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UniProtKB - P01888 (B2MG_BOVIN)
Protein
Beta-2-microglobulin
Gene
B2M
Organism
Bos taurus (Bovine)
Status
Functioni
Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
GO - Molecular functioni
- MHC class II protein complex binding Source: GO_Central
GO - Biological processi
- antigen processing and presentation of exogenous peptide antigen via MHC class II Source: GO_Central
- antigen processing and presentation of peptide antigen via MHC class I Source: UniProtKB-KW
- immune response Source: InterPro
- peptide antigen assembly with MHC class II protein complex Source: GO_Central
- positive regulation of T cell activation Source: GO_Central
Keywordsi
Biological process | Immunity |
Enzyme and pathway databases
Reactomei | R-BTA-1236974, ER-Phagosome pathway R-BTA-1236977, Endosomal/Vacuolar pathway R-BTA-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-BTA-2424491, DAP12 signaling R-BTA-6798695, Neutrophil degranulation R-BTA-983170, Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
Names & Taxonomyi
Protein namesi | Recommended name: Beta-2-microglobulinAlternative name(s): Lactollin |
Gene namesi | Name:B2M |
Organismi | Bos taurus (Bovine) |
Taxonomic identifieri | 9913 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Proteomesi |
|
Organism-specific databases
VEuPathDBi | HostDB:ENSBTAG00000012330 |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Plasma Membrane
- MHC class I protein complex Source: UniProtKB-KW
- MHC class II protein complex Source: GO_Central
Keywords - Cellular componenti
MHC I, SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 20 | 1 PublicationAdd BLAST | 20 | |
ChainiPRO_0000018756 | 21 – 118 | Beta-2-microglobulinAdd BLAST | 98 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 45 ↔ 99 | PROSITE-ProRule annotation1 Publication |
Keywords - PTMi
Disulfide bondProteomic databases
PaxDbi | P01888 |
PeptideAtlasi | P01888 |
PRIDEi | P01888 |
PTM databases
CarbonylDBi | P01888 |
Expressioni
Gene expression databases
Bgeei | ENSBTAG00000012330, Expressed in leukocyte and 98 other tissues |
Interactioni
Subunit structurei
Heterodimer of an alpha chain and a beta chain. Beta-2-microglobulin is the beta-chain of major histocompatibility complex class I molecules (PubMed:23613577).
Forms a heterotrimer with MR1 and a metabolite antigen (By similarity).
By similarity1 PublicationProtein-protein interaction databases
STRINGi | 9913.ENSBTAP00000016359 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
AlphaFoldDBi | P01888 |
SMRi | P01888 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P01888 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 25 – 112 | Ig-like C1-typeAdd BLAST | 88 |
Sequence similaritiesi
Belongs to the beta-2-microglobulin family.Curated
Keywords - Domaini
Immunoglobulin domain, SignalPhylogenomic databases
eggNOGi | ENOG502S8GM, Eukaryota |
GeneTreei | ENSGT00690000102227 |
HOGENOMi | CLU_163066_0_0_1 |
InParanoidi | P01888 |
OMAi | FHPPKID |
OrthoDBi | 1556447at2759 |
TreeFami | TF334167 |
Family and domain databases
CDDi | cd05770, IgC_beta2m, 1 hit |
Gene3Di | 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR015707, B2Microglobulin IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003006, Ig/MHC_CS IPR003597, Ig_C1-set |
PANTHERi | PTHR19944:SF62, PTHR19944:SF62, 1 hit |
Pfami | View protein in Pfam PF07654, C1-set, 1 hit |
SMARTi | View protein in SMART SM00407, IGc1, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit PS00290, IG_MHC, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P01888-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MARFVALVLL GLLSLSGLDA IQRPPKIQVY SRHPPEDGKP NYLNCYVYGF
