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Protein

HLA class II histocompatibility antigen, DQ alpha 1 chain

Gene

HLA-DQA1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • MHC class II receptor activity Source: UniProtKB
  • peptide antigen binding Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processImmunity

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-202424 Downstream TCR signaling
R-HSA-202427 Phosphorylation of CD3 and TCR zeta chains
R-HSA-202430 Translocation of ZAP-70 to Immunological synapse
R-HSA-202433 Generation of second messenger molecules
R-HSA-2132295 MHC class II antigen presentation
R-HSA-389948 PD-1 signaling
R-HSA-877300 Interferon gamma signaling

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P01909

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
HLA class II histocompatibility antigen, DQ alpha 1 chain
Alternative name(s):
DC-1 alpha chain
DC-alpha
HLA-DCA
MHC class II DQA1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000196735.11

Human Gene Nomenclature Database

More...
HGNCi
HGNC:4942 HLA-DQA1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
146880 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P01909

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini24 – 216ExtracellularSequence analysisAdd BLAST193
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei217 – 239HelicalSequence analysisAdd BLAST23
Topological domaini240 – 254CytoplasmicAdd BLAST15

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Endosome, Golgi apparatus, Lysosome, Membrane, MHC II

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
3117

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...
GeneReviewsi
HLA-DQA1

MalaCards human disease database

More...
MalaCardsi
HLA-DQA1

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
391490 Adult-onset myasthenia gravis
930 Idiopathic achalasia
555 NON RARE IN EUROPE: Celiac disease
243377 NON RARE IN EUROPE: Diabetes mellitus type 1

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA35066

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
HLA-DQA1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
122188

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 231 PublicationAdd BLAST23
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001897024 – 254HLA class II histocompatibility antigen, DQ alpha 1 chainAdd BLAST231

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi103N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi132 ↔ 188PROSITE-ProRule annotation3 Publications
Glycosylationi143N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
P01909

PRoteomics IDEntifications database

More...
PRIDEi
P01909

ProteomicsDB human proteome resource

More...
ProteomicsDBi
51510

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000196735 Expressed in 186 organ(s), highest expression level in leukocyte

CleanEx database of gene expression profiles

More...
CleanExi
HS_HLA-DQA1

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P01909 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P01909 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA012315

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. In the endoplasmic reticulum (ER) it forms a heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as invariant chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74 undergoes sequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II molecule. MHC class II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and facilitate the binding of antigenic peptides.4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
HLA-DQB1P019208EBI-713389,EBI-1038012

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
109362, 34 interactors
1529240, 1 interactor

Protein interaction database and analysis system

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IntActi
P01909, 12 interactors

Molecular INTeraction database

More...
MINTi
P01909

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1254
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P01909

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P01909

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P01909

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini112 – 204Ig-like C1-typeAdd BLAST93

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni24 – 119Alpha-1Add BLAST96
Regioni120 – 203Alpha-2Add BLAST84
Regioni204 – 216Connecting peptideAdd BLAST13

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the MHC class II family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG006862

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P01909

KEGG Orthology (KO)

More...
KOi
K06752

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0IC9

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P01909

TreeFam database of animal gene trees

More...
TreeFami
TF333797

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 1 hit
3.10.320.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set
IPR011162 MHC_I/II-like_Ag-recog
IPR014745 MHC_II_a/b_N
IPR001003 MHC_II_a_N

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07654 C1-set, 1 hit
PF00993 MHC_II_alpha, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00407 IGc1, 1 hit
SM00920 MHC_II_alpha, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726 SSF48726, 1 hit
SSF54452 SSF54452, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS00290 IG_MHC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 11 potential isoforms that are computationally mapped.Show allAlign All

P01909-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MILNKALMLG ALALTTVMSP CGGEDIVADH VASYGVNLYQ SYGPSGQYTH
60 70 80 90 100
EFDGDEQFYV DLGRKETVWC LPVLRQFRFD PQFALTNIAV LKHNLNSLIK
110 120 130 140 150
RSNSTAATNE VPEVTVFSKS PVTLGQPNIL ICLVDNIFPP VVNITWLSNG
160 170 180 190 200
HSVTEGVSET SFLSKSDHSF FKISYLTLLP SAEESYDCKV EHWGLDKPLL
210 220 230 240 250
KHWEPEIPAP MSELTETVVC ALGLSVGLVG IVVGTVFIIR GLRSVGASRH

