UniProtKB - P01887 (B2MG_MOUSE)
Protein
Beta-2-microglobulin
Gene
B2m
Organism
Mus musculus (Mouse)
Status
Functioni
Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
GO - Molecular functioni
- identical protein binding Source: MGI
- protein homodimerization activity Source: MGI
GO - Biological processi
- amyloid fibril formation Source: MGI
- antibacterial humoral response Source: MGI
- antigen processing and presentation of endogenous peptide antigen via MHC class I Source: MGI
- antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent Source: MGI
- antimicrobial humoral immune response mediated by antimicrobial peptide Source: MGI
- cellular defense response Source: MGI
- cellular response to iron(III) ion Source: MGI
- cellular response to iron ion Source: MGI
- cellular response to lipopolysaccharide Source: MGI
- cellular response to nicotine Source: MGI
- defense response to Gram-negative bacterium Source: MGI
- defense response to Gram-positive bacterium Source: MGI
- innate immune response Source: MGI
- iron ion homeostasis Source: MGI
- iron ion transport Source: MGI
- learning or memory Source: ARUK-UCL
- modulation of age-related behavioral decline Source: ARUK-UCL
- multicellular organism development Source: ARUK-UCL
- negative regulation of epithelial cell proliferation Source: MGI
- negative regulation of forebrain neuron differentiation Source: ARUK-UCL
- negative regulation of neurogenesis Source: ARUK-UCL
- negative regulation of neuron projection development Source: MGI
- negative regulation of receptor binding Source: MGI
- positive regulation of cellular senescence Source: MGI
- positive regulation of ferrous iron binding Source: MGI
- positive regulation of protein binding Source: MGI
- positive regulation of receptor binding Source: MGI
- positive regulation of receptor-mediated endocytosis Source: MGI
- positive regulation of T cell cytokine production Source: MGI
- positive regulation of T cell mediated cytotoxicity Source: MGI
- positive regulation of transferrin receptor binding Source: MGI
- protein homotetramerization Source: MGI
- protein refolding Source: MGI
- regulation of erythrocyte differentiation Source: MGI
- regulation of iron ion transport Source: MGI
- regulation of membrane depolarization Source: MGI
- response to cadmium ion Source: Ensembl
- response to drug Source: Ensembl
- response to molecule of bacterial origin Source: MGI
- T cell differentiation in thymus Source: MGI
Keywordsi
Biological process | Immunity |
Enzyme and pathway databases
Reactomei | R-MMU-1236974, ER-Phagosome pathway R-MMU-1236977, Endosomal/Vacuolar pathway R-MMU-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-MMU-2172127, DAP12 interactions R-MMU-2424491, DAP12 signaling R-MMU-6798695, Neutrophil degranulation R-MMU-983170, Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
Names & Taxonomyi
Protein namesi | Recommended name: Beta-2-microglobulin |
Gene namesi | Name:B2m |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:88127, B2m |
Subcellular locationi
Extracellular region or secreted
Cytosol
- cytosol Source: MGI
Endoplasmic reticulum
- MHC class I peptide loading complex Source: MGI
Extracellular region or secreted
- extracellular space Source: BHF-UCL
Golgi apparatus
- Golgi apparatus Source: MGI
Plasma Membrane
- external side of plasma membrane Source: MGI
- HFE-transferrin receptor complex Source: MGI
- MHC class I protein complex Source: UniProtKB-KW
- plasma membrane Source: MGI
Other locations
- phagocytic vesicle membrane Source: Reactome
Keywords - Cellular componenti
MHC I, SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 20 | 2 PublicationsAdd BLAST | 20 | |
ChainiPRO_0000018784 | 21 – 119 | Beta-2-microglobulinAdd BLAST | 99 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 45 ↔ 100 |
Keywords - PTMi
Disulfide bondProteomic databases
CPTACi | non-CPTAC-3965 |
EPDi | P01887 |
jPOSTi | P01887 |
PaxDbi | P01887 |
PeptideAtlasi | P01887 |
PRIDEi | P01887 |
2D gel databases
SWISS-2DPAGEi | P01887 |
PTM databases
iPTMneti | P01887 |
PhosphoSitePlusi | P01887 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000060802, Expressed in spleen and 305 other tissues |
Genevisiblei | P01887, MM |
Interactioni
Subunit structurei
Heterodimer of an alpha chain and a beta chain. Beta-2-microglobulin is the beta-chain of major histocompatibility complex class I molecules.
