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Entry version 214 (07 Apr 2021)
Sequence version 2 (10 Feb 2021)
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Protein

HLA class II histocompatibility antigen, DR alpha chain

Gene

HLA-DRA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

An alpha chain of antigen-presenting major histocompatibility complex class II (MHCII) molecule. In complex with the beta chain HLA-DRB, displays antigenic peptides on professional antigen presenting cells (APCs) for recognition by alpha-beta T cell receptor (TCR) on HLA-DR-restricted CD4-positive T cells. This guides antigen-specific T-helper effector functions, both antibody-mediated immune response and macrophage activation, to ultimately eliminate the infectious agents and transformed cells (PubMed:29884618, PubMed:17334368, PubMed:8145819, PubMed:15322540, PubMed:22327072, PubMed:27591323, PubMed:31495665, PubMed:15265931, PubMed:9075930, PubMed:24190431). Typically presents extracellular peptide antigens of 10 to 30 amino acids that arise from proteolysis of endocytosed antigens in lysosomes (PubMed:8145819). In the tumor microenvironment, presents antigenic peptides that are primarily generated in tumor-resident APCs likely via phagocytosis of apoptotic tumor cells or macropinocytosis of secreted tumor proteins (PubMed:31495665). Presents peptides derived from intracellular proteins that are trapped in autolysosomes after macroautophagy, a mechanism especially relevant for T cell selection in the thymus and central immune tolerance (PubMed:17182262, PubMed:23783831). The selection of the immunodominant epitopes follows two processing modes: 'bind first, cut/trim later' for pathogen-derived antigenic peptides and 'cut first, bind later' for autoantigens/self-peptides (PubMed:25413013). The anchor residue at position 1 of the peptide N-terminus, usually a large hydrophobic residue, is essential for high affinity interaction with MHCII molecules (PubMed:8145819).13 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei34Self- and pathogen-derived peptide antigenCombined sources4 Publications1
Sitei74Self-peptide antigen1 Publication1
Sitei76Self- and pathogen-derived peptide antigen2 Publications1
Sitei77Self-peptide antigen1 Publication1
Sitei78Self- and pathogen-derived peptide antigen4 Publications1
Sitei80Pathogen-derived peptide antigenCombined sources1 Publication1
Sitei87Self- and pathogen-derived peptide antigenCombined sources5 Publications1
Sitei94Pathogen-derived peptide antigenCombined sources4 Publications1
Sitei101Self- and pathogen-derived peptide antigenCombined sources4 Publications1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAdaptive immunity, Host-virus interaction, Immunity

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
P01903

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-202424, Downstream TCR signaling
R-HSA-202427, Phosphorylation of CD3 and TCR zeta chains
R-HSA-202430, Translocation of ZAP-70 to Immunological synapse
R-HSA-202433, Generation of second messenger molecules
R-HSA-2132295, MHC class II antigen presentation
R-HSA-389948, PD-1 signaling
R-HSA-877300, Interferon gamma signaling

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P01903

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
HLA class II histocompatibility antigen, DR alpha chain
Alternative name(s):
MHC class II antigen DRA
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HLA-DRA
Synonyms:HLA-DRA1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:4947, HLA-DRA

Online Mendelian Inheritance in Man (OMIM)

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MIMi
142860, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P01903

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000204287.13

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini26 – 216ExtracellularSequence analysisAdd BLAST191
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei217 – 239HelicalSequence analysisAdd BLAST23
Topological domaini240 – 254CytoplasmicSequence analysisAdd BLAST15

Keywords - Cellular componenti

Cell membrane, Cytoplasmic vesicle, Endoplasmic reticulum, Endosome, Lysosome, Membrane, MHC II

