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Protein

Beta-2-microglobulin

Gene

B2m

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processImmunity

Enzyme and pathway databases

ReactomeiR-MMU-1236974 ER-Phagosome pathway
R-MMU-1236977 Endosomal/Vacuolar pathway
R-MMU-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-MMU-2172127 DAP12 interactions
R-MMU-2424491 DAP12 signaling
R-MMU-6798695 Neutrophil degranulation
R-MMU-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-2-microglobulin
Gene namesi
Name:B2m
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:88127 B2m

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

MHC I, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 202 PublicationsAdd BLAST20
ChainiPRO_000001878421 – 119Beta-2-microglobulinAdd BLAST99

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi45 ↔ 100

Keywords - PTMi

Disulfide bond

Proteomic databases

EPDiP01887
PaxDbiP01887
PeptideAtlasiP01887
PRIDEiP01887

2D gel databases

SWISS-2DPAGEiP01887

PTM databases

iPTMnetiP01887
PhosphoSitePlusiP01887

Miscellaneous databases

PMAP-CutDBiP01887

Expressioni

Gene expression databases

BgeeiENSMUSG00000060802 Expressed in 291 organ(s), highest expression level in spleen
CleanExiMM_B2M
GenevisibleiP01887 MM

Interactioni

Subunit structurei

Heterodimer of an alpha chain and a beta chain. Beta-2-microglobulin is the beta-chain of major histocompatibility complex class I molecules.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi198291, 3 interactors
DIPiDIP-6111N
IntActiP01887, 5 interactors
MINTiP01887
STRINGi10090.ENSMUSP00000099534

Structurei

Secondary structure

1119
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP01887
SMRiP01887
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01887

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 114Ig-like C1-typeAdd BLAST90

Sequence similaritiesi

Belongs to the beta-2-microglobulin family.Curated

Keywords - Domaini

Immunoglobulin domain, Signal

Phylogenomic databases

eggNOGiENOG410J15A Eukaryota
ENOG410YTDG LUCA
GeneTreeiENSGT00690000102227
HOGENOMiHOG000043084
HOVERGENiHBG006197
InParanoidiP01887
KOiK08055
OMAiPNFLNCY
OrthoDBiEOG091G0ZOW
TreeFamiTF334167

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR015707 B2Microglobulin
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set
PANTHERiPTHR19944:SF62 PTHR19944:SF62, 1 hit
PfamiView protein in Pfam
PF07654 C1-set, 1 hit
SMARTiView protein in SMART
SM00407 IGc1, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS00290 IG_MHC, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01887-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MARSVTLVFL VLVSLTGLYA IQKTPQIQVY SRHPPENGKP NILNCYVTQF
60 70 80 90 100
HPPHIEIQML KNGKKIPKVE MSDMSFSKDW SFYILAHTEF TPTETDTYAC
110
RVKHASMAEP KTVYWDRDM
Length:119
Mass (Da):13,779
Last modified:October 3, 2012 - v2
Checksum:i94F649EBCF1D7A4E
GO

Polymorphismi

The following alleles of B2M are known: A, B, W2, W3, W4 and W5 (C). The sequence shown is that of allele B.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti8V → I in allele W3. 1 Publication1
Natural varianti54H → Q in allele W4. 1 Publication1
Natural varianti64K → E in allele W3. 1 Publication1
Natural varianti101R → T in allele W2. 1 Publication1
Natural varianti105A → D in allele A. 6 Publications1
Natural varianti105A → V in allele W2, W4 and W5. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X01838 mRNA Translation: CAA25970.1
M12485 Genomic DNA No translation available.
M84363 Genomic DNA Translation: AAA39667.1
M84364 Genomic DNA Translation: AAA39668.1
M84365 Genomic DNA Translation: AAA39669.1
M84366 Genomic DNA Translation: AAA39670.1
M84367 Genomic DNA Translation: AAA39671.1
AK019389 mRNA Translation: BAB31695.1
AK028378 mRNA Translation: BAC25917.1
AK166067 mRNA Translation: BAE38551.1
AL845457 Genomic DNA Translation: CAM21783.1
CH466519 Genomic DNA Translation: EDL28084.1
BC085164 mRNA Translation: AAH85164.1
M10389 mRNA Translation: AAA39536.1
M10416 mRNA Translation: AAA39537.1
CCDSiCCDS16654.1
PIRiA90822 MGMSB2
RefSeqiNP_033865.2, NM_009735.3
UniGeneiMm.163