Forms a heterotrimer with MR1 and a metabolite antigen.
By similarityGO - Molecular functioni
- identical protein binding Source: MGI
- protein homodimerization activity Source: MGI
Protein-protein interaction databases
BioGRIDi | 198291, 10 interactors |
DIPi | DIP-6111N |
IntActi | P01887, 6 interactors |
MINTi | P01887 |
STRINGi | 10090.ENSMUSP00000099534 |
Miscellaneous databases
RNActi | P01887, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P01887 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P01887 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 25 – 114 | Ig-like C1-typeAdd BLAST | 90 |
Sequence similaritiesi
Belongs to the beta-2-microglobulin family.Curated
Keywords - Domaini
Immunoglobulin domain, SignalPhylogenomic databases
eggNOGi | ENOG502S8GM, Eukaryota |
GeneTreei | ENSGT00690000102227 |
HOGENOMi | CLU_163066_0_0_1 |
InParanoidi | P01887 |
OMAi | FHPPKID |
OrthoDBi | 1556447at2759 |
TreeFami | TF334167 |
Family and domain databases
CDDi | cd05770, IgC_beta2m, 1 hit |
Gene3Di | 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR015707, B2Microglobulin IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003006, Ig/MHC_CS IPR003597, Ig_C1-set |
PANTHERi | PTHR19944:SF62, PTHR19944:SF62, 1 hit |
Pfami | View protein in Pfam PF07654, C1-set, 1 hit |
SMARTi | View protein in SMART SM00407, IGc1, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit PS00290, IG_MHC, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P01887-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MARSVTLVFL VLVSLTGLYA IQKTPQIQVY SRHPPENGKP NILNCYVTQF
60 70 80 90 100
HPPHIEIQML KNGKKIPKVE MSDMSFSKDW SFYILAHTEF TPTETDTYAC
110
RVKHASMAEP KTVYWDRDM
Polymorphismi
The following alleles of B2M are known: A, B, W2, W3, W4 and W5 (C). The sequence shown is that of allele B.Curated
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural varianti | 8 | V → I in allele W3. 1 Publication | 1 | |
Natural varianti | 54 | H → Q in allele W4. 1 Publication | 1 | |
Natural varianti | 64 | K → E in allele W3. 1 Publication | 1 | |
Natural varianti | 101 | R → T in allele W2. 1 Publication | 1 | |
Natural varianti | 105 | A → D in allele A. 6 Publications | 1 | |
Natural varianti | 105 | A → V in allele W2, W4 and W5. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X01838 mRNA Translation: CAA25970.1 M12485 Genomic DNA No translation available. M84363 Genomic DNA Translation: AAA39667.1 M84364 Genomic DNA Translation: AAA39668.1 M84365 Genomic DNA Translation: AAA39669.1 M84366 Genomic DNA Translation: AAA39670.1 M84367 Genomic DNA Translation: AAA39671.1 AK019389 mRNA Translation: BAB31695.1 AK028378 mRNA Translation: BAC25917.1 AK166067 mRNA Translation: BAE38551.1 AL845457 Genomic DNA No translation available. CH466519 Genomic DNA Translation: EDL28084.1 BC085164 mRNA Translation: AAH85164.1 M10389 mRNA Translation: AAA39536.1 M10416 mRNA Translation: AAA39537.1 |
