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Entry version 221 (31 Jul 2019)
Sequence version 1 (13 Aug 1987)
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Protein

HLA class I histocompatibility antigen, A-2 alpha chain

Gene

HLA-A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Antigen-presenting major histocompatibility complex class I (MHCI) molecule, HLA-A*02 serotype. In complex with B2M/beta 2 microglobulin displays primarily viral and tumor-derived peptides on antigen-presenting cells for recognition by alpha-beta T cell receptor (TCR) on HLA-A*02-restricted CD8-positive T cells, guiding antigen-specific T cell immune response to eliminate infected or transformed cells (PubMed:7694806, PubMed:2784196, PubMed:12138174, PubMed:12796775, PubMed:28250417, PubMed:8906788, PubMed:19542454, PubMed:20619457). May also present self-peptides derived from the signal sequence of secreted or membrane proteins, although T cells specific for these peptides are usually inactivated to prevent autoreactivity (PubMed:7935798). Both the peptide and the MHC molecule are recognized by TCR, the peptide is responsible for the fine specificity of antigen recognition and MHC residues account for the MHC restriction of T cells (PubMed:12796775, PubMed:18275829, PubMed:19542454, PubMed:28250417). Typically presents intracellular peptide antigens of 8 to 11 amino acids that arise from cytosolic proteolysis via IFNG-induced immunoproteasome (PubMed:17079320, PubMed:26929325). Can bind different peptides that share a common structural motif defined by the nature of the peptide anchor residues (PubMed:7935798, PubMed:8906788, PubMed:8805302, PubMed:8630735, PubMed:22245737). HLA-A*02:01, a major allele in human populations, presents immunodominant viral epitopes derived from IAV M/matrix protein 1 (GILGFVFTL), HIV-1 env (TLTSCNTSV), HIV-1 gag-pol (ILKEPVHGV), HTLV-1 Tax (LLFGYPVYV), HBV C/core antigen (FLPSDFFPS), HCMV UL83/pp65 (NLVPMVATV) as well as tumor peptide antigens including MAGEA4 (GVYDGREHTV), WT1 (RMFPNAPYL) and CTAG1A/NY-ESO-1 (SLLMWITQC), all having in common hydrophobic amino acids at position 2 and at C-terminal anchors (PubMed:12796775, PubMed:8805302, PubMed:8630735, PubMed:9177355, PubMed:20619457, PubMed:18275829, PubMed:28250417, PubMed:7694806, PubMed:8906788, PubMed:11502003, PubMed:19542454, PubMed:12138174).17 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei31Self- and pathogen-derived peptide antigen2 Publications1
Binding sitei87Pathogen-derived peptide antigen1 Publication1
Binding sitei89Pathogen-derived peptide antigen2 Publications1
Binding sitei90Self- and pathogen-derived peptide antigen2 Publications1
Binding sitei101Pathogen-derived peptide antigen1 Publication1
Binding sitei108Self- and pathogen-derived peptide antigen4 Publications1
Binding sitei123Self-peptide antigen1 Publication1
Binding sitei166Self- and pathogen-derived peptide antigen7 Publications1
Binding sitei170Self- and pathogen-derived peptide antigen2 Publications1
Binding sitei171Self- and pathogen-derived peptide antigen3 Publications1
Binding sitei183Self- and pathogen-derived peptide antigen8 Publications1
Binding sitei195Self- and pathogen-derived peptide antigen8 Publications1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAdaptive immunity, Host-virus interaction, Immunity

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1236974 ER-Phagosome pathway
R-HSA-1236977 Endosomal/Vacuolar pathway
R-HSA-164940 Nef mediated downregulation of MHC class I complex cell surface expression
R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-877300 Interferon gamma signaling
R-HSA-8866654 E3 ubiquitin ligases ubiquitinate target proteins
R-HSA-909733 Interferon alpha/beta signaling
R-HSA-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P01892

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
HLA class I histocompatibility antigen, A-2 alpha chain
Alternative name(s):
Human leukocyte antigen A*02
Short name:
HLA-A*021 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HLA-AImported
Synonyms:HLAA
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:4931 HLA-A

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
142800 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P01892

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini25 – 308ExtracellularSequence analysisAdd BLAST284
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei309 – 332HelicalSequence analysisAdd BLAST24
Topological domaini333 – 365CytoplasmicSequence analysisAdd BLAST33