Genome annotation databases

EnsembliENSMUST00000102476; ENSMUSP00000099534; ENSMUSG00000060802
GeneIDi12010
KEGGimmu:12010
UCSCiuc008maf.1 mouse

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X01838 mRNA Translation: CAA25970.1
M12485 Genomic DNA No translation available.
M84363 Genomic DNA Translation: AAA39667.1
M84364 Genomic DNA Translation: AAA39668.1
M84365 Genomic DNA Translation: AAA39669.1
M84366 Genomic DNA Translation: AAA39670.1
M84367 Genomic DNA Translation: AAA39671.1
AK019389 mRNA Translation: BAB31695.1
AK028378 mRNA Translation: BAC25917.1
AK166067 mRNA Translation: BAE38551.1
AL845457 Genomic DNA Translation: CAM21783.1
CH466519 Genomic DNA Translation: EDL28084.1
BC085164 mRNA Translation: AAH85164.1
M10389 mRNA Translation: AAA39536.1
M10416 mRNA Translation: AAA39537.1
CCDSiCCDS16654.1
PIRiA90822 MGMSB2
RefSeqiNP_033865.2, NM_009735.3
UniGeneiMm.163

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BIIX-ray2.40B1-119[»]
1BQHX-ray2.80B/E21-119[»]
1BZ9X-ray2.80B21-119[»]
1CD1X-ray2.67B/D21-119[»]
1DDHX-ray3.10B22-119[»]
1FFNX-ray2.70B/E21-119[»]
1FFOX-ray2.65B/E21-119[»]
1FFPX-ray2.60B/E21-119[»]
1FG2X-ray2.75B/E/H/K21-119[»]
1FO0X-ray2.50L21-119[»]
1FZJX-ray1.90B21-119[»]
1FZKX-ray1.70B21-119[»]
1FZMX-ray1.80B21-119[»]
1FZOX-ray1.80B21-119[»]
1G6RX-ray2.80L/M21-119[»]
1G7PX-ray1.50B21-119[»]
1G7QX-ray1.60B21-119[»]
1HOCX-ray2.40B21-119[»]
1INQX-ray2.20B21-119[»]
1JPFX-ray2.18B21-119[»]
1JPGX-ray2.20B21-119[»]
1JUFX-ray2.00B21-119[»]
1K8DX-ray2.30B21-119[»]
1KBGX-ray2.20L21-119[»]
1KJ2X-ray2.71L/M21-119[»]
1KJ3X-ray2.30L/M21-119[»]
1KPUX-ray1.50B21-119[»]
1KPVX-ray1.71B21-119[»]
1L6Qmodel-B21-119[»]
1LD9X-ray2.40B/E21-119[»]
1LDPX-ray3.10L21-119[»]
1LEGX-ray1.75B21-119[»]
1LEKX-ray2.15B21-119[»]
1LK2X-ray1.35B21-119[»]
1MHCX-ray2.10B/E21-119[»]
1MWAX-ray2.40L/M21-119[»]
1N3NX-ray3.00B/D/F/H21-119[»]
1N59X-ray2.95B/D21-119[»]
1N5AX-ray2.85B/E/H/K21-119[»]
1NAMX-ray2.70L21-119[»]
1NANX-ray2.30I/P21-119[»]
1NEZX-ray2.10B21-119[»]
1OSZX-ray2.10B21-119[»]
1P1ZX-ray3.26B21-119[»]
1P4LX-ray2.90B21-119[»]
1PQZX-ray2.10B21-119[»]
1QO3X-ray2.30B21-119[»]
1RJYX-ray1.90B/E21-119[»]
1RJZX-ray2.60B/E21-119[»]
1RK0X-ray2.61B21-119[»]
1RK1X-ray2.10B21-119[»]
1S7QX-ray1.99B21-119[»]
1S7RX-ray2.95B/E21-119[»]
1S7SX-ray1.99B21-119[»]
1S7TX-ray2.30B/E21-119[»]
1S7UX-ray2.20B/E/H/K21-119[»]
1S7VX-ray2.20B/E21-119[»]
1S7WX-ray2.40B/E/H/K21-119[»]
1S7XX-ray2.41B/E/H/K21-119[»]
1T0MX-ray2.00B/E21-119[»]
