03, allele DQA101:04, allele DQA101:05 and allele DQA101:07. Corresponds to variant dbSNP:rs2308891Ensembl.	1
Natural variantⁱVAR_050387	209	A → T in allele DQA103:01, allele DQA103:02 and allele DQA1*03:03. Corresponds to variant dbSNP:rs9272785Ensembl.	1
Natural variantⁱVAR_050388	221	A → T in allele DQA1*01:04. Corresponds to variant dbSNP:rs35087390Ensembl.	1
Natural variantⁱVAR_033411	229	V → M in allele DQA1*01:02. Corresponds to variant dbSNP:rs9260Ensembl.	1
Natural variantⁱVAR_060533	230	G → C in allele DQA1*05:07. Corresponds to variant dbSNP:rs41545416Ensembl.	1
Natural variantⁱVAR_033412	237	F → L in allele DQA102:01, allele DQA103:01, allele DQA103:02 and allele DQA103:03. Corresponds to variant dbSNP:rs1048430Ensembl.	1
Natural variantⁱVAR_033413	240	R → Q in allele DQA101:01, allele DQA101:02, allele DQA101:03, allele DQA101:04 and allele DQA1*01:05. Corresponds to variant dbSNP:rs1048439Ensembl.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X00033 mRNA Translation: CAA24917.1 X00370 mRNA No translation available. X00452 mRNA Translation: CAA25141.1 M16995 mRNA Translation: AAA59760.1 U92032 Genomic DNA Translation: AAB91990.1 AY663395 Genomic DNA Translation: AAU87978.1 AY663398 Genomic DNA Translation: AAU87987.1 AY663400 Genomic DNA Translation: AAU87992.1 AY663406 Genomic DNA Translation: AAU88007.1 AY663411 Genomic DNA Translation: AAU88022.1 AY663413 Genomic DNA Translation: AAU88028.1 DQ178403 , DQ178400, DQ178401, DQ178402 Genomic DNA Translation: ABA86855.1 DQ178407 , DQ178404, DQ178405, DQ178406 Genomic DNA Translation: ABA86856.1 DQ178411 , DQ178408, DQ178409, DQ178410 Genomic DNA Translation: ABA86857.1 DQ178415 , DQ178412, DQ178413, DQ178414 Genomic DNA Translation: ABA86858.1 M29616, M29613 Genomic DNA Translation: AAA59759.1 AF322870 , AF322867, AF322868, AF322869 Genomic DNA Translation: AAK11577.1 AF395700 , AF395697, AF395698, AF395699 Genomic DNA Translation: AAM69677.1 CR450297 mRNA Translation: CAG29293.1 AM042559 Genomic DNA Translation: CAJ14960.1 AM042560 Genomic DNA Translation: CAJ14961.1 AK313975 mRNA Translation: BAG36689.1 BX248406 Genomic DNA No translation available. AL662789 Genomic DNA No translation available. Z84489 Genomic DNA Translation: CAB06491.1 BC008585 mRNA Translation: AAH08585.1 BC157865 mRNA Translation: AAI57866.1 L46875 mRNA No translation available. L46876 mRNA No translation available. L46877 mRNA No translation available. L46878 mRNA No translation available. L46880 mRNA No translation available. L46881 mRNA No translation available. M11124 mRNA Translation: AAA59754.1 M20431 mRNA Translation: AAA59758.1 L34082 mRNA Translation: AAC41950.1 L34085 mRNA Translation: AAC41953.1 L34086 mRNA Translation: AAC41954.1 L34089 mRNA Translation: AAC41957.1 L34090 mRNA Translation: AAC41958.1 L34092 mRNA Translation: AAC41960.1 L34093 mRNA Translation: AAC41961.1 L34094 mRNA Translation: AAC41962.1 L42625 mRNA Translation: AAA85334.1 AY197775 Genomic DNA Translation: AAO45622.1 AY547314 Genomic DNA Translation: AAS49496.1 AY206406 Genomic DNA Translation: AAO47362.1 AY585236 Genomic DNA Translation: AAT09985.1 M34997 Genomic DNA Translation: AAA35772.1 M34999 Genomic DNA Translation: AAA74633.1 U85035 Genomic DNA Translation: AAB41891.1 AF109734 Genomic DNA Translation: AAD56720.1 Sequence problems. U03675 Genomic DNA Translation: AAB60341.1 M20506 mRNA Translation: AAA59774.1 J00199 mRNA No translation available. M17846 mRNA Translation: AAA59707.1
PIRⁱ	A02211 HLHUD1 A02213 HLHUDQ A02214 HLHUD7 A02215 HLHU3C A93326 HLHUDC B27628 D34512
NCBI Reference Sequences More...RefSeqⁱ	NP_002113.2, NM_002122.3
UniGeneⁱ	Hs.387679 Hs.591798 Hs.706240

