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Protein

Beta-2-microglobulin

Gene

B2m

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.

GO - Molecular functioni

GO - Biological processi

  • antigen processing and presentation of endogenous peptide antigen via MHC class I Source: MGI
  • antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent Source: MGI
  • cellular defense response Source: MGI
  • cellular response to iron(III) ion Source: MGI
  • cellular response to iron ion Source: MGI
  • ferric iron import Source: MGI
  • immune response Source: InterPro
  • iron ion homeostasis Source: MGI
  • iron ion transport Source: MGI
  • negative regulation of neuron projection development Source: MGI
  • negative regulation of receptor binding Source: MGI
  • positive regulation of ferrous iron binding Source: MGI
  • positive regulation of protein binding Source: MGI
  • positive regulation of receptor binding Source: MGI
  • positive regulation of receptor-mediated endocytosis Source: MGI
  • positive regulation of T cell cytokine production Source: MGI
  • positive regulation of T cell mediated cytotoxicity Source: MGI
  • positive regulation of transferrin receptor binding Source: MGI
  • protein refolding Source: MGI
  • regulation of erythrocyte differentiation Source: MGI
  • regulation of iron ion import Source: MGI
  • response to cadmium ion Source: Ensembl
  • response to drug Source: Ensembl
  • response to molecule of bacterial origin Source: MGI
  • T cell differentiation in thymus Source: MGI

Keywordsi

Biological processImmunity

Enzyme and pathway databases

ReactomeiR-MMU-1236974 ER-Phagosome pathway
R-MMU-1236977 Endosomal/Vacuolar pathway
R-MMU-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-MMU-2172127 DAP12 interactions
R-MMU-2424491 DAP12 signaling
R-MMU-6798695 Neutrophil degranulation
R-MMU-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-2-microglobulin
Gene namesi
Name:B2m
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:88127 B2m

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

MHC I, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 202 PublicationsAdd BLAST20
ChainiPRO_000001878421 – 119Beta-2-microglobulinAdd BLAST99

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi45 ↔ 100

Keywords - PTMi

Disulfide bond

Proteomic databases

EPDiP01887
PaxDbiP01887
PeptideAtlasiP01887
PRIDEiP01887

2D gel databases

SWISS-2DPAGEiP01887

PTM databases

iPTMnetiP01887
PhosphoSitePlusiP01887

Miscellaneous databases

PMAP-CutDBiP01887

Expressioni

Gene expression databases

BgeeiENSMUSG00000060802
CleanExiMM_B2M
GenevisibleiP01887 MM

Interactioni

Subunit structurei

Heterodimer of an alpha chain and a beta chain. Beta-2-microglobulin is the beta-chain of major histocompatibility complex class I molecules.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi198291, 3 interactors
DIPiDIP-6111N
IntActiP01887, 10 interactors
MINTiP01887
STRINGi10090.ENSMUSP00000099534

Structurei

Secondary structure

1119
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi26 – 33Combined sources8
Beta strandi37 – 39Combined sources3
Beta strandi41 – 53Combined sources13
Beta strandi56 – 61Combined sources6
Beta strandi64 – 66Combined sources3
Beta strandi70 – 76Combined sources7
Turni78 – 80Combined sources3
Beta strandi82 – 90Combined sources9
Beta strandi94 – 96Combined sources3
Beta strandi98 – 103Combined sources6
Beta strandi107 – 109Combined sources3
Beta strandi111 – 114Combined sources4

3D structure databases

ProteinModelPortaliP01887
SMRiP01887
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01887

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 114Ig-like C1-typeAdd BLAST90

Sequence similaritiesi

Belongs to the beta-2-microglobulin family.Curated

Keywords - Domaini

Immunoglobulin domain, Signal

Phylogenomic databases

eggNOGiENOG410J15A Eukaryota
ENOG410YTDG LUCA
GeneTreeiENSGT00690000102227
HOGENOMiHOG000043084
HOVERGENiHBG006197
InParanoidiP01887
KOiK08055
OMAiPNFLNCY
OrthoDBiEOG091G0ZOW
TreeFamiTF334167

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR015707 B2Microglobulin
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set
PANTHERiPTHR19944:SF62 PTHR19944:SF62, 1 hit
PfamiView protein in Pfam
PF07654 C1-set, 1 hit
SMARTiView protein in SMART
SM00407 IGc1, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS00290 IG_MHC, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01887-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARSVTLVFL VLVSLTGLYA IQKTPQIQVY SRHPPENGKP NILNCYVTQF
60 70 80 90 100
HPPHIEIQML KNGKKIPKVE MSDMSFSKDW SFYILAHTEF TPTETDTYAC
110
RVKHASMAEP KTVYWDRDM
Length:119
Mass (Da):13,779
Last modified:October 3, 2012 - v2
Checksum:i94F649EBCF1D7A4E
GO

Polymorphismi

The following alleles of B2M are known: A, B, W2, W3, W4 and W5 (C). The sequence shown is that of allele B.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti8V → I in allele W3. 1 Publication1
Natural varianti54H → Q in allele W4. 1 Publication1
Natural varianti64K → E in allele W3. 1 Publication1
Natural varianti101R → T in allele W2. 1 Publication1
Natural varianti105A → D in allele A. 6 Publications1
Natural varianti105A → V in allele W2, W4 and W5. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X01838 mRNA Translation: CAA25970.1
M12485 Genomic DNA No translation available.
M84363 Genomic DNA Translation: AAA39667.1
M84364 Genomic DNA Translation: AAA39668.1
M84365 Genomic DNA Translation: AAA39669.1
M84366 Genomic DNA Translation: AAA39670.1
M84367 Genomic DNA Translation: AAA39671.1
AK019389 mRNA Translation: BAB31695.1
AK028378 mRNA Translation: BAC25917.1
AK166067 mRNA Translation: BAE38551.1
AL845457 Genomic DNA Translation: CAM21783.1
CH466519 Genomic DNA Translation: EDL28084.1
BC085164 mRNA Translation: AAH85164.1
M10389 mRNA Translation: AAA39536.1
M10416 mRNA Translation: AAA39537.1
CCDSiCCDS16654.1
PIRiA90822 MGMSB2
RefSeqiNP_033865.2, NM_009735.3
UniGeneiMm.163

Genome annotation databases

EnsembliENSMUST00000102476; ENSMUSP00000099534; ENSMUSG00000060802
GeneIDi12010
KEGGimmu:12010
UCSCiuc008maf.1 mouse

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiB2MG_MOUSE
AccessioniPrimary (citable) accession number: P01887
Secondary accession number(s): Q91XJ8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: October 3, 2012
Last modified: July 18, 2018
This is version 196 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

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