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Protein

HLA class II histocompatibility antigen, DR alpha chain

Gene

HLA-DRA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading.

GO - Molecular functioni

  • MHC class II protein complex binding Source: UniProtKB
  • MHC class II receptor activity Source: UniProtKB
  • peptide antigen binding Source: UniProtKB

GO - Biological processi

Keywordsi

Biological processHost-virus interaction, Immunity

Enzyme and pathway databases

ReactomeiR-HSA-202424 Downstream TCR signaling
R-HSA-202427 Phosphorylation of CD3 and TCR zeta chains
R-HSA-202430 Translocation of ZAP-70 to Immunological synapse
R-HSA-202433 Generation of second messenger molecules
R-HSA-2132295 MHC class II antigen presentation
R-HSA-389948 PD-1 signaling
R-HSA-877300 Interferon gamma signaling
SIGNORiP01903

Names & Taxonomyi

Protein namesi
Recommended name:
HLA class II histocompatibility antigen, DR alpha chain
Alternative name(s):
MHC class II antigen DRA
Gene namesi
Name:HLA-DRA
Synonyms:HLA-DRA1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000204287.13
HGNCiHGNC:4947 HLA-DRA
MIMi142860 gene
neXtProtiNX_P01903

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini26 – 216ExtracellularSequence analysisAdd BLAST191
Transmembranei217 – 239HelicalSequence analysisAdd BLAST23
Topological domaini240 – 254CytoplasmicSequence analysisAdd BLAST15

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Endosome, Golgi apparatus, Lysosome, Membrane, MHC II

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi244K → R: Almost no change in down-regulation of MHC class II. No ubiquitination and complete loss of down-regulation of MHC class II; when associated with 'R-254' of HLA-DRB. 1 Publication1

Organism-specific databases

DisGeNETi3122
MalaCardsiHLA-DRA
MIMi610424 phenotype
Orphaneti505 Graham Little-Piccardi-Lassueur syndrome
PharmGKBiPA35071

Protein family/group databases

Allergomei8362 Hom s HLA-DR-alpha

Polymorphism and mutation databases

BioMutaiHLA-DRA
DMDMi122206

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 253 PublicationsAdd BLAST25
ChainiPRO_000001894726 – 254HLA class II histocompatibility antigen, DR alpha chainAdd BLAST229

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi103N-linked (GlcNAc...) asparagine2 Publications1
Disulfide bondi132 ↔ 188PROSITE-ProRule annotation5 Publications
Glycosylationi143N-linked (GlcNAc...) asparagine2 Publications1
Cross-linki244Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication

Post-translational modificationi

Ubiquitinated by MARCH1 or MARCH8 at Lys-244 leading to down-regulation of MHC class II. When associated with ubiquitination of the beta subunit of HLA-DR: HLA-DRB4 'Lys-254', the down-regulation of MHC class II may be highly effective.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiP01903
MaxQBiP01903
PaxDbiP01903
PeptideAtlasiP01903
PRIDEiP01903
ProteomicsDBi51508

PTM databases

GlyConnecti1368
iPTMnetiP01903
PhosphoSitePlusiP01903
SwissPalmiP01903

Expressioni

Gene expression databases

BgeeiENSG00000204287 Expressed in 221 organ(s), highest expression level in lung
CleanExiHS_HLA-DRA
ExpressionAtlasiP01903 baseline and differential
GenevisibleiP01903 HS

Organism-specific databases

HPAiCAB002798
CAB015402
HPA050162
HPA053176

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. In the endoplasmic reticulum (ER) it forms a heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as invariant chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74 undergoes sequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II molecule. MHC class II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and facilitate the binding of antigenic peptides.7 Publications
(Microbial infection) Interacts with Epstein-Barr virus BZLF2/gp42.1 Publication

Protein-protein interaction databases

BioGridi109367, 44 interactors
DIPiDIP-6063N
IntActiP01903, 10 interactors
MINTiP01903
STRINGi9606.ENSP00000378786

Structurei

Secondary structure

1254
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP01903
SMRiP01903
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01903

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini112 – 204Ig-like C1-typeAdd BLAST93

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni26 – 109Alpha-1Add BLAST84
Regioni110 – 203Alpha-2Add BLAST94
Regioni204 – 216Connecting peptideAdd BLAST13

Sequence similaritiesi

Belongs to the MHC class II family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IZMF Eukaryota
ENOG410YHX9 LUCA
HOVERGENiHBG006862
InParanoidiP01903
KOiK06752
OrthoDBiEOG091G0IC9
PhylomeDBiP01903
TreeFamiTF333797