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi65E → K: Impairs the interaction with HLA-DM complex, CLIP dissociation and peptide exchange. 2 Publications1
Mutagenesisi68W → F: Decreases the interaction with HLA-DM complex and peptide exchange. 1 Publication1
Mutagenesisi74G → S: Increases the interaction with HLA-DM complex and peptide exchange. 1 Publication1
Mutagenesisi76F → A, S, V or L: Impairs the interaction with HLA-DM complex, CLIP dissociation and peptide exchange. 2 Publications1
Mutagenesisi76F → W: Increases the interaction with HLA-DM complex and peptide exchange. 1 Publication1
Mutagenesisi78S → D or H: Decreases the interaction with HLA-DM complex and peptide exchange. 1 Publication1
Mutagenesisi79F → A or C: Increases the interaction with HLA-DM complex and peptide exchange. 1 Publication1
Mutagenesisi80E → A: Increases the interaction with HLA-DM complex and peptide exchange. Decreases the affinity of the interaction with TCR by more than five-fold. 2 Publications1
Mutagenesisi82Q → A: Decreases the interaction with HLA-DM complex and peptide exchange. 1 Publication1
Mutagenesisi93A → L: Decreases the affinity of the interaction with TCR by more than five-fold. 1 Publication1
Mutagenesisi115T → R: Decreases the interaction with CD4. 1 Publication1
Mutagenesisi117L → R: Decreases the interaction with CD4. 1 Publication1
Mutagenesisi121P → S: Decreases the interaction with HLA-DM complex and peptide exchange. 1 Publication1
Mutagenesisi125R → A: Impairs the interaction with HLA-DM complex and peptide exchange. 1 Publication1
Mutagenesisi244K → R: Almost no change in down-regulation of MHCII. No ubiquitination and complete loss of down-regulation of MHCII; when associated with 'R-254' of HLA-DRB. 1 Publication1

Organism-specific databases

DisGeNET

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DisGeNETi
3122

MalaCards human disease database

More...
MalaCardsi
HLA-DRA
MIMi610424, phenotype

NIAGADS Genomics Database

More...
NIAGADSi
ENSG00000204287

Open Targets

More...
OpenTargetsi
ENSG00000204287

Orphanet; a database dedicated to information on rare diseases and orphan drugs

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Orphaneti
505, Graham Little-Piccardi-Lassueur syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA35071

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

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Pharosi
P01903, Tbio

Protein family/group databases

Allergome; a platform for allergen knowledge

More...
Allergomei
8362, Hom s HLA-DR-alpha

Chemistry databases

Drug and drug target database

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DrugBanki
DB05121, 1D09C3
DB11294, Coccidioides immitis spherule

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
HLA-DRA

Domain mapping of disease mutations (DMDM)

More...
DMDMi
122206

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 253 PublicationsAdd BLAST25
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001894726 – 254HLA class II histocompatibility antigen, DR alpha chainAdd BLAST229

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi103N-linked (GlcNAc...) asparagine2 Publications1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi132 ↔ 188PROSITE-ProRule annotation6 Publications
Glycosylationi143N-linked (GlcNAc...) asparagine2 Publications1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki244Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Ubiquitinated by MARCHF1 or MARCHF8 at Lys-244 leading to down-regulation of MHCII. When associated with ubiquitination of the beta chain at 'Lys-254', the down-regulation of MHCII may be highly effective.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Isopeptide bond, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P01903

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P01903

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
P01903

MaxQB - The MaxQuant DataBase

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MaxQBi
P01903

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P01903

PeptideAtlas

More...
PeptideAtlasi
P01903

PRoteomics IDEntifications database

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PRIDEi
P01903

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
51508

PTM databases

GlyConnect protein glycosylation platform

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GlyConnecti
1368, 16 N-Linked glycans (2 sites)

GlyGen: Computational and Informatics Resources for Glycoscience

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GlyGeni
P01903, 4 sites

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P01903

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P01903

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P01903

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in professional APCs: macrophages, dendritic cells and B cells (at protein level) (PubMed:31495665, PubMed:15322540, PubMed:23783831). Expressed in thymic epithelial cells (at protein level) (PubMed:23783831).3 Publications