CCDSi | CCDS16654.1 |
PIRi | A90822, MGMSB2 |
RefSeqi | NP_033865.2, NM_009735.3 |
Genome annotation databases
Ensembli | ENSMUST00000102476; ENSMUSP00000099534; ENSMUSG00000060802 |
GeneIDi | 12010 |
KEGGi | mmu:12010 |
UCSCi | uc008maf.1, mouse |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X01838 mRNA Translation: CAA25970.1 M12485 Genomic DNA No translation available. M84363 Genomic DNA Translation: AAA39667.1 M84364 Genomic DNA Translation: AAA39668.1 M84365 Genomic DNA Translation: AAA39669.1 M84366 Genomic DNA Translation: AAA39670.1 M84367 Genomic DNA Translation: AAA39671.1 AK019389 mRNA Translation: BAB31695.1 AK028378 mRNA Translation: BAC25917.1 AK166067 mRNA Translation: BAE38551.1 AL845457 Genomic DNA No translation available. CH466519 Genomic DNA Translation: EDL28084.1 BC085164 mRNA Translation: AAH85164.1 M10389 mRNA Translation: AAA39536.1 M10416 mRNA Translation: AAA39537.1 |
CCDSi | CCDS16654.1 |
PIRi | A90822, MGMSB2 |
RefSeqi | NP_033865.2, NM_009735.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1BII | X-ray | 2.40 | B | 1-119 | [»] | |
1BQH | X-ray | 2.80 | B/E | 21-119 | [»] | |
1BZ9 | X-ray | 2.80 | B | 21-119 | [»] | |
1CD1 | X-ray | 2.67 | B/D | 21-119 | [»] | |
1DDH | X-ray | 3.10 | B | 22-119 | [»] | |
1FFN | X-ray | 2.70 | B/E | 21-119 | [»] | |
1FFO | X-ray | 2.65 | B/E | 21-119 | [»] | |
1FFP | X-ray | 2.60 | B/E | 21-119 | [»] | |
1FG2 | X-ray | 2.75 | B/E/H/K | 21-119 | [»] | |
1FO0 | X-ray | 2.50 | L | 21-119 | [»] | |
1FZJ | X-ray | 1.90 | B | 21-119 | [»] | |
1FZK | X-ray | 1.70 | B | 21-119 | [»] | |
1FZM | X-ray | 1.80 | B | 21-119 | [»] | |
1FZO | X-ray | 1.80 | B | 21-119 | [»] | |
1G6R | X-ray | 2.80 | L/M | 21-119 | [»] | |
1G7P | X-ray | 1.50 | B | 21-119 | [»] | |
1G7Q | X-ray | 1.60 | B | 21-119 | [»] | |
1HOC | X-ray | 2.40 | B | 21-119 | [»] | |
1INQ | X-ray | 2.20 | B | 21-119 | [»] | |
1JPF | X-ray | 2.18 | B | 21-119 | [»] | |
1JPG | X-ray | 2.20 | B | 21-119 | [»] | |
1JUF | X-ray | 2.00 | B | 21-119 | [»] | |
1K8D | X-ray | 2.30 | B | 21-119 | [»] | |
1KBG | X-ray | 2.20 | L | 21-119 | [»] | |
1KJ2 | X-ray | 2.71 | L/M | 21-119 | [»] | |
1KJ3 | X-ray | 2.30 | L/M | 21-119 | [»] | |
1KPU | X-ray | 1.50 | B | 21-119 | [»] | |
1KPV | X-ray | 1.71 | B | 21-119 | [»] | |
1L6Q | model | - | B | 21-119 | [»] | |
1LD9 | X-ray | 2.40 | B/E | 21-119 | [»] | |
1LDP | X-ray | 3.10 | L | 21-119 | [»] | |
1LEG | X-ray | 1.75 | B | 21-119 | [»] | |
1LEK | X-ray | 2.15 | B | 21-119 | [»] | |
1LK2 | X-ray | 1.35 | B | 21-119 | [»] | |
1MHC | X-ray | 2.10 | B/E | 21-119 | [»] | |
