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Entry version 194 (13 Feb 2019)
Sequence version 3 (01 Feb 1991)
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Protein

HLA class I histocompatibility antigen, B-7 alpha chain

Gene

HLA-B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in the presentation of foreign antigens to the immune system.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • peptide antigen binding Source: UniProtKB
  • signaling receptor binding Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processHost-virus interaction, Immunity

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1236974 ER-Phagosome pathway
R-HSA-1236977 Endosomal/Vacuolar pathway
R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-6798695 Neutrophil degranulation
R-HSA-877300 Interferon gamma signaling
R-HSA-909733 Interferon alpha/beta signaling
R-HSA-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P01889

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
HLA class I histocompatibility antigen, B-7 alpha chain
Alternative name(s):
MHC class I antigen B*7
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HLA-B
Synonyms:HLAB
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000234745.9

Human Gene Nomenclature Database

More...
HGNCi
HGNC:4932 HLA-B

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
142830 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P01889

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini25 – 309ExtracellularSequence analysisAdd BLAST285
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei310 – 333HelicalSequence analysisAdd BLAST24
Topological domaini334 – 362CytoplasmicSequence analysisAdd BLAST29

Keywords - Cellular componenti

Membrane, MHC I

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
3106

MalaCards human disease database

More...
MalaCardsi
HLA-B

Open Targets

More...
OpenTargetsi
ENSG00000234745

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA35056

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
HLA-B

Domain mapping of disease mutations (DMDM)

More...
DMDMi
122162

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 241 PublicationAdd BLAST24
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001883325 – 362HLA class I histocompatibility antigen, B-7 alpha chainAdd BLAST338

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi110N-linked (GlcNAc...) asparagine1 Publication1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi125 ↔ 188
Disulfide bondi227 ↔ 283

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P01889

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P01889

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P01889

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P01889

PeptideAtlas

More...
PeptideAtlasi
P01889

PRoteomics IDEntifications database

More...
PRIDEi
P01889

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
1348

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P01889

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P01889

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000234745 Expressed in 92 organ(s), highest expression level in blood

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P01889 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P01889 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB015418

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Dimer of alpha chain and a beta chain (beta-2-microglobulin).By similarity
(Microbial infection) Interacts with HTLV-1 accessory protein p12I.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
109351, 111 interactors

Protein interaction database and analysis system

More...
IntActi
P01889, 18 interactors

Molecular INTeraction database

More...
MINTi
P01889

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000399168

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1362
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3VCLX-ray1.70A25-299[»]
4U1HX-ray1.59A25-300[»]
4U1KX-ray2.09A/D25-300[»]
5EO0X-ray1.70A25-299[»]
5EO1X-ray1.85A25-299[»]
5WMNX-ray1.82A/C25-300[»]
5WMOX-ray1.62A25-300[»]
5WMPX-ray1.60A25-300[»]
6AT5X-ray1.50A1-362[»]
6AVFX-ray2.03H1-362[»]
6AVGX-ray2.60F/G1-362[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P01889

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P01889

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini209 – 295Ig-like C1-typeAdd BLAST87

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni25 – 114Alpha-1Add BLAST90
Regioni115 – 206Alpha-2Add BLAST92
Regioni207 – 298Alpha-3Add BLAST92
Regioni299 – 309Connecting peptideAdd BLAST11

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the MHC class I family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410II5V Eukaryota
ENOG4111K8F LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153872

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG016709

KEGG Orthology (KO)

More...
KOi
K06751

Identification of Orthologs from Complete Genome Data

More...
OMAi
VPGYYNQ

Database of Orthologous Groups

More...
OrthoDBi
1390181at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P01889

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 1 hit
3.30.500.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set
IPR011161 MHC_I-like_Ag-recog
IPR037055 MHC_I-like_Ag-recog_sf
IPR011162 MHC_I/II-like_Ag-recog
IPR001039 MHC_I_a_a1/a2
IPR010579 MHC_I_a_C

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07654 C1-set, 1 hit
PF00129 MHC_I, 1 hit
PF06623 MHC_I_C, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01638 MHCCLASSI