QGPL
Length:254
Mass (Da):27,805
Last modified:July 21, 1986 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i84E12B5A80E2A028
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PMV2E9PMV2_HUMAN
HLA class II histocompatibility ant...
HLA-DQA1
214Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5Y7H0Q5Y7H0_HUMAN
HLA class II histocompatibility ant...
HLA-DQA1
255Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q08AS3Q08AS3_HUMAN
HLA class II histocompatibility ant...
HLA-DQA1
254Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1W2PP70A0A1W2PP70_HUMAN
HLA class II histocompatibility ant...
HLA-DQA1
190Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PI37E9PI37_HUMAN
HLA class II histocompatibility ant...
HLA-DQA1
53Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JKJ3A0A0G2JKJ3_HUMAN
HLA class II histocompatibility ant...
HLA-DQA1
115Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A140TA20A0A140TA20_HUMAN
HLA class II histocompatibility ant...
HLA-DQA1
41Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6UB03F6UB03_HUMAN
HLA class II histocompatibility ant...
HLA-DQA1
24Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A182DWH0A0A182DWH0_HUMAN
HLA class II histocompatibility ant...
HLA-DQA1
24Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A182DWF8A0A182DWF8_HUMAN
HLA class II histocompatibility ant...
HLA-DQA1
24Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There is more potential isoformShow all

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAD56720 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti11A → S in AAA59760 (PubMed:3584986).Curated1
Sequence conflicti23 – 27Missing in AAA59754 (PubMed:3879967).Curated5
Sequence conflicti91L → H in AAA59760 (PubMed:3584986).Curated1
Sequence conflicti107A → P in AAA59754 (PubMed:3879967).Curated1
Sequence conflicti156G → D in CAA25141 (PubMed:6584734).Curated1
Sequence conflicti213E → D in AAA59754 (PubMed:3879967).Curated1

<p>This subsection of the ‘Sequence’ section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement_in_disease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