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated in dendritic cells upon maturation.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000204287, Expressed in lung and 235 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P01903, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P01903, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000204287, Tissue enhanced (lymphoid)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterotrimer that consists of an alpha chain HLA-DRA, a beta chain HLA-DRB and a peptide (peptide-MHCII) (PubMed:7477400, PubMed:9354468, PubMed:9782128, PubMed:31619516, PubMed:32668259, PubMed:11080454, PubMed:11163233, PubMed:12244309, PubMed:16079912, PubMed:17583734, PubMed:18697946). Newly synthesized alpha and beta chains forms a heterodimer (MHCII) that associates with the CD74/invariant chain (Ii) in the endoplasmic reticulum (ER). Ii is a trimer composed of three subunits and each subunit interacts with one MHCII dimer, blocking the peptide-binding cleft (PubMed:7479981). As a result, MHCII molecules can not bind peptides present in the ER (PubMed:7479981). The complex of MHCII and CD74/Ii is transported in vesicles from ER to Golgi to lysosomes, where it encounters antigenic peptides generated via proteolysis of endocytosed antigens. MHCII dimers are dissociated from CD74/Ii by the combined action of proteolysis and HLA-DM (PubMed:25413013, PubMed:23260142, PubMed:21115828). Lysosomal enzymes such as cathepsin, degrade CD74/Ii leaving a 24 amino acid remnant called class II-associated Ii or CLIP.

Interacts (via the peptide binding cleft) with CLIP; this interaction inhibits antigen peptide binding before entry in the endosomal compartment (PubMed:9075930, PubMed:7477400). The displacement of CLIP and replacement by a high affinity peptide in lysosomes is performed by HLA-DM heterodimer. HLA-DM catalyzes CLIP dissociation from MHCII, stabilizes empty MHCII and mediates the selection of high affinity peptides (PubMed:23260142, PubMed:11070170, PubMed:9075930).

Interacts with HLA-DM heterodimer; this interaction is direct (PubMed:25413013).

Interacts (via alpha-1 domain) with TCR (via CDRs) (PubMed:17334368, PubMed:29884618).

Interacts (via alpha-2 domain) with CD4 (via Ig-like V-type domain); this interaction increases the affinity of TCR for peptide-MHCII (PubMed:27114505).

20 Publications

(Microbial infection) Interacts with Epstein-Barr virus BZLF2/gp42.

1 Publication

(Microbial infection) Interacts with Staphylococcus aureus enterotoxin A/entA, enterotoxin B/entB, enterotoxin C1/entC1, enterotoxin D/entD, and enterotoxin H/entH.

5 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
109367, 47 interactors

Database of interacting proteins

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DIPi
DIP-6063N

Protein interaction database and analysis system

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IntActi
P01903, 35 interactors

Molecular INTeraction database

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MINTi
P01903

STRING: functional protein association networks

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STRINGi
9606.ENSP00000378786

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

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RNActi
P01903, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1254
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P01903

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

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PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
P01903

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini112 – 204Ig-like C1-typeAdd BLAST93

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni26 – 109Alpha-1Add BLAST84
Regioni110 – 203Alpha-2Add BLAST94
Regioni204 – 216Connecting peptideAdd BLAST13

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The alpha-1 domain is a structural part of the peptide-binding cleft. It contains one alpha helix and 4 beta sheets, respectively forming part of the wall and the floor of the peptide-binding cleft. The other 4 beta sheets of the floor and the second alpha helix wall is formed by the beta-1 domain of HLA-DRB. Forms hydrogen bonds with the peptide main chain via conserved amino acids (PubMed:8145819, PubMed:9354468, PubMed:9782128, PubMed:17583734, PubMed:29884618). The peptide-bound alpha-1 domain forms hydrogen bonds with CDR2 and CDR3 alpha-domain of TCR (PubMed:29884618).5 Publications
The alpha-2 Ig-like domain mediates the interaction with CD4 coreceptor.1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the MHC class II family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG502RXYJ, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00940000160997

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_069380_0_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P01903

Database of Orthologous Groups

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OrthoDBi
1132781at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P01903