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Membrane, MHC I

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

May act as a susceptibility gene in Diabetes mellitus, insulin-dependent (IDDM) (PubMed:22245737, PubMed:18802479). In a glucose-dependent way, HLA-A*02:01 may aberrantly present the signal peptide of preproinsulin (ALWGPDPAAA) on the surface of pancreatic beta cells to autoreactive CD8-positive T cells, potentially driving T-cell mediated cytotoxicity in pancreatic islets (PubMed:22245737, PubMed:18802479).2 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi110N → Q: Impairs the recruitment of HLA-A*02 in the peptide-loading complex. 1 Publication1
Mutagenesisi156S → C: Impairs the maturation of a peptide-receptive HLA-A*02-B2M complex. 1 Publication1
Mutagenesisi158T → K: Impairs binding to TAP1-TAP2 transporter, resulting in impaired presentation of intracellular peptides. 2 Publications1
Mutagenesisi269A → V: Impairs binding to CD8A and reduces recognition by antigen-specific CD8-positive T cells. 1 Publication1

Keywords - Diseasei

Diabetes mellitus

Organism-specific databases

DisGeNET

More...
DisGeNETi
3105

MalaCards human disease database

More...
MalaCardsi
HLA-A

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB02740 3-Indolebutyric Acid

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
HLA-A

Domain mapping of disease mutations (DMDM)

More...
DMDMi
122138

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 241 PublicationAdd BLAST24
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001881425 – 365HLA class I histocompatibility antigen, A-2 alpha chainAdd BLAST341

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi110N-linked (GlcNAc...) asparagine1 Publication1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi125 ↔ 188PROSITE-ProRule annotation2 Publications
Disulfide bondi227 ↔ 283PROSITE-ProRule annotation2 Publications
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei343PhosphoserineBy similarity1
Modified residuei344PhosphotyrosineBy similarity1
Modified residuei345PhosphoserineBy similarity1
Modified residuei349PhosphoserineBy similarity1
Modified residuei350PhosphoserineCombined sources1
Modified residuei352PhosphoserineCombined sources1
Modified residuei356PhosphoserineCombined sources1
Modified residuei359PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-linked glycosylation at ASN-110.2 Publications
(Microbial infection) Polyubiquitinated in a post ER compartment through interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P01892

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P01892

PeptideAtlas

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PeptideAtlasi
P01892

PRoteomics IDEntifications database

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PRIDEi
P01892

ProteomicsDB human proteome resource

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ProteomicsDBi
51506

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
1319

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P01892

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P01892

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P01892

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous.Curated

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated by IFNG, and proinflammatory cytokines IL1B and TNF.2 Publications

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterotrimer that consists of an alpha chain HLA-A*02, a beta chain B2M and a peptide (peptide-HLA-A*02-B2M) (PubMed:8805302, PubMed:7694806, PubMed:7935798, PubMed:9177355, PubMed:18275829, PubMed:22245737, PubMed:28250417, PubMed:11502003). Early in biogenesis, HLA-A*02-B2M dimer interacts with the components of the peptide-loading complex composed of TAPBP, TAP1-TAP2, TAPBPL, PDIA3/ERP57 and CALR (PubMed:21263072).

Interacts with TAP1-TAP2 transporter via TAPBP; this interaction is obligatory for the loading of peptide epitopes delivered to the ER by TAP1-TAP2 transporter (PubMed:8805302, PubMed:8630735, PubMed:21263072).

Interacts with TAPBPL; TAPBPL binds peptide-free HLA-A*02-B2M complexes or those loaded with low affinity peptides, likely facilitating peptide exchange for higher affinity peptides (PubMed:26869717). Only optimally assembled peptide-HLA-A*02-B2M trimer translocates to the surface of antigen-presenting cells, where it interacts with TCR and CD8 coreceptor on the surface of T cells. HLA-A*02 (via polymorphic alpha-1 and alpha-2 domains) interacts with antigen-specific TCR (via CDR3 domains) (PubMed:22245737, PubMed:12796775, PubMed:18275829). One HLA-A*02 molecule (mainly via nonpolymorphic alpha-3 domain) interacts with one CD8A homodimer (via CDR-like loop); this interaction insures peptide-HLA-A*02-B2M recognition by CD8-positive T cells only (PubMed:9177355, PubMed:2784196).

13 Publications

(Microbial infection)

Interacts with HHV-8 MIR1 protein.