The following alleles of DQA1 are known: DQA1*01:01, DQA1*01:02, DQA1*01:03, DQA1*01:04, DQA1*01:05, DQA1*01:06, DQA1*01:07, DQA1*02:01, DQA1*03:01, DQA1*03:02, DQA1*03:03, DQA1*04:01, DQA1*04:02, DQA1*04:03, DQA1*04:04, DQA1*05:01, DQA1*05:02, DQA1*05:03, DQA1*05:04, DQA1*05:05, DQA1*05:06, DQA1*05:07, DQA1*05:08, DQA1*05:09, DQA1*06:01, DQA1*06:02. The sequence shown is that of DQA1*05:01.
DQ2 (heterodimer of DQA1*05:01/DQB1*02:01) is associated with more than 90% of celiac disease patients. A minority displays DQ8 (heterodimer of DQA1*03/DQB1*03:02). DQ0602 (heterodimer of DQA1*01:02/DQB1*06:02) confers dominant protection against type 1 diabetes (T1D) and strong susceptibility to narcolepsy.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0333998M → L in allele DQA1*01:01, allele DQA1*01:02, allele DQA1*01:03, allele DQA1*01:04, allele DQA1*01:05, allele DQA1*04:01 and allele DQA1*06:01. Corresponds to variant dbSNP:rs1047989Ensembl.1
Natural variantiVAR_03340011A → T in allele DQA1*05:05, allele DQA1*05:08 and allele DQA1*05:09. Corresponds to variant dbSNP:rs1047992Ensembl.1
Natural variantiVAR_05038017V → M in allele DQA1*01:04 and allele DQA1*01:05. Corresponds to variant dbSNP:rs12722039Ensembl.1
Natural variantiVAR_05038118M → T in allele DQA1*03:03. Corresponds to variant dbSNP:rs11545686Ensembl.1
Natural variantiVAR_06049324E → K in allele DQA1*05:09. Corresponds to variant dbSNP:rs41545012Ensembl.1
Natural variantiVAR_05038225D → G in allele DQA1*01:04 and allele DQA1*01:05. Corresponds to variant dbSNP:rs12722042Ensembl.1
Natural variantiVAR_06049434Y → C in allele DQA1*01:01, allele DQA1*01:02, allele DQA1*01:03, allele DQA1*01:04, allele DQA1*01:05, allele DQA1*01:06 and allele DQA1*01:07. Corresponds to variant dbSNP:rs1129740Ensembl.1
Natural variantiVAR_03340141S → F in allele DQA1*01:01, allele DQA1*01:02, allele DQA1*01:03, allele DQA1*01:04, allele DQA1*01:05, allele DQA1*01:06 and allele DQA1*01:07. Corresponds to variant dbSNP:rs1071630Ensembl.1
Natural variantiVAR_06049544P → L in allele DQA1*05:04. Corresponds to variant dbSNP:rs41549715Ensembl.1
Natural variantiVAR_03340248Y → F in allele DQA1*02:01, allele DQA1*01:03, allele DQA1*06:01 and allele DQA1*06:02. Corresponds to variant dbSNP:rs12722051Ensembl.1
Natural variantiVAR_03340349T → S in allele DQA1*03:01, allele DQA1*03:02 and allele DQA1*03:03. Corresponds to variant dbSNP:rs1048023Ensembl.1
Natural variantiVAR_01460457Q → E in allele DQA1*01:01, allele DQA1*01:04, allele DQA1*01:05, allele DQA1*01:07, allele DQA1*02:01, allele DQA1*03:01, allele DQA1*03:02 and allele DQA1*03:03. Corresponds to variant dbSNP:rs10093Ensembl.1
Natural variantiVAR_06049663G → E in allele DQA1*01:01, allele DQA1*01:02, allele DQA1*01:03, allele DQA1*01:04, allele DQA1*01:05, allele DQA1*01:06, allele DQA1*01:07, allele DQA1*02:01, allele DQA1*03:01, allele DQA1*03:02 and allele DQA1*03:03. Corresponds to variant dbSNP:rs1142323Ensembl.1
Natural variantiVAR_05038364R → K in allele DQA1*01:03. Corresponds to variant dbSNP:rs36219699Ensembl.1
Natural variantiVAR_06049767T → A in allele DQA1*01:06. Corresponds to variant dbSNP:rs41543221Ensembl.1
Natural variantiVAR_06049868V → A in allele DQA1*01:01, allele DQA1*01:02, allele DQA1*01:03, allele DQA1*01:04, allele DQA1*01:05, allele DQA1*01:06 and allele DQA1*01:07. Corresponds to variant dbSNP:rs1142324Ensembl.1
Natural variantiVAR_06049970C → K in allele DQA1*02:01; requires 2 nucleotide substitutions. 1
Natural variantiVAR_06050070C → Q in allele DQA1*03:01, allele DQA1*03:02 and allele DQA1*03:03; requires 2 nucleotide substitutions. 1
