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Protein

Ig mu chain C region

Gene
N/A
Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-GGA-2132263 Creation of classical C3 convertase
R-GGA-2132286 Classical antibody-mediated complement activation

Names & Taxonomyi

Protein namesi
Recommended name:
Ig mu chain C region
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000153618‹1 – 446Ig mu chain C regionAdd BLAST›446

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi16Interchain (with a light chain)PROSITE-ProRule annotation
Disulfide bondi27 ↔ 85PROSITE-ProRule annotation
Glycosylationi45N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi46N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi73N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi130N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi135 ↔ 190PROSITE-ProRule annotation
Glycosylationi198N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi237 ↔ 296PROSITE-ProRule annotation
Disulfide bondi284Interchain (with a heavy chain)PROSITE-ProRule annotation
Disulfide bondi344 ↔ 406PROSITE-ProRule annotation
Glycosylationi382N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi433N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi445Interchain (with a heavy chain)PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliP01875
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 105CH1Add BLAST105
Regioni106 – 209CH2Add BLAST104
Regioni210 – 316CH3Add BLAST107
Regioni317 – 427CH4Add BLAST111
Regioni428 – 446C-terminal regionAdd BLAST19

Keywords - Domaini

Immunoglobulin C region, Immunoglobulin domain

Phylogenomic databases

HOVERGENiHBG005814
PhylomeDBiP01875

Family and domain databases

Gene3Di2.60.40.10, 4 hits
InterProiView protein in InterPro
IPR013162 CD80_C2-set
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set
IPR013151 Immunoglobulin
PfamiView protein in Pfam
PF07654 C1-set, 2 hits
PF08205 C2-set_2, 1 hit
PF00047 ig, 1 hit
SMARTiView protein in SMART
SM00407 IGc1, 2 hits
SUPFAMiSSF48726 SSF48726, 4 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 4 hits
PS00290 IG_MHC, 3 hits

Sequencei

Sequence statusi: Complete.

P01875-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
ASASPSPPRL FPLVLCSPSD SVYTVGCAAF DFQPSSIAFT WFDSNNSSVS
60 70 80 90 100
GMDVIPKVIS GPPYRAVSRI QMNQSEGKEK QPFRCRAAHP RGNVEVSVMN
110 120 130 140 150
PGPIPTPNGI PLFVTMHPPS REDFEGPFRN ASILCQTRGR RRPTEVTWYK
160 170 180 190 200
NGSPVAAAAT TATTVGPEVV AESRISVTES EWDTGATFSC VVEGEMRNTS
210 220 230 240 250
KRMECGLEPV VQQDIAIRVI TPSFVDIFIS KSATLTCRVS NMVNADGLEV
260 270 280 290 300
SWWKEKGGKL ETALGKRVLQ SNGLYTVDGV ATVCASEWDG GDGYVCKVNH
310 320 330 340 350
PDLLFPMEEK MRKTKASNAR PPSVYVFPPP TEQLNGNQRL SVTCMAQGFN
360 370 380 390 400
PPHLFVRWMR NGEPLPQSQS VTSAPMAENP ENESYVAYSV LGVGAEEWGA
410 420 430 440
GNVYTCLVGH EALPLQLAQK SVDRASGKAS AVNVSLVLAD SAAACY
Length:446
Mass (Da):48,174
Last modified:February 1, 1991 - v2
Checksum:i3CB0CE108949BD17
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X01613 mRNA Translation: CAA25762.1
PIRiA02170 MHCH

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X01613 mRNA Translation: CAA25762.1
PIRiA02170 MHCH

3D structure databases

ProteinModelPortaliP01875
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG005814
PhylomeDBiP01875

Enzyme and pathway databases

ReactomeiR-GGA-2132263 Creation of classical C3 convertase
R-GGA-2132286 Classical antibody-mediated complement activation

Family and domain databases

Gene3Di2.60.40.10, 4 hits
InterProiView protein in InterPro
IPR013162 CD80_C2-set
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set
IPR013151 Immunoglobulin
PfamiView protein in Pfam
PF07654 C1-set, 2 hits
PF08205 C2-set_2, 1 hit
PF00047 ig, 1 hit
SMARTiView protein in SMART
SM00407 IGc1, 2 hits
SUPFAMiSSF48726 SSF48726, 4 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 4 hits
PS00290 IG_MHC, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiIGHM_CHICK
AccessioniPrimary (citable) accession number: P01875
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: February 1, 1991
Last modified: May 23, 2018
This is version 84 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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