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.10.320.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set
IPR011162 MHC_I/II-like_Ag-recog
IPR014745 MHC_II_a/b_N
IPR001003 MHC_II_a_N
PfamiView protein in Pfam
PF07654 C1-set, 1 hit
PF00993 MHC_II_alpha, 1 hit
SMARTiView protein in SMART
SM00407 IGc1, 1 hit
SM00920 MHC_II_alpha, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF54452 SSF54452, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS00290 IG_MHC, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

P01903-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAISGVPVLG FFIIAVLMSA QESWAIKEEH VIIQAEFYLN PDQSGEFMFD
60 70 80 90 100
FDGDEIFHVD MAKKETVWRL EEFGRFASFE AQGALANIAV DKANLEIMTK
110 120 130 140 150
RSNYTPITNV PPEVTVLTNS PVELREPNVL ICFIDKFTPP VVNVTWLRNG
160 170 180 190 200
KPVTTGVSET VFLPREDHLF RKFHYLPFLP STEDVYDCRV EHWGLDEPLL
210 220 230 240 250
KHWEFDAPSP LPETTENVVC ALGLTVGLVG IIIGTIFIIK GVRKSNAAER

RGPL
Length:254
Mass (Da):28,607
Last modified:July 21, 1986 - v1
Checksum:i3CD1CDBA952B2350
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q30118Q30118_HUMAN
HLA class II histocompatibility ant...
HLA-DRA
229Annotation score:
A0A0G2JMH6A0A0G2JMH6_HUMAN
HLA class II histocompatibility ant...
HLA-DRA
254Annotation score:
A0A0G2JH46A0A0G2JH46_HUMAN
HLA class II histocompatibility ant...
HLA-DRA
229Annotation score:

Sequence cautioni

The sequence CAA25076 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti28 – 29EE → AD AA sequence (PubMed:6812963).Curated2
Sequence conflicti33I → T AA sequence (PubMed:6812963).Curated1
Sequence conflicti34 – 35QA → YP AA sequence (PubMed:6812963).Curated2
Sequence conflicti48M → Q AA sequence (PubMed:6812963).Curated1
Sequence conflicti54D → T AA sequence (PubMed:6812963).Curated1
Sequence conflicti59V → Y AA sequence (PubMed:6600932).Curated1
Sequence conflicti64K → L AA sequence (PubMed:6600932).Curated1
Sequence conflicti67V → A AA sequence (PubMed:6955253).Curated1
Sequence conflicti69R → L AA sequence (PubMed:6600932).Curated1
Sequence conflicti75R → P AA sequence (PubMed:6600932).Curated1
Sequence conflicti78S → D AA sequence (PubMed:6600932).Curated1
Sequence conflicti149N → E AA sequence (PubMed:6955253).Curated1

Polymorphismi

The following alleles of DRA are known: DRA*01:01 and DRA*01:02. The sequence shown is that of DRA*01:01.
Genetic variations in HLA-DRA influence susceptibility to hepatitis B virus (HBV) infection [MIMi:610424].

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03524116V → L. Corresponds to variant dbSNP:rs16822586Ensembl.1
Natural variantiVAR_004399242V → L in allele DRA*01:02. Corresponds to variant dbSNP:rs7192Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00194 mRNA Translation: AAA36275.1
K01171 mRNA Translation: AAA59785.1
X00274 Genomic DNA Translation: CAA25076.1 Different initiation.
J00204, J00203 Genomic DNA Translation: AAA36302.1
M60334 mRNA Translation: AAA59783.1
CR457013 mRNA Translation: CAG33294.1
AL662796 Genomic DNA No translation available.
AL670296 Genomic DNA No translation available.
AL935032 Genomic DNA No translation available.
BX120007 Genomic DNA No translation available.
Z84814 Genomic DNA Translation: CAB06609.1
CH471081 Genomic DNA Translation: EAX03630.1
BC032350 mRNA Translation: AAH32350.1
BC071659 mRNA Translation: AAH71659.1
V00523 mRNA Translation: CAA23782.1
J00201 Genomic DNA Translation: AAA36301.1
AF481359 Genomic DNA Translation: AAO23887.1
CCDSiCCDS4750.1
PIRiA93952 HLHUDA
RefSeqiNP_061984.2, NM_019111.4
UniGeneiHs.520048