Natural variantiVAR_06050170C → R in allele DQA1*01:01, allele DQA1*01:02, allele DQA1*01:03, allele DQA1*01:04, allele DQA1*01:05, allele DQA1*01:06 and allele DQA1*01:07. Corresponds to variant dbSNP:rs1142326Ensembl.1
Natural variantiVAR_03340470C → Y. Corresponds to variant dbSNP:rs3207983Ensembl.1
Natural variantiVAR_06050271L → W in allele DQA1*01:01, allele DQA1*01:02,allele DQA1*01:03, allele DQA1*01:04, allele DQA1*01:05, allele DQA1*01:06 and allele DQA1*01:07. Corresponds to variant dbSNP:rs1142328Ensembl.1
Natural variantiVAR_03340673V → D. Corresponds to variant dbSNP:rs760671632Ensembl.1
Natural variantiVAR_06050373V → E in allele DQA1*01:01, allele DQA1*01:02, allele DQA1*01:03, allele DQA1*01:04, allele DQA1*01:05, allele DQA1*01:06 and allele DQA1*01:07. Corresponds to variant dbSNP:rs3208105Ensembl.1
Natural variantiVAR_03340573V → L in allele DQA1*02:01, allele DQA1*03:01, allele DQA1*03:02 and allele DQA1*03:03. Corresponds to variant dbSNP:rs12722061Ensembl.1
Natural variantiVAR_06050474L → F in allele DQA1*01:01, allele DQA1*01:02, allele DQA1*01:03, allele DQA1*01:04, allele DQA1*01:05, allele DQA1*01:06, allele DQA1*01:07, allele DQA1*02:01, allele DQA1*03:01, allele DQA1*03:02 and allele DQA1*03:03. Corresponds to variant dbSNP:rs9272698Ensembl.1
Natural variantiVAR_06050575R → H in allele DQA1*02:01. 1
Natural variantiVAR_06050675R → S in allele DQA1*01:01, allele DQA1*01:02, allele DQA1*01:03, allele DQA1*01:04, allele DQA1*01:05, allele DQA1*01:06 and allele DQA1*01:07. Corresponds to variant dbSNP:rs9272699Ensembl.1
Natural variantiVAR_06050776Q → K in allele DQA1*01:01, allele DQA1*01:02, allele DQA1*01:03, allele DQA1*01:04, allele DQA1*01:05, allele DQA1*01:06 and allele DQA1*01:07. Corresponds to variant dbSNP:rs1048052Ensembl.1
Natural variantiVAR_06050876Q → R in allele DQA1*02:01, allele DQA1*03:01, allele DQA1*03:02 and allele DQA1*03:03. Corresponds to variant dbSNP:rs12722069Ensembl.1
Natural variantiVAR_06050977F → L in allele DQA1*02:01. Corresponds to variant dbSNP:rs3188043Ensembl.1
Natural variantiVAR_06051078R → GG in allele DQA1*01:01, allele DQA1*01:02, allele DQA1*01:03, allele DQA1*01:04, allele DQA1*01:05,allele DQA1*01:06 and allele DQA1*01:07. Corresponds to variant dbSNP:rs4193Ensembl.1
Natural variantiVAR_06051178R → RR in allele DQA1*03:01, allele DQA1*03:02 and allele DQA1*03:03. 1
Natural variantiVAR_06051281P → R in allele DQA1*05:02. Corresponds to variant dbSNP:rs41541412Ensembl.1
Natural variantiVAR_06051383F → G in allele DQA1*01:01, allele DQA1*01:02, allele DQA1*01:03, allele DQA1*01:04, allele DQA1*01:05, allele DQA1*01:06 and allele DQA1*01:07; requires 2 nucleotide substitutions. 1
Natural variantiVAR_03340886T → R in allele DQA1*01:01, allele DQA1*01:02, allele DQA1*01:03, allele DQA1*01:04, allele DQA1*01:05, allele DQA1*01:06 and allele DQA1*01:07. Corresponds to variant dbSNP:rs1142333Ensembl.1
Natural variantiVAR_03340988I → M in allele DQA1*01:01, allele DQA1*01:02, allele DQA1*01:03, allele DQA1*01:04, allele DQA1*01:05, allele DQA1*01:06 and allele DQA1*01:07. Corresponds to variant dbSNP:rs1142334Ensembl.1
Natural variantiVAR_06051491L → A in allele DQA1*01:01, allele DQA1*01:02, allele DQA1*01:03, allele DQA1*01:04, allele DQA1*01:05, allele DQA1*01:06 and allele DQA1*01:07; requires 2 nucleotide substitutions. 1
Natural variantiVAR_06051591L → T in allele DQA1*04:01, allele DQA1*04:02, allele DQA1*04:04, allele DQA1*06:01 and allele DQA1*06:02; requires 2 nucleotide substitutions. 1
Natural variantiVAR_06051697S → I in allele DQA1*01:01, allele DQA1*01:02, allele DQA1*01:03, allele DQA1*01:04, allele DQA1*01:05, allele DQA1*01:06, allele DQA1*01:07, allele DQA1*02:01, allele DQA1*03:01, allele DQA1*03:02, allele DQA1*03:03, allele DQA1*04:01, allele DQA1*04:02, allele DQA1*04:04, allele DQA1*06:01 and allele DQA1*06:02. Corresponds to variant dbSNP:rs9279910Ensembl.1