1T0NX-ray1.80B/E21-119[»]
1U58X-ray1.90B21-119[»]
1VACX-ray2.50B21-119[»]
1VADX-ray2.50B21-119[»]
1WBXX-ray1.90B21-119[»]
1WBYX-ray2.30B21-119[»]
1WBZX-ray2.00B/D21-119[»]
1YN6X-ray2.20B21-119[»]
1YN7X-ray2.20B21-119[»]
1Z5LX-ray2.20B/D21-119[»]
1ZHBX-ray2.70B/E/H/K21-119[»]
1ZHNX-ray2.80B21-119[»]
1ZT1X-ray2.50B21-119[»]
1ZT7X-ray3.00B/D21-119[»]
2AKRX-ray1.90B/D21-119[»]
2CKBX-ray3.00L/M21-119[»]
2CLVX-ray1.90B/P21-119[»]
2CLZX-ray1.90B/P21-119[»]
2FIKX-ray1.80B21-119[»]
2FO4X-ray2.70B21-119[»]
2FWOX-ray2.60B21-119[»]
2GAZX-ray2.61B21-119[»]
2MHAX-ray2.50B/D21-119[»]
2OL3X-ray2.90L21-119[»]
2Q7YX-ray1.95B/D21-119[»]
2QRIX-ray2.00A/B21-119[»]
2QRSX-ray2.00A/B21-119[»]
2QRTX-ray1.80A/B21-119[»]
2VAAX-ray2.30B21-119[»]
2VABX-ray2.50B21-119[»]
2VE6X-ray2.65B/E/H/K22-119[»]
2ZOKX-ray2.10B/D/F/H21-119[»]
2ZOLX-ray2.70B/D21-119[»]
2ZSVX-ray1.80B/D21-119[»]
2ZSWX-ray2.80B/D/F/H21-119[»]
3ARBX-ray2.70B21-119[»]
3ARDX-ray3.01B21-119[»]
3AREX-ray2.80B21-119[»]
3ARFX-ray2.90B21-119[»]
3ARGX-ray3.00B21-119[»]
3AU1X-ray2.50B21-119[»]
3BUYX-ray2.60B21-119[»]
3C8KX-ray2.90B21-119[»]
3CC5X-ray1.91B/E21-119[»]
3CCHX-ray2.60B/E/H/K21-119[»]
3CH1X-ray2.30B/E/H/K21-119[»]
3CPLX-ray2.50B/D21-119[»]
3CVHX-ray2.90B/N21-119[»]
3DMMX-ray2.60B21-119[»]
3E6FX-ray2.41B22-119[»]
3E6HX-ray2.10B21-119[»]
3ECBX-ray1.70B21-119[»]
3FOLX-ray2.50B21-119[»]
3FOMX-ray2.10B21-119[»]
3FONX-ray2.03B/D21-119[»]
3FTGX-ray2.60B21-119[»]
3G08X-ray1.60B21-119[»]
3GMLX-ray1.70B21-119[»]
3GMMX-ray1.80B21-119[»]
3GMNX-ray1.70B21-119[»]
3GMOX-ray1.60B21-119[»]
3GMPX-ray1.70B21-119[»]
3GMQX-ray1.80B21-119[»]
3GMRX-ray1.90B21-119[»]
3HE6X-ray2.90B21-119[»]
3HE7X-ray2.80B21-119[»]
3ILPX-ray1.85B21-119[»]
3ILQX-ray2.05D21-119[»]
3L3HX-ray2.70B21-119[»]
3MA7X-ray2.29B/D21-119[»]
3NWMX-ray2.70A21-119[»]
3O8XX-ray2.74B21-119[»]
3O9WX-ray2.80B21-119[»]
3P4MX-ray2.50B/E21-119[»]
3P4NX-ray2.50B/E21-119[»]
3P4OX-ray2.30B/E21-119[»]
3P9LX-ray2.00B/E21-119[»]
3P9MX-ray2.00B/E21-119[»]
3PABX-ray2.20B/E21-119[»]
3PQYX-ray3.19B/G/L/Q21-119[»]
3PWUX-ray1.90B21-119[»]
3QI9X-ray2.30B21-119[»]
3QUKX-ray2.41B/E21-119[»]
3QULX-ray2.00B/E/H/K21-119[»]
3QUXX-ray2.91B21-119[»]
3QUYX-ray2.25B21-119[»]
3QUZX-ray2.30B21-119[»]
3RGVX-ray2.90D21-119[»]
3ROLX-ray2.60B/D21-119[»]
3ROOX-ray2.00B/D21-119[»]
3RTQX-ray2.80B21-119[»]
3RUGX-ray2.20B/D21-119[»]
3RZCX-ray2.80B21-119[»]
3SCMX-ray2.50B21-119[»]
3SDAX-ray2.80B21-119[»]
3SDCX-ray3.10B21-119[»]
3SDDX-ray3.00B21-119[»]
3T1FX-ray1.70B21-119[»]
