UniProtKB - P01900 (HA12_MOUSE)
Protein
H-2 class I histocompatibility antigen, D-D alpha chain
Gene
H2-D1
Organism
Mus musculus (Mouse)
Status
Functioni
Involved in the presentation of foreign antigens to the immune system.
GO - Molecular functioni
- beta-2-microglobulin binding Source: MGI
- CD8 receptor binding Source: MGI
- peptide antigen binding Source: MGI
- peptide binding Source: MGI
- protein-containing complex binding Source: MGI
- signaling receptor binding Source: MGI
- TAP binding Source: MGI
- TAP complex binding Source: MGI
- T cell receptor binding Source: MGI
GO - Biological processi
- antigen processing and presentation of endogenous peptide antigen via MHC class Ib Source: GO_Central
- antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent Source: MGI
- immune response Source: InterPro
- negative regulation of neuron projection development Source: MGI
- positive regulation of T cell mediated cytotoxicity Source: MGI
Keywordsi
Biological process | Immunity |
Names & Taxonomyi
Protein namesi | Recommended name: H-2 class I histocompatibility antigen, D-D alpha chainShort name: H-2D(D) |
Gene namesi | Name:H2-D1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:95896, H2-D1 |
Subcellular locationi
Other locations
Endoplasmic reticulum
- endoplasmic reticulum Source: MGI
- endoplasmic reticulum exit site Source: MGI
- integral component of lumenal side of endoplasmic reticulum membrane Source: Reactome
- MHC class I peptide loading complex Source: MGI
Extracellular region or secreted
- extracellular space Source: GO_Central
Golgi apparatus
- Golgi apparatus Source: MGI
- Golgi medial cisterna Source: MGI
Plasma Membrane
- external side of plasma membrane Source: MGI
- MHC class I protein complex Source: MGI
- plasma membrane Source: MGI
Other locations
- cell surface Source: MGI
- phagocytic vesicle membrane Source: Reactome
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 25 – 311 | ExtracellularSequence analysisAdd BLAST | 287 | |
Transmembranei | 312 – 334 | HelicalSequence analysisAdd BLAST | 23 | |
Topological domaini | 335 – 365 | CytoplasmicSequence analysisAdd BLAST | 31 |
Keywords - Cellular componenti
Membrane, MHC IPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 24 | 1 PublicationAdd BLAST | 24 | |
ChainiPRO_0000018924 | 25 – 365 | H-2 class I histocompatibility antigen, D-D alpha chainAdd BLAST | 341 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 110 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 125 ↔ 188 | PROSITE-ProRule annotation | ||
Glycosylationi | 200 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 227 ↔ 283 | PROSITE-ProRule annotation | ||
Modified residuei | 356 | PhosphoserineCombined sources | 1 | |
Modified residuei | 359 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
EPDi | P01900 |
jPOSTi | P01900 |
MaxQBi | P01900 |
PeptideAtlasi | P01900 |
PRIDEi | P01900 |
PTM databases
iPTMneti | P01900 |
PhosphoSitePlusi | P01900 |
SwissPalmi | P01900 |
Interactioni
Subunit structurei
Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin).
GO - Molecular functioni
- beta-2-microglobulin binding Source: MGI
- CD8 receptor binding Source: MGI
- signaling receptor binding Source: MGI
- TAP binding Source: MGI
- T cell receptor binding Source: MGI
Protein-protein interaction databases
DIPi | DIP-6110N |
MINTi | P01900 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P01900 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P01900 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 209 – 297 | Ig-like C1-typeAdd BLAST | 89 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 25 – 114 | Alpha-1Add BLAST | 90 | |
Regioni | 115 – 206 | Alpha-2Add BLAST | 92 | |
Regioni | 207 – 298 | Alpha-3Add BLAST | 92 | |
Regioni | 299 – 311 | Connecting peptideAdd BLAST | 13 |
Sequence similaritiesi
Belongs to the MHC class I family.Curated
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixFamily and domain databases