1MWA | X-ray | 2.40 | L/M | 21-119 | [»] | |
1N3N | X-ray | 3.00 | B/D/F/H | 21-119 | [»] | |
1N59 | X-ray | 2.95 | B/D | 21-119 | [»] | |
1N5A | X-ray | 2.85 | B/E/H/K | 21-119 | [»] | |
1NAM | X-ray | 2.70 | L | 21-119 | [»] | |
1NAN | X-ray | 2.30 | I/P | 21-119 | [»] | |
1NEZ | X-ray | 2.10 | B | 21-119 | [»] | |
1OSZ | X-ray | 2.10 | B | 21-119 | [»] | |
1P1Z | X-ray | 3.26 | B | 21-119 | [»] | |
1P4L | X-ray | 2.90 | B | 21-119 | [»] | |
1PQZ | X-ray | 2.10 | B | 21-119 | [»] | |
1QO3 | X-ray | 2.30 | B | 21-119 | [»] | |
1RJY | X-ray | 1.90 | B/E | 21-119 | [»] | |
1RJZ | X-ray | 2.60 | B/E | 21-119 | [»] | |
1RK0 | X-ray | 2.61 | B | 21-119 | [»] | |
1RK1 | X-ray | 2.10 | B | 21-119 | [»] | |
1S7Q | X-ray | 1.99 | B | 21-119 | [»] | |
1S7R | X-ray | 2.95 | B/E | 21-119 | [»] | |
1S7S | X-ray | 1.99 | B | 21-119 | [»] | |
1S7T | X-ray | 2.30 | B/E | 21-119 | [»] | |
1S7U | X-ray | 2.20 | B/E/H/K | 21-119 | [»] | |
1S7V | X-ray | 2.20 | B/E | 21-119 | [»] | |
1S7W | X-ray | 2.40 | B/E/H/K | 21-119 | [»] | |
1S7X | X-ray | 2.41 | B/E/H/K | 21-119 | [»] | |
1T0M | X-ray | 2.00 | B/E | 21-119 | [»] | |
1T0N | X-ray | 1.80 | B/E | 21-119 | [»] | |
1U58 | X-ray | 1.90 | B | 21-119 | [»] | |
1VAC | X-ray | 2.50 | B | 21-119 | [»] | |
1VAD | X-ray | 2.50 | B | 21-119 | [»] | |
1WBX | X-ray | 1.90 | B | 21-119 | [»] | |
1WBY | X-ray | 2.30 | B | 21-119 | [»] | |
1WBZ | X-ray | 2.00 | B/D | 21-119 | [»] | |
1YN6 | X-ray | 2.20 | B | 21-119 | [»] | |
1YN7 | X-ray | 2.20 | B | 21-119 | [»] | |
1Z5L | X-ray | 2.20 | B/D | 21-119 | [»] | |
1ZHB | X-ray | 2.70 | B/E/H/K | 21-119 | [»] | |
1ZHN | X-ray | 2.80 | B | 21-119 | [»] | |
1ZT1 | X-ray | 2.50 | B | 21-119 | [»] | |
1ZT7 | X-ray | 3.00 | B/D | 21-119 | [»] | |
2AKR | X-ray | 1.90 | B/D | 21-119 | [»] | |
2CKB | X-ray | 3.00 | L/M | 21-119 | [»] | |
2CLV | X-ray | 1.90 | B/P | 21-119 | [»] | |
2CLZ | X-ray | 1.90 | B/P | 21-119 | [»] | |
2FIK | X-ray | 1.80 | B | 21-119 | [»] | |
2FO4 | X-ray | 2.70 | B | 21-119 | [»] | |
2FWO | X-ray | 2.60 | B | 21-119 | [»] | |
2GAZ | X-ray | 2.61 | B | 21-119 | [»] | |
2MHA | X-ray | 2.50 | B/D | 21-119 | [»] | |
2OL3 | X-ray | 2.90 | L | 21-119 | [»] | |
2Q7Y | X-ray | 1.95 | B/D | 21-119 | [»] | |
2QRI | X-ray | 2.00 | A/B | 21-119 | [»] | |
2QRS | X-ray | 2.00 | A/B | 21-119 | [»] | |
2QRT | X-ray | 1.80 | A/B | 21-119 | [»] | |
2VAA | X-ray | 2.30 | B | 21-119 | [»] | |
2VAB | X-ray | 2.50 | B | 21-119 | [»] | |
2VE6 | X-ray | 2.65 | B/E/H/K | 22-119 | [»] | |
2ZOK | X-ray | 2.10 | B/D/F/H | 21-119 | [»] | |
2ZOL | X-ray | 2.70 | B/D | 21-119 | [»] | |
2ZSV | X-ray | 1.80 | B/D | 21-119 | [»] | |
2ZSW | X-ray | 2.80 | B/D/F/H | 21-119 | [»] | |
3ARB | X-ray | 2.70 | B | 21-119 | [»] | |
3ARD | X-ray | 3.01 | B | 21-119 | [»] | |