1 Publication

(Microbial infection)

Interacts with HTLV-1 accessory protein p12I.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
109350, 101 interactors

Protein interaction database and analysis system

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IntActi
P01892, 33 interactors

Molecular INTeraction database

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MINTi
P01892

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1365
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P01892

Database of comparative protein structure models

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ModBasei
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
P01892

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini209 – 295Ig-like C1-typeSequence analysisAdd BLAST87

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni25 – 114Alpha-1Sequence analysisAdd BLAST90
Regioni115 – 206Alpha-2Sequence analysisAdd BLAST92
Regioni207 – 298Alpha-3Sequence analysisAdd BLAST92
Regioni299 – 308Connecting peptideSequence analysis10

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The alpha-1 domain is a structural part of the peptide-binding cleft.6 Publications
The alpha-2 domain is a structural part of the peptide-binding cleft (PubMed:7694806, PubMed:8906788, PubMed:2784196, PubMed:28250417, PubMed:22245737, PubMed:19542454, PubMed:20619457). Mediates the interaction with TAP1-TAP2 complex (PubMed:8805302).8 Publications
The alpha-3 Ig-like domain mediates the interaction with CD8 coreceptor.1 Publication

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the MHC class I family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 1 hit
3.30.500.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set
IPR011161 MHC_I-like_Ag-recog
IPR037055 MHC_I-like_Ag-recog_sf
IPR011162 MHC_I/II-like_Ag-recog
IPR001039 MHC_I_a_a1/a2
IPR010579 MHC_I_a_C

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07654 C1-set, 1 hit
PF00129 MHC_I, 1 hit
PF06623 MHC_I_C, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR01638 MHCCLASSI

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00407 IGc1, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF48726 SSF48726, 1 hit
SSF54452 SSF54452, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS00290 IG_MHC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 47 potential isoforms that are computationally mapped.Show allAlign All

P01892-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAVMAPRTLV LLLSGALALT QTWAGSHSMR YFFTSVSRPG RGEPRFIAVG
60 70 80 90 100
YVDDTQFVRF DSDAASQRME PRAPWIEQEG PEYWDGETRK VKAHSQTHRV
110 120 130 140 150
DLGTLRGYYN QSEAGSHTVQ RMYGCDVGSD WRFLRGYHQY AYDGKDYIAL
160 170 180 190 200
KEDLRSWTAA DMAAQTTKHK WEAAHVAEQL RAYLEGTCVE WLRRYLENGK
210 220 230 240 250
ETLQRTDAPK THMTHHAVSD HEATLRCWAL SFYPAEITLT WQRDGEDQTQ
260 270 280 290 300
DTELVETRPA GDGTFQKWAA VVVPSGQEQR YTCHVQHEGL PKPLTLRWEP
310 320 330 340 350
SSQPTIPIVG IIAGLVLFGA VITGAVVAAV MWRRKSSDRK GGSYSQAASS
360
DSAQGSDVSL TACKV
Length:365
Mass (Da):40,922
Last modified:August 13, 1987 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB54A97B24B337C08
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 47 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P304431A01_HUMAN
HLA class I histocompatibility anti...
HLA-A HLAA
365Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
P044391A03_HUMAN
HLA class I histocompatibility anti...
HLA-A HLAA
365Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
P018911A68_HUMAN
HLA class I histocompatibility anti...
HLA-A HLAA
365Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
P137461A11_HUMAN
HLA class I histocompatibility anti...
HLA-A HLAA
365Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
P055341A24_HUMAN
HLA class I histocompatibility anti...
HLA-A HLAA
365Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
P161881A30_HUMAN
HLA class I histocompatibility anti...
HLA-A HLAA
365Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
P304501A26_HUMAN
HLA class I histocompatibility anti...
HLA-A HLAA
365Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
P103141A32_HUMAN
HLA class I histocompatibility anti...
HLA-A HLAA
365Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
P304531A34_HUMAN
HLA class I histocompatibility anti...
HLA-A HLAA
365Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
P304591A74_HUMAN
HLA class I histocompatibility anti...
HLA-A HLAA
365Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAA41022 differs from that shown. The sequence differs from that shown extensively.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti115G → V in AAA52656 (PubMed:3863816).Curated1
Sequence conflicti140Y → V in AAA52656 (PubMed:3863816).Curated1
Sequence conflicti277Q → E in AAA52656 (PubMed:3863816).Curated1
Sequence conflicti318F → L in AAA52656 (PubMed:3863816).Curated1

<p>This subsection of the ‘Sequence’ section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement_in_disease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

