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Protein

HLA class I histocompatibility antigen, B-7 alpha chain

Gene

HLA-B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the presentation of foreign antigens to the immune system.

GO - Molecular functioni

  • peptide antigen binding Source: UniProtKB
  • signaling receptor binding Source: UniProtKB

GO - Biological processi

Keywordsi

Biological processHost-virus interaction, Immunity

Enzyme and pathway databases

ReactomeiR-HSA-1236974 ER-Phagosome pathway
R-HSA-1236977 Endosomal/Vacuolar pathway
R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-6798695 Neutrophil degranulation
R-HSA-877300 Interferon gamma signaling
R-HSA-909733 Interferon alpha/beta signaling
R-HSA-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC
SIGNORiP01889

Names & Taxonomyi

Protein namesi
Recommended name:
HLA class I histocompatibility antigen, B-7 alpha chain
Alternative name(s):
MHC class I antigen B*7
Gene namesi
Name:HLA-B
Synonyms:HLAB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000234745.9
HGNCiHGNC:4932 HLA-B
MIMi142830 gene
neXtProtiNX_P01889

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 309ExtracellularSequence analysisAdd BLAST285
Transmembranei310 – 333HelicalSequence analysisAdd BLAST24
Topological domaini334 – 362CytoplasmicSequence analysisAdd BLAST29

Keywords - Cellular componenti

Membrane, MHC I

Pathology & Biotechi

Organism-specific databases

DisGeNETi3106
MalaCardsiHLA-B
OpenTargetsiENSG00000234745
PharmGKBiPA35056

Polymorphism and mutation databases

BioMutaiZCCHC6
DMDMi122162

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 241 PublicationAdd BLAST24
ChainiPRO_000001883325 – 362HLA class I histocompatibility antigen, B-7 alpha chainAdd BLAST338

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi110N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi125 ↔ 188
Disulfide bondi227 ↔ 283

Post-translational modificationi

Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Ubl conjugation

Proteomic databases

EPDiP01889
MaxQBiP01889
PaxDbiP01889
PeptideAtlasiP01889
PRIDEiP01889

PTM databases

GlyConnecti1348
iPTMnetiP01889
SwissPalmiP01889

Expressioni

Gene expression databases

BgeeiENSG00000234745 Expressed in 92 organ(s), highest expression level in blood
CleanExiHS_HLA-B
ExpressionAtlasiP01889 baseline and differential
GenevisibleiP01889 HS

Organism-specific databases

HPAiCAB015418

Interactioni

Subunit structurei

Dimer of alpha chain and a beta chain (beta-2-microglobulin).By similarity
(Microbial infection) Interacts with HTLV-1 accessory protein p12I.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi109351, 108 interactors
IntActiP01889, 17 interactors
STRINGi9606.ENSP00000399168

Structurei

Secondary structure

1362
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP01889
SMRiP01889
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini209 – 295Ig-like C1-typeAdd BLAST87

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni25 – 114Alpha-1Add BLAST90
Regioni115 – 206Alpha-2Add BLAST92
Regioni207 – 298Alpha-3Add BLAST92
Regioni299 – 309Connecting peptideAdd BLAST11

Sequence similaritiesi

Belongs to the MHC class I family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410II5V Eukaryota
ENOG4111K8F LUCA
GeneTreeiENSGT00760000118960
HOVERGENiHBG016709
KOiK06751
OMAiVPGYYNQ
OrthoDBiEOG091G09OH
PhylomeDBiP01889

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.30.500.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set
IPR011161 MHC_I-like_Ag-recog
IPR037055 MHC_I-like_Ag-recog_sf
IPR011162 MHC_I/II-like_Ag-recog
IPR001039 MHC_I_a_a1/a2
IPR010579 MHC_I_a_C
PfamiView protein in Pfam
PF07654 C1-set, 1 hit
PF00129 MHC_I, 1 hit
PF06623 MHC_I_C, 1 hit
PRINTSiPR01638 MHCCLASSI
SMARTiView protein in SMART
SM00407 IGc1, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF54452 SSF54452, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS00290 IG_MHC, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 54 potential isoforms that are computationally mapped.Show allAlign All