3ARE | X-ray | 2.80 | B | 21-119 | [»] | |
3ARF | X-ray | 2.90 | B | 21-119 | [»] | |
3ARG | X-ray | 3.00 | B | 21-119 | [»] | |
3AU1 | X-ray | 2.50 | B | 21-119 | [»] | |
3BUY | X-ray | 2.60 | B | 21-119 | [»] | |
3C8K | X-ray | 2.90 | B | 21-119 | [»] | |
3CC5 | X-ray | 1.91 | B/E | 21-119 | [»] | |
3CCH | X-ray | 2.60 | B/E/H/K | 21-119 | [»] | |
3CH1 | X-ray | 2.30 | B/E/H/K | 21-119 | [»] | |
3CPL | X-ray | 2.50 | B/D | 21-119 | [»] | |
3CVH | X-ray | 2.90 | B/N | 21-119 | [»] | |
3DMM | X-ray | 2.60 | B | 21-119 | [»] | |
3E6F | X-ray | 2.41 | B | 22-119 | [»] | |
3E6H | X-ray | 2.10 | B | 21-119 | [»] | |
3ECB | X-ray | 1.70 | B | 21-119 | [»] | |
3FOL | X-ray | 2.50 | B | 21-119 | [»] | |
3FOM | X-ray | 2.10 | B | 21-119 | [»] | |
3FON | X-ray | 2.03 | B/D | 21-119 | [»] | |
3FTG | X-ray | 2.60 | B | 21-119 | [»] | |
3G08 | X-ray | 1.60 | B | 21-119 | [»] | |
3GML | X-ray | 1.70 | B | 21-119 | [»] | |
3GMM | X-ray | 1.80 | B | 21-119 | [»] | |
3GMN | X-ray | 1.70 | B | 21-119 | [»] | |
3GMO | X-ray | 1.60 | B | 21-119 | [»] | |
3GMP | X-ray | 1.70 | B | 21-119 | [»] | |
3GMQ | X-ray | 1.80 | B | 21-119 | [»] | |
3GMR | X-ray | 1.90 | B | 21-119 | [»] | |
3HE6 | X-ray | 2.90 | B | 21-119 | [»] | |
3HE7 | X-ray | 2.80 | B | 21-119 | [»] | |
3ILP | X-ray | 1.85 | B | 21-119 | [»] | |
3ILQ | X-ray | 2.05 | D | 21-119 | [»] | |
3L3H | X-ray | 2.70 | B | 21-119 | [»] | |
3MA7 | X-ray | 2.29 | B/D | 21-119 | [»] | |
3NWM | X-ray | 2.70 | A | 21-119 | [»] | |
3O8X | X-ray | 2.74 | B | 21-119 | [»] | |
3O9W | X-ray | 2.80 | B | 21-119 | [»] | |
3P4M | X-ray | 2.50 | B/E | 21-119 | [»] | |
3P4N | X-ray | 2.50 | B/E | 21-119 | [»] | |
3P4O | X-ray | 2.30 | B/E | 21-119 | [»] | |
3P9L | X-ray | 2.00 | B/E | 21-119 | [»] | |
3P9M | X-ray | 2.00 | B/E | 21-119 | [»] | |
3PAB | X-ray | 2.20 | B/E | 21-119 | [»] | |
3PQY | X-ray | 3.19 | B/G/L/Q | 21-119 | [»] | |
3PWU | X-ray | 1.90 | B | 21-119 | [»] | |
3QI9 | X-ray | 2.30 | B | 21-119 | [»] | |
3QUK | X-ray | 2.41 | B/E | 21-119 | [»] | |
3QUL | X-ray | 2.00 | B/E/H/K | 21-119 | [»] | |
3QUX | X-ray | 2.91 | B | 21-119 | [»] | |
3QUY | X-ray | 2.25 | B | 21-119 | [»] | |
3QUZ | X-ray | 2.30 | B | 21-119 | [»] | |
3RGV | X-ray | 2.90 | D | 21-119 | [»] | |
3ROL | X-ray | 2.60 | B/D | 21-119 | [»] | |
3ROO | X-ray | 2.00 | B/D | 21-119 | [»] | |
3RTQ | X-ray | 2.80 | B | 21-119 | [»] | |
3RUG | X-ray | 2.20 | B/D | 21-119 | [»] | |
3RZC | X-ray | 2.80 | B | 21-119 | [»] | |
3SCM | X-ray | 2.50 | B | 21-119 | [»] | |
3SDA | X-ray | 2.80 | B | 21-119 | [»] | |
3SDC | X-ray | 3.10 | B | 21-119 | [»] | |
3SDD | X-ray | 3.00 | B | 21-119 | [»] | |
3T1F | X-ray | 1.70 | B | 21-119 | [»] | |
3TA3 | X-ray | 2.70 | B | 21-119 | [»] | |
3TBS | X-ray | 2.49 | B/E | 21-119 | [»] | |