TreeFam database of animal gene trees

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TreeFami
TF333797

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.60.40.10, 1 hit
3.10.320.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR003006, Ig/MHC_CS
IPR003597, Ig_C1-set
IPR011162, MHC_I/II-like_Ag-recog
IPR014745, MHC_II_a/b_N
IPR001003, MHC_II_a_N

Pfam protein domain database

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Pfami
View protein in Pfam
PF07654, C1-set, 1 hit
PF00993, MHC_II_alpha, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00407, IGc1, 1 hit
SM00920, MHC_II_alpha, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF48726, SSF48726, 1 hit
SSF54452, SSF54452, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS50835, IG_LIKE, 1 hit
PS00290, IG_MHC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P01903-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAISGVPVLG FFIIAVLMSA QESWAIKEEH VIIQAEFYLN PDQSGEFMFD
60 70 80 90 100
FDGDEIFHVD MAKKETVWRL EEFGRFASFE AQGALANIAV DKANLEIMTK
110 120 130 140 150
RSNYTPITNV PPEVTVLTNS PVELREPNVL ICFIDKFTPP VVNVTWLRNG
160 170 180 190 200
KPVTTGVSET VFLPREDHLF RKFHYLPFLP STEDVYDCRV EHWGLDEPLL
210 220 230 240 250
KHWEFDAPSP LPETTENVVC ALGLTVGLVG IIIGTIFIIK GLRKSNAAER

RGPL
Length:254
Mass (Da):28,621
Last modified:February 10, 2021 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3CD1CDBA89D92350
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q30118Q30118_HUMAN
HLA class II histocompatibility ant...
HLA-DRA
229Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JH46A0A0G2JH46_HUMAN
HLA class II histocompatibility ant...
HLA-DRA
229Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAA25076 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti28 – 29EE → AD AA sequence (PubMed:6812963).Curated2
Sequence conflicti33I → T AA sequence (PubMed:6812963).Curated1
Sequence conflicti34 – 35QA → YP AA sequence (PubMed:6812963).Curated2
Sequence conflicti48M → Q AA sequence (PubMed:6812963).Curated1
Sequence conflicti54D → T AA sequence (PubMed:6812963).Curated1
Sequence conflicti59V → Y AA sequence (PubMed:6600932).Curated1
Sequence conflicti64K → L AA sequence (PubMed:6600932).Curated1
Sequence conflicti67V → A AA sequence (PubMed:6955253).Curated1
Sequence conflicti69R → L AA sequence (PubMed:6600932).Curated1
Sequence conflicti75R → P AA sequence (PubMed:6600932).Curated1
Sequence conflicti78S → D AA sequence (PubMed:6600932).Curated1
Sequence conflicti149N → E AA sequence (PubMed:6955253).Curated1

<p>This subsection of the 'Sequence' section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement%5Fin%5Fdisease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

The following alleles of DRA are known: DRA*01:01 and DRA*01:02. The sequence shown is that of DRA*01:02.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03524116V → L. Corresponds to variant dbSNP:rs16822586Ensembl.1
Natural variantiVAR_004399242L → V in allele DRA*01:01. Corresponds to variant dbSNP:rs7192Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
J00194 mRNA Translation: AAA36275.1
K01171 mRNA Translation: AAA59785.1
M60334 mRNA Translation: AAA59783.1
X00274 Genomic DNA Translation: CAA25076.1 Different initiation.
J00204, J00203 Genomic DNA Translation: AAA36302.1
CR457013 mRNA Translation: CAG33294.1
AL662796 Genomic DNA No translation available.
AL670296 Genomic DNA No translation available.
AL935032 Genomic DNA No translation available.
BX120007 Genomic DNA No translation available.
Z84814 Genomic DNA Translation: CAB06609.1
CH471081 Genomic DNA Translation: EAX03630.1
V00523 mRNA Translation: CAA23782.1
J00201 Genomic DNA Translation: AAA36301.1
AF481359 Genomic DNA Translation: AAO23887.1
BC032350 mRNA Translation: AAH32350.1
BC071659 mRNA Translation: AAH71659.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS4750.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A93952, HLHUDA

