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Protein

HLA class I histocompatibility antigen, A-2 alpha chain

Gene

HLA-A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the presentation of foreign antigens to the immune system.

GO - Molecular functioni

  • beta-2-microglobulin binding Source: UniProtKB
  • peptide antigen binding Source: UniProtKB
  • RNA binding Source: UniProtKB
  • signaling receptor binding Source: BHF-UCL
  • TAP binding Source: UniProtKB
  • T cell receptor binding Source: UniProtKB

GO - Biological processi

Keywordsi

Biological processHost-virus interaction, Immunity

Enzyme and pathway databases

ReactomeiR-HSA-1236974 ER-Phagosome pathway
R-HSA-1236977 Endosomal/Vacuolar pathway
R-HSA-164940 Nef mediated downregulation of MHC class I complex cell surface expression
R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-877300 Interferon gamma signaling
R-HSA-8866654 E3 ubiquitin ligases ubiquitinate target proteins
R-HSA-909733 Interferon alpha/beta signaling
R-HSA-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC
SIGNORiP01892

Names & Taxonomyi

Protein namesi
Recommended name:
HLA class I histocompatibility antigen, A-2 alpha chain
Alternative name(s):
MHC class I antigen A*2
Gene namesi
Name:HLA-A
Synonyms:HLAA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:4931 HLA-A
MIMi142800 gene
neXtProtiNX_P01892

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 308ExtracellularSequence analysisAdd BLAST284
Transmembranei309 – 332HelicalSequence analysisAdd BLAST24
Topological domaini333 – 365CytoplasmicSequence analysisAdd BLAST33

Keywords - Cellular componenti

Membrane, MHC I

Pathology & Biotechi

Organism-specific databases

DisGeNETi3105
MalaCardsiHLA-A

Chemistry databases

DrugBankiDB02740 3-Indolebutyric Acid

Polymorphism and mutation databases

DMDMi122138

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 241 PublicationAdd BLAST24
ChainiPRO_000001881425 – 365HLA class I histocompatibility antigen, A-2 alpha chainAdd BLAST341

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi110N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi125 ↔ 188PROSITE-ProRule annotation1 Publication
Disulfide bondi227 ↔ 283PROSITE-ProRule annotation1 Publication
Modified residuei343PhosphoserineBy similarity1
Modified residuei344PhosphotyrosineBy similarity1
Modified residuei345PhosphoserineBy similarity1
Modified residuei349PhosphoserineBy similarity1
Modified residuei350PhosphoserineCombined sources1
Modified residuei352PhosphoserineCombined sources1
Modified residuei356PhosphoserineCombined sources1
Modified residuei359PhosphoserineCombined sources1

Post-translational modificationi

Polyubiquitinated in a post ER compartment through interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP01892
PeptideAtlasiP01892
PRIDEiP01892

PTM databases

iPTMnetiP01892
PhosphoSitePlusiP01892
SwissPalmiP01892

Expressioni

Gene expression databases

CleanExiHS_HLA-A

Interactioni

Subunit structurei

Dimer of alpha chain and a beta chain (beta-2-microglobulin).1 Publication
(Microbial infection) Interacts with human herpesvirus 8 MIR1 protein.1 Publication
(Microbial infection) Interacts with HTLV-1 accessory protein p12I.1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

  • beta-2-microglobulin binding Source: UniProtKB
  • signaling receptor binding Source: BHF-UCL
  • TAP binding Source: UniProtKB
  • T cell receptor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi109350, 90 interactors
IntActiP01892, 31 interactors
MINTiP01892

Structurei

Secondary structure

1365
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi27 – 36Combined sources10
Beta strandi41 – 43Combined sources3
Beta strandi45 – 52Combined sources8
Beta strandi55 – 61Combined sources7
Beta strandi64 – 66Combined sources3
Beta strandi70 – 73Combined sources4
Helixi74 – 78Combined sources5
Helixi81 – 108Combined sources28
Beta strandi113 – 115Combined sources3
Beta strandi118 – 127Combined sources10
Beta strandi129 – 131Combined sources3
Beta strandi133 – 142Combined sources10
Beta strandi145 – 150Combined sources6
Beta strandi152 – 155Combined sources4
Beta strandi157 – 159Combined sources3
Helixi162 – 173Combined sources12
Helixi176 – 185Combined sources10
Helixi187 – 198Combined sources12
Helixi200 – 203Combined sources4
Beta strandi210 – 235Combined sources26
Beta strandi238 – 243Combined sources6
Beta strandi246 – 248Combined sources3
Helixi249 – 251Combined sources3
Beta strandi252 – 254Combined sources3
Beta strandi261 – 263Combined sources3
Beta strandi265 – 274Combined sources10
Beta strandi275 – 277Combined sources3
Helixi278 – 280Combined sources3
Beta strandi281 – 286Combined sources6
Beta strandi290 – 292Combined sources3
Beta strandi294 – 296Combined sources3
Beta strandi348 – 350Combined sources3

