HLA-B

Functionⁱ

Involved in the presentation of foreign antigens to the immune system.

GO - Molecular functionⁱ

peptide antigen binding Source: UniProtKB
signaling receptor binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 8046333

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent Source: Reactome
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent Source: Reactome
antigen processing and presentation of peptide antigen via MHC class I Source: Reactome
immune response
Source: UniProtKB
Non-traceable author statementⁱ
- 518865
interferon-gamma-mediated signaling pathway Source: Reactome
neutrophil degranulation Source: Reactome
protection from natural killer cell mediated cytotoxicity
Source: UniProtKB
Inferred from direct assayⁱ
- 2784569
- 8046333
regulation of dendritic cell differentiation
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 20008523
regulation of immune response Source: Reactome
regulation of interleukin-12 production
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 20008523
regulation of interleukin-6 production
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 20008523
regulation of T cell anergy
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 20008523
type I interferon signaling pathway Source: Reactome
viral process Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Host-virus interaction, Immunity

Biological process

Host-virus interaction, Immunity

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1236974 ER-Phagosome pathway R-HSA-1236977 Endosomal/Vacuolar pathway R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-6798695 Neutrophil degranulation R-HSA-877300 Interferon gamma signaling R-HSA-909733 Interferon alpha/beta signaling R-HSA-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC
SIGNORⁱ	P01889

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: HLA class I histocompatibility antigen, B-7 alpha chain Alternative name(s): MHC class I antigen B*7
Gene namesⁱ	Name:HLA-B Synonyms:HLAB
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 6

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000234745.9
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:4932 HLA-B
MIMⁱ	142830 gene
neXtProtⁱ	NX_P01889

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	25 – 309	ExtracellularSequence analysisAdd BLAST	285
Transmembraneⁱ	310 – 333	HelicalSequence analysisAdd BLAST	24
Topological domainⁱ	334 – 362	CytoplasmicSequence analysisAdd BLAST	29

Keywords - Cellular componentⁱ

Membrane, MHC I

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	3106
MalaCards human disease database More...MalaCardsⁱ	HLA-B
Open Targets More...OpenTargetsⁱ	ENSG00000234745
PharmGKBⁱ	PA35056

Polymorphism and mutation databases

BioMutaⁱ	HLA-B
DMDMⁱ	122162

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 24	1 PublicationAdd BLAST		24
ChainⁱPRO_0000018833	25 – 362	HLA class I histocompatibility antigen, B-7 alpha chainAdd BLAST		338

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	110	N-linked (GlcNAc...) asparagine1 Publication	1
Disulfide bondⁱ	125 ↔ 188
Disulfide bondⁱ	227 ↔ 283

Post-translational modificationⁱ

Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system (By similarity).By similarity

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	P01889
jPOSTⁱ	P01889
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P01889
PaxDbⁱ	P01889
PeptideAtlas More...PeptideAtlasⁱ	P01889
PRIDEⁱ	P01889

PTM databases

GlyConnectⁱ	1348
iPTMnetⁱ	P01889
SwissPalmⁱ	P01889

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000234745 Expressed in 92 organ(s), highest expression level in blood
CleanExⁱ	HS_HLA-B
ExpressionAtlasⁱ	P01889 baseline and differential
Genevisibleⁱ	P01889 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB015418

HPAⁱ

CAB015418

Interactionⁱ

Subunit structureⁱ

Dimer of alpha chain and a beta chain (beta-2-microglobulin).By similarity

(Microbial infection) Interacts with HTLV-1 accessory protein p12I.1 Publication

GO - Molecular functionⁱ

signaling receptor binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 8046333

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	109351, 110 interactors
IntActⁱ	P01889, 17 interactors
STRINGⁱ	9606.ENSP00000399168