The HLA-A*02 allele group comprises at least 825 different alleles. Polymorphic residues encode for alpha-1 and alpha-2 domains of the peptide-binding cleft, where they contribute to variations in peptide binding and TCR recognition among different alleles. The sequence shown is that of HLA-A*02:01, which represents the major allele expressed in nearly half of the human population worldwide.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_00433433F → Y in allele A*02:05, allele A*02:06, allele A*02:08, allele A*02:10 and allele A*02:21. Corresponds to variant dbSNP:rs2075684Ensembl.1
Natural variantiVAR_00433554D → N in allele A*02:21. Corresponds to variant dbSNP:rs41549215Ensembl.1
Natural variantiVAR_01672665A → G in allele A*02:31. Corresponds to variant dbSNP:rs41557613Ensembl.1
Natural variantiVAR_00433667Q → R in allele A*02:02, allele A*02:05 and allele A*02:08. Corresponds to variant dbSNP:rs41559117Ensembl.1
Natural variantiVAR_07644689R → G Polymorphism. 1 PublicationCorresponds to variant dbSNP:rs199474430Ensembl.1
Natural variantiVAR_00433790K → N in allele A*02:08 and allele A*02:20. Corresponds to variant dbSNP:rs199474436Ensembl.1
Natural variantiVAR_01672794H → Q in allele A*02:34 and allele A*02:35. Corresponds to variant dbSNP:rs78306866Ensembl.1
Natural variantiVAR_00433897T → I in allele A*02:11. Corresponds to variant dbSNP:rs199474457Ensembl.1
Natural variantiVAR_01672898H → D in allele A*02:11 and allele A*02:35. Corresponds to variant dbSNP:rs1136683Ensembl.1
Natural variantiVAR_004339119V → L in allele A*02:02, allele A*02:05, allele A*02:08 and allele A*02:17. Corresponds to variant dbSNP:rs1071743Ensembl.1
Natural variantiVAR_004340121R → M in allele A*02:04 and allele A*02:17. Corresponds to variant dbSNP:rs199474485Ensembl.1
Natural variantiVAR_004341123Y → C in allele A*02:07 and allele A*02:18. Corresponds to variant dbSNP:rs1136697Ensembl.1
Natural variantiVAR_004342123Y → F in allele A*02:10 and allele A*02:17. Corresponds to variant dbSNP:rs1136697Ensembl.1
Natural variantiVAR_004343131W → G in allele A*02:10. Corresponds to variant dbSNP:rs1136702Ensembl.1
Natural variantiVAR_004344162M → K in allele A*02:18. Corresponds to variant dbSNP:rs41549316Ensembl.1
Natural variantiVAR_004345173A → T in allele A*02:03. Corresponds to variant dbSNP:rs1059526Ensembl.1
Natural variantiVAR_004346176V → E in allele A*02:03 and allele A*02:13. Combined sourcesCorresponds to variant dbSNP:rs9256983Ensembl.1
Natural variantiVAR_004348180L → Q in allele A*02:12, allele A*02:13 and allele A*02:37. 1
Natural variantiVAR_004347180L → W in allele A*02:02, allele A*02:03, allele A*02:05 and allele A*02:08. Combined sourcesCorresponds to variant dbSNP:rs9260156Ensembl.1
Natural variantiVAR_004349187T → E in allele A*02:16; requires 2 nucleotide substitutions. 1
Natural variantiVAR_016729190E → D in allele A*02:36 and allele A*02:37. Corresponds to variant dbSNP:rs879577815Ensembl.1
Natural variantiVAR_016730191W → G in allele A*02:36 and allele A*02:37. Corresponds to variant dbSNP:rs3098019Ensembl.1
Natural variantiVAR_004350260A → E in allele A*02:09. Corresponds to variant dbSNP:rs41540417Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X02457 mRNA Translation: CAA26297.1
M11887 mRNA Translation: AAA52656.1
U03862 mRNA Translation: AAA03603.1
U03863 mRNA Translation: AAA03604.1
Z23071 mRNA Translation: CAA80612.1
M24042 mRNA Translation: AAA59653.1
M84379 mRNA Translation: AAA59606.1
X57954 mRNA Translation: CAA41022.1 Sequence problems.
X60764 mRNA No translation available.
M84377 mRNA Translation: AAA59603.1
M84378 mRNA Translation: AAA59604.1
M86404 mRNA No translation available.
Z27120 mRNA Translation: CAA81644.1
Z46633 mRNA Translation: CAA86602.1
U18930 mRNA Translation: AAA87076.1
X96724 mRNA Translation: CAA65501.1
D83515 mRNA Translation: BAA11935.1
U56825 mRNA Translation: AAB17465.1
K02883 Genomic DNA Translation: AAA98727.1
AH003586 Genomic DNA Translation: AAB02120.1
AH000042 Genomic DNA Translation: AAA03683.2
U02935 Genomic DNA Translation: AAA76608.2
AH007560 Genomic DNA Translation: AAD23437.1
AH007704 Genomic DNA Translation: AAD30272.1
AH008013 Genomic DNA Translation: AAD45690.1
AH008012 Genomic DNA Translation: AAD45689.1
AH008007 Genomic DNA Translation: AAD45324.1
AJ555412 Genomic DNA Translation: CAD87771.1