3D structure databases

ProteinModelPortaliP01892
SMRiP01892
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01892

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini209 – 295Ig-like C1-typeAdd BLAST87

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni25 – 114Alpha-1Add BLAST90
Regioni115 – 206Alpha-2Add BLAST92
Regioni207 – 298Alpha-3Add BLAST92
Regioni299 – 308Connecting peptide10

Sequence similaritiesi

Belongs to the MHC class I family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG016709

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.30.500.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set
IPR011161 MHC_I-like_Ag-recog
IPR037055 MHC_I-like_Ag-recog_sf
IPR011162 MHC_I/II-like_Ag-recog
IPR001039 MHC_I_a_a1/a2
IPR010579 MHC_I_a_C
PfamiView protein in Pfam
PF07654 C1-set, 1 hit
PF00129 MHC_I, 1 hit
PF06623 MHC_I_C, 1 hit
PRINTSiPR01638 MHCCLASSI
SMARTiView protein in SMART
SM00407 IGc1, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF54452 SSF54452, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS00290 IG_MHC, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01892-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVMAPRTLV LLLSGALALT QTWAGSHSMR YFFTSVSRPG RGEPRFIAVG
60 70 80 90 100
YVDDTQFVRF DSDAASQRME PRAPWIEQEG PEYWDGETRK VKAHSQTHRV
110 120 130 140 150
DLGTLRGYYN QSEAGSHTVQ RMYGCDVGSD WRFLRGYHQY AYDGKDYIAL
160 170 180 190 200
KEDLRSWTAA DMAAQTTKHK WEAAHVAEQL RAYLEGTCVE WLRRYLENGK
210 220 230 240 250
ETLQRTDAPK THMTHHAVSD HEATLRCWAL SFYPAEITLT WQRDGEDQTQ
260 270 280 290 300
DTELVETRPA GDGTFQKWAA VVVPSGQEQR YTCHVQHEGL PKPLTLRWEP
310 320 330 340 350
SSQPTIPIVG IIAGLVLFGA VITGAVVAAV MWRRKSSDRK GGSYSQAASS
360
DSAQGSDVSL TACKV
Length:365
Mass (Da):40,922
Last modified:August 13, 1987 - v1
Checksum:iB54A97B24B337C08
GO

Sequence cautioni

The sequence CAA41022 differs from that shown. The sequence differs from that shown extensively.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti115G → V in AAA52656 (PubMed:3863816).Curated1
Sequence conflicti140Y → V in AAA52656 (PubMed:3863816).Curated1
Sequence conflicti277Q → E in AAA52656 (PubMed:3863816).Curated1
Sequence conflicti318F → L in AAA52656 (PubMed:3863816).Curated1