60 70 80 90 100
HPPQIEIDLL KNGEKIKSEQ SDLSFSKDWS FYLLSHAEFT PNSKDQYSCR
110
VKHVTLEQPR IVKWDRDL
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 37 | D → N AA sequence (PubMed:6174509).Curated | 1 | |
Sequence conflicti | 92 | N → D AA sequence (PubMed:6174509).Curated | 1 | |
Sequence conflicti | 96 | Q → E AA sequence (PubMed:6174509).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X69084 mRNA Translation: CAA48828.1 AY911322 mRNA Translation: AAW82090.1 BC118352 mRNA Translation: AAI18353.1 |
PIRi | I46000, MGBOB2 |
RefSeqi | NP_776318.1, NM_173893.3 XP_001251108.1, XM_001251107.5 XP_002691165.1, XM_002691119.3 |
Genome annotation databases
Ensembli | ENSBTAT00000016359; ENSBTAP00000016359; ENSBTAG00000012330 |
GeneIDi | 280729 783680 |
KEGGi | bta:280729 bta:783680 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X69084 mRNA Translation: CAA48828.1 AY911322 mRNA Translation: AAW82090.1 BC118352 mRNA Translation: AAI18353.1 |
PIRi | I46000, MGBOB2 |
RefSeqi | NP_776318.1, NM_173893.3 XP_001251108.1, XM_001251107.5 XP_002691165.1, XM_002691119.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1BMG | X-ray | 2.50 | A | 21-118 | [»] | |
2XFX | X-ray | 1.90 | B | 20-118 | [»] | |
3L9R | X-ray | 2.30 | B/D/F/H | 21-118 | [»] | |
3PWV | X-ray | 2.70 | B/E | 21-118 | [»] | |
4F7C | X-ray | 2.86 | B/D | 21-118 | [»] | |
4F7E | X-ray | 2.40 | B | 21-118 | [»] | |
4IIQ | X-ray | 2.86 | C | 21-118 | [»] | |
4L8S | X-ray | 2.90 | C | 21-118 | [»] | |
4L9L | X-ray | 3.40 | C | 21-118 | [»] | |
4LCC | X-ray | 3.26 | C | 21-118 | [»] | |
AlphaFoldDBi | P01888 | |||||
SMRi | P01888 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000016359 |
PTM databases
CarbonylDBi | P01888 |
Proteomic databases
PaxDbi | P01888 |
PeptideAtlasi | P01888 |
PRIDEi | P01888 |
Genome annotation databases
Ensembli | ENSBTAT00000016359; ENSBTAP00000016359; ENSBTAG00000012330 |
GeneIDi | 280729 783680 |
KEGGi | bta:280729 bta:783680 |
Organism-specific databases
CTDi | 567 |
VEuPathDBi | HostDB:ENSBTAG00000012330 |
Phylogenomic databases
eggNOGi | ENOG502S8GM, Eukaryota |
GeneTreei | ENSGT00690000102227 |
HOGENOMi | CLU_163066_0_0_1 |
InParanoidi | P01888 |
OMAi | FHPPKID |
OrthoDBi | 1556447at2759 |
TreeFami | TF334167 |
Enzyme and pathway databases
Reactomei | R-BTA-1236974, ER-Phagosome pathway R-BTA-1236977, Endosomal/Vacuolar pathway R-BTA-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-BTA-2424491, DAP12 signaling R-BTA-6798695, Neutrophil degranulation R-BTA-983170, Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
Miscellaneous databases
EvolutionaryTracei | P01888 |
Gene expression databases
Bgeei | ENSBTAG00000012330, Expressed in leukocyte and 98 other tissues |
Family and domain databases
CDDi | cd05770, IgC_beta2m, 1 hit |
Gene3Di | 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR015707, B2Microglobulin IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003006, Ig/MHC_CS IPR003597, Ig_C1-set |
PANTHERi | PTHR19944:SF62, PTHR19944:SF62, 1 hit |
Pfami | View protein in Pfam PF07654, C1-set, 1 hit |
SMARTi | View protein in SMART SM00407, IGc1, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit PS00290, IG_MHC, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | B2MG_BOVIN | |
Accessioni | P01888Primary (citable) accession number: P01888 Secondary accession number(s): Q148G6, Q56K05 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 21, 1986 |
Last sequence update: | February 1, 1994 | |
Last modified: | May 25, 2022 | |
This is version 169 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families