Protein sequence database of the Protein Information Resource

More...
PIRi
B24512 HLHU10
I37470
I37542
I38418
I38442
I38443
I55948 HLHUA2
I61857
I61902
I84448

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000457879; ENSP00000403575; ENSG00000235657
ENST00000547271; ENSP00000447962; ENSG00000235657
ENST00000547522; ENSP00000448077; ENSG00000227715

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

IPD-IMGT/HLA

Immuno Polymorphism Database-ImMunoGeneTics/HLA

IEDB

The Immune Epitope Database

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02457 mRNA Translation: CAA26297.1
M11887 mRNA Translation: AAA52656.1
U03862 mRNA Translation: AAA03603.1
U03863 mRNA Translation: AAA03604.1
Z23071 mRNA Translation: CAA80612.1
M24042 mRNA Translation: AAA59653.1
M84379 mRNA Translation: AAA59606.1
X57954 mRNA Translation: CAA41022.1 Sequence problems.
X60764 mRNA No translation available.
M84377 mRNA Translation: AAA59603.1
M84378 mRNA Translation: AAA59604.1
M86404 mRNA No translation available.
Z27120 mRNA Translation: CAA81644.1
Z46633 mRNA Translation: CAA86602.1
U18930 mRNA Translation: AAA87076.1
X96724 mRNA Translation: CAA65501.1
D83515 mRNA Translation: BAA11935.1
U56825 mRNA Translation: AAB17465.1
K02883 Genomic DNA Translation: AAA98727.1
AH003586 Genomic DNA Translation: AAB02120.1
AH000042 Genomic DNA Translation: AAA03683.2
U02935 Genomic DNA Translation: AAA76608.2
AH007560 Genomic DNA Translation: AAD23437.1
AH007704 Genomic DNA Translation: AAD30272.1
AH008013 Genomic DNA Translation: AAD45690.1
AH008012 Genomic DNA Translation: AAD45689.1
AH008007 Genomic DNA Translation: AAD45324.1
AJ555412 Genomic DNA Translation: CAD87771.1
PIRiB24512 HLHU10
I37470
I37542
I38418
I38442
I38443
I55948 HLHUA2
I61857
I61902
I84448