Polymorphismi

The following alleles of A-2 are known: A*02:01, A*02:02, A*02:03, A*02:04, A*02:05, A*02:06 (A2.4A), A*02:07, A*02:08, A*02:09, A*02:10, A*02:11 (A2.5), A*02:12, A*02:13 (A*02SLU), A*02:16, A*02:17, A*02:18 (A2K), A*02:19, A*02:20, A*02:21, A*02:31, A*02:34 (A*AAT), A*02:35, A*02:36 and A*02:37. The sequence shown is that of A*02:01.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_00433433F → Y in allele A*02:05, allele A*02:06, allele A*02:08, allele A*02:10 and allele A*02:21. Corresponds to variant dbSNP:rs2075684Ensembl.1
Natural variantiVAR_00433554D → N in allele A*02:21. Corresponds to variant dbSNP:rs41549215Ensembl.1
Natural variantiVAR_01672665A → G in allele A*02:31. Corresponds to variant dbSNP:rs41557613Ensembl.1
Natural variantiVAR_00433667Q → R in allele A*02:02, allele A*02:05 and allele A*02:08. Corresponds to variant dbSNP:rs41559117Ensembl.1
Natural variantiVAR_07644689R → G Polymorphism. 1 PublicationCorresponds to variant dbSNP:rs199474430Ensembl.1
Natural variantiVAR_00433790K → N in allele A*02:08 and allele A*02:20. Corresponds to variant dbSNP:rs199474436Ensembl.1
Natural variantiVAR_01672794H → Q in allele A*02:34 and allele A*02:35. Corresponds to variant dbSNP:rs78306866Ensembl.1
Natural variantiVAR_00433897T → I in allele A*02:11. Corresponds to variant dbSNP:rs199474457Ensembl.1
Natural variantiVAR_01672898H → D in allele A*02:11 and allele A*02:35. Corresponds to variant dbSNP:rs1136683Ensembl.1
Natural variantiVAR_004339119V → L in allele A*02:02, allele A*02:05, allele A*02:08 and allele A*02:17. Corresponds to variant dbSNP:rs1071743Ensembl.1
Natural variantiVAR_004340121R → M in allele A*02:04 and allele A*02:17. Corresponds to variant dbSNP:rs199474485Ensembl.1
Natural variantiVAR_004341123Y → C in allele A*02:07 and allele A*02:18. Corresponds to variant dbSNP:rs1136697Ensembl.1
Natural variantiVAR_004342123Y → F in allele A*02:10 and allele A*02:17. Corresponds to variant dbSNP:rs1136697Ensembl.1
Natural variantiVAR_004343131W → G in allele A*02:10. Corresponds to variant dbSNP:rs1136702Ensembl.1
Natural variantiVAR_004344162M → K in allele A*02:18. Corresponds to variant dbSNP:rs41549316Ensembl.1
Natural variantiVAR_004345173A → T in allele A*02:03. Corresponds to variant dbSNP:rs1059526Ensembl.1
Natural variantiVAR_004346176V → E in allele A*02:03 and allele A*02:13. Combined sourcesCorresponds to variant dbSNP:rs9256983Ensembl.1
Natural variantiVAR_004348180L → Q in allele A*02:12, allele A*02:13 and allele A*02:37. 1
Natural variantiVAR_004347180L → W in allele A*02:02, allele A*02:03, allele A*02:05 and allele A*02:08. Combined sourcesCorresponds to variant dbSNP:rs9260156Ensembl.1
Natural variantiVAR_004349187T → E in allele A*02:16; requires 2 nucleotide substitutions. 1
Natural variantiVAR_016729190E → D in allele A*02:36 and allele A*02:37. Corresponds to variant dbSNP:rs879577815Ensembl.1
Natural variantiVAR_016730191W → G in allele A*02:36 and allele A*02:37. Corresponds to variant dbSNP:rs3098019Ensembl.1
Natural variantiVAR_004350260A → E in allele A*02:09. Corresponds to variant dbSNP:rs41540417Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K02883 Genomic DNA Translation: AAA98727.1
M84379 mRNA Translation: AAA59606.1
X02457 mRNA Translation: CAA26297.1
M11887 mRNA Translation: AAA52656.1
M19670 Genomic DNA Translation: AAA03683.2
AH003586 Genomic DNA Translation: AAB02120.1
U03863 mRNA Translation: AAA03604.1
M86404 mRNA No translation available.
X57954 mRNA Translation: CAA41022.1 Sequence problems.
U02935 Genomic DNA Translation: AAA76608.2
AJ555412 Genomic DNA Translation: CAD87771.1
U03862 mRNA Translation: AAA03603.1
M24042 mRNA Translation: AAA59653.1
Z23071 mRNA Translation: CAA80612.1
M84377 mRNA Translation: AAA59603.1
X60764 mRNA No translation available.
M84378 mRNA Translation: AAA59604.1
Z27120 mRNA Translation: CAA81644.1
Z46633 mRNA Translation: CAA86602.1
U18930 mRNA Translation: AAA87076.1
D83515 mRNA Translation: BAA11935.1
X96724 mRNA Translation: CAA65501.1
U56825 mRNA Translation: AAB17465.1
AH007560 Genomic DNA Translation: AAD23437.1
AH007704 Genomic DNA Translation: AAD30272.1
AH008013 Genomic DNA Translation: AAD45690.1
AH008012 Genomic DNA Translation: AAD45689.1
AH008007 Genomic DNA Translation: AAD45324.1
PIRiB24512 HLHU10
I37470
I37542
I38418
I38442
I38443
I55948 HLHUA2
I61857
I61902
I84448
UniGeneiHs.181244
Hs.713441

Genome annotation databases

EnsembliENST00000457879; ENSP00000403575; ENSG00000235657
ENST00000547271; ENSP00000447962; ENSG00000235657
ENST00000547522; ENSP00000448077; ENSG00000227715

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry namei1A02_HUMAN
AccessioniPrimary (citable) accession number: P01892
Secondary accession number(s): O19619
, P06338, P10313, P30444, P30445, P30446, P30514, Q29680, Q29837, Q29899, Q95352, Q95380, Q9TPX8, Q9TPX9, Q9TPY0, Q9TQH5, Q9TQI3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: August 13, 1987
Last modified: July 18, 2018
This is version 211 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

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