3TBT | X-ray | 2.30 | B/E/H/K | 21-119 | [»] | |
3TBV | X-ray | 2.10 | B/D/F/H | 21-119 | [»] | |
3TBW | X-ray | 2.15 | B/D/F/H | 21-119 | [»] | |
3TBY | X-ray | 2.50 | B/E/H/K | 21-119 | [»] | |
3TN0 | X-ray | 3.20 | B | 21-119 | [»] | |
3TO4 | X-ray | 3.10 | B | 21-119 | [»] | |
3TVM | X-ray | 2.80 | B/F | 21-119 | [»] | |
3UBX | X-ray | 3.10 | B/E | 21-119 | [»] | |
3VJ6 | X-ray | 1.90 | B | 21-119 | [»] | |
3WS3 | X-ray | 2.34 | B/D | 21-119 | [»] | |
3WS6 | X-ray | 1.98 | C/D | 21-119 | [»] | |
4APQ | X-ray | 3.00 | B | 21-119 | [»] | |
4EI5 | X-ray | 3.10 | B/F | 21-119 | [»] | |
4ELM | X-ray | 3.48 | B/D | 21-119 | [»] | |
4HS3 | X-ray | 2.10 | B | 21-119 | [»] | |
4HUU | X-ray | 2.00 | B/E | 21-119 | [»] | |
4HUV | X-ray | 2.50 | B/E | 21-119 | [»] | |
4HUW | X-ray | 3.16 | B/D/F/H | 21-119 | [»] | |
4HUX | X-ray | 2.20 | B | 21-119 | [»] | |
4HV8 | X-ray | 2.00 | B/D | 21-119 | [»] | |
4IHO | X-ray | 2.80 | B/E | 21-119 | [»] | |
4IRJ | X-ray | 3.00 | B | 21-119 | [»] | |
4IRS | X-ray | 2.80 | B | 21-119 | [»] | |
4L8B | X-ray | 2.20 | B | 21-119 | [»] | |
4L8C | X-ray | 2.80 | B/D/F/H | 21-119 | [»] | |
4L8D | X-ray | 1.90 | B/D | 21-119 | [»] | |
4MNG | X-ray | 3.01 | B/D | 21-119 | [»] | |
4MQ7 | X-ray | 2.60 | B | 21-119 | [»] | |
4MX7 | X-ray | 2.24 | B | 21-119 | [»] | |
4NSK | X-ray | 2.60 | B | 21-119 | [»] | |
4PG2 | X-ray | 2.80 | C | 21-119 | [»] | |
4PG9 | X-ray | 2.40 | B | 21-119 | [»] | |
4PGB | X-ray | 2.80 | B/E | 21-119 | [»] | |
4PGC | X-ray | 2.30 | B/E | 21-119 | [»] | |
4PGD | X-ray | 2.70 | B | 21-119 | [»] | |
4PGE | X-ray | 2.00 | B | 21-119 | [»] | |
4PV8 | X-ray | 2.31 | B/D | 21-119 | [»] | |
4PV9 | X-ray | 2.00 | B/D | 21-119 | [»] | |
4Y16 | X-ray | 2.60 | B | 21-119 | [»] | |
4Y2D | X-ray | 3.05 | B/F | 21-119 | [»] | |
4Y4F | X-ray | 3.19 | B/F | 21-119 | [»] | |
4Y4H | X-ray | 3.10 | B/F | 21-119 | [»] | |
4Y4K | X-ray | 2.90 | B | 21-119 | [»] | |
4ZAK | X-ray | 2.82 | B | 21-119 | [»] | |
4ZUS | X-ray | 2.60 | B | 21-119 | [»] | |
4ZUT | X-ray | 2.60 | B | 21-119 | [»] | |
4ZUU | X-ray | 2.20 | B | 21-119 | [»] | |
4ZUV | X-ray | 2.30 | B/E | 21-119 | [»] | |
4ZUW | X-ray | 2.60 | B | 21-119 | [»] | |
5E8N | X-ray | 2.25 | B/E/H/K | 21-119 | [»] | |
5E8O | X-ray | 1.98 | B/E | 21-119 | [»] | |
5E8P | X-ray | 2.00 | B/E | 21-119 | [»] | |
5EFI | X-ray | 1.80 | B | 21-119 | [»] | |
5FKP | X-ray | 1.80 | B | 21-119 | [»] | |
5IVX | X-ray | 2.10 | B | 21-119 | [»] | |
5J6G | X-ray | 3.30 | B/D | 21-119 | [»] | |
5J6H | X-ray | 2.30 | B | 21-119 | [»] | |
5JWD | X-ray | 2.50 | B | 21-119 | [»] | |
5JWE | X-ray | 2.40 | B/D/F/H | 21-119 | [»] | |
5KD4 | X-ray | 3.05 | B/D | 21-119 | [»] | |
5KD7 | X-ray | 2.35 | B/D/G/J | 21-119 | [»] | |
5M00 | X-ray | 1.95 | B | 21-119 | [»] | |