NCBI Reference Sequences

More...
RefSeqi
NP_061984.2, NM_019111.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000383127; ENSP00000372608; ENSG00000227993
ENST00000383259; ENSP00000372746; ENSG00000206308
ENST00000395388; ENSP00000378786; ENSG00000204287
ENST00000411524; ENSP00000405295; ENSG00000234794
ENST00000414698; ENSP00000402951; ENSG00000230726
ENST00000416883; ENSP00000410443; ENSG00000228987
ENST00000442960; ENSP00000404533; ENSG00000226260

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3122

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:3122

UCSC genome browser

More...
UCSCi
uc003obh.5, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00194 mRNA Translation: AAA36275.1
K01171 mRNA Translation: AAA59785.1
M60334 mRNA Translation: AAA59783.1
X00274 Genomic DNA Translation: CAA25076.1 Different initiation.
J00204, J00203 Genomic DNA Translation: AAA36302.1
CR457013 mRNA Translation: CAG33294.1
AL662796 Genomic DNA No translation available.
AL670296 Genomic DNA No translation available.
AL935032 Genomic DNA No translation available.
BX120007 Genomic DNA No translation available.
Z84814 Genomic DNA Translation: CAB06609.1
CH471081 Genomic DNA Translation: EAX03630.1
V00523 mRNA Translation: CAA23782.1
J00201 Genomic DNA Translation: AAA36301.1
AF481359 Genomic DNA Translation: AAO23887.1
BC032350 mRNA Translation: AAH32350.1
BC071659 mRNA Translation: AAH71659.1
CCDSiCCDS4750.1
PIRiA93952, HLHUDA
RefSeqiNP_061984.2, NM_019111.4