Natural variantiVAR_06051798L → M in allele DQA1*01:01, allele DQA1*01:02, allele DQA1*01:03, allele DQA1*01:04, allele DQA1*01:05, allele DQA1*01:06 and allele DQA1*01:07. Corresponds to variant dbSNP:rs1064944Ensembl.1
Natural variantiVAR_06051898L → V in allele DQA1*03:01, allele DQA1*03:02 and allele DQA1*03:03. Corresponds to variant dbSNP:rs1064944Ensembl.1
Natural variantiVAR_060519101R → C in allele DQA1*01:07. Corresponds to variant dbSNP:rs41542116Ensembl.1
Natural variantiVAR_050384102S → Y in allele DQA1*01:01, allele DQA1*01:02, allele DQA1*01:03, allele DQA1*01:04, allele DQA1*01:05, allele DQA1*01:06 and allele DQA1*01:07. Corresponds to variant dbSNP:rs1129808Ensembl.1
Natural variantiVAR_060520124L → V in allele DQA1*05:06. Corresponds to variant dbSNP:rs41555012Ensembl.1
Natural variantiVAR_050385129I → T in allele DQA1*01:01, allele DQA1*01:02, allele DQA1*01:03, allele DQA1*01:04, allele DQA1*01:05, allele DQA1*01:07, allele DQA1*02:01, allele DQA1*03:01, allele DQA1*03:02, allele DQA1*03:03, allele DQA1*04:01, allele DQA1*04:02, allele DQA1*04:04, allele DQA1*06:01 and allele DQA1*06:02. Corresponds to variant dbSNP:rs707952Ensembl.1
Natural variantiVAR_050386151H → Q in allele DQA1*01:01, allele DQA1*01:02, allele DQA1*01:04, allele DQA1*01:05 and allele DQA1*01:07. Corresponds to variant dbSNP:rs707950Ensembl.1
Natural variantiVAR_060521152S → A in allele DQA1*01:03. Corresponds to variant dbSNP:rs41547417Ensembl.1
Natural variantiVAR_060522160T → I in allele DQA1*04:02. Corresponds to variant dbSNP:rs41545514Ensembl.1
Natural variantiVAR_060524161S → I in allele DQA1*05:08. Corresponds to variant dbSNP:rs41544114Ensembl.1
Natural variantiVAR_060523161S → R in allele DQA1*06:02. Corresponds to variant dbSNP:rs41552014Ensembl.1
Natural variantiVAR_060525175Y → H in allele DQA1*04:04. Corresponds to variant dbSNP:rs41550317Ensembl.1
Natural variantiVAR_060526178L → F in allele DQA1*01:01, allele DQA1*01:02, allele DQA1*01:03, allele DQA1*01:04, allele DQA1*01:05, allele DQA1*01:07, allele DQA1*02:01, allele DQA1*03:01, allele DQA1*03:02, allele DQA1*03:03, allele DQA1*04:01, allele DQA1*04:02, allele DQA1*04:04, allele DQA1*06:01 and allele DQA1*06:02. Corresponds to variant dbSNP:rs707949Ensembl.1
Natural variantiVAR_060527182A → D in allele DQA1*03:02 and allele DQA1*03:03. Corresponds to variant dbSNP:rs7990Ensembl.1
Natural variantiVAR_060528182A → S in allele DQA1*05:03, allele DQA1*05:06 and allele DQA1*05:07. Corresponds to variant dbSNP:rs41561312Ensembl.1
Natural variantiVAR_060529183E → D in allele DQA1*01:01, allele DQA1*01:02, allele DQA1*01:03, allele DQA1*01:04, allele DQA1*01:05, allele DQA1*01:07, allele DQA1*02:01, allele DQA1*03:01, allele DQA1*03:02, allele DQA1*03:03, allele DQA1*04:01, allele DQA1*04:02, allele DQA1*04:04, allele DQA1*06:01 and allele DQA1*06:02. Corresponds to variant dbSNP:rs707963Ensembl.1
Natural variantiVAR_060530185S → I in allele DQA1*01:01, allele DQA1*01:02, allele DQA1*01:03, allele DQA1*01:04, allele DQA1*01:05, allele DQA1*01:07, allele DQA1*02:01, allele DQA1*03:01, allele DQA1*03:02, allele DQA1*03:03, allele DQA1*04:01, allele DQA1*04:02, allele DQA1*04:04, allele DQA1*06:01 and allele DQA1*06:02. Corresponds to variant dbSNP:rs707962Ensembl.1
Natural variantiVAR_060531197K → E in allele DQA1*02:01, allele DQA1*03:01, allele DQA1*03:02, allele DQA1*03:03, allele DQA1*04:01, allele DQA1*04:02, allele DQA1*04:04, allele DQA1*06:01 and allele DQA1*06:02. Corresponds to variant dbSNP:rs2308891Ensembl.1