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00407 IGc1, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726 SSF48726, 1 hit
SSF54452 SSF54452, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS00290 IG_MHC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 54 potential isoforms that are computationally mapped.Show allAlign All

P01889-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLVMAPRTVL LLLSAALALT ETWAGSHSMR YFYTSVSRPG RGEPRFISVG
60 70 80 90 100
YVDDTQFVRF DSDAASPREE PRAPWIEQEG PEYWDRNTQI YKAQAQTDRE
110 120 130 140 150
SLRNLRGYYN QSEAGSHTLQ SMYGCDVGPD GRLLRGHDQY AYDGKDYIAL
160 170 180 190 200
NEDLRSWTAA DTAAQITQRK WEAAREAEQR RAYLEGECVE WLRRYLENGK
210 220 230 240 250
DKLERADPPK THVTHHPISD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ
260 270 280 290 300
DTELVETRPA GDRTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEP
310 320 330 340 350
SSQSTVPIVG IVAGLAVLAV VVIGAVVAAV MCRRKSSGGK GGSYSQAACS
360
DSAQGSDVSL TA
Length:362
Mass (Da):40,460
Last modified:February 1, 1991 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5E5A7BDE031403D6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 54 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P039891B27_HUMAN
HLA class I histocompatibility anti...
HLA-B HLAB
362Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
P304601B08_HUMAN
HLA class I histocompatibility anti...
HLA-B HLAB
362Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q048261B40_HUMAN
HLA class I histocompatibility anti...
HLA-B HLAB
362Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
P304751B39_HUMAN
HLA class I histocompatibility anti...
HLA-B HLAB
362Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q953651B38_HUMAN
HLA class I histocompatibility anti...
HLA-B HLAB
362Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
P304861B48_HUMAN
HLA class I histocompatibility anti...
HLA-B HLAB
362Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q298361B67_HUMAN
HLA class I histocompatibility anti...
HLA-B HLAB
362Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
P304641B15_HUMAN
HLA class I histocompatibility anti...
HLA-B HLAB
362Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q316101B81_HUMAN
HLA class I histocompatibility anti...
HLA-B HLAB
362Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
P304801B42_HUMAN
HLA class I histocompatibility anti...
HLA-B HLAB
362Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti15 – 18AALA → GPW in AAA59622 (PubMed:2993161).Curated4
Sequence conflicti266Q → E AA sequence (PubMed:518865).Curated1
Sequence conflicti268W → S in AAA59622 (PubMed:2993161).Curated1
Sequence conflicti297R → G in AAA59622 (PubMed:2993161).Curated1
Sequence conflicti314 – 315GL → RP in AAA59622 (PubMed:2993161).Curated2

<p>This subsection of the ‘Sequence’ section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement_in_disease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