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AKJX-ray2.65A25-300[»]
1AO7X-ray2.60A25-299[»]
1AQDX-ray2.45C/F/I/L127-141[»]
1B0GX-ray2.50A/D25-299[»]
1B0RX-ray2.90A25-299[»]
1BD2X-ray2.50A25-299[»]
1DUYX-ray2.15A/D25-299[»]
1DUZX-ray1.80A/D25-299[»]
1EEYX-ray2.25A/D25-299[»]
1EEZX-ray2.30A/D25-299[»]
1HHGX-ray2.60A/D25-299[»]
1HHHX-ray3.00A25-299[»]
1HHIX-ray2.50A/D25-299[»]
1HHJX-ray2.50A/D25-299[»]
1HHKX-ray2.50A/D25-299[»]
1HLAX-ray3.50A25-294[»]
1I1FX-ray2.80A/D25-299[»]
1I1YX-ray2.20A/D25-299[»]
1I4FX-ray1.40A25-299[»]
1I7RX-ray2.20A/D25-299[»]
1I7TX-ray2.80A/D25-299[»]
1I7UX-ray1.80A/D25-299[»]
1IM3X-ray2.20A/E/I/M25-299[»]
1JF1X-ray1.85A25-299[»]
1JHTX-ray2.15A25-299[»]
1LP9X-ray2.00A/H25-299[»]
1OGAX-ray1.40A25-300[»]
1P7QX-ray3.40A25-300[»]
1QEWX-ray2.20A25-299[»]
1QR1X-ray2.40A/D25-299[»]
1QRNX-ray2.80A25-298[»]
1QSEX-ray2.80A25-298[»]
1QSFX-ray2.80A25-298[»]
1S8DX-ray2.20A25-299[»]
1S9WX-ray2.20A25-298[»]
1S9XX-ray2.50A25-298[»]
1S9YX-ray2.30A25-298[»]
1T1WX-ray2.20A25-299[»]
1T1XX-ray2.20A25-299[»]
1T1YX-ray2.00A25-299[»]
1T1ZX-ray1.90A25-299[»]
1T20X-ray2.20A25-299[»]
1T21X-ray2.19A25-299[»]
1T22X-ray2.20A25-299[»]
1TVBX-ray1.80A/D25-299[»]
1TVHX-ray1.80A/D25-299[»]
1UR7model-A25-299[»]
2AV1X-ray1.95A/D25-299[»]
2AV7X-ray2.05A/D25-299[»]
2BNQX-ray1.70A25-300[»]
2BNRX-ray1.90A25-300[»]
2C7UX-ray2.38A/D25-300[»]
2CLRX-ray2.00A/D25-299[»]
2F53X-ray2.10A25-299[»]
2F54X-ray2.70A/F25-298[»]
2GITX-ray1.70A/D25-299[»]
2GJ6X-ray2.56A25-299[»]
2GT9X-ray1.75A/D25-299[»]
2GTWX-ray1.55A/D25-299[»]
2GTZX-ray1.70A/D25-299[»]
2GUOX-ray1.90A/D25-299[»]
2J8UX-ray2.88A/H25-299[»]
2JCCX-ray2.50A/H25-299[»]
2P5EX-ray1.89A25-300[»]
2P5WX-ray2.20A25-300[»]
2PYEX-ray2.30A25-300[»]
2UWEX-ray2.40A/H25-299[»]
2V2WX-ray1.60A/D25-300[»]
2V2XX-ray1.60A/D25-300[»]
2VLJX-ray2.40A25-300[»]
2VLKX-ray2.50A25-300[»]
2VLLX-ray1.60A/D25-300[»]
2VLRX-ray2.30A/F25-300[»]
2X4NX-ray2.34A/D25-299[»]
2X4OX-ray2.30A/D25-299[»]
2X4PX-ray2.30A/D25-299[»]
2X4QX-ray1.90A/D25-299[»]
2X4RX-ray2.30A/D25-299[»]
2X4SX-ray2.55A/D25-299[»]
2X4TX-ray2.30A/D25-299[»]
2X4UX-ray2.10A/D25-299[»]
2X70X-ray2.00A/D25-299[»]
3BGMX-ray1.60A25-298[»]
3BH8X-ray1.65A25-298[»]
3BH9X-ray1.70A25-299[»]
3BHBX-ray2.20A25-298[»]
3D25X-ray1.30A25-298[»]
3D39X-ray2.81A25-299[»]
3D3VX-ray2.80A25-299[»]
3FQNX-ray1.65A25-299[»]
3FQRX-ray1.70A25-299[»]
3FQTX-ray1.80A25-299[»]
3FQUX-ray1.80A25-299[»]
3FQWX-ray1.93A25-299[»]
3FQXX-ray1.70A25-299[»]
3FT2X-ray1.80A25-299[»]
3FT3X-ray1.95A25-299[»]
3FT4X-ray1.90A25-299[»]
3GIVX-ray2.00A/D25-299[»]
3GJFX-ray1.90A/D25-300[»]
3GSNX-ray2.80H25-298[»]
3GSOX-ray1.60A25-298[»]
3GSQX-ray2.12A25-298[»]
3GSRX-ray1.95A25-298[»]
3GSUX-ray1.80A25-299[»]
3GSVX-ray1.90A25-299[»]
3GSWX-ray1.81A25-298[»]
3GSXX-ray2.10A25-298[»]
3H7BX-ray1.88A/D25-299[»]
3H9HX-ray2.00A/D25-299[»]
3H9SX-ray2.70A25-299[»]
3HAEX-ray2.90A/D/J/P25-300[»]
3HLAX-ray2.60A25-294[»]
3HPJX-ray2.00A/D25-299[»]
3I6GX-ray2.20A/D25-299[»]
3I6KX-ray2.80A/E25-299[»]
3IXAX-ray2.10A/D25-299[»]
3KLAX-ray1.65A/D25-299[»]
3MGOX-ray2.30A/D/G/J25-299[»]
3MGTX-ray2.20A/D/G/J25-299[»]
3MR9X-ray1.93A25-300[»]
3MRBX-ray1.40A25-300[»]
3MRCX-ray1.80A25-300[»]
3MRDX-ray1.70A25-300[»]
3MREX-ray1.10A25-300[»]
3MRFX-ray2.30A25-300[»]
3MRGX-ray1.30A25-300[»]
3MRHX-ray2.40A25-300[»]
3MRIX-ray2.10A25-300[»]
3MRJX-ray1.87A25-300[»]
3MRKX-ray1.40A25-300[»]
3MRLX-ray2.41A25-300[»]
3MRMX-ray1.90A25-300[»]
3MRNX-ray2.30A25-300[»]
3MROX-ray2.35A25-300[»]