Natural variantiVAR_060532197K → Q in allele DQA1*01:01, allele DQA1*01:02, allele DQA1*01:03, allele DQA1*01:04, allele DQA1*01:05 and allele DQA1*01:07. Corresponds to variant dbSNP:rs2308891Ensembl.1
Natural variantiVAR_050387209A → T in allele DQA1*03:01, allele DQA1*03:02 and allele DQA1*03:03. Corresponds to variant dbSNP:rs9272785Ensembl.1
Natural variantiVAR_050388221A → T in allele DQA1*01:04. Corresponds to variant dbSNP:rs35087390Ensembl.1
Natural variantiVAR_033411229V → M in allele DQA1*01:02. Corresponds to variant dbSNP:rs9260Ensembl.1
Natural variantiVAR_060533230G → C in allele DQA1*05:07. Corresponds to variant dbSNP:rs41545416Ensembl.1
Natural variantiVAR_033412237F → L in allele DQA1*02:01, allele DQA1*03:01, allele DQA1*03:02 and allele DQA1*03:03. Corresponds to variant dbSNP:rs1048430Ensembl.1
Natural variantiVAR_033413240R → Q in allele DQA1*01:01, allele DQA1*01:02, allele DQA1*01:03, allele DQA1*01:04 and allele DQA1*01:05. Corresponds to variant dbSNP:rs1048439Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X00033 mRNA Translation: CAA24917.1
X00370 mRNA No translation available.
X00452 mRNA Translation: CAA25141.1
M16995 mRNA Translation: AAA59760.1
U92032 Genomic DNA Translation: AAB91990.1
AY663395 Genomic DNA Translation: AAU87978.1
AY663398 Genomic DNA Translation: AAU87987.1
AY663400 Genomic DNA Translation: AAU87992.1
AY663406 Genomic DNA Translation: AAU88007.1
AY663411 Genomic DNA Translation: AAU88022.1
AY663413 Genomic DNA Translation: AAU88028.1
DQ178403
, DQ178400, DQ178401, DQ178402 Genomic DNA Translation: ABA86855.1
DQ178407
, DQ178404, DQ178405, DQ178406 Genomic DNA Translation: ABA86856.1
DQ178411
, DQ178408, DQ178409, DQ178410 Genomic DNA Translation: ABA86857.1
DQ178415
, DQ178412, DQ178413, DQ178414 Genomic DNA Translation: ABA86858.1
M29616, M29613 Genomic DNA Translation: AAA59759.1
AF322870
, AF322867, AF322868, AF322869 Genomic DNA Translation: AAK11577.1
AF395700
, AF395697, AF395698, AF395699 Genomic DNA Translation: AAM69677.1
CR450297 mRNA Translation: CAG29293.1
AM042559 Genomic DNA Translation: CAJ14960.1
AM042560 Genomic DNA Translation: CAJ14961.1
AK313975 mRNA Translation: BAG36689.1
BX248406 Genomic DNA No translation available.
AL662789 Genomic DNA No translation available.
Z84489 Genomic DNA Translation: CAB06491.1
BC008585 mRNA Translation: AAH08585.1
BC157865 mRNA Translation: AAI57866.1
L46875 mRNA No translation available.
L46876 mRNA No translation available.
L46877 mRNA No translation available.
L46878 mRNA No translation available.
L46880 mRNA No translation available.
L46881 mRNA No translation available.
M11124 mRNA Translation: AAA59754.1
M20431 mRNA Translation: AAA59758.1
L34082 mRNA Translation: AAC41950.1
L34085 mRNA Translation: AAC41953.1
L34086 mRNA Translation: AAC41954.1
L34089 mRNA Translation: AAC41957.1
L34090 mRNA Translation: AAC41958.1
L34092 mRNA Translation: AAC41960.1
L34093 mRNA Translation: AAC41961.1
L34094 mRNA Translation: AAC41962.1
L42625 mRNA Translation: AAA85334.1
AY197775 Genomic DNA Translation: AAO45622.1
AY547314 Genomic DNA Translation: AAS49496.1
AY206406 Genomic DNA Translation: AAO47362.1
AY585236 Genomic DNA Translation: AAT09985.1
M34997 Genomic DNA Translation: AAA35772.1
M34999 Genomic DNA Translation: AAA74633.1
U85035 Genomic DNA Translation: AAB41891.1
AF109734 Genomic DNA Translation: AAD56720.1 Sequence problems.
U03675 Genomic DNA Translation: AAB60341.1
M20506 mRNA Translation: AAA59774.1
J00199 mRNA No translation available.
M17846 mRNA Translation: AAA59707.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A02211 HLHUD1
A02213 HLHUDQ
A02214 HLHUD7
A02215 HLHU3C
A93326 HLHUDC
B27628
D34512