Genome annotation databases

EnsembliENST00000383127; ENSP00000372608; ENSG00000227993
ENST00000383259; ENSP00000372746; ENSG00000206308
ENST00000395388; ENSP00000378786; ENSG00000204287
ENST00000411524; ENSP00000405295; ENSG00000234794
ENST00000414698; ENSP00000402951; ENSG00000230726
ENST00000416883; ENSP00000410443; ENSG00000228987
ENST00000442960; ENSP00000404533; ENSG00000226260
GeneIDi3122
KEGGihsa:3122
UCSCiuc003obh.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00194 mRNA Translation: AAA36275.1
K01171 mRNA Translation: AAA59785.1
X00274 Genomic DNA Translation: CAA25076.1 Different initiation.
J00204, J00203 Genomic DNA Translation: AAA36302.1
M60334 mRNA Translation: AAA59783.1
CR457013 mRNA Translation: CAG33294.1
AL662796 Genomic DNA No translation available.
AL670296 Genomic DNA No translation available.
AL935032 Genomic DNA No translation available.
BX120007 Genomic DNA No translation available.
Z84814 Genomic DNA Translation: CAB06609.1
CH471081 Genomic DNA Translation: EAX03630.1
BC032350 mRNA Translation: AAH32350.1
BC071659 mRNA Translation: AAH71659.1
V00523 mRNA Translation: CAA23782.1
J00201 Genomic DNA Translation: AAA36301.1
AF481359 Genomic DNA Translation: AAO23887.1
CCDSiCCDS4750.1
PIRiA93952 HLHUDA
RefSeqiNP_061984.2, NM_019111.4
UniGeneiHs.520048

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1A6AX-ray2.75A30-205[»]
1AQDX-ray2.45A/D/G/J26-217[»]
1BX2X-ray2.60A/D27-206[»]
1D5MX-ray2.00A26-206[»]
1D5XX-ray2.45A26-206[»]
1D5ZX-ray2.00A26-206[»]
1D6EX-ray2.45A26-206[»]
1DLHX-ray2.80A/D28-207[»]
1FV1X-ray1.90A/D26-206[»]
1FYTX-ray2.60A26-206[»]
1H15X-ray3.10A/D26-207[»]
1HQRX-ray3.20A26-206[»]
1HXYX-ray2.60A26-207[»]
1J8HX-ray2.40A26-206[»]
1JWMX-ray2.70A26-207[»]
1JWSX-ray2.60A26-207[»]
1JWUX-ray2.30A26-207[»]
1KG0X-ray2.65A28-207[»]
1KLGX-ray2.40A29-205[»]
1KLUX-ray1.93A29-207[»]
1LO5X-ray3.20A26-207[»]
1PYWX-ray2.10A26-207[»]
1R5IX-ray2.60A/E26-206[»]
1SEBX-ray2.70A/E26-206[»]
1SJEX-ray2.45A28-207[»]
1SJHX-ray2.25A28-207[»]
1T5WX-ray2.40A/D27-206[»]
1T5XX-ray2.50A27-207[»]
1YMMX-ray3.50A26-216[»]
1ZGLX-ray2.80A/D/G/J26-206[»]
2FSEX-ray3.10A/C29-205[»]
2G9HX-ray2.00A26-207[»]
2IAMX-ray2.80A26-207[»]
2IANX-ray2.80A/F/K/P26-207[»]
2ICWX-ray2.41A/D28-206[»]
2IPKX-ray2.30A26-207[»]
2OJEX-ray3.00A/E27-206[»]
2Q6WX-ray2.25A/D26-207[»]
2SEBX-ray2.50A26-206[»]
2WBJX-ray3.00A/E26-218[»]
2XN9X-ray2.30D26-207[»]
3C5JX-ray1.80A26-206[»]
3L6FX-ray2.10A26-207[»]
3O6FX-ray2.80A/E26-207[»]
3PDOX-ray1.95A26-217[»]
3PGCX-ray2.66A/D26-217[»]
3PGDX-ray2.72A/D26-217[»]
3QXAX-ray2.71A/D26-207[»]
3QXDX-ray2.30A/D26-207[»]
3S4SX-ray2.40A/D26-207[»]
3S5LX-ray2.10A/D26-207[»]
3T0EX-ray4.00A26-207[»]
4AENX-ray2.20A26-217[»]
4AH2X-ray2.36A26-217[»]
4C56X-ray2.90D/J26-207[»]
4E41X-ray2.60A/F26-207[»]
4FQXX-ray2.60A26-216[»]
4GBXX-ray3.00A26-216[»]
4H1LX-ray3.30A/D28-205[»]
4H25X-ray2.20A/D28-207[»]
4H26X-ray2.50A/D28-206[»]
4I5BX-ray2.12A/D27-213[»]
4IS6X-ray2.50A26-207[»]
4MCYX-ray2.30A26-206[»]
4MCZX-ray2.41A26-206[»]
4MD0X-ray2.19A26-206[»]
4MD4X-ray1.95A26-206[»]
4MD5X-ray1.65A26-206[»]
4MDIX-ray2.00A26-206[»]
4MDJX-ray1.70A26-206[»]
4OV5X-ray2.20A/D/G/J/M/P26-207[»]
4X5WX-ray1.34A26-217[»]
4X5XX-ray3.20A/C26-217[»]
4Y19X-ray2.50A26-206[»]
4Y1AX-ray4.00A26-206[»]
5JLZX-ray1.99A/C26-206[»]
5LAXX-ray2.60A/C26-206[»]
5NI9X-ray1.33A26-206[»]
5NIGX-ray1.35A26-206[»]
5V4MX-ray2.10A/D/G/J26-206[»]
5V4NX-ray3.40A/D26-206[»]
6ATFX-ray1.90A/D26-206[»]
6ATIX-ray1.98A/D26-206[»]
6ATZX-ray2.70A/C29-205[»]
6BIJX-ray2.10A29-205[»]
6BILX-ray2.40A26-206[»]
6BINX-ray2.50A30-206[»]
6BIRX-ray2.30A26-206[»]
6BIVX-ray2.90B26-206[»]
6BIXX-ray2.20A26-206[»]
6BIYX-ray2.05A26-206[»]
6BIZX-ray2.10A26-206[»]
6CPLX-ray2.45A26-254[»]
6CPNX-ray2.00A26-206[»]
6CPOX-ray2.40A/D26-207[»]
6CQJX-ray2.75A/D/G26-207[»]
6CQLX-ray2.40A26-206[»]
6CQNX-ray2.50A26-206[»]
6CQQX-ray2.80A/F26-207[»]
6CQRX-ray3.04A/F26-207[»]
ProteinModelPortaliP01903
SMRiP01903
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109367, 44 interactors
DIPiDIP-6063N
IntActiP01903, 10 interactors
MINTiP01903
STRINGi9606.ENSP00000378786