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	27 – 36	Combined sources	10
Beta strandⁱ	41 – 43	Combined sources	3
Beta strandⁱ	45 – 52	Combined sources	8
Beta strandⁱ	55 – 61	Combined sources	7
Beta strandⁱ	64 – 66	Combined sources	3
Beta strandⁱ	70 – 73	Combined sources	4
Helixⁱ	74 – 76	Combined sources	3
Helixⁱ	81 – 108	Combined sources	28
Beta strandⁱ	113 – 115	Combined sources	3
Beta strandⁱ	118 – 127	Combined sources	10
Beta strandⁱ	133 – 142	Combined sources	10
Beta strandⁱ	145 – 150	Combined sources	6
Beta strandⁱ	157 – 161	Combined sources	5
Helixⁱ	162 – 173	Combined sources	12
Helixⁱ	176 – 185	Combined sources	10
Helixⁱ	187 – 198	Combined sources	12
Helixⁱ	200 – 203	Combined sources	4
Beta strandⁱ	210 – 219	Combined sources	10
Beta strandⁱ	222 – 235	Combined sources	14
Beta strandⁱ	238 – 243	Combined sources	6
Turnⁱ	249 – 251	Combined sources	3
Beta strandⁱ	252 – 254	Combined sources	3
Beta strandⁱ	261 – 263	Combined sources	3
Beta strandⁱ	265 – 274	Combined sources	10
Helixⁱ	278 – 280	Combined sources	3
Beta strandⁱ	281 – 286	Combined sources	6
Beta strandⁱ	290 – 292	Combined sources	3
Beta strandⁱ	294 – 296	Combined sources	3

Show more details

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	3VCL	X-ray	1.70	A	25-299	[»]
	4U1H	X-ray	1.59	A	25-300	[»]
	4U1K	X-ray	2.09	A/D	25-300	[»]
	5EO0	X-ray	1.70	A	25-299	[»]
	5EO1	X-ray	1.85	A	25-299	[»]
	5WMN	X-ray	1.82	A/C	25-300	[»]
	5WMO	X-ray	1.62	A	25-300	[»]
	5WMP	X-ray	1.60	A	25-300	[»]
	6AT5	X-ray	1.50	A	1-362	[»]
	6AVF	X-ray	2.03	H	1-362	[»]
	6AVG	X-ray	2.60	F/G	1-362	[»]
ProteinModelPortalⁱ	P01889
SMRⁱ	P01889
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	209 – 295	Ig-like C1-typeAdd BLAST		87

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	25 – 114	Alpha-1Add BLAST	90
Regionⁱ	115 – 206	Alpha-2Add BLAST	92
Regionⁱ	207 – 298	Alpha-3Add BLAST	92
Regionⁱ	299 – 309	Connecting peptideAdd BLAST	11

Sequence similaritiesⁱ

Belongs to the MHC class I family.Curated

Keywords - Domainⁱ

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410II5V Eukaryota ENOG4111K8F LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00940000153872
HOVERGENⁱ	HBG016709
KEGG Orthology (KO) More...KOⁱ	K06751
OMAⁱ	VPGYYNQ
Database of Orthologous Groups More...OrthoDBⁱ	1390181at2759
PhylomeDBⁱ	P01889

Family and domain databases

Gene3Dⁱ	2.60.40.10, 1 hit 3.30.500.10, 1 hit
InterProⁱ	View protein in InterPro IPR007110 Ig-like_dom IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR003006 Ig/MHC_CS IPR003597 Ig_C1-set IPR011161 MHC_I-like_Ag-recog IPR037055 MHC_I-like_Ag-recog_sf IPR011162 MHC_I/II-like_Ag-recog IPR001039 MHC_I_a_a1/a2 IPR010579 MHC_I_a_C
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07654 C1-set, 1 hit PF00129 MHC_I, 1 hit PF06623 MHC_I_C, 1 hit
PRINTSⁱ	PR01638 MHCCLASSI
SMARTⁱ	View protein in SMART SM00407 IGc1, 1 hit
SUPFAMⁱ	SSF48726 SSF48726, 1 hit SSF54452 SSF54452, 1 hit
PROSITEⁱ	View protein in PROSITE PS50835 IG_LIKE, 1 hit PS00290 IG_MHC, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 54 potential isoforms that are computationally mapped.Show all Align All