NCBI Reference Sequences

More...
RefSeqi
NP_002113.2, NM_002122.3

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.387679
Hs.591798
Hs.706240

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000343139; ENSP00000339398; ENSG00000196735
ENST00000374949; ENSP00000364087; ENSG00000196735
ENST00000383251; ENSP00000372738; ENSG00000206305
ENST00000395363; ENSP00000378767; ENSG00000196735
ENST00000399675; ENSP00000382583; ENSG00000206305
ENST00000399678; ENSP00000382586; ENSG00000206305
ENST00000418023; ENSP00000387892; ENSG00000232062
ENST00000444296; ENSP00000413237; ENSG00000232062

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3117

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:3117

UCSC genome browser

More...
UCSCi
uc003obr.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X00033 mRNA Translation: CAA24917.1
X00370 mRNA No translation available.
X00452 mRNA Translation: CAA25141.1
M16995 mRNA Translation: AAA59760.1
U92032 Genomic DNA Translation: AAB91990.1
AY663395 Genomic DNA Translation: AAU87978.1
AY663398 Genomic DNA Translation: AAU87987.1
AY663400 Genomic DNA Translation: AAU87992.1
AY663406 Genomic DNA Translation: AAU88007.1
AY663411 Genomic DNA Translation: AAU88022.1
AY663413 Genomic DNA Translation: AAU88028.1
DQ178403
, DQ178400, DQ178401, DQ178402 Genomic DNA Translation: ABA86855.1
DQ178407
, DQ178404, DQ178405, DQ178406 Genomic DNA Translation: ABA86856.1
DQ178411
, DQ178408, DQ178409, DQ178410 Genomic DNA Translation: ABA86857.1
DQ178415
, DQ178412, DQ178413, DQ178414 Genomic DNA Translation: ABA86858.1
M29616, M29613 Genomic DNA Translation: AAA59759.1
AF322870
, AF322867, AF322868, AF322869 Genomic DNA Translation: AAK11577.1
AF395700
, AF395697, AF395698, AF395699 Genomic DNA Translation: AAM69677.1
CR450297 mRNA Translation: CAG29293.1
AM042559 Genomic DNA Translation: CAJ14960.1
AM042560 Genomic DNA Translation: CAJ14961.1
AK313975 mRNA Translation: BAG36689.1
BX248406 Genomic DNA No translation available.
AL662789 Genomic DNA No translation available.
Z84489 Genomic DNA Translation: CAB06491.1
BC008585 mRNA Translation: AAH08585.1
BC157865 mRNA Translation: AAI57866.1
L46875 mRNA No translation available.
L46876 mRNA No translation available.
L46877 mRNA No translation available.
L46878 mRNA No translation available.
L46880 mRNA No translation available.
L46881 mRNA No translation available.
M11124 mRNA Translation: AAA59754.1
M20431 mRNA Translation: AAA59758.1
L34082 mRNA Translation: AAC41950.1
L34085 mRNA Translation: AAC41953.1
L34086 mRNA Translation: AAC41954.1
L34089 mRNA Translation: AAC41957.1
L34090 mRNA Translation: AAC41958.1
L34092 mRNA Translation: AAC41960.1
L34093 mRNA Translation: AAC41961.1
L34094 mRNA Translation: AAC41962.1
L42625 mRNA Translation: AAA85334.1
AY197775 Genomic DNA Translation: AAO45622.1
AY547314 Genomic DNA Translation: AAS49496.1
AY206406 Genomic DNA Translation: AAO47362.1
AY585236 Genomic DNA Translation: AAT09985.1
M34997 Genomic DNA Translation: AAA35772.1
M34999 Genomic DNA Translation: AAA74633.1
U85035 Genomic DNA Translation: AAB41891.1
AF109734 Genomic DNA Translation: AAD56720.1 Sequence problems.
U03675 Genomic DNA Translation: AAB60341.1
M20506 mRNA Translation: AAA59774.1
J00199 mRNA No translation available.
M17846 mRNA Translation: AAA59707.1
PIRiA02211 HLHUD1
A02213 HLHUDQ
A02214 HLHUD7
A02215 HLHU3C
A93326 HLHUDC
B27628
D34512
RefSeqiNP_002113.2, NM_002122.3
UniGeneiHs.387679
Hs.591798
Hs.706240