The following alleles of B-7 are known: B*07:02 (B7.2), B*07:03 (BPOT), B*07:04, B*07:05, B*07:06 (B7_L79), B*07:18 and B*07:24. The sequence shown is B*07:02.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0503324M → T. Corresponds to variant dbSNP:rs1050458Ensembl.1
Natural variantiVAR_0503339V → L. Corresponds to variant dbSNP:rs1050462Ensembl.1
Natural variantiVAR_05033417L → V. Corresponds to variant dbSNP:rs1131165Ensembl.1
Natural variantiVAR_05033535S → A. Corresponds to variant dbSNP:rs1131170Ensembl.1
Natural variantiVAR_05033636V → M. Corresponds to variant dbSNP:rs1050486Ensembl.1
Natural variantiVAR_06138648S → A. Corresponds to variant dbSNP:rs713031Ensembl.1
Natural variantiVAR_06138748S → P. Corresponds to variant dbSNP:rs713031Ensembl.1
Natural variantiVAR_06138848S → T. Corresponds to variant dbSNP:rs713031Ensembl.1
Natural variantiVAR_05033765A → TCombined sourcesCorresponds to variant dbSNP:rs1050529Ensembl.1
Natural variantiVAR_05033887N → D. Corresponds to variant dbSNP:rs1050570Ensembl.1
Natural variantiVAR_05946787N → K. Corresponds to variant dbSNP:rs1065386Ensembl.1
Natural variantiVAR_01635193 – 95AQA → TNT in allele B*07:03. 3
Natural variantiVAR_05033997T → A. Corresponds to variant dbSNP:rs1050393Ensembl.1
Natural variantiVAR_05946898D → Y. Corresponds to variant dbSNP:rs1131215Ensembl.1
Natural variantiVAR_050340101S → N. Corresponds to variant dbSNP:rs1050388Ensembl.1
Natural variantiVAR_016352118 – 119TL → II in allele B*07:18. Corresponds to variant dbSNP:rs796332753Ensembl.2
Natural variantiVAR_016353121S → R in allele B*07:18. Corresponds to variant dbSNP:rs1140412Ensembl.1
Natural variantiVAR_050341137H → Y. Corresponds to variant dbSNP:rs1050379Ensembl.1
Natural variantiVAR_061389138D → H. Corresponds to variant dbSNP:rs709055Ensembl.1
Natural variantiVAR_016354138D → N in allele B*07:05 and allele B*07:06. Combined sourcesCorresponds to variant dbSNP:rs709055Ensembl.1
Natural variantiVAR_050342155R → SCombined sourcesCorresponds to variant dbSNP:rs1050654Ensembl.1
Natural variantiVAR_016355180R → D in allele B*07:04; requires 2 nucleotide substitutions. 1
Natural variantiVAR_059469187E → A. Corresponds to variant dbSNP:rs2308466Ensembl.1
Natural variantiVAR_059470187E → G. Corresponds to variant dbSNP:rs2308466Ensembl.1
Natural variantiVAR_059471187E → K. Corresponds to variant dbSNP:rs2523600Ensembl.1
Natural variantiVAR_016616187E → L in allele B*07:24; requires 2 nucleotide substitutions. 1
Natural variantiVAR_059472187E → Q. Corresponds to variant dbSNP:rs2523600Ensembl.1
Natural variantiVAR_059473187E → V. Corresponds to variant dbSNP:rs2308466Ensembl.1
Natural variantiVAR_050343195Y → H. Corresponds to variant dbSNP:rs1050696Ensembl.1
Natural variantiVAR_016356306V → I in allele B*07:05. Corresponds to variant dbSNP:rs1131500Ensembl.1
Natural variantiVAR_050344329A → T. Corresponds to variant dbSNP:rs1051488Ensembl.1
Natural variantiVAR_061390349C → S. Corresponds to variant dbSNP:rs2308655Ensembl.1
Natural variantiVAR_061391349C → Y. Corresponds to variant dbSNP:rs2308655Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
M32317 mRNA Translation: AAA36230.1
M16102 mRNA Translation: AAA59622.1 Sequence problems.
U29057 mRNA Translation: AAA91229.1
X64454 mRNA Translation: CAA45785.1
U04245 mRNA Translation: AAA87398.1
L33922 mRNA Translation: AAA65639.1
U21052 mRNA Translation: AAA92563.1
U21053 mRNA Translation: AAA92564.1
X91749 mRNA Translation: CAA62864.1
AF189017 mRNA Translation: AAF01052.1
AJ309047 Genomic DNA Translation: CAC35468.1
AJ292075 Genomic DNA Translation: CAC33440.1
AL671883 Genomic DNA No translation available.
AK313911 mRNA Translation: BAG36634.1
AJ401222 Genomic DNA Translation: CAC10402.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS34394.1

Protein sequence database of the Protein Information Resource

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PIRi
B35997 HLHUB7
I54418
I59651
S60601

NCBI Reference Sequences

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RefSeqi
NP_005505.2, NM_005514.7

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.654404
Hs.726974
Hs.77961

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000412585; ENSP00000399168; ENSG00000234745