5M02 | X-ray | 1.75 | B | 21-119 | [»] | |
5MZM | X-ray | 2.40 | B/E | 21-119 | [»] | |
5OQF | X-ray | 2.27 | A/B | 21-119 | [»] | |
5OQG | X-ray | 1.90 | A/B | 21-119 | [»] | |
5OQH | X-ray | 2.05 | A/B | 21-109 | [»] | |
5OQI | X-ray | 2.40 | A/B | 21-119 | [»] | |
5SWS | X-ray | 2.86 | B | 21-119 | [»] | |
5SWZ | X-ray | 2.65 | B/G/L/Q | 21-119 | [»] | |
5T7G | X-ray | 1.96 | B/D | 21-119 | [»] | |
5TIL | X-ray | 2.83 | B/E | 21-119 | [»] | |
5TJE | X-ray | 3.20 | B/D | 21-119 | [»] | |
5TW2 | X-ray | 1.75 | B | 21-119 | [»] | |
5TW5 | X-ray | 1.85 | B | 21-117 | [»] | |
5VCJ | X-ray | 3.16 | B | 21-119 | [»] | |
5VCL | X-ray | 2.05 | B | 21-119 | [»] | |
5WES | X-ray | 2.71 | B | 21-119 | [»] | |
5WET | X-ray | 2.64 | B | 21-119 | [»] | |
5WEU | X-ray | 1.58 | B | 21-119 | [»] | |
5WLG | X-ray | 2.10 | B/G | 21-119 | [»] | |
5WLI | X-ray | 2.20 | B/E/H/K | 21-119 | [»] | |
6A97 | X-ray | 2.15 | B/D | 21-119 | [»] | |
6BMH | X-ray | 2.30 | B/D/F/H | 21-119 | [»] | |
6BMK | X-ray | 2.43 | B/D | 21-119 | [»] | |
6BNK | X-ray | 3.20 | B/F | 21-119 | [»] | |
6BNL | X-ray | 2.60 | B/F | 21-119 | [»] | |
6C5M | X-ray | 2.45 | B | 21-119 | [»] | |
6C69 | X-ray | 1.94 | B | 21-119 | [»] | |
6C6A | X-ray | 2.45 | B | 21-119 | [»] | |
6C6C | X-ray | 2.08 | B | 21-119 | [»] | |
6C6E | X-ray | 2.18 | B | 21-119 | [»] | |
6C6F | X-ray | 1.67 | B | 21-119 | [»] | |
6C6H | X-ray | 2.00 | B | 21-119 | [»] | |
6C6J | X-ray | 1.79 | B | 22-119 | [»] | |
6CW6 | X-ray | 2.85 | B | 21-119 | [»] | |
6CW9 | X-ray | 2.00 | B | 22-118 | [»] | |
6CWB | X-ray | 2.85 | B | 21-119 | [»] | |
6CWE | X-ray | 2.20 | B | 21-119 | [»] | |
6CX5 | X-ray | 2.40 | B | 21-119 | [»] | |
6CX7 | X-ray | 2.60 | B | 21-119 | [»] | |
6CX9 | X-ray | 2.36 | B | 21-119 | [»] | |
6CXA | X-ray | 2.65 | B | 21-119 | [»] | |
6CXE | X-ray | 2.05 | B | 21-119 | [»] | |
6CXF | X-ray | 2.50 | B | 21-118 | [»] | |
6CYW | X-ray | 1.95 | B | 21-119 | [»] | |
6E1I | X-ray | 1.99 | A | 24-119 | [»] | |
6G9Q | X-ray | 1.89 | B | 1-119 | [»] | |
6G9R | X-ray | 2.70 | B/D/F/H | 21-119 | [»] | |
6GB5 | X-ray | 2.30 | B/D | 21-119 | [»] | |
6GB6 | X-ray | 1.78 | B/E | 21-119 | [»] | |
6GB7 | X-ray | 2.15 | B/D/F/H | 21-119 | [»] | |
6H6D | X-ray | 2.40 | B/E | 21-119 | [»] | |
6H6H | X-ray | 2.40 | B/E | 21-119 | [»] | |
6I8C | X-ray | 1.92 | A | 21-119 | [»] | |
6JQ2 | X-ray | 2.40 | B | 21-119 | [»] | |
6JQ3 | X-ray | 2.50 | B | 21-119 | [»] | |
6MIV | Other | 2.05 | B | 21-119 | [»] | |
6MIY | X-ray | 2.75 | B/F | 21-119 | [»] | |
6MJ4 | X-ray | 2.00 | B | 21-119 | [»] | |
6MJ6 | X-ray | 2.45 | B | 21-119 | [»] | |
6MJA | X-ray | 2.35 | B | 21-119 | [»] | |
6MJI | X-ray | 2.30 | B | 21-119 | [»] | |
6MJJ | X-ray | 1.93 | B | 21-119 | [»] | |