Genome annotation databases

Ensemblⁱ	ENST00000343139; ENSP00000339398; ENSG00000196735 ENST00000374949; ENSP00000364087; ENSG00000196735 ENST00000383251; ENSP00000372738; ENSG00000206305 ENST00000395363; ENSP00000378767; ENSG00000196735 ENST00000399675; ENSP00000382583; ENSG00000206305 ENST00000399678; ENSP00000382586; ENSG00000206305 ENST00000418023; ENSP00000387892; ENSG00000232062 ENST00000444296; ENSP00000413237; ENSG00000232062
GeneIDⁱ	3117
KEGGⁱ	hsa:3117
UCSC genome browser More...UCSCⁱ	uc003obr.4 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P01909	HLA class II histocompatibility antigen, DQ alpha 2 chain		HUMAN		254	UniRef100_P01909
MHC class II antigen (Fragment)		HUMAN		254
MHC class II HLA-DQ-alpha chain (Fragment)		HUMAN		226
MHC class II antigen (Fragment)		HUMAN		226
MHC class II antigen (Fragment)		HUMAN		226
+13

Protein	Similar proteins		Species	Score	Length	Source
P01909	HLA class II histocompatibility antigen, DQ alpha 2 chain		HUMAN		254	UniRef90_P01909
Uncharacterized protein		CERAT		267
MHC class II protein		MACNE		265
Uncharacterized protein		MACMU		256
MHC class II antigen		MACFA		255
+456

Protein	Similar proteins		Species	Score	Length	Source
P01909	HLA class II histocompatibility antigen, DQ alpha 2 chain		HUMAN		255	UniRef50_P01909
Uncharacterized protein		CERAT		267
MHC class II protein		MACNE		265
Major histocompatibility complex, class II, DQ alpha 1		GORGO		256
MHC class II antigen		MACMU		256
+511