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1A6AX-ray2.75A30-205[»]
1AQDX-ray2.45A/D/G/J26-217[»]
1BX2X-ray2.60A/D27-206[»]
1D5MX-ray2.00A26-206[»]
1D5XX-ray2.45A26-206[»]
1D5ZX-ray2.00A26-206[»]
1D6EX-ray2.45A26-206[»]
1DLHX-ray2.80A/D28-207[»]
1FV1X-ray1.90A/D26-206[»]
1FYTX-ray2.60A26-206[»]
1H15X-ray3.10A/D26-207[»]
1HQRX-ray3.20A26-206[»]
1HXYX-ray2.60A26-207[»]
1J8HX-ray2.40A26-206[»]
1JWMX-ray2.70A26-207[»]
1JWSX-ray2.60A26-207[»]
1JWUX-ray2.30A26-207[»]
1KG0X-ray2.65A28-207[»]
1KLGX-ray2.40A29-205[»]
1KLUX-ray1.93A29-207[»]
1LO5X-ray3.20A26-207[»]
1PYWX-ray2.10A26-207[»]
1R5IX-ray2.60A/E26-206[»]
1SEBX-ray2.70A/E26-206[»]
1SJEX-ray2.45A28-207[»]
1SJHX-ray2.25A28-207[»]
1T5WX-ray2.40A/D27-206[»]
1T5XX-ray2.50A27-207[»]
1YMMX-ray3.50A26-216[»]
1ZGLX-ray2.80A/D/G/J26-206[»]
2FSEX-ray3.10A/C29-205[»]
2G9HX-ray2.00A26-207[»]
2IAMX-ray2.80A26-207[»]
2IANX-ray2.80A/F/K/P26-207[»]
2ICWX-ray2.41A/D28-206[»]
2IPKX-ray2.30A26-207[»]
2OJEX-ray3.00A/E27-206[»]
2Q6WX-ray2.25A/D26-207[»]
2SEBX-ray2.50A26-206[»]
2WBJX-ray3.00A/E26-218[»]
2XN9X-ray2.30D26-207[»]
3C5JX-ray1.80A26-206[»]
3L6FX-ray2.10A26-207[»]
3O6FX-ray2.80A/E26-207[»]
3PDOX-ray1.95A26-217[»]
3PGCX-ray2.66A/D26-217[»]
3PGDX-ray2.72A/D26-217[»]
3QXAX-ray2.71A/D26-207[»]
3QXDX-ray2.30A/D26-207[»]
3S4SX-ray2.40A/D26-207[»]
3S5LX-ray2.10A/D26-207[»]
3T0EX-ray4.00A26-207[»]
4AENX-ray2.20A26-217[»]
4AH2X-ray2.36A26-217[»]
4C56X-ray2.90D/J26-207[»]
4E41X-ray2.60A/F26-207[»]
4FQXX-ray2.60A26-216[»]
4GBXX-ray3.00A26-216[»]
4H1LX-ray3.30A/D28-205[»]
4H25X-ray2.20A/D28-207[»]
4H26X-ray2.50A/D28-206[»]
4I5BX-ray2.12A/D27-213[»]
4IS6X-ray2.50A26-207[»]
4MCYX-ray2.30A26-206[»]
4MCZX-ray2.41A26-206[»]
4MD0X-ray2.19A26-206[»]
4MD4X-ray1.95A26-206[»]
4MD5X-ray1.65A26-206[»]
4MDIX-ray2.00A26-206[»]
4MDJX-ray1.70A26-206[»]
4OV5X-ray2.20A/D/G/J/M/P26-207[»]
4X5WX-ray1.34A26-217[»]
4X5XX-ray3.20A/C26-217[»]
4Y19X-ray2.50A26-206[»]
4Y1AX-ray4.00A26-206[»]
5JLZX-ray1.99A/C26-206[»]
5LAXX-ray2.60A/C26-206[»]
5NI9X-ray1.33A26-206[»]
5NIGX-ray1.35A26-206[»]
5V4MX-ray2.10A/D/G/J26-206[»]
5V4NX-ray3.40A/D26-206[»]
6ATFX-ray1.90A/D26-206[»]
6ATIX-ray1.98A/D26-206[»]
6ATZX-ray2.70A/C29-205[»]
6BIJX-ray2.10A29-205[»]
6BILX-ray2.40A26-206[»]
6BINX-ray2.50A30-206[»]
6BIRX-ray2.30A26-206[»]
6BIVX-ray2.90B26-206[»]
6BIXX-ray2.20A26-206[»]
6BIYX-ray2.05A26-206[»]
6BIZX-ray2.10A26-206[»]
6CPLX-ray2.45A26-254[»]
6CPNX-ray2.00A26-206[»]
6CPOX-ray2.40A/D26-207[»]
6CQJX-ray2.75A/D/G26-207[»]
6CQLX-ray2.40A26-206[»]
6CQNX-ray2.50A26-206[»]
6CQQX-ray2.80A/F26-207[»]
6CQRX-ray3.04A/F26-207[»]
6NIXX-ray2.10A30-206[»]
6QZAX-ray3.09AAA/DDD26-207[»]
6QZCX-ray1.64AAA28-207[»]
6QZDX-ray2.66AAA/DDD28-207[»]
6R0EX-ray1.91AAA26-207[»]
6V0YX-ray2.70A26-206[»]
6V13X-ray2.75A30-206[»]
6V15X-ray2.80A30-206[»]
6V18X-ray2.35A26-206[»]
6V19X-ray2.60A26-206[»]
6V1AX-ray2.29A26-206[»]
SMRiP01903
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi109367, 47 interactors
DIPiDIP-6063N
IntActiP01903, 35 interactors
MINTiP01903
STRINGi9606.ENSP00000378786

Chemistry databases

DrugBankiDB05121, 1D09C3
DB11294, Coccidioides immitis spherule

Protein family/group databases

Allergomei8362, Hom s HLA-DR-alpha

PTM databases

GlyConnecti1368, 16 N-Linked glycans (2 sites)
GlyGeniP01903, 4 sites
iPTMnetiP01903
PhosphoSitePlusiP01903
SwissPalmiP01903