P01889-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MLVMAPRTVL LLLSAALALT ETWAGSHSMR YFYTSVSRPG RGEPRFISVG 
        60         70         80         90        100
YVDDTQFVRF DSDAASPREE PRAPWIEQEG PEYWDRNTQI YKAQAQTDRE 
       110        120        130        140        150
SLRNLRGYYN QSEAGSHTLQ SMYGCDVGPD GRLLRGHDQY AYDGKDYIAL 
       160        170        180        190        200
NEDLRSWTAA DTAAQITQRK WEAAREAEQR RAYLEGECVE WLRRYLENGK 
       210        220        230        240        250
DKLERADPPK THVTHHPISD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ 
       260        270        280        290        300
DTELVETRPA GDRTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEP 
       310        320        330        340        350
SSQSTVPIVG IVAGLAVLAV VVIGAVVAAV MCRRKSSGGK GGSYSQAACS 
       360 
DSAQGSDVSL TA

Length:362

Mass (Da):40,460

Last modified:February 1, 1991 - v3

Checksum:ⁱ5E5A7BDE031403D6

GO

Computationally mapped potential isoform sequencesⁱ

There are 54 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name	Protein names	Gene names	Length	Annotation

	P03989	1B27_HUMAN	HLA class I histocompatibility anti... HLA class I histocompatibility antigen, B-27 alpha chain (MHC class I antigen B*27)	HLA-B HLAB	362	Annotation score:
	P30460	1B08_HUMAN	HLA class I histocompatibility anti... HLA class I histocompatibility antigen, B-8 alpha chain (MHC class I antigen B*8)	HLA-B HLAB	362	Annotation score:
	Q04826	1B40_HUMAN	HLA class I histocompatibility anti... HLA class I histocompatibility antigen, B-40 alpha chain (Bw-60) (MHC class I antigen B*40)	HLA-B HLAB	362	Annotation score:
	P30475	1B39_HUMAN	HLA class I histocompatibility anti... HLA class I histocompatibility antigen, B-39 alpha chain (MHC class I antigen B*39)	HLA-B HLAB	362	Annotation score:
	Q95365	1B38_HUMAN	HLA class I histocompatibility anti... HLA class I histocompatibility antigen, B-38 alpha chain (Bw-4) (MHC class I antigen B*38)	HLA-B HLAB	362	Annotation score:
	P30486	1B48_HUMAN	HLA class I histocompatibility anti... HLA class I histocompatibility antigen, B-48 alpha chain (Bw-48) (MHC class I antigen B*48)	HLA-B HLAB	362	Annotation score:
	Q29836	1B67_HUMAN	HLA class I histocompatibility anti... HLA class I histocompatibility antigen, B-67 alpha chain (MHC class I antigen B*67)	HLA-B HLAB	362	Annotation score:
	P30464	1B15_HUMAN	HLA class I histocompatibility anti... HLA class I histocompatibility antigen, B-15 alpha chain (MHC class I antigen B*15)	HLA-B HLAB	362	Annotation score:
	Q31610	1B81_HUMAN	HLA class I histocompatibility anti... HLA class I histocompatibility antigen, B-81 alpha chain (B'DT) (MHC class I antigen B*81)	HLA-B HLAB	362	Annotation score:
	P30480	1B42_HUMAN	HLA class I histocompatibility anti... HLA class I histocompatibility antigen, B-42 alpha chain (MHC class I antigen B*42)	HLA-B HLAB	362	Annotation score:
There are more potential isoformsShow all

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	15 – 18	AALA → GPW in AAA59622 (PubMed:2993161).Curated	4
Sequence conflictⁱ	266	Q → E AA sequence (PubMed:518865).Curated	1
Sequence conflictⁱ	268	W → S in AAA59622 (PubMed:2993161).Curated	1
Sequence conflictⁱ	297	R → G in AAA59622 (PubMed:2993161).Curated	1
Sequence conflictⁱ	314 – 315	GL → RP in AAA59622 (PubMed:2993161).Curated	2

Polymorphismⁱ

The following alleles of B-7 are known: B*07:02 (B7.2), B*07:03 (BPOT), B*07:04, B*07:05, B*07:06 (B7_L79), B*07:18 and B*07:24. The sequence shown is B*07:02.