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1JK8X-ray2.40A27-206[»]
1NBNmodel-A27-206[»]
1S9VX-ray2.22A/D24-216[»]
1UVQX-ray1.80A24-218[»]
2NNAX-ray2.10A24-206[»]
4GG6X-ray3.20A/C24-206[»]
4OZFX-ray2.70A24-206[»]
4OZGX-ray3.00A/C24-206[»]
4OZHX-ray2.80A/C24-206[»]
4OZIX-ray3.20A/C24-206[»]
5KSAX-ray2.00A24-206[»]
5KSBX-ray2.90A/C24-206[»]
5KSUX-ray2.73A/D24-216[»]
5KSVX-ray2.19A24-216[»]
ProteinModelPortaliP01909
SMRiP01909
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109362, 34 interactors
1529240, 1 interactor
IntActiP01909, 12 interactors
MINTiP01909

Polymorphism and mutation databases

BioMutaiHLA-DQA1
DMDMi122188

Proteomic databases

PeptideAtlasiP01909
PRIDEiP01909
ProteomicsDBi51510

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
3117
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000343139; ENSP00000339398; ENSG00000196735
ENST00000374949; ENSP00000364087; ENSG00000196735
ENST00000383251; ENSP00000372738; ENSG00000206305
ENST00000395363; ENSP00000378767; ENSG00000196735
ENST00000399675; ENSP00000382583; ENSG00000206305
ENST00000399678; ENSP00000382586; ENSG00000206305
ENST00000418023; ENSP00000387892; ENSG00000232062
ENST00000444296; ENSP00000413237; ENSG00000232062
GeneIDi3117
KEGGihsa:3117
UCSCiuc003obr.4 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
3117
DisGeNETi3117
EuPathDBiHostDB:ENSG00000196735.11

GeneCards: human genes, protein and diseases

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GeneCardsi
HLA-DQA1
GeneReviewsiHLA-DQA1
HGNCiHGNC:4942 HLA-DQA1
HPAiHPA012315
MalaCardsiHLA-DQA1
MIMi146880 gene
neXtProtiNX_P01909
Orphaneti391490 Adult-onset myasthenia gravis
930 Idiopathic achalasia
555 NON RARE IN EUROPE: Celiac disease
243377 NON RARE IN EUROPE: Diabetes mellitus type 1
PharmGKBiPA35066

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

HOVERGENiHBG006862
InParanoidiP01909
KOiK06752
OrthoDBiEOG091G0IC9
PhylomeDBiP01909
TreeFamiTF333797

Enzyme and pathway databases

ReactomeiR-HSA-202424 Downstream TCR signaling
R-HSA-202427 Phosphorylation of CD3 and TCR zeta chains
R-HSA-202430 Translocation of ZAP-70 to Immunological synapse
R-HSA-202433 Generation of second messenger molecules
R-HSA-2132295 MHC class II antigen presentation
R-HSA-389948 PD-1 signaling
R-HSA-877300 Interferon gamma signaling
SIGNORiP01909

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
HLA-DQA1 human
EvolutionaryTraceiP01909

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
3117

Protein Ontology

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PROi
PR:P01909

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000196735 Expressed in 186 organ(s), highest expression level in leukocyte
CleanExiHS_HLA-DQA1
ExpressionAtlasiP01909 baseline and differential
GenevisibleiP01909 HS

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.10.320.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set
IPR011162 MHC_I/II-like_Ag-recog
IPR014745 MHC_II_a/b_N
IPR001003 MHC_II_a_N
PfamiView protein in Pfam
PF07654 C1-set, 1 hit
PF00993 MHC_II_alpha, 1 hit
SMARTiView protein in SMART
SM00407 IGc1, 1 hit
SM00920 MHC_II_alpha, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF54452 SSF54452, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS00290 IG_MHC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDQA1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P01909
Secondary accession number(s): O19630
, O19706, P01907, P01908, P04225, P04226, P05536, P79553, Q06751, Q29876, Q29994, Q2Q6Y6, Q2Q6Y7, Q2Q6Y8, Q2WCM3, Q30064, Q30067, Q30068, Q30070, Q30071, Q30072, Q30073, Q30086, Q30101, Q5Y7D5, Q5Y7F5, Q6ICU6, Q6PR46, Q6QDB1, Q860W2, Q860W4, Q9BD37, Q9TPM3, Q9UM31
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: December 5, 2018
This is version 182 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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