P01889-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLVMAPRTVL LLLSAALALT ETWAGSHSMR YFYTSVSRPG RGEPRFISVG
60 70 80 90 100
YVDDTQFVRF DSDAASPREE PRAPWIEQEG PEYWDRNTQI YKAQAQTDRE
110 120 130 140 150
SLRNLRGYYN QSEAGSHTLQ SMYGCDVGPD GRLLRGHDQY AYDGKDYIAL
160 170 180 190 200
NEDLRSWTAA DTAAQITQRK WEAAREAEQR RAYLEGECVE WLRRYLENGK
210 220 230 240 250
DKLERADPPK THVTHHPISD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ
260 270 280 290 300
DTELVETRPA GDRTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEP
310 320 330 340 350
SSQSTVPIVG IVAGLAVLAV VVIGAVVAAV MCRRKSSGGK GGSYSQAACS
360
DSAQGSDVSL TA
Length:362
Mass (Da):40,460
Last modified:February 1, 1991 - v3
Checksum:i5E5A7BDE031403D6
GO

Computationally mapped potential isoform sequencesi

There are 54 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P039891B27_HUMAN
HLA class I histocompatibility anti...
HLA-B HLAB
362Annotation score:
P304601B08_HUMAN
HLA class I histocompatibility anti...
HLA-B HLAB
362Annotation score:
Q048261B40_HUMAN
HLA class I histocompatibility anti...
HLA-B HLAB
362Annotation score:
P304751B39_HUMAN
HLA class I histocompatibility anti...
HLA-B HLAB
362Annotation score:
Q953651B38_HUMAN
HLA class I histocompatibility anti...
HLA-B HLAB
362Annotation score:
P304861B48_HUMAN
HLA class I histocompatibility anti...
HLA-B HLAB
362Annotation score:
Q298361B67_HUMAN
HLA class I histocompatibility anti...
HLA-B HLAB
362Annotation score:
P304641B15_HUMAN
HLA class I histocompatibility anti...
HLA-B HLAB
362Annotation score:
Q316101B81_HUMAN
HLA class I histocompatibility anti...
HLA-B HLAB
362Annotation score:
P304801B42_HUMAN
HLA class I histocompatibility anti...
HLA-B HLAB
362Annotation score:
There are more potential isoformsShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti15 – 18AALA → GPW in AAA59622 (PubMed:2993161).Curated4
Sequence conflicti266Q → E AA sequence (PubMed:518865).Curated1
Sequence conflicti268W → S in AAA59622 (PubMed:2993161).Curated1
Sequence conflicti297R → G in AAA59622 (PubMed:2993161).Curated1
Sequence conflicti314 – 315GL → RP in AAA59622 (PubMed:2993161).Curated2