Database of genes from NCBI RefSeq genomes

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GeneIDi
3106

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:3106

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M32317 mRNA Translation: AAA36230.1
M16102 mRNA Translation: AAA59622.1 Sequence problems.
U29057 mRNA Translation: AAA91229.1
X64454 mRNA Translation: CAA45785.1
U04245 mRNA Translation: AAA87398.1
L33922 mRNA Translation: AAA65639.1
U21052 mRNA Translation: AAA92563.1
U21053 mRNA Translation: AAA92564.1
X91749 mRNA Translation: CAA62864.1
AF189017 mRNA Translation: AAF01052.1
AJ309047 Genomic DNA Translation: CAC35468.1
AJ292075 Genomic DNA Translation: CAC33440.1
AL671883 Genomic DNA No translation available.
AK313911 mRNA Translation: BAG36634.1
AJ401222 Genomic DNA Translation: CAC10402.1
CCDSiCCDS34394.1
PIRiB35997 HLHUB7
I54418
I59651
S60601
RefSeqiNP_005505.2, NM_005514.7
UniGeneiHs.654404
Hs.726974
Hs.77961

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3VCLX-ray1.70A25-299[»]
4U1HX-ray1.59A25-300[»]
4U1KX-ray2.09A/D25-300[»]
5EO0X-ray1.70A25-299[»]
5EO1X-ray1.85A25-299[»]
5WMNX-ray1.82A/C25-300[»]
5WMOX-ray1.62A25-300[»]
5WMPX-ray1.60A25-300[»]
6AT5X-ray1.50A1-362[»]
6AVFX-ray2.03H1-362[»]
6AVGX-ray2.60F/G1-362[»]
ProteinModelPortaliP01889
SMRiP01889
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109351, 111 interactors
IntActiP01889, 18 interactors
MINTiP01889
STRINGi9606.ENSP00000399168

PTM databases

GlyConnecti1348
iPTMnetiP01889
SwissPalmiP01889

Polymorphism and mutation databases

BioMutaiHLA-B
DMDMi122162

Proteomic databases

EPDiP01889
jPOSTiP01889
MaxQBiP01889
PaxDbiP01889
PeptideAtlasiP01889
PRIDEiP01889

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000412585; ENSP00000399168; ENSG00000234745
GeneIDi3106
KEGGihsa:3106

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
3106
DisGeNETi3106
EuPathDBiHostDB:ENSG00000234745.9

GeneCards: human genes, protein and diseases

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GeneCardsi
HLA-B
HGNCiHGNC:4932 HLA-B
HPAiCAB015418
MalaCardsiHLA-B
MIMi142830 gene
neXtProtiNX_P01889
OpenTargetsiENSG00000234745
PharmGKBiPA35056

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410II5V Eukaryota
ENOG4111K8F LUCA
GeneTreeiENSGT00940000153872
HOVERGENiHBG016709
KOiK06751
OMAiVPGYYNQ
OrthoDBi1390181at2759
PhylomeDBiP01889

Enzyme and pathway databases

ReactomeiR-HSA-1236974 ER-Phagosome pathway
R-HSA-1236977 Endosomal/Vacuolar pathway
R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-6798695 Neutrophil degranulation
R-HSA-877300 Interferon gamma signaling
R-HSA-909733 Interferon alpha/beta signaling
R-HSA-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC
SIGNORiP01889

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
HLA-B human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
HLA-B

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
3106

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000234745 Expressed in 92 organ(s), highest expression level in blood
ExpressionAtlasiP01889 baseline and differential
GenevisibleiP01889 HS

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.30.500.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set
IPR011161 MHC_I-like_Ag-recog
IPR037055 MHC_I-like_Ag-recog_sf
IPR011162 MHC_I/II-like_Ag-recog
IPR001039 MHC_I_a_a1/a2
IPR010579 MHC_I_a_C
PfamiView protein in Pfam
PF07654 C1-set, 1 hit
PF00129 MHC_I, 1 hit
PF06623 MHC_I_C, 1 hit
PRINTSiPR01638 MHCCLASSI
SMARTiView protein in SMART
SM00407 IGc1, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF54452 SSF54452, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS00290 IG_MHC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry namei1B07_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P01889
Secondary accession number(s): Q29638
, Q29681, Q29854, Q29861, Q31613, Q5SRJ2, Q9GIX1, Q9TP95
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: February 1, 1991
Last modified: February 13, 2019
This is version 194 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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