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_050332	4	M → T. Corresponds to variant dbSNP:rs1050458Ensembl.	1
Natural variantⁱVAR_050333	9	V → L. Corresponds to variant dbSNP:rs1050462Ensembl.	1
Natural variantⁱVAR_050334	17	L → V. Corresponds to variant dbSNP:rs1131165Ensembl.	1
Natural variantⁱVAR_050335	35	S → A. Corresponds to variant dbSNP:rs1131170Ensembl.	1
Natural variantⁱVAR_050336	36	V → M. Corresponds to variant dbSNP:rs1050486Ensembl.	1
Natural variantⁱVAR_061386	48	S → A. Corresponds to variant dbSNP:rs713031Ensembl.	1
Natural variantⁱVAR_061387	48	S → P. Corresponds to variant dbSNP:rs713031Ensembl.	1
Natural variantⁱVAR_061388	48	S → T. Corresponds to variant dbSNP:rs713031Ensembl.	1
Natural variantⁱVAR_050337	65	A → TCombined sourcesCorresponds to variant dbSNP:rs1050529Ensembl.	1
Natural variantⁱVAR_050338	87	N → D. Corresponds to variant dbSNP:rs1050570Ensembl.	1
Natural variantⁱVAR_059467	87	N → K. Corresponds to variant dbSNP:rs1065386Ensembl.	1
Natural variantⁱVAR_016351	93 – 95	AQA → TNT in allele B*07:03.	3
Natural variantⁱVAR_050339	97	T → A. Corresponds to variant dbSNP:rs1050393Ensembl.	1
Natural variantⁱVAR_059468	98	D → Y. Corresponds to variant dbSNP:rs1131215Ensembl.	1
Natural variantⁱVAR_050340	101	S → N. Corresponds to variant dbSNP:rs1050388Ensembl.	1
Natural variantⁱVAR_016352	118 – 119	TL → II in allele B*07:18. Corresponds to variant dbSNP:rs796332753Ensembl.	2
Natural variantⁱVAR_016353	121	S → R in allele B*07:18. Corresponds to variant dbSNP:rs1140412Ensembl.	1
Natural variantⁱVAR_050341	137	H → Y. Corresponds to variant dbSNP:rs1050379Ensembl.	1
Natural variantⁱVAR_061389	138	D → H. Corresponds to variant dbSNP:rs709055Ensembl.	1
Natural variantⁱVAR_016354	138	D → N in allele B07:05 and allele B07:06. Combined sourcesCorresponds to variant dbSNP:rs709055Ensembl.	1
Natural variantⁱVAR_050342	155	R → SCombined sourcesCorresponds to variant dbSNP:rs1050654Ensembl.	1
Natural variantⁱVAR_016355	180	R → D in allele B*07:04; requires 2 nucleotide substitutions.	1
Natural variantⁱVAR_059469	187	E → A. Corresponds to variant dbSNP:rs2308466Ensembl.	1
Natural variantⁱVAR_059470	187	E → G. Corresponds to variant dbSNP:rs2308466Ensembl.	1
Natural variantⁱVAR_059471	187	E → K. Corresponds to variant dbSNP:rs2523600Ensembl.	1
Natural variantⁱVAR_016616	187	E → L in allele B*07:24; requires 2 nucleotide substitutions.	1
Natural variantⁱVAR_059472	187	E → Q. Corresponds to variant dbSNP:rs2523600Ensembl.	1
Natural variantⁱVAR_059473	187	E → V. Corresponds to variant dbSNP:rs2308466Ensembl.	1
Natural variantⁱVAR_050343	195	Y → H. Corresponds to variant dbSNP:rs1050696Ensembl.	1
Natural variantⁱVAR_016356	306	V → I in allele B*07:05. Corresponds to variant dbSNP:rs1131500Ensembl.	1
Natural variantⁱVAR_050344	329	A → T. Corresponds to variant dbSNP:rs1051488Ensembl.	1
Natural variantⁱVAR_061390	349	C → S. Corresponds to variant dbSNP:rs2308655Ensembl.	1
Natural variantⁱVAR_061391	349	C → Y. Corresponds to variant dbSNP:rs2308655Ensembl.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M32317 mRNA Translation: AAA36230.1 M16102 mRNA Translation: AAA59622.1 Sequence problems. U29057 mRNA Translation: AAA91229.1 X64454 mRNA Translation: CAA45785.1 U04245 mRNA Translation: AAA87398.1 L33922 mRNA Translation: AAA65639.1 U21052 mRNA Translation: AAA92563.1 U21053 mRNA Translation: AAA92564.1 X91749 mRNA Translation: CAA62864.1 AF189017 mRNA Translation: AAF01052.1 AJ309047 Genomic DNA Translation: CAC35468.1 AJ292075 Genomic DNA Translation: CAC33440.1 AL671883 Genomic DNA No translation available. AK313911 mRNA Translation: BAG36634.1 AJ401222 Genomic DNA Translation: CAC10402.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS34394.1
PIRⁱ	B35997 HLHUB7 I54418 I59651 S60601
NCBI Reference Sequences More...RefSeqⁱ	NP_005505.2, NM_005514.7
UniGeneⁱ	Hs.654404 Hs.726974 Hs.77961