Gene3Di | 2.60.40.10, 1 hit 3.30.500.10, 1 hit |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003006, Ig/MHC_CS IPR003597, Ig_C1-set IPR011161, MHC_I-like_Ag-recog IPR037055, MHC_I-like_Ag-recog_sf IPR011162, MHC_I/II-like_Ag-recog IPR001039, MHC_I_a_a1/a2 IPR010579, MHC_I_a_C |
Pfami | View protein in Pfam PF07654, C1-set, 1 hit PF00129, MHC_I, 1 hit PF06623, MHC_I_C, 1 hit |
PRINTSi | PR01638, MHCCLASSI |
SMARTi | View protein in SMART SM00407, IGc1, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit SSF54452, SSF54452, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit PS00290, IG_MHC, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All
P01900-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGAMAPRTLL LLLAAALGPT QTRAGSHSLR YFVTAVSRPG FGEPRYMEVG
60 70 80 90 100
YVDNTEFVRF DSDAENPRYE PRARWIEQEG PEYWERETRR AKGNEQSFRV
110 120 130 140 150
DLRTALRYYN QSAGGSHTLQ WMAGCDVESD GRLLRGYWQF AYDGCDYIAL
160 170 180 190 200
NEDLKTWTAA DMAAQITRRK WEQAGAAERD RAYLEGECVE WLRRYLKNGN
210 220 230 240 250
ATLLRTDPPK AHVTHHRRPE GDVTLRCWAL GFYPADITLT WQLNGEELTQ
260 270 280 290 300
EMELVETRPA GDGTFQKWAS VVVPLGKEQK YTCHVEHEGL PEPLTLRWGK
310 320 330 340 350
EEPPSSTKTN TVIIAVPVVL GAVVILGAVM AFVMKRRRNT GGKGGDYALA
360
PGSQSSDMSL PDCKV
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP01899 | HA11_MOUSE | H-2 class I histocompatibility anti... | H2-D1 | 362 | Annotation score: | ||
P14426 | HA13_MOUSE | H-2 class I histocompatibility anti... | H2-D1 | 362 | Annotation score: | ||
P01895 | HA1Y_MOUSE | H-2 class I histocompatibility anti... | H2-D1 | 298 | Annotation score: | ||
P14427 | HA14_MOUSE | H-2 class I histocompatibility anti... | H2-D1 | 368 | Annotation score: | ||
G3UZP7 | G3UZP7_MOUSE | H-2 class I histocompatibility anti... | H2-D1 | 380 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L29190 Genomic DNA Translation: AAA39581.1 U47326 mRNA Translation: AAB17604.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L29190 Genomic DNA Translation: AAA39581.1 U47326 mRNA Translation: AAB17604.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1BII | X-ray | 2.40 | A | 1-365 | [»] | |
1DDH | X-ray | 3.10 | A | 26-298 | [»] | |
1QO3 | X-ray | 2.30 | A | 26-301 | [»] | |
3DMM | X-ray | 2.60 | A | 26-299 | [»] | |
3E6F | X-ray | 2.41 | A | 26-298 | [»] | |
3E6H | X-ray | 2.10 | A | 26-299 | [»] | |
3ECB | X-ray | 1.70 | A | 26-301 | [»] | |
5IVX | X-ray | 2.10 | A | 26-301 | [»] | |
5KD4 | X-ray | 3.05 | A/C | 26-301 | [»] | |
5KD7 | X-ray | 2.35 | A/C/F/I | 26-300 | [»] | |
5T7G | X-ray | 1.96 | A/C | 26-300 | [»] | |
5WER | X-ray | 3.41 | A/D/G/J | 26-301 | [»] | |
5WES | X-ray | 2.71 | A | 26-301 | [»] | |
5WET | X-ray | 2.64 | A | 26-301 | [»] | |
5WEU | X-ray | 1.58 | A | 26-301 | [»] | |
6NPR | X-ray | 2.37 | A/C | 26-301 | [»] | |
SMRi | P01900 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
DIPi | DIP-6110N |
MINTi | P01900 |
PTM databases
iPTMneti | P01900 |
PhosphoSitePlusi | P01900 |
SwissPalmi | P01900 |
Proteomic databases
EPDi | P01900 |
jPOSTi | P01900 |
MaxQBi | P01900 |
PeptideAtlasi | P01900 |
PRIDEi | P01900 |
Organism-specific databases
MGIi | MGI:95896, H2-D1 |
Miscellaneous databases
ChiTaRSi | H2-D1, mouse |
EvolutionaryTracei | P01900 |
SOURCEi | Search... |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit 3.30.500.10, 1 hit |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003006, Ig/MHC_CS IPR003597, Ig_C1-set IPR011161, MHC_I-like_Ag-recog IPR037055, MHC_I-like_Ag-recog_sf IPR011162, MHC_I/II-like_Ag-recog IPR001039, MHC_I_a_a1/a2 IPR010579, MHC_I_a_C |
Pfami | View protein in Pfam PF07654, C1-set, 1 hit PF00129, MHC_I, 1 hit PF06623, MHC_I_C, 1 hit |
PRINTSi | PR01638, MHCCLASSI |
SMARTi | View protein in SMART SM00407, IGc1, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit SSF54452, SSF54452, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit PS00290, IG_MHC, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | HA12_MOUSE | |
Accessioni | P01900Primary (citable) accession number: P01900 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 21, 1986 |
Last sequence update: | August 13, 1987 | |
Last modified: | June 17, 2020 | |
This is version 174 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families