6MJQ | X-ray | 3.00 | B/F | 21-119 | [»] | |
6MP0 | X-ray | 2.00 | A | 21-119 | [»] | |
6MP1 | X-ray | 2.21 | A | 21-119 | [»] | |
6MSS | X-ray | 3.00 | D | 21-119 | [»] | |
6OJP | X-ray | 2.17 | B | 21-119 | [»] | |
6OMG | X-ray | 2.10 | B | 21-119 | [»] | |
6OOR | X-ray | 2.45 | B | 21-119 | [»] | |
SMRi | P01887 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 198291, 10 interactors |
DIPi | DIP-6111N |
IntActi | P01887, 6 interactors |
MINTi | P01887 |
STRINGi | 10090.ENSMUSP00000099534 |
PTM databases
iPTMneti | P01887 |
PhosphoSitePlusi | P01887 |
2D gel databases
SWISS-2DPAGEi | P01887 |
Proteomic databases
CPTACi | non-CPTAC-3965 |
EPDi | P01887 |
jPOSTi | P01887 |
PaxDbi | P01887 |
PeptideAtlasi | P01887 |
PRIDEi | P01887 |
Protocols and materials databases
Antibodypediai | 1913, 2334 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000102476; ENSMUSP00000099534; ENSMUSG00000060802 |
GeneIDi | 12010 |
KEGGi | mmu:12010 |
UCSCi | uc008maf.1, mouse |
Organism-specific databases
CTDi | 567 |
MGIi | MGI:88127, B2m |
Phylogenomic databases
eggNOGi | ENOG502S8GM, Eukaryota |
GeneTreei | ENSGT00690000102227 |
HOGENOMi | CLU_163066_0_0_1 |
InParanoidi | P01887 |
OMAi | FHPPKID |
OrthoDBi | 1556447at2759 |
TreeFami | TF334167 |
Enzyme and pathway databases
Reactomei | R-MMU-1236974, ER-Phagosome pathway R-MMU-1236977, Endosomal/Vacuolar pathway R-MMU-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-MMU-2172127, DAP12 interactions R-MMU-2424491, DAP12 signaling R-MMU-6798695, Neutrophil degranulation R-MMU-983170, Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
Miscellaneous databases
BioGRID-ORCSi | 12010, 2 hits in 23 CRISPR screens |
ChiTaRSi | B2m, mouse |
EvolutionaryTracei | P01887 |
PROi | PR:P01887 |
RNActi | P01887, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000060802, Expressed in spleen and 305 other tissues |
Genevisiblei | P01887, MM |
Family and domain databases
CDDi | cd05770, IgC_beta2m, 1 hit |
Gene3Di | 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR015707, B2Microglobulin IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003006, Ig/MHC_CS IPR003597, Ig_C1-set |
PANTHERi | PTHR19944:SF62, PTHR19944:SF62, 1 hit |
Pfami | View protein in Pfam PF07654, C1-set, 1 hit |
SMARTi | View protein in SMART SM00407, IGc1, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit PS00290, IG_MHC, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | B2MG_MOUSE | |
Accessioni | P01887Primary (citable) accession number: P01887 Secondary accession number(s): Q91XJ8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 21, 1986 |
Last sequence update: | October 3, 2012 | |
Last modified: | December 2, 2020 | |
This is version 215 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families