Polymorphismi

The following alleles of B-7 are known: B*07:02 (B7.2), B*07:03 (BPOT), B*07:04, B*07:05, B*07:06 (B7_L79), B*07:18 and B*07:24. The sequence shown is B*07:02.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0503324M → T. Corresponds to variant dbSNP:rs1050458Ensembl.1
Natural variantiVAR_0503339V → L. Corresponds to variant dbSNP:rs1050462Ensembl.1
Natural variantiVAR_05033417L → V. Corresponds to variant dbSNP:rs1131165Ensembl.1
Natural variantiVAR_05033535S → A. Corresponds to variant dbSNP:rs1131170Ensembl.1
Natural variantiVAR_05033636V → M. Corresponds to variant dbSNP:rs1050486Ensembl.1
Natural variantiVAR_06138648S → A. Corresponds to variant dbSNP:rs713031Ensembl.1
Natural variantiVAR_06138748S → P. Corresponds to variant dbSNP:rs713031Ensembl.1
Natural variantiVAR_06138848S → T. Corresponds to variant dbSNP:rs713031Ensembl.1
Natural variantiVAR_05033765A → TCombined sourcesCorresponds to variant dbSNP:rs1050529Ensembl.1
Natural variantiVAR_05033887N → D. Corresponds to variant dbSNP:rs1050570Ensembl.1
Natural variantiVAR_05946787N → K. Corresponds to variant dbSNP:rs1065386Ensembl.1
Natural variantiVAR_01635193 – 95AQA → TNT in allele B*07:03. 3
Natural variantiVAR_05033997T → A. Corresponds to variant dbSNP:rs1050393Ensembl.1
Natural variantiVAR_05946898D → Y. Corresponds to variant dbSNP:rs1131215Ensembl.1
Natural variantiVAR_050340101S → N. Corresponds to variant dbSNP:rs1050388Ensembl.1
Natural variantiVAR_016352118 – 119TL → II in allele B*07:18. Corresponds to variant dbSNP:rs796332753Ensembl.2
Natural variantiVAR_016353121S → R in allele B*07:18. Corresponds to variant dbSNP:rs1140412Ensembl.1
Natural variantiVAR_050341137H → Y. Corresponds to variant dbSNP:rs1050379Ensembl.1
Natural variantiVAR_061389138D → H. Corresponds to variant dbSNP:rs709055Ensembl.1
Natural variantiVAR_016354138D → N in allele B*07:05 and allele B*07:06. Combined sourcesCorresponds to variant dbSNP:rs709055Ensembl.1
Natural variantiVAR_050342155R → SCombined sourcesCorresponds to variant dbSNP:rs1050654Ensembl.1
Natural variantiVAR_016355180R → D in allele B*07:04; requires 2 nucleotide substitutions. 1
Natural variantiVAR_059469187E → A. Corresponds to variant dbSNP:rs2308466Ensembl.1
Natural variantiVAR_059470187E → G. Corresponds to variant dbSNP:rs2308466Ensembl.1
Natural variantiVAR_059471187E → K. Corresponds to variant dbSNP:rs2523600Ensembl.1
Natural variantiVAR_016616187E → L in allele B*07:24; requires 2 nucleotide substitutions. 1
Natural variantiVAR_059472187E → Q. Corresponds to variant dbSNP:rs2523600Ensembl.1
Natural variantiVAR_059473187E → V. Corresponds to variant dbSNP:rs2308466Ensembl.1
Natural variantiVAR_050343195Y → H. Corresponds to variant dbSNP:rs1050696Ensembl.1
Natural variantiVAR_016356306V → I in allele B*07:05. Corresponds to variant dbSNP:rs1131500Ensembl.1
Natural variantiVAR_050344329A → T. Corresponds to variant dbSNP:rs1051488Ensembl.1
Natural variantiVAR_061390349C → S. Corresponds to variant dbSNP:rs2308655Ensembl.1
Natural variantiVAR_061391349C → Y. Corresponds to variant dbSNP:rs2308655Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M32317 mRNA Translation: AAA36230.1
M16102 mRNA Translation: AAA59622.1 Sequence problems.
U29057 mRNA Translation: AAA91229.1
X64454 mRNA Translation: CAA45785.1
U04245 mRNA Translation: AAA87398.1
L33922 mRNA Translation: AAA65639.1
U21052 mRNA Translation: AAA92563.1
U21053 mRNA Translation: AAA92564.1
X91749 mRNA Translation: CAA62864.1
AF189017 mRNA Translation: AAF01052.1
AJ309047 Genomic DNA Translation: CAC35468.1
AJ292075 Genomic DNA Translation: CAC33440.1
AL671883 Genomic DNA No translation available.
AK313911 mRNA Translation: BAG36634.1
AJ401222 Genomic DNA Translation: CAC10402.1
CCDSiCCDS34394.1
PIRiB35997 HLHUB7
I54418
I59651
S60601
RefSeqiNP_005505.2, NM_005514.7
UniGeneiHs.654404
Hs.726974
Hs.77961

Genome annotation databases

EnsembliENST00000412585; ENSP00000399168; ENSG00000234745
GeneIDi3106
KEGGihsa:3106