3TA3X-ray2.70B21-119[»]
3TBSX-ray2.49B/E21-119[»]
3TBTX-ray2.30B/E/H/K21-119[»]
3TBVX-ray2.10B/D/F/H21-119[»]
3TBWX-ray2.15B/D/F/H21-119[»]
3TBYX-ray2.50B/E/H/K21-119[»]
3TN0X-ray3.20B21-119[»]
3TO4X-ray3.10B21-119[»]
3TVMX-ray2.80B/F21-119[»]
3UBXX-ray3.10B/E21-119[»]
3VJ6X-ray1.90B21-119[»]
3WS3X-ray2.34B/D21-119[»]
3WS6X-ray1.98C/D21-119[»]
4APQX-ray3.00B21-119[»]
4EI5X-ray3.10B/F21-119[»]
4ELMX-ray3.48B/D21-119[»]
4HS3X-ray2.10B21-119[»]
4HUUX-ray2.00B/E21-119[»]
4HUVX-ray2.50B/E21-119[»]
4HUWX-ray3.16B/D/F/H21-119[»]
4HUXX-ray2.20B21-119[»]
4HV8X-ray2.00B/D21-119[»]
4IHOX-ray2.80B/E21-119[»]
4IRJX-ray3.00B21-119[»]
4IRSX-ray2.80B21-119[»]
4L8BX-ray2.20B21-119[»]
4L8CX-ray2.80B/D/F/H21-119[»]
4L8DX-ray1.90B/D21-119[»]
4MNGX-ray3.01B/D21-119[»]
4MQ7X-ray2.60B21-119[»]
4MX7X-ray2.24B21-119[»]
4NSKX-ray2.60B21-119[»]
4PG2X-ray2.80C21-119[»]
4PG9X-ray2.40B21-119[»]
4PGBX-ray2.80B/E21-119[»]
4PGCX-ray2.30B/E21-119[»]
4PGDX-ray2.70B21-119[»]
4PGEX-ray2.00B21-119[»]
4PV8X-ray2.31B/D21-119[»]
4PV9X-ray2.00B/D21-119[»]
4Y16X-ray2.60B21-119[»]
4Y2DX-ray3.05B/F21-119[»]
4Y4FX-ray3.19B/F21-119[»]
4Y4HX-ray3.10B/F21-119[»]
4Y4KX-ray2.90B21-119[»]
4ZAKX-ray2.82B21-119[»]
4ZUSX-ray2.60B21-119[»]
4ZUTX-ray2.60B21-119[»]
4ZUUX-ray2.20B21-119[»]
4ZUVX-ray2.30B/E21-119[»]
4ZUWX-ray2.60B21-119[»]
5E8NX-ray2.25B/E/H/K21-119[»]
5E8OX-ray1.98B/E21-119[»]
5E8PX-ray2.00B/E21-119[»]
5EFIX-ray1.80B21-119[»]
5FKPX-ray1.80B21-119[»]
5IVXX-ray2.10B21-119[»]
5J6GX-ray3.30B/D21-119[»]
5J6HX-ray2.30B21-119[»]
5JWDX-ray2.50B21-119[»]
5JWEX-ray2.40B/D/F/H21-119[»]
5KD4X-ray3.05B/D21-119[»]
5KD7X-ray2.35B/D/G/J21-119[»]
5M00X-ray1.95B21-119[»]
5M02X-ray1.75B21-119[»]
5MZMX-ray2.40B/E21-119[»]
5OQFX-ray2.27A/B21-119[»]
5OQGX-ray1.90A/B21-119[»]
5OQHX-ray2.05A/B21-109[»]
5OQIX-ray2.40A/B21-119[»]
5SWSX-ray2.86B21-119[»]
5SWZX-ray2.65B/G/L/Q21-119[»]
5T7GX-ray1.96B/D21-119[»]
5TILX-ray2.83B/E21-119[»]
5TJEX-ray3.20B/D21-119[»]
5TW2X-ray1.75B21-119[»]
5TW5X-ray1.85B21-117[»]
5VCJX-ray3.16B21-119[»]
5VCLX-ray2.05B21-119[»]
5WESX-ray2.71B21-119[»]
5WETX-ray2.64B21-119[»]
5WEUX-ray1.58B21-119[»]
5WLGX-ray2.10B/G21-119[»]
5WLIX-ray2.20B/E/H/K21-119[»]
6BMHX-ray2.30B/D/F/H21-119[»]
6BMKX-ray2.43B/D21-119[»]
6BNKX-ray3.20B/F21-119[»]
6BNLX-ray2.60B/F21-119[»]
ProteinModelPortaliP01887
SMRiP01887
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198291, 3 interactors
DIPiDIP-6111N
IntActiP01887, 5 interactors
MINTiP01887
STRINGi10090.ENSMUSP00000099534