3MRPX-ray2.10A25-300[»]
3MRQX-ray2.20A25-300[»]
3MRRX-ray1.60A25-300[»]
3MYJX-ray1.89A/D25-299[»]
3O3AX-ray1.80A/D25-299[»]
3O3BX-ray1.90A/D25-299[»]
3O3DX-ray1.70A/D25-299[»]
3O3EX-ray1.85A/D25-299[»]
3O4LX-ray2.54A25-300[»]
3PWJX-ray1.70A/D25-299[»]
3PWLX-ray1.65A/D25-299[»]
3PWNX-ray1.60A/D25-299[»]
3PWPX-ray2.69A25-299[»]
3QDGX-ray2.69A25-299[»]
3QDJX-ray2.30A25-299[»]
3QDMX-ray2.80A25-299[»]
3QEQX-ray2.59A25-299[»]
3QFDX-ray1.68A/D25-299[»]
3QFJX-ray2.29A25-299[»]
3REWX-ray1.90A/D25-299[»]
3TO2X-ray2.60A25-299[»]
3UTQX-ray1.67A25-300[»]
3UTSX-ray2.71A/F25-300[»]
3UTTX-ray2.60A/F25-299[»]
3V5DX-ray2.00A/D25-299[»]
3V5HX-ray1.63A/D25-299[»]
3V5KX-ray2.31A/D25-299[»]
4E5XX-ray1.95A/D25-299[»]
4EMZX-ray2.90D/E338-365[»]
4EN2X-ray2.58D/E338-365[»]
4EUPX-ray2.88A/D25-299[»]
4FTVX-ray2.74A25-299[»]
4GKNX-ray2.75A/D25-300[»]
4GKSX-ray2.35A/D25-300[»]
4I4WX-ray1.77A25-300[»]
4JFDX-ray2.46A25-300[»]
4JFEX-ray2.70A25-300[»]
4JFFX-ray2.43A25-300[»]
4JFOX-ray2.11A/D25-299[»]
4JFPX-ray1.91A/D25-300[»]
4JFQX-ray1.90A/D25-300[»]
4K7FX-ray2.00A/D25-299[»]
4L29X-ray3.09A/C/E/G/I/K/M/O/Q/S/U/W/Y/a25-300[»]
4L3CX-ray2.64A/C/E/G/I/K/M/O/Q/S/U/W/Y/a25-300[»]
4L3EX-ray2.56A25-299[»]
4MNQX-ray2.74A25-300[»]
4NNXX-ray2.10A25-298[»]
4NNYX-ray1.90A25-298[»]
4NO0X-ray2.70A25-300[»]
4NO2X-ray2.00A25-298[»]
4NO3X-ray1.70A25-298[»]
4NO5X-ray2.10A25-299[»]
4OV5X-ray2.20C/F/I/L/O/R128-141[»]
4QOKX-ray3.00A25-300[»]
4U6XX-ray1.68A25-300[»]
4U6YX-ray1.47A25-300[»]
4UQ3X-ray2.10A/C25-299[»]
4WJ5X-ray1.65A/D25-299[»]
4WUUX-ray3.05A25-300[»]
5C07X-ray2.11A/F25-300[»]
5C08X-ray2.33A/F25-300[»]
5C09X-ray2.48A/F25-300[»]
5C0AX-ray2.46A/F25-300[»]
5C0BX-ray2.03A/F25-299[»]
5C0CX-ray1.97A/F25-300[»]
5C0DX-ray1.68A25-300[»]
5C0EX-ray1.49A25-300[»]
5C0FX-ray1.46A25-300[»]
5C0GX-ray1.37A25-300[»]
5C0IX-ray1.53A25-300[»]
5C0JX-ray1.64A25-300[»]
5D2LX-ray3.51A/C/G/M25-299[»]
5D2NX-ray2.10A/H25-299[»]
5D9SX-ray1.87A25-298[»]
5DDHX-ray1.50A25-298[»]
5E00X-ray1.70A25-299[»]
5E6IX-ray4.00C/I/M/R25-299[»]
5E9DX-ray2.51A/F25-299[»]
5ENWX-ray1.85A25-298[»]
5EOTX-ray2.10A26-298[»]
5EU3X-ray1.97A25-300[»]
5EU4X-ray2.12A/D25-300[»]
5EU5X-ray1.54A25-300[»]
5EU6X-ray2.02A25-300[»]
5EUOX-ray2.10A/C25-299[»]
5F7DX-ray2.30A26-298[»]
5F9JX-ray2.51A25-298[»]
5FA3X-ray1.86A26-298[»]
5FA4X-ray2.40A25-298[»]
5FDWX-ray2.70A25-298[»]
5HHMX-ray2.50A/F25-300[»]
5HHNX-ray2.03A25-298[»]
5HHOX-ray2.95A25-300[»]
5HHPX-ray1.90A25-298[»]
5HHQX-ray2.10A25-298[»]
5HYJX-ray3.06A/F25-300[»]
5IROX-ray2.64A/E/I/M/Q/U25-299[»]
5ISZX-ray2.06A25-299[»]
5JHDX-ray2.46A/F25-299[»]
5JZIX-ray2.50A/F25-299[»]
5MENX-ray2.81A25-300[»]
5MEOX-ray1.77A25-300[»]
5MEPX-ray2.71A/D25-300[»]
5MEQX-ray2.27A25-300[»]
5MERX-ray1.88A/D25-300[»]
5N1YX-ray1.39A25-300[»]
5N6BX-ray1.71A/D25-300[»]
5NHTX-ray3.20H25-300[»]
5NMEX-ray2.94A/F25-300[»]
5NMFX-ray2.89A/F25-300[»]
5NMGX-ray2.75A/F25-300[»]
5NMHX-ray1.55A25-300[»]
5NMKX-ray1.66A25-300[»]
5NQKX-ray3.25H25-300[»]
5SWQX-ray2.00A25-300[»]
5TEZX-ray1.70A25-299[»]
5W1WX-ray3.10C/H/M/R3-11[»]
5WSHX-ray2.00A25-299[»]
5YXNX-ray2.03C25-299[»]
5YXUX-ray2.70C/E25-299[»]
6AM5X-ray2.39A25-299[»]
6AMTX-ray2.50A/D25-299[»]
6AMUX-ray2.15A26-298[»]
6APNX-ray2.22A/B26-301[»]
6D78X-ray2.35A25-299[»]
6D7GX-ray2.75A25-299[»]
6DKPX-ray2.97A25-299[»]
6EQAX-ray3.16A25-300[»]
6EQBX-ray2.81A25-300[»]
6EWAX-ray2.39A/E25-300[»]
6EWCX-ray3.20A/E25-300[»]
6EWOX-ray2.30A/E25-300[»]
6G3JX-ray2.45A/D25-300[»]
SMRiP01892
ModBaseiSearch...