Genome annotation databases

Ensemblⁱ	ENST00000412585; ENSP00000399168; ENSG00000234745
GeneIDⁱ	3106
KEGGⁱ	hsa:3106

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P01889	MHC class I antigen		HUMAN		362	UniRef100_P01889
cDNA FLJ51097, highly similar to HLA class I histocompatibility antigen, B-7alpha chain		HUMAN		241

Protein	Similar proteins		Species	Score	Length	Source
P01889	MHC class I antigen		HUMAN		362	UniRef90_P01889
Lymphocyte antigen		PANTR		362
MHC class I antigen		PONPY		362
MHC class I antigen		PANPA		362
MHC class I antigen		PONAB		362
+1416

Protein	Similar proteins		Species	Score	Length	Source
P01889	HLA class I histocompatibility antigen, Cw-17 alpha chain		HUMAN		372	UniRef50_Q95604
Uncharacterized protein		PANTR		397
Uncharacterized protein		GORGO		370
MHC class I antigen		PONPY		366
MHC class I heavy chain antigen (Fragment)		western gorilla		348
+8901

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M32317 mRNA Translation: AAA36230.1 M16102 mRNA Translation: AAA59622.1 Sequence problems. U29057 mRNA Translation: AAA91229.1 X64454 mRNA Translation: CAA45785.1 U04245 mRNA Translation: AAA87398.1 L33922 mRNA Translation: AAA65639.1 U21052 mRNA Translation: AAA92563.1 U21053 mRNA Translation: AAA92564.1 X91749 mRNA Translation: CAA62864.1 AF189017 mRNA Translation: AAF01052.1 AJ309047 Genomic DNA Translation: CAC35468.1 AJ292075 Genomic DNA Translation: CAC33440.1 AL671883 Genomic DNA No translation available. AK313911 mRNA Translation: BAG36634.1 AJ401222 Genomic DNA Translation: CAC10402.1
CCDSⁱ	CCDS34394.1
PIRⁱ	B35997 HLHUB7 I54418 I59651 S60601
RefSeqⁱ	NP_005505.2, NM_005514.7
UniGeneⁱ	Hs.654404 Hs.726974 Hs.77961

3D structure databases

Select the link destinations: PDBeⁱ RCSB PDBⁱ PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	3VCL	X-ray	1.70	A	25-299	[»]
	4U1H	X-ray	1.59	A	25-300	[»]
	4U1K	X-ray	2.09	A/D	25-300	[»]
	5EO0	X-ray	1.70	A	25-299	[»]
	5EO1	X-ray	1.85	A	25-299	[»]
	5WMN	X-ray	1.82	A/C	25-300	[»]
	5WMO	X-ray	1.62	A	25-300	[»]
	5WMP	X-ray	1.60	A	25-300	[»]
	6AT5	X-ray	1.50	A	1-362	[»]
	6AVF	X-ray	2.03	H	1-362	[»]
	6AVG	X-ray	2.60	F/G	1-362	[»]
ProteinModelPortalⁱ	P01889
SMRⁱ	P01889
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	109351, 110 interactors
IntActⁱ	P01889, 17 interactors
STRINGⁱ	9606.ENSP00000399168

