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Protein

H-2 class I histocompatibility antigen, Q10 alpha chain

Gene

H2-Q10

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the presentation of foreign antigens to the immune system.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processImmunity

Enzyme and pathway databases

ReactomeiR-MMU-1236974 ER-Phagosome pathway
R-MMU-1236977 Endosomal/Vacuolar pathway
R-MMU-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-MMU-6798695 Neutrophil degranulation
R-MMU-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC

Names & Taxonomyi

Protein namesi
Recommended name:
H-2 class I histocompatibility antigen, Q10 alpha chain
Gene namesi
Name:H2-Q10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:95929 H2-Q10

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 310ExtracellularSequence analysisAdd BLAST286
Transmembranei311 – 324HelicalSequence analysisAdd BLAST14

Keywords - Cellular componenti

Membrane, MHC I

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000001893625 – 325H-2 class I histocompatibility antigen, Q10 alpha chainAdd BLAST301

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi110N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi125 ↔ 188PROSITE-ProRule annotation
Disulfide bondi227 ↔ 283PROSITE-ProRule annotation
Glycosylationi280N-linked (GlcNAc...) asparagine1 Publication1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiP01898
MaxQBiP01898
PaxDbiP01898
PeptideAtlasiP01898
PRIDEiP01898

PTM databases

iPTMnetiP01898
PhosphoSitePlusiP01898

Expressioni

Gene expression databases

BgeeiENSMUSG00000067235 Expressed in 101 organ(s), highest expression level in liver
CleanExiMM_H2-Q10
GenevisibleiP01898 MM

Interactioni

Subunit structurei

Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin).

GO - Molecular functioni

Protein-protein interaction databases

BioGridi200177, 1 interactor
STRINGi10090.ENSMUSP00000066419

Structurei

Secondary structure

1325
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP01898
SMRiP01898
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini209 – 297Ig-like C1-typeAdd BLAST89

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni25 – 114Alpha-1Add BLAST90
Regioni115 – 206Alpha-2Add BLAST92
Regioni207 – 298Alpha-3Add BLAST92
Regioni299 – 310Connecting peptideAdd BLAST12

Sequence similaritiesi

Belongs to the MHC class I family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410II5V Eukaryota
ENOG4111K8F LUCA
GeneTreeiENSGT00760000118960
HOGENOMiHOG000296917
HOVERGENiHBG016709
InParanoidiP01898
KOiK06751
OMAiHIFQRIH
OrthoDBiEOG091G09OH
PhylomeDBiP01898
TreeFamiTF336617

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.30.500.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set
IPR011161 MHC_I-like_Ag-recog
IPR037055 MHC_I-like_Ag-recog_sf
IPR011162 MHC_I/II-like_Ag-recog
IPR001039 MHC_I_a_a1/a2
PfamiView protein in Pfam
PF07654 C1-set, 1 hit
PF00129 MHC_I, 1 hit
PRINTSiPR01638 MHCCLASSI
SMARTiView protein in SMART
SM00407 IGc1, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF54452 SSF54452, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS00290 IG_MHC, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01898-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGAMAPRTLL LLLAAALAPT QTQAGSHSMR YFETSVSRPG LGEPRFIIVG
60 70 80 90 100
YVDDTQFVRF DSDAETPRME PRAPWMEQEG PEYWERETQR AKGNEQSFHV
110 120 130 140 150
SLRTLLGYYN QSESGSHTIQ WMYGCKVGSD GRFLRGYLQY AYDGRDYIAL
160 170 180 190 200
NEDLKTWTAA DVAAIITRRK WEQAGAAEYY RAYLEAECVE WLLRYLELGK
210 220 230 240 250
ETLLRTDPPK THVTHHPGSE GDVTLRCWAL GFYPADITLT WQLNGEELTQ
260 270 280 290 300
DMELVETRPA GDGTFQKWAS VVVPLGKEQN YTCHVYHEGL PEPLTLRWEP
310 320
PPSTDSIMSH IADLLWPSLK LWWYL
Length:325
Mass (Da):37,251
Last modified:March 6, 2007 - v3
Checksum:i82B8B7B9140CD72A
GO