Genetic variation databases

BioMutaiHLA-DRA
DMDMi122206

Proteomic databases

EPDiP01903
jPOSTiP01903
MassIVEiP01903
MaxQBiP01903
PaxDbiP01903
PeptideAtlasiP01903
PRIDEiP01903
ProteomicsDBi51508

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...
ABCDi
P01903, 21 sequenced antibodies

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
28584, 1812 antibodies

The CPTC Antibody Portal

More...
CPTCi
P01903, 1 antibody

The DNASU plasmid repository

More...
DNASUi
3122

Genome annotation databases

EnsembliENST00000383127; ENSP00000372608; ENSG00000227993
ENST00000383259; ENSP00000372746; ENSG00000206308
ENST00000395388; ENSP00000378786; ENSG00000204287
ENST00000411524; ENSP00000405295; ENSG00000234794
ENST00000414698; ENSP00000402951; ENSG00000230726
ENST00000416883; ENSP00000410443; ENSG00000228987
ENST00000442960; ENSP00000404533; ENSG00000226260
GeneIDi3122
KEGGihsa:3122
UCSCiuc003obh.5, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3122
DisGeNETi3122

GeneCards: human genes, protein and diseases

More...
GeneCardsi
HLA-DRA
HGNCiHGNC:4947, HLA-DRA
HPAiENSG00000204287, Tissue enhanced (lymphoid)
MalaCardsiHLA-DRA
MIMi142860, gene
610424, phenotype
neXtProtiNX_P01903
NIAGADSiENSG00000204287
OpenTargetsiENSG00000204287
Orphaneti505, Graham Little-Piccardi-Lassueur syndrome
PharmGKBiPA35071
VEuPathDBiHostDB:ENSG00000204287.13

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502RXYJ, Eukaryota
GeneTreeiENSGT00940000160997
HOGENOMiCLU_069380_0_0_1
InParanoidiP01903
OrthoDBi1132781at2759
PhylomeDBiP01903
TreeFamiTF333797

Enzyme and pathway databases

PathwayCommonsiP01903
ReactomeiR-HSA-202424, Downstream TCR signaling
R-HSA-202427, Phosphorylation of CD3 and TCR zeta chains
R-HSA-202430, Translocation of ZAP-70 to Immunological synapse
R-HSA-202433, Generation of second messenger molecules
R-HSA-2132295, MHC class II antigen presentation
R-HSA-389948, PD-1 signaling
R-HSA-877300, Interferon gamma signaling
SIGNORiP01903

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
3122, 5 hits in 983 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
HLA-DRA, human
EvolutionaryTraceiP01903

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
HLA-DRA

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
3122
PharosiP01903, Tbio

Protein Ontology

More...
PROi
PR:P01903
RNActiP01903, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000204287, Expressed in lung and 235 other tissues
ExpressionAtlasiP01903, baseline and differential
GenevisibleiP01903, HS

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.10.320.10, 1 hit
InterProiView protein in InterPro
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR003006, Ig/MHC_CS
IPR003597, Ig_C1-set
IPR011162, MHC_I/II-like_Ag-recog
IPR014745, MHC_II_a/b_N
IPR001003, MHC_II_a_N
PfamiView protein in Pfam
PF07654, C1-set, 1 hit
PF00993, MHC_II_alpha, 1 hit
SMARTiView protein in SMART
SM00407, IGc1, 1 hit
SM00920, MHC_II_alpha, 1 hit
SUPFAMiSSF48726, SSF48726, 1 hit
SSF54452, SSF54452, 1 hit
PROSITEiView protein in PROSITE
PS50835, IG_LIKE, 1 hit
PS00290, IG_MHC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDRA_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P01903
Secondary accession number(s): A2BET4
, Q30160, Q6IAZ1, Q861I2, Q9TP70
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: February 10, 2021
Last modified: April 7, 2021
This is version 214 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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