PTM databases

iPTMnetiP01887
PhosphoSitePlusiP01887

2D gel databases

SWISS-2DPAGEiP01887

Proteomic databases

EPDiP01887
PaxDbiP01887
PeptideAtlasiP01887
PRIDEiP01887

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000102476; ENSMUSP00000099534; ENSMUSG00000060802
GeneIDi12010
KEGGimmu:12010
UCSCiuc008maf.1 mouse

Organism-specific databases

CTDi567
MGIiMGI:88127 B2m

Phylogenomic databases

eggNOGiENOG410J15A Eukaryota
ENOG410YTDG LUCA
GeneTreeiENSGT00690000102227
HOGENOMiHOG000043084
HOVERGENiHBG006197
InParanoidiP01887
KOiK08055
OMAiPNFLNCY
OrthoDBiEOG091G0ZOW
TreeFamiTF334167

Enzyme and pathway databases

ReactomeiR-MMU-1236974 ER-Phagosome pathway
R-MMU-1236977 Endosomal/Vacuolar pathway
R-MMU-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-MMU-2172127 DAP12 interactions
R-MMU-2424491 DAP12 signaling
R-MMU-6798695 Neutrophil degranulation
R-MMU-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC

Miscellaneous databases

EvolutionaryTraceiP01887
PMAP-CutDBiP01887
PROiPR:P01887
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000060802 Expressed in 291 organ(s), highest expression level in spleen
CleanExiMM_B2M
GenevisibleiP01887 MM

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR015707 B2Microglobulin
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set
PANTHERiPTHR19944:SF62 PTHR19944:SF62, 1 hit
PfamiView protein in Pfam
PF07654 C1-set, 1 hit
SMARTiView protein in SMART
SM00407 IGc1, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS00290 IG_MHC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiB2MG_MOUSE
AccessioniPrimary (citable) accession number: P01887
Secondary accession number(s): Q91XJ8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: October 3, 2012
Last modified: September 12, 2018
This is version 197 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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