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M32317 mRNA Translation: AAA36230.1
M16102 mRNA Translation: AAA59622.1 Sequence problems.
U29057 mRNA Translation: AAA91229.1
X64454 mRNA Translation: CAA45785.1
U04245 mRNA Translation: AAA87398.1
L33922 mRNA Translation: AAA65639.1
U21052 mRNA Translation: AAA92563.1
U21053 mRNA Translation: AAA92564.1
X91749 mRNA Translation: CAA62864.1
AF189017 mRNA Translation: AAF01052.1
AJ309047 Genomic DNA Translation: CAC35468.1
AJ292075 Genomic DNA Translation: CAC33440.1
AL671883 Genomic DNA No translation available.
AK313911 mRNA Translation: BAG36634.1
AJ401222 Genomic DNA Translation: CAC10402.1
CCDSiCCDS34394.1
PIRiB35997 HLHUB7
I54418
I59651
S60601
RefSeqiNP_005505.2, NM_005514.7
UniGeneiHs.654404
Hs.726974
Hs.77961

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3VCLX-ray1.70A25-299[»]
4U1HX-ray1.59A25-300[»]
4U1KX-ray2.09A/D25-300[»]
5EO0X-ray1.70A25-299[»]
5EO1X-ray1.85A25-299[»]
5WMNX-ray1.82A/C25-300[»]
5WMOX-ray1.62A25-300[»]
5WMPX-ray1.60A25-300[»]
6AT5X-ray1.50A1-362[»]
6AVFX-ray2.03H1-362[»]
6AVGX-ray2.60F/G1-362[»]
ProteinModelPortaliP01889
SMRiP01889
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109351, 108 interactors
IntActiP01889, 17 interactors
STRINGi9606.ENSP00000399168

PTM databases

GlyConnecti1348
iPTMnetiP01889
SwissPalmiP01889

Polymorphism and mutation databases

BioMutaiZCCHC6
DMDMi122162

Proteomic databases

EPDiP01889
MaxQBiP01889
PaxDbiP01889
PeptideAtlasiP01889
PRIDEiP01889

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000412585; ENSP00000399168; ENSG00000234745
GeneIDi3106
KEGGihsa:3106

Organism-specific databases

CTDi3106
DisGeNETi3106
EuPathDBiHostDB:ENSG00000234745.9
GeneCardsiHLA-B
HGNCiHGNC:4932 HLA-B
HPAiCAB015418
MalaCardsiHLA-B
MIMi142830 gene
neXtProtiNX_P01889
OpenTargetsiENSG00000234745
PharmGKBiPA35056
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410II5V Eukaryota
ENOG4111K8F LUCA
GeneTreeiENSGT00760000118960
HOVERGENiHBG016709
KOiK06751
OMAiVPGYYNQ
OrthoDBiEOG091G09OH
PhylomeDBiP01889

Enzyme and pathway databases

ReactomeiR-HSA-1236974 ER-Phagosome pathway
R-HSA-1236977 Endosomal/Vacuolar pathway
R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-6798695 Neutrophil degranulation
R-HSA-877300 Interferon gamma signaling
R-HSA-909733 Interferon alpha/beta signaling
R-HSA-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC
SIGNORiP01889

Miscellaneous databases

ChiTaRSiHLA-B human
GeneWikiiHLA-B
GenomeRNAii3106
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000234745 Expressed in 92 organ(s), highest expression level in blood
CleanExiHS_HLA-B
ExpressionAtlasiP01889 baseline and differential
GenevisibleiP01889 HS

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.30.500.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set
IPR011161 MHC_I-like_Ag-recog
IPR037055 MHC_I-like_Ag-recog_sf
IPR011162 MHC_I/II-like_Ag-recog
IPR001039 MHC_I_a_a1/a2
IPR010579 MHC_I_a_C
PfamiView protein in Pfam
PF07654 C1-set, 1 hit
PF00129 MHC_I, 1 hit
PF06623 MHC_I_C, 1 hit
PRINTSiPR01638 MHCCLASSI
SMARTiView protein in SMART
SM00407 IGc1, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF54452 SSF54452, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS00290 IG_MHC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry namei1B07_HUMAN
AccessioniPrimary (citable) accession number: P01889
Secondary accession number(s): Q29638
, Q29681, Q29854, Q29861, Q31613, Q5SRJ2, Q9GIX1, Q9TP95
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: February 1, 1991
Last modified: October 10, 2018
This is version 191 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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