Protein-protein interaction databases

BioGridi109350, 101 interactors
IntActiP01892, 33 interactors
MINTiP01892

Chemistry databases

DrugBankiDB02740 3-Indolebutyric Acid

PTM databases

GlyConnecti1319
iPTMnetiP01892
PhosphoSitePlusiP01892
SwissPalmiP01892

Polymorphism and mutation databases

BioMutaiHLA-A
DMDMi122138

Proteomic databases

EPDiP01892
jPOSTiP01892
PeptideAtlasiP01892
PRIDEiP01892
ProteomicsDBi51506

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...
ABCDi
P01892
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000457879; ENSP00000403575; ENSG00000235657
ENST00000547271; ENSP00000447962; ENSG00000235657
ENST00000547522; ENSP00000448077; ENSG00000227715

Organism-specific databases

DisGeNETi3105

GeneCards: human genes, protein and diseases

More...
GeneCardsi
HLA-A
HGNCiHGNC:4931 HLA-A
MalaCardsiHLA-A
MIMi142800 gene
neXtProtiNX_P01892

GenAtlas: human gene database

More...
GenAtlasi
Search...

Enzyme and pathway databases

ReactomeiR-HSA-1236974 ER-Phagosome pathway
R-HSA-1236977 Endosomal/Vacuolar pathway
R-HSA-164940 Nef mediated downregulation of MHC class I complex cell surface expression
R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-877300 Interferon gamma signaling
R-HSA-8866654 E3 ubiquitin ligases ubiquitinate target proteins
R-HSA-909733 Interferon alpha/beta signaling
R-HSA-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC
SIGNORiP01892

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
HLA-A human
EvolutionaryTraceiP01892

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.30.500.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set
IPR011161 MHC_I-like_Ag-recog
IPR037055 MHC_I-like_Ag-recog_sf
IPR011162 MHC_I/II-like_Ag-recog
IPR001039 MHC_I_a_a1/a2
IPR010579 MHC_I_a_C
PfamiView protein in Pfam
PF07654 C1-set, 1 hit
PF00129 MHC_I, 1 hit
PF06623 MHC_I_C, 1 hit
PRINTSiPR01638 MHCCLASSI
SMARTiView protein in SMART
SM00407 IGc1, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF54452 SSF54452, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS00290 IG_MHC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry namei1A02_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P01892
Secondary accession number(s): O19619
, P06338, P10313, P30444, P30445, P30446, P30514, Q29680, Q29837, Q29899, Q95352, Q95380, Q9TPX8, Q9TPX9, Q9TPY0, Q9TQH5, Q9TQI3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: August 13, 1987
Last modified: July 31, 2019
This is version 221 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
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