PTM databases

GlyConnectⁱ	1348
iPTMnetⁱ	P01889
SwissPalmⁱ	P01889

Polymorphism and mutation databases

BioMutaⁱ	HLA-B
DMDMⁱ	122162

Proteomic databases

EPDⁱ	P01889
jPOSTⁱ	P01889
MaxQBⁱ	P01889
PaxDbⁱ	P01889
PeptideAtlasⁱ	P01889
PRIDEⁱ	P01889

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000412585; ENSP00000399168; ENSG00000234745
GeneIDⁱ	3106
KEGGⁱ	hsa:3106

Organism-specific databases

CTDⁱ	3106
DisGeNETⁱ	3106
EuPathDBⁱ	HostDB:ENSG00000234745.9
GeneCardsⁱ	HLA-B
HGNCⁱ	HGNC:4932 HLA-B
HPAⁱ	CAB015418
MalaCardsⁱ	HLA-B
MIMⁱ	142830 gene
neXtProtⁱ	NX_P01889
OpenTargetsⁱ	ENSG00000234745
PharmGKBⁱ	PA35056
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410II5V Eukaryota ENOG4111K8F LUCA
GeneTreeⁱ	ENSGT00940000153872
HOVERGENⁱ	HBG016709
KOⁱ	K06751
OMAⁱ	VPGYYNQ
OrthoDBⁱ	1390181at2759
PhylomeDBⁱ	P01889

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1236974 ER-Phagosome pathway R-HSA-1236977 Endosomal/Vacuolar pathway R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-6798695 Neutrophil degranulation R-HSA-877300 Interferon gamma signaling R-HSA-909733 Interferon alpha/beta signaling R-HSA-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC
SIGNORⁱ	P01889

Miscellaneous databases

ChiTaRSⁱ	HLA-B human
GeneWikiⁱ	HLA-B
GenomeRNAiⁱ	3106
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000234745 Expressed in 92 organ(s), highest expression level in blood
CleanExⁱ	HS_HLA-B
ExpressionAtlasⁱ	P01889 baseline and differential
Genevisibleⁱ	P01889 HS

Family and domain databases

Gene3Dⁱ	2.60.40.10, 1 hit 3.30.500.10, 1 hit
InterProⁱ	View protein in InterPro IPR007110 Ig-like_dom IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR003006 Ig/MHC_CS IPR003597 Ig_C1-set IPR011161 MHC_I-like_Ag-recog IPR037055 MHC_I-like_Ag-recog_sf IPR011162 MHC_I/II-like_Ag-recog IPR001039 MHC_I_a_a1/a2 IPR010579 MHC_I_a_C
Pfamⁱ	View protein in Pfam PF07654 C1-set, 1 hit PF00129 MHC_I, 1 hit PF06623 MHC_I_C, 1 hit
PRINTSⁱ	PR01638 MHCCLASSI
SMARTⁱ	View protein in SMART SM00407 IGc1, 1 hit
SUPFAMⁱ	SSF48726 SSF48726, 1 hit SSF54452 SSF54452, 1 hit
PROSITEⁱ	View protein in PROSITE PS50835 IG_LIKE, 1 hit PS00290 IG_MHC, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	1B07_HUMAN
Accessionⁱ	P01889Primary (citable) accession number: P01889 Secondary accession number(s): Q29638 Q9TP95
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
	Last sequence update:	February 1, 1991
	Last modified:	January 16, 2019
	This is version 193 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM

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UniProtKB - P01889 (1B07_HUMAN)

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HLA class I histocompatibility antigen, B-7 alpha chain

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

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Endoplasmic reticulum

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Extracellular region or secreted

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Topology

Keywords - Cellular componenti

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Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

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Phylogenomic databases

Family and domain databases

Experimental Info

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Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

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Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

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<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