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Protein

H-2 class II histocompatibility antigen, E-D alpha chain

Gene

H2-Ea

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

Keywordsi

Biological processImmunity

Names & Taxonomyi

Protein namesi
Recommended name:
H-2 class II histocompatibility antigen, E-D alpha chain
Short name:
H2-IE-alpha
Gene namesi
Name:H2-Ea
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:95900 H2-Ea

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini26 – 216ExtracellularSequence analysisAdd BLAST191
Transmembranei217 – 242HelicalSequence analysisAdd BLAST26
Topological domaini243 – 255CytoplasmicSequence analysisAdd BLAST13

Keywords - Cellular componenti

Membrane, MHC II

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Add BLAST25
ChainiPRO_000001897826 – 255H-2 class II histocompatibility antigen, E-D alpha chainAdd BLAST230

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi132 ↔ 188PROSITE-ProRule annotation
Glycosylationi143N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP01904

Interactioni

Protein-protein interaction databases

IntActiP01904, 1 interactor
MINTiP01904

Structurei

Secondary structure

1255
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP01904
SMRiP01904
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01904

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini112 – 204Ig-like C1-typeAdd BLAST93

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni26 – 109Alpha-1Add BLAST84
Regioni110 – 203Alpha-2Add BLAST94
Regioni204 – 216Connecting peptideAdd BLAST13

Sequence similaritiesi

Belongs to the MHC class II family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG006862
InParanoidiP01904

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.10.320.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set
IPR011162 MHC_I/II-like_Ag-recog
IPR014745 MHC_II_a/b_N
IPR001003 MHC_II_a_N
PfamiView protein in Pfam
PF07654 C1-set, 1 hit
PF00993 MHC_II_alpha, 1 hit
SMARTiView protein in SMART
SM00407 IGc1, 1 hit
SM00920 MHC_II_alpha, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF54452 SSF54452, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS00290 IG_MHC, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P01904-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATIGALVLR FFFIAVLMSS QKSWAIKEEH TIIQAEFYLL PDKRGEFMFD
60 70 80 90 100
FDGDEIFHVD IEKSETIWRL EEFAKFASFE AQGALANIAV DKANLDVMKE
110 120 130 140 150
RSNNTPDANV APEVTVLSRS PVNLGEPNIL ICFIDKFSPP VVNVTWLRNG
160 170 180 190 200
RPVTEGVSET VFLPRDDHLF RKFHYLTFLP STDDFYDCEV DHWGLEEPLR
210 220 230 240 250
KTWEFEEKTL LPETKENVMC ALGLFVGLVG IVVGIILIMK GIKKRNVVER

RQGAL
Length:255
Mass (Da):29,117
Last modified:January 1, 1990 - v2
Checksum:i0852EA3AA4EE2674
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P14439HA23_MOUSE
H-2 class II histocompatibility ant...
H2-Ea H2-Ea-ps
255Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti155E → T in AAA39582 (PubMed:6815800).Curated1
Sequence conflicti202T → A in AAA39582 (PubMed:6815800).Curated1
Sequence conflicti239M → A no nucleotide entry (PubMed:6415003).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K00971 Genomic DNA Translation: AAA98624.1
J00396 Genomic DNA Translation: AAA39582.1
PIRiB91743 HLMSED
UniGeneiMm.15680

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K00971 Genomic DNA Translation: AAA98624.1
J00396 Genomic DNA Translation: AAA39582.1
PIRiB91743 HLMSED
UniGeneiMm.15680

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1IEAX-ray2.30A/C26-217[»]
1IEBX-ray2.70A/C26-217[»]
1KT2X-ray2.80A/C26-207[»]
1KTDX-ray2.40A/C26-207[»]
ProteinModelPortaliP01904
SMRiP01904
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP01904, 1 interactor
MINTiP01904

Proteomic databases

PRIDEiP01904

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:95900 H2-Ea

Phylogenomic databases

HOVERGENiHBG006862
InParanoidiP01904

Miscellaneous databases

EvolutionaryTraceiP01904
SOURCEiSearch...

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.10.320.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set
IPR011162 MHC_I/II-like_Ag-recog
IPR014745 MHC_II_a/b_N
IPR001003 MHC_II_a_N
PfamiView protein in Pfam
PF07654 C1-set, 1 hit
PF00993 MHC_II_alpha, 1 hit
SMARTiView protein in SMART
SM00407 IGc1, 1 hit
SM00920 MHC_II_alpha, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF54452 SSF54452, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS00290 IG_MHC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHA21_MOUSE
AccessioniPrimary (citable) accession number: P01904
Secondary accession number(s): Q31157
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 1, 1990
Last modified: February 28, 2018
This is version 127 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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