Sequence cautioni

The sequence AAA39574 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAA39676 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti99H → R in AAH11215 (PubMed:15489334).Curated1
Sequence conflicti108Y → H in AAA39574 (PubMed:6420070).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K01207, K01205 Genomic DNA Translation: AAA39574.1 Different initiation.
X16426 Genomic DNA Translation: CAA34449.1
AK131620 mRNA Translation: BAE20725.1
BC011215 mRNA Translation: AAH11215.1
M12484 Genomic DNA Translation: AAA39676.1 Different initiation.
K00614 mRNA Translation: AAA39681.1
X16206 Genomic DNA Translation: CAA34326.1
CCDSiCCDS37599.1
PIRiA02199 HLMSTR
A21125
S20045
RefSeqiNP_034521.1, NM_010391.4
UniGeneiMm.88795

Genome annotation databases

EnsembliENSMUST00000068291; ENSMUSP00000066419; ENSMUSG00000067235
ENSMUST00000174525; ENSMUSP00000134163; ENSMUSG00000067235
GeneIDi15007
KEGGimmu:15007
UCSCiuc008cht.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K01207, K01205 Genomic DNA Translation: AAA39574.1 Different initiation.
X16426 Genomic DNA Translation: CAA34449.1
AK131620 mRNA Translation: BAE20725.1
BC011215 mRNA Translation: AAH11215.1
M12484 Genomic DNA Translation: AAA39676.1 Different initiation.
K00614 mRNA Translation: AAA39681.1
X16206 Genomic DNA Translation: CAA34326.1
CCDSiCCDS37599.1
PIRiA02199 HLMSTR
A21125
S20045
RefSeqiNP_034521.1, NM_010391.4
UniGeneiMm.88795

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5J6GX-ray3.30A/C25-280[»]
5J6HX-ray2.30A25-325[»]
ProteinModelPortaliP01898
SMRiP01898
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200177, 1 interactor
STRINGi10090.ENSMUSP00000066419

PTM databases

iPTMnetiP01898
PhosphoSitePlusiP01898

Proteomic databases

EPDiP01898
MaxQBiP01898
PaxDbiP01898
PeptideAtlasiP01898
PRIDEiP01898

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000068291; ENSMUSP00000066419; ENSMUSG00000067235
ENSMUST00000174525; ENSMUSP00000134163; ENSMUSG00000067235
GeneIDi15007
KEGGimmu:15007
UCSCiuc008cht.1 mouse

Organism-specific databases

CTDi15007
MGIiMGI:95929 H2-Q10

Phylogenomic databases

eggNOGiENOG410II5V Eukaryota
ENOG4111K8F LUCA
GeneTreeiENSGT00760000118960
HOGENOMiHOG000296917
HOVERGENiHBG016709
InParanoidiP01898
KOiK06751
OMAiHIFQRIH
OrthoDBiEOG091G09OH
PhylomeDBiP01898
TreeFamiTF336617

Enzyme and pathway databases

ReactomeiR-MMU-1236974 ER-Phagosome pathway
R-MMU-1236977 Endosomal/Vacuolar pathway
R-MMU-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-MMU-6798695 Neutrophil degranulation
R-MMU-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC

Miscellaneous databases

ChiTaRSiH2-Q10 mouse
PROiPR:P01898
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000067235 Expressed in 101 organ(s), highest expression level in liver
CleanExiMM_H2-Q10
GenevisibleiP01898 MM

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.30.500.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set
IPR011161 MHC_I-like_Ag-recog
IPR037055 MHC_I-like_Ag-recog_sf
IPR011162 MHC_I/II-like_Ag-recog
IPR001039 MHC_I_a_a1/a2
PfamiView protein in Pfam
PF07654 C1-set, 1 hit
PF00129 MHC_I, 1 hit
PRINTSiPR01638 MHCCLASSI
SMARTiView protein in SMART
SM00407 IGc1, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF54452 SSF54452, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS00290 IG_MHC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHA10_MOUSE
AccessioniPrimary (citable) accession number: P01898
Secondary accession number(s): O19475, Q31214, Q95HC3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: March 6, 2007
Last modified: September 12, 2018
This is version 161 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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