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X00033 mRNA Translation: CAA24917.1 X00370 mRNA No translation available. X00452 mRNA Translation: CAA25141.1 M16995 mRNA Translation: AAA59760.1 U92032 Genomic DNA Translation: AAB91990.1 AY663395 Genomic DNA Translation: AAU87978.1 AY663398 Genomic DNA Translation: AAU87987.1 AY663400 Genomic DNA Translation: AAU87992.1 AY663406 Genomic DNA Translation: AAU88007.1 AY663411 Genomic DNA Translation: AAU88022.1 AY663413 Genomic DNA Translation: AAU88028.1 DQ178403 , DQ178400, DQ178401, DQ178402 Genomic DNA Translation: ABA86855.1 DQ178407 , DQ178404, DQ178405, DQ178406 Genomic DNA Translation: ABA86856.1 DQ178411 , DQ178408, DQ178409, DQ178410 Genomic DNA Translation: ABA86857.1 DQ178415 , DQ178412, DQ178413, DQ178414 Genomic DNA Translation: ABA86858.1 M29616, M29613 Genomic DNA Translation: AAA59759.1 AF322870 , AF322867, AF322868, AF322869 Genomic DNA Translation: AAK11577.1 AF395700 , AF395697, AF395698, AF395699 Genomic DNA Translation: AAM69677.1 CR450297 mRNA Translation: CAG29293.1 AM042559 Genomic DNA Translation: CAJ14960.1 AM042560 Genomic DNA Translation: CAJ14961.1 AK313975 mRNA Translation: BAG36689.1 BX248406 Genomic DNA No translation available. AL662789 Genomic DNA No translation available. Z84489 Genomic DNA Translation: CAB06491.1 BC008585 mRNA Translation: AAH08585.1 BC157865 mRNA Translation: AAI57866.1 L46875 mRNA No translation available. L46876 mRNA No translation available. L46877 mRNA No translation available. L46878 mRNA No translation available. L46880 mRNA No translation available. L46881 mRNA No translation available. M11124 mRNA Translation: AAA59754.1 M20431 mRNA Translation: AAA59758.1 L34082 mRNA Translation: AAC41950.1 L34085 mRNA Translation: AAC41953.1 L34086 mRNA Translation: AAC41954.1 L34089 mRNA Translation: AAC41957.1 L34090 mRNA Translation: AAC41958.1 L34092 mRNA Translation: AAC41960.1 L34093 mRNA Translation: AAC41961.1 L34094 mRNA Translation: AAC41962.1 L42625 mRNA Translation: AAA85334.1 AY197775 Genomic DNA Translation: AAO45622.1 AY547314 Genomic DNA Translation: AAS49496.1 AY206406 Genomic DNA Translation: AAO47362.1 AY585236 Genomic DNA Translation: AAT09985.1 M34997 Genomic DNA Translation: AAA35772.1 M34999 Genomic DNA Translation: AAA74633.1 U85035 Genomic DNA Translation: AAB41891.1 AF109734 Genomic DNA Translation: AAD56720.1 Sequence problems. U03675 Genomic DNA Translation: AAB60341.1 M20506 mRNA Translation: AAA59774.1 J00199 mRNA No translation available. M17846 mRNA Translation: AAA59707.1
PIRⁱ	A02211 HLHUD1 A02213 HLHUDQ A02214 HLHUD7 A02215 HLHU3C A93326 HLHUDC B27628 D34512
RefSeqⁱ	NP_002113.2, NM_002122.3
UniGeneⁱ	Hs.387679 Hs.591798 Hs.706240

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1JK8	X-ray	2.40	A	27-206	[»]
	1NBN	model	-	A	27-206	[»]
	1S9V	X-ray	2.22	A/D	24-216	[»]
	1UVQ	X-ray	1.80	A	24-218	[»]
	2NNA	X-ray	2.10	A	24-206	[»]
	4GG6	X-ray	3.20	A/C	24-206	[»]
	4OZF	X-ray	2.70	A	24-206	[»]
	4OZG	X-ray	3.00	A/C	24-206	[»]
	4OZH	X-ray	2.80	A/C	24-206	[»]
	4OZI	X-ray	3.20	A/C	24-206	[»]
	5KSA	X-ray	2.00	A	24-206	[»]
	5KSB	X-ray	2.90	A/C	24-206	[»]
	5KSU	X-ray	2.73	A/D	24-216	[»]
	5KSV	X-ray	2.19	A	24-216	[»]
ProteinModelPortalⁱ	P01909
SMRⁱ	P01909
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	109362, 34 interactors 1529240, 1 interactor
IntActⁱ	P01909, 12 interactors
MINTⁱ	P01909