Protein family/group databases

Allergomei8362 Hom s HLA-DR-alpha

PTM databases

GlyConnecti1368
iPTMnetiP01903
PhosphoSitePlusiP01903
SwissPalmiP01903

Polymorphism and mutation databases

BioMutaiHLA-DRA
DMDMi122206

Proteomic databases

EPDiP01903
MaxQBiP01903
PaxDbiP01903
PeptideAtlasiP01903
PRIDEiP01903
ProteomicsDBi51508

Protocols and materials databases

DNASUi3122
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000383127; ENSP00000372608; ENSG00000227993
ENST00000383259; ENSP00000372746; ENSG00000206308
ENST00000395388; ENSP00000378786; ENSG00000204287
ENST00000411524; ENSP00000405295; ENSG00000234794
ENST00000414698; ENSP00000402951; ENSG00000230726
ENST00000416883; ENSP00000410443; ENSG00000228987
ENST00000442960; ENSP00000404533; ENSG00000226260
GeneIDi3122
KEGGihsa:3122
UCSCiuc003obh.5 human

Organism-specific databases

CTDi3122
DisGeNETi3122
EuPathDBiHostDB:ENSG00000204287.13
GeneCardsiHLA-DRA
H-InvDBiHIX0005752
HIX0031098
HIX0166957
HIX0167205
HIX0167443
HGNCiHGNC:4947 HLA-DRA
HPAiCAB002798
CAB015402
HPA050162
HPA053176
MalaCardsiHLA-DRA
MIMi142860 gene
610424 phenotype
neXtProtiNX_P01903
Orphaneti505 Graham Little-Piccardi-Lassueur syndrome
PharmGKBiPA35071
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IZMF Eukaryota
ENOG410YHX9 LUCA
HOVERGENiHBG006862
InParanoidiP01903
KOiK06752
OrthoDBiEOG091G0IC9
PhylomeDBiP01903
TreeFamiTF333797

Enzyme and pathway databases

ReactomeiR-HSA-202424 Downstream TCR signaling
R-HSA-202427 Phosphorylation of CD3 and TCR zeta chains
R-HSA-202430 Translocation of ZAP-70 to Immunological synapse
R-HSA-202433 Generation of second messenger molecules
R-HSA-2132295 MHC class II antigen presentation
R-HSA-389948 PD-1 signaling
R-HSA-877300 Interferon gamma signaling
SIGNORiP01903

Miscellaneous databases

ChiTaRSiHLA-DRA human
EvolutionaryTraceiP01903
GeneWikiiHLA-DRA
GenomeRNAii3122
PROiPR:P01903
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000204287 Expressed in 221 organ(s), highest expression level in lung
CleanExiHS_HLA-DRA
ExpressionAtlasiP01903 baseline and differential
GenevisibleiP01903 HS

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.10.320.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set
IPR011162 MHC_I/II-like_Ag-recog
IPR014745 MHC_II_a/b_N
IPR001003 MHC_II_a_N
PfamiView protein in Pfam
PF07654 C1-set, 1 hit
PF00993 MHC_II_alpha, 1 hit
SMARTiView protein in SMART
SM00407 IGc1, 1 hit
SM00920 MHC_II_alpha, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF54452 SSF54452, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS00290 IG_MHC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDRA_HUMAN
AccessioniPrimary (citable) accession number: P01903
Secondary accession number(s): A2BET4
, Q30160, Q6IAZ1, Q861I2, Q9TP70
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: October 10, 2018
This is version 196 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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