Polymorphism and mutation databases

BioMutaⁱ	HLA-DQA1
DMDMⁱ	122188

Proteomic databases

PeptideAtlasⁱ	P01909
PRIDEⁱ	P01909
ProteomicsDBⁱ	51510

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	3117
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000343139; ENSP00000339398; ENSG00000196735 ENST00000374949; ENSP00000364087; ENSG00000196735 ENST00000383251; ENSP00000372738; ENSG00000206305 ENST00000395363; ENSP00000378767; ENSG00000196735 ENST00000399675; ENSP00000382583; ENSG00000206305 ENST00000399678; ENSP00000382586; ENSG00000206305 ENST00000418023; ENSP00000387892; ENSG00000232062 ENST00000444296; ENSP00000413237; ENSG00000232062
GeneIDⁱ	3117
KEGGⁱ	hsa:3117
UCSCⁱ	uc003obr.4 human

Organism-specific databases

CTDⁱ	3117
DisGeNETⁱ	3117
EuPathDBⁱ	HostDB:ENSG00000196735.11
GeneCardsⁱ	HLA-DQA1
GeneReviewsⁱ	HLA-DQA1
HGNCⁱ	HGNC:4942 HLA-DQA1
HPAⁱ	HPA012315
MalaCardsⁱ	HLA-DQA1
MIMⁱ	146880 gene
neXtProtⁱ	NX_P01909
Orphanetⁱ	391490 Adult-onset myasthenia gravis 930 Idiopathic achalasia 555 NON RARE IN EUROPE: Celiac disease 243377 NON RARE IN EUROPE: Diabetes mellitus type 1
PharmGKBⁱ	PA35066
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

HOVERGENⁱ	HBG006862
InParanoidⁱ	P01909
KOⁱ	K06752
OrthoDBⁱ	EOG091G0IC9
PhylomeDBⁱ	P01909
TreeFamⁱ	TF333797

Enzyme and pathway databases

Reactomeⁱ	R-HSA-202424 Downstream TCR signaling R-HSA-202427 Phosphorylation of CD3 and TCR zeta chains R-HSA-202430 Translocation of ZAP-70 to Immunological synapse R-HSA-202433 Generation of second messenger molecules R-HSA-2132295 MHC class II antigen presentation R-HSA-389948 PD-1 signaling R-HSA-877300 Interferon gamma signaling
SIGNORⁱ	P01909

Miscellaneous databases

ChiTaRSⁱ	HLA-DQA1 human
EvolutionaryTraceⁱ	P01909
GenomeRNAiⁱ	3117
Protein Ontology More...PROⁱ	PR:P01909
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000196735 Expressed in 186 organ(s), highest expression level in leukocyte
CleanExⁱ	HS_HLA-DQA1
ExpressionAtlasⁱ	P01909 baseline and differential
Genevisibleⁱ	P01909 HS

Family and domain databases

Gene3Dⁱ	2.60.40.10, 1 hit 3.10.320.10, 1 hit
InterProⁱ	View protein in InterPro IPR007110 Ig-like_dom IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR003006 Ig/MHC_CS IPR003597 Ig_C1-set IPR011162 MHC_I/II-like_Ag-recog IPR014745 MHC_II_a/b_N IPR001003 MHC_II_a_N
Pfamⁱ	View protein in Pfam PF07654 C1-set, 1 hit PF00993 MHC_II_alpha, 1 hit
SMARTⁱ	View protein in SMART SM00407 IGc1, 1 hit SM00920 MHC_II_alpha, 1 hit
SUPFAMⁱ	SSF48726 SSF48726, 1 hit SSF54452 SSF54452, 1 hit
PROSITEⁱ	View protein in PROSITE PS50835 IG_LIKE, 1 hit PS00290 IG_MHC, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	DQA1_HUMAN
Accessionⁱ	P01909Primary (citable) accession number: P01909 Secondary accession number(s): O19630 Q9UM31
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
	Last sequence update:	July 21, 1986
	Last modified:	December 5, 2018
	This is version 182 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families
Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

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UniProtKB - P01909 (DQA1_HUMAN)

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HLA class II histocompatibility antigen, DQ alpha 1 chain

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Golgi apparatus

Endoplasmic reticulum

Endosome

Lysosome

Plasma membrane

Endoplasmic reticulum

Endosome

Golgi